• 제목/요약/키워드: Time projection chamber

검색결과 2건 처리시간 0.017초

Determination of the number of 235U target nuclei in the irregular target using a fission time projection chamber

  • Jiajun Zhang;Jun Xiao;Junjie Sun;Mingzhi Zhang;Taiping Peng;Pu Zheng
    • Nuclear Engineering and Technology
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    • 제56권2호
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    • pp.444-450
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    • 2024
  • Based on multiple measurements of ionization loss, the Time Projection Chamber (TPC) combines strong tracking ability with particle identification ability in a large momentum range, which is an important advantage of TPC detection technology over traditional ionization measurement technology. According to these two characteristics of TPC, applying it to the measurement of fission cross-section can greatly improve the measurement accuracy. During the measurement of the fission cross-section, the number of target nuclei is required to be accurately measured. So this paper introduces a method for measuring the number of 235U target nuclei using a fission TPC system. The measurement result agrees with the reference value, and relative error is around 1 %.

Vascular Morphometric Changes During Tumor Growth and Chemotherapy in a Murine Mammary Tumor Model Using OCT Angiography: a Preliminary Study

  • Kim, Hoonsup;Eom, Tae Joong;Kim, Jae Gwan
    • Current Optics and Photonics
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    • 제3권1호
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    • pp.54-65
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    • 2019
  • To develop a biomarker predicting tumor treatment efficacy is helpful to reduce time, medical expenditure, and efforts in oncology therapy. In clinics, microvessel density using immunohistochemistry has been proposed as an indicator that correlates with both tumor size and metastasis of cancer. In the preclinical study, we hypothesized that vascular morphometrics using optical coherence tomography angiography (OCTA) could be potential indicators to estimate the treatment efficacy of breast cancer. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber which was applied to a nude mouse, and the change in vascular morphology was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily OCTA maximum intensity projection map, multiple vessel parameters (vessel skeleton density, vessel diameter index, fractal dimension, and lacunarity) were compared with the tumor size in no tumor, treated tumor, and untreated tumor cases. Although each case has only one animal, we found that the vessel skeleton density (VSD), vessel diameter index and fractal dimension (FD) tended to be positively correlated with tumor size while lacunarity showed a partially negative correlation. Moreover, we observed that the changes in the VSD and FD are prior to the morphological change of the tumor. This feasibility study would be helpful in evaluating the tumor vascular response to treatment in preclinical settings.