• 제목/요약/키워드: Time of Concentration

검색결과 11,212건 처리시간 0.044초

혈중 목표 농도 자동 조절기(TCI) 개발 PART2: 시스템 구현 및 평가 (Development of Target-Controlled Infusion system in Plasma Concentration. PART2: Design and Evaluation)

  • 안재목
    • 대한의용생체공학회:의공학회지
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    • 제24권1호
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    • pp.45-53
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    • 2003
  • Based on the 4-compartmental pharmacokinetic model developed in PART1, target-controlled infusion(TCI) pump system was designed and evaluated. The TCI system consists of digital board including microcontroller and digital signal process(DSP), analog board, motor-driven actuator, user friendly interface, power management and controller. It provides two modes according to the drugs: plasma target concentration and effect target concentration. Anaesthetist controls the depth of anaesthesia for patients by adjusting the required concentration to maintain both plasma and effect site in drug concentration. The data estimated in DSP include infusion rate, initial load dose, and rotation number of motor encoder. During TCI operation, plasma concentration. effect site concentration, awaken concentration, context-sensitive decrement time and system error information are displayed in real time. Li-ion battery guarantees above 2 hours without power line failure. For high reliability of the system, two microprocessors were used to perform independent functions for both pharmacokinetic algorithm and motor control strategy.

수종유화제(數種乳化劑)가 Goldfish와 Rat에서 Antipyrine의 흡수(吸收)에 미치는 영향(影響) (Effect of Some Surfactants on the Absorption of Antipyrine in Goldfish and Rat)

  • 염철호;이진환
    • Journal of Pharmaceutical Investigation
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    • 제12권1호
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    • pp.23-30
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    • 1982
  • The effect of various surfactants on the absorption of antipyrine was studied using goldfish and rat. The results are as follows. The threshold concentration of antipyrine was reduced by various surfactants. Overturn time and death time of goldfish, in solution containing different concentration of antipyrine was reduced by the presence of various surfactants. Plots of reciprocal death time versus antipyrine concentration were linear with a positive concentration intercept such as minimum effective concentration. The absorption of antipyrine from rat small intestine was increased by administration with surfactants. As results, is believed to be one of rendering the goldfish membrane or rat small intestine more permeable to antipyrine.

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Al-Mg합금의 컬러에 미치는 양극산화 및 착색처리의 영향 (Effect of Anodizing and Dyeing Treatments on Coloring of Al-Mg)

  • 배성화;이현우;손인준
    • 한국표면공학회지
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    • 제52권1호
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    • pp.30-36
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    • 2019
  • In this study, we investigated the effects of anodizing time, dyeing treatment time, and variations in coloring concentration on the color of an AA5052 alloy processed by dye-treated anodizing. The outward color of the anodized film changed to deep red according to increases in anodizing time, dyeing treatment time, and coloring concentration; accordingly, lightness $L^*$ decreased and saturation $a^*$ and $b^*$ increased. The concentration of the dye and the UV-visible absorbance showed a nearly perfect linear relationship, allowing a quantitative analysis of the absorbed dye. Because the quantity of absorbed dye increased as anodizing time, dyeing treatment time, and coloring concentration increased, the outward color of the anodized film deepened. In addition, from the GD-OES depth profile, we found that the dye was preferentially absorbed on the surface of the porous anodized film.

마우스 비장세포에서의 Polychlorinated Biphenyls(Aroclor 1234)의 면역 독성 (Immunotoxicity of Polychlorinated Biphenyls (Aroclor 1254) in Mouse Splenocytes)

  • 반상자;안광수;김주환;임종준;김수연;기미경;이명숙;조수열;김영훈
    • Toxicological Research
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    • 제19권4호
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    • pp.277-283
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    • 2003
  • Polychlorinated biphenyls (PCBs) has been widely used as plasticizer, insulator, lubricant, paint and ink. The persistence of PCBs in the environment and their bioaccumulation in living organism make a raise concerns regarding their toxic effects in immune system and subsequent effects on human health. However little has been known about effect of PCB, an endocrine disrupter, on splenocytes. In this study, for identifying the effect on the organs and immune cell of mice by the concentration and time of commercial PCB mixture (Aroclor 1254), each 3 mice were tested at the concentration of 3, 30, 300, 1,000 mg/kg respectively, and their organ's weight were measured in 4, 7, 14 days, respectively. Also according to concentration and time, PCB was evaluated for the effects on splenocyte viability and lipopolysaccaride (LPS) and concanavaline A (Con A)-induced splenocyte proliferation on mice spleen. In liver and lung, there were significantly defferent by concentration and time of PCB (p < 0.0001). In respect of concentration of PCB, no significant effects on mice's liver by Aroclor 1254 concentration below than 300 mg/kg were observed except at the concentration of 1,000 mg/kg doses (p < 0.0001). But there was not significant different change in mice spleen by concentration and time of PCB (p=0.2206) and the mode of weight change of spleen was different to of liver and of lung. Viabilities of splenocytes were decreased following treatment with high concentration of PCB. Also, LPS and Con A-induced cell proliferations were decreased by Aroclor 1254 at 1,000 mg/kg. These data suggest that Aroclor 1254 is the immunotoxic compound that may have an effect on mouse immune system.

황산구리를 이용한 면/폴리에스터 교직물의 탄화가공 (Burn-out Finishing of Cotton/Polyester Fiber Mixed Fabrics using Cupric Sulfate)

  • 김수미;송화순
    • 대한가정학회지
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    • 제42권8호
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    • pp.113-121
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    • 2004
  • This study used cupric sulfate as a bum-out agent. The concentration of cupric sulfate, temperature and time were varied with glycerin included or excluded on the properties of polyester ground fabrics. The results are as follows. The effect of carbonization with glycerin included was decreased, but removal of carbide with glycerin included was easier than that with glycerin excluded. The white index and tensile strength of polyester ground fabrics were decreased as the processing concentration, temperature and time increased. The shrinkage was increased as the processing concentration, temperature and time increased. The optimum conditions with cupric sulfate as the bum-out agent was 5% concentration, 140$^{\circ}C$, 3min., and 3kgf/cm$^2$ and with cupric sulfate added to glycerin was 5% concentration, 150$^{\circ}C$, 5min., and 3kgf/cm$^2$.

생성메카니즘에 따른 부유분진 등 입자상 nitrate 농도 (Concentration of Particulate Nitrate Classified by Formation Mechanism in Seoul Ambient Air)

  • 천만영;김희강
    • 한국대기환경학회지
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    • 제11권1호
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    • pp.37-44
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    • 1995
  • Concentration of particulate nitrate classified by formation mechanism and particle diameter in ambient air was determined from Feb. to Oct. 1993. Sampling was carried out using a two-stage Andersen air sampler at the top of a five-story building located at Kon-Kuk University in seoul. Concentration of N $H_{4}$N $O_{3}$ in TSP was measured by pyrolysis of sample filters at 160.deg.C for 1hr. concentration of N $H_{4}$N $O_{3}$ was higher in winter time compared with that in summmer time. Also, concentration of N $H_{4}$N $O_{3}$ was higher in fine particles compared with that in coarse particle. The range of N $H_{4}$N $O_{3}$ concentration was between 2.9 and 9.9.mu.g/ $m^{3}$. Weight fraction of N $H_{4}$N $O_{3}$ in total particulate nitrate was 31.1 .sim. 59.5%, and weight fraction of N $H_{4}$N $O_{3}$ in TSP was 2.1 .sim. 11.2%. Concentration of NaN $O_{3}$, which originated from sea salt, was highest in spring time and lowest in summer time,and the concentration range was between 0.1 and 0.7.mu.g/ $m^{3}$. NaN $O_{3}$/TSP ratio was very low (0.1 .sim. 0.4%) indicating that the portion of NaN $O_{3}$in TSP was negligible. Concentration of particulate nitrate originated from soil was 2.4 .sim. 2.9.mu.g/ $m^{3}$. Weight fraction of that in total particulate nitrate was 14.0 .sim. 37.1%.

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공단지역내 이산화질소농도에 관한 연구 (A Study of Nitrogen Dioxide Concentration in Industrial Areas)

  • 손부순;김우재;김윤신
    • 환경위생공학
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    • 제16권3호
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    • pp.42-53
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    • 2001
  • This study were conducted to estimate property of nitrogen dioxide concentration at industrial areas in Korea. The nitrogen dioxide concentrations were measured for 50 dwellings at Ulsan and Yeochon, respectively using the nitrogen dioxide filter badge forming the passive sampler from summer time 1998 to winter time 1999. The major results obtained from this study were as follows: 1. The mean indoor, outdoor, and personal concentrations of nitrogen dioxide during summer time 1998 in Ulsan were 28.9 ppb, 24.8 ppb, 24.8 pub, respectively. 2. The mean indoor, outdoor, and personal concentrations of nitrogen dioxide during winter time 1999 in Yeochon were 11.4 ppb, 12.5 ppb, 15.5 ppb, respectively. 3. The mean concentration of nitrogen dioxide during winter time 1998 were higher than the corresponding levels during summer time 1997 in Ulsan. 4. The mean concentration of nitrogen dioxide in Ulsan were in general higher than the corresponding levels in Yeochon. 5. This results in slightly positive correlation among indoor, outdoor, and personal nitrogen dioxide concentrations for summer time in Ulsan, then it statistical significance is showed(p <.05). These results suggest that nitrogen dioxide concentrations in industrial areas seem to be affected by traffic density and conditions of industrialization.

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소 동결분할배의 생존선에 영향을 미치는 요인에 관한 연구 (Studies on the Factors Influencing Survival Rates of Frozen Bovine Demi-Embryos)

  • 김상근;남윤이;이만휘;현병화
    • 한국가축번식학회지
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    • 제21권3호
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    • pp.287-292
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    • 1997
  • This study was carried out to investigate the effects of concentration and kinds of cryoprotectants, equilibraction time, thawing temperature and time, sucrose concentration on the survival rates of frozen bovine demi-embryos. The bovine demi-embryos following dehydration by cryoprotectants a various concentration of sucrose were freezed by cell freezer and thawed in 3$0^{\circ}C$ water bath. Survival and in vitro developmental rates was defined as development rates on in vitro culture or FDA-test. The results are summarized as follows : 1. The high survival rates of demi-embryos after frozen-thawing in freezing medium was attained 2.0M glycerol. The high survival rates of demi-embryos after frozen-thawing in freezing medium was obtained using single cryoprotectant(25.0~30.0%) than mixed cryoprotectants(16.7~19.0%). 2. The survival rates of demi-embryos after frozen-thawing in freezing medium added 1.5M, 2.0M glycerol+0.25M sucrose(37.5~33.3%) were higher survival rates than those of sucrose concentration of 0.50, 0.75M(12.5~26.7%). 3. The equilibration time on the survival rates of demi-embryos was attained after short period of time(30.0~35.0%) in the freezing medium higher than long period of time(21.1%). 4. The thawing temperature on the survival rates of demi-embryos was attained at 3$0^{\circ}C$ of thawing temperature(26.7~40.0%) higher than $25^{\circ}C$ or 37$^{\circ}C$ of thawing temperature(13.3~20.0%). 5. The thawing time on the survival rates of demi-embryos was attained at 1~5 minutes of thawing time(26.7~33.3%) in the freezing medium higher than 10 minutes of thawing time(13.3~18.8%).

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주택에 설치한 온돌 마루 및 붙박이 가구에서 발생하는 휘발성유기화합물의 농도 감소 예측 (Prediction of Concentration Decay of Volatile Organic Compounds from Ondol Floor and Furniture)

  • 조현;방승기;백용규;손장열
    • KIEAE Journal
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    • 제5권1호
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    • pp.51-57
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    • 2005
  • In this study, time-dependent concentration variations of VOCs from fixed furniture and Ondol floor widely used as finishing material of the floor were measured, and prediction equations were developed based on the measured results. VOCs were measured and analyzed based on EPA TO-17 and NIOSH 1500, 1501 method respectively, and GC/FID were used for the analysis of VOCs concentration. Measurements were carried out for 10 days after the installation of furniture and for 40 days after the installation of the floor in the residence constructed more than 10 years ago. In both case of floor and furniture installation, time-dependent concentration decay of VOCs can be properly converted into logarithmic scale. Especially in case of furniture, toluene showed the highest concentration and took longest time to decay. As a result of the prediction of VOCs concentration decay under different air change rate using estimated equations, concentration decay rate of indoor VOCs increased rapidly as the air change rate also increased.

유동층 연소로에서 유$cdot$무연탄 혼합 연소시 대기오염물질 배출에 관한 연구 (A Study on Contaminant Emission and Combustion of Anthracite-Bituminous Coal Blend in a Fluidized Bed Coal Combustor)

  • 조상원;정종현;손병현;김영식;오광중
    • 한국환경보건학회지
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    • 제22권3호
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    • pp.28-36
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    • 1996
  • The objects of this study were to investigate emissions of air pollutant the particles as well as the combustibility of the low grade domestic anthracite coal and imported high-calorific bituminous coal in the fluidized bed coal combustor. The production of air pollution from anthracite-bituminous coal blend combustion in a fluidized bed coal combustor was evaluated. The effects of air velocity and anthracite fraction on the reaching time of steady state condition was also evaluated. We used coal samples the domestic low grade anthracite coal with heating value of 2,010 kcal/kg and the imported high grade bituminous coal with heating value of 6,520 kcal/kg. The experimental results are presented as follows. The time of reaching to steady state was affected by the temperature variation. The steady state time was about 120 minute at 0.3 m/s which was the fastest. It has been found that $O_2$ and $CO_2$ concentration were reached steady state at about 100 minute. As the height of fluidized bed becomes higher, the concentration s of $SO_2$ and $NO_x$ mainly increased. The concentration of freeboard was the highest and emission concentration was diminished. Also, as anthracite fraction increased, the emission of $SO_x$ concentration was increased. But, it has been found that the variation of $NO_x$ concentration with anthracite fraction was negligible and the difference of emission concentration according to air flow rates was negligible, too. It has been found that $O_2$ concentration decreased and $CO_2$ concentration increased as the height of fluidized bed increased. As anthracite fraction increased, the mass of elutriation particles increased, and $CO_2$ concentration decreased. Also, as air velocity increased, $O_2$ concentration decreased and $CO_2$ concentration increased. Regardless-of anthracite fraction and flow rate, the combustible weight percentage in elutriation particles were high in the case of fine particles.

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