• Proceedings of the Korean Society of Applied Pharmacology
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• 2005.04a
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• pp.5-14
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• 2005

Recently, data from several groups have raised the concept of 'checkpoint' in transcription. As capping of nascent RNA transcript is tightly coupled to RNA polymerase II transcription, we seek to obtain direct evidence that transcripiton checkpoint via capping enzyme functions in this early regulatory step. One of temperature sensitive (ts) alleles of ceg1, a guanylyltransferase subunit of the Saccharomyces cerevisiaecapping enzyme, showed 6-azauracil (6AU) sensitivity at the permissive growth temperature, which is a phenotype that is correlated with a transcription elongational defect. This ts allele, ceg1-63 also has an impaired ability to induce PUR5 in response to a 6AU treatment. However, this cellular and molecular defect is not due to the preferential degradation of the transcript attributed from a lack of guanylyltransferase activity. On the contrary, the data suggests that the guanylyltransferase subunit of the capping enzyme plays a role in transcription elongation. First, in addition to the 6AU sensitivity, ceg1-63is synthetically lethal with elongation defective mutations of the largest subunit of RNA polymerase II. Secondly, it exhibited a lower GAL1 mRNA turn-over after glucoseshut off. Third, it decreased the transcription read through a tandem array of promoter proximal pause sites in an orientation dependent manner. Interestingly, this mutant also showed lower pass through a pause site located further downstream of the promoter. Taken together, these results suggest that the capping enzyme plays the role of an early transcription checkpoint possibly in the step of the reversion of repression by stimulating polymerase to escape from the promoter proximal arrest once RNA becomes appropriately capped.

• Journal of Intelligence and Information Systems
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• v.5 no.1
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• pp.13-34
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• 1999

Building a knowledge base effectively has been an important research area in the expert systems field. A variety of approaches have been studied including rules, semantic networks, and frames to represent the knowledge base for expert systems. As the size and complexity of the knowledge base get larger and more complicated, the integration of knowledge based with database technology cecomes more important to process the large amount of data. However, relational database management systems show many limitations in handing the complicated human knowledge due to its simple two dimensional table structure. In this paper, we propose Object-Oriented Knowledge Store (OOKS), a knowledge base model on the basis of a frame sturcture using an object-oriented database. In the proposed model, managing rules for inferencing and facts about objects in one uniform structure, knowledge and data can be tightly coupled and the performance of reasoning can be improved. For building a knowledge base, a knowledge script file representing rules and facts is used and the script file is transferred into a frame structure in database systems. Specifically, designing a frame structure in the database model as it is, it can facilitate management and utilization of knowledge in expert systems. To test the appropriateness of the proposed knowledge base model, a prototype system has been developed using a commercial ODBMS called ObjectStore and C++ programming language.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.11b
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• pp.122-127
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• 2002

A frequency-domain PES estimation and its prediction method are proposed for the tightly-coupled servo/mechanical design of high-TPI HDD system above 100 kTPI. The major two disturbance energies which are related with mechanical vibrations inside of HDD are used to predict the drive-level PES, while considering closed-loop servo dynamics. One is the torque disturbance which mainly comes from aerodynamic excitation of HSA system and the other is the displacement disturbance from disk-spindle dynamics. In order to obtain the accurate error transfer function of closed-loop servo control, the plant model is measured by accurate experiment. The measured PES is compared with predicted one in terms of frequency-domain PES spectrum and its standard variation value. It is proved that the proposed frequency-domain PES estimation/prediction method is capable of predicting drive-level PES of high-TPI hard disk drive.

• Journal of Institute of Control, Robotics and Systems
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• v.12 no.2
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• pp.174-185
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• 2006

This paper describes a DR construction for land navigation and the sigma point based receding horizon Kalman FIR (SPRHKF) filter for DR/GPS hybrid navigation system. A simple DR construction is adopted to improve the performance both of the pure DR navigation and the DR/GSP hybrid navigation system. In order to overcome the flaws of the EKF, the SPKF is merged with the receding horizon strategy. This filter has several advantages over the EKF, the SPKF, and the RHKF filter. The advantages include the robustness to the system model uncertainty, the initial estimation error, temporary unknown bias, and etc. The computational burden is reduced. Especially, the proposed filter works well even in the case of exiting the unmodeled random walk of the inertial sensors, which can be occurred in the MEMS inertial sensors by temperature variation. Therefore, the SPRHKF filter can provide the navigation information with good quality in the DR/GPS hybrid navigation system for land navigation seamlessly.

• The Transactions of the Korea Information Processing Society
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• v.2 no.2
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• pp.168-175
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• 1995

It has been commonly accepted for a while that a successful tool environment must provide for smooth interfaces between its tools. Recent integrated CASE environment must be-based on well-integrated data repository which supports a tightly coupled, consistent environment. For the maintenance tool, it requires a careful design of the maintenance chest's database. Information about a program exists in many different forms after analyses have been performed. It must be possible to associate and select objects for data repository from this information as necessary. This paper suggests a new integrated scheme for the data repository in building software maintenancec environment. The scheme provides many basic services, including storage and management of objects/entities and links/ relations; version and configuration control, query service, data interchange service.

• Journal of the Korea Society of Computer and Information
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• v.16 no.4
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• pp.43-52
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• 2011

With the rapid development of technology, skyscrapers are widely spread and they are tightly coupled. If fire occurs in a building, it is easily spread to neighboring buildings, resulting in the large number of victims and property damages. To remove fire disasters, the need for early fire detection techniques is increasing. To detect fire, detecting devices for heat, smoke, and flame have been used widely. However, this paper surveys and presents the latest research which focuses on early smoke and flame detection algorithms and systems with camera's input images. In addition, this paper implements and evaluates the performance of these flame and smoke detection algorithms with several types of movies.

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.8
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• pp.810-816
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• 2007

A security robot system named EGIS-SR is a mobile security robot through one of the new growth engine project in robotic industries. It allows home surveillance through an autonomous mobile platform using onboard cameras and wireless security sensors. EGIS-SR has many sensors to allow autonomous navigation, hierarchical control architecture to handle lots of situations in monitoring home surveillance and mighty networks to achieve unmanned security services. EGIS-SR is tightly coupled with a networked security environment, where the information of the robot is remotely connected with the remote cockpit and patrol man. It achieved an intelligent unmanned security service. The robot is a two-wheeled mobile robot and has casters and suspension to overcome a doorsill. The dynamic motion is verified through $ADAMS^{TM}$ simulation. For the main controller, PXA270 based hardware platform based on linux kernel 2.6 is developed. In the linux platform, data handling for various sensors and the localization algorithm are performed. Also, a local path planning algorithm for object avoidance with ultrasonic sensors and localization using $StarGazer^{TM}$ is developed. Finally, for the automatic charging, a docking algorithm with infrared ray system is implemented.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2000.11a
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• pp.83-85
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• 2000

A lot of microbial genome sequencing projects is being done in many genome centers around the world, since the first genome, Haemophilus influenzae, was sequenced in 1995. The deluge of microbial genome sequence data demands new and highly automatic data flow system in order for genome researchers to manage and analyze their own bulky sequence data from low-level to high-level. In such an aspect, we developed the automatic data management system for microbial genome projects, which consists mainly of local database, analysis programs, and user-friendly interface. We designed and implemented the local database for large-scale sequencing projects, which makes systematic and consistent data management and retrieval possible and is tightly coupled with analysis programs and web-based user interface, That is, parsing and storage of the results of analysis programs in local database is possible and user can retrieve the data in any level of data process by means of web-based graphical user interface. Contig assembly, homology search, and ORF prediction, which are essential in genome projects, make analysis programs in our system. All but Contig assembly program are open as public domain. These programs are connected with each other by means of a lot of utility programs. As a result, this system will maximize the efficiency in cost and time in genome research.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.11B
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• pp.1216-1224
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• 2009

This paper presents cross-layer based packet scheduling and routing algorithm to effectively transmit delay-sensitive multimedia data over mobile ad hoc network. At first, packet urgency, node urgency, and route urgency are defined based on the end-to-end delay requirement of each packet and the number of hops over a route. Based on the urgency metric, the proposed transmission scheme is that packet scheduling algorithm at the MAC layer and routing algorithm at the network layer are tightly-coupled to improve the transmission performance for delay-sensitive multimedia. Finally, simulation results are provided to show the performance of proposed transmission scheme.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.2
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• pp.288-299
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• 1993

This paper proposes the new bus protocol in the tightly coupled multiprocessor system. The bus protocol uses the pipelined data transfer and block transfer scheme to increase the bus bandwidth, The bus also has the independent transfer lines for the address and data respectively, and it can transfer the data up to maximum 264 Mbytes /sec. This paper also models the multiprocessor system where each processor boards have the private cache. Simulation evaluates the bus and system performance according to hit ratio of the reference data in cache memory, In the case of using this bus, the bus is evaluated not to be saturated when up to 10 processor boards are connected to the bus. As for up to 4 memory interleavng, the performance increases linearly.