• 대한정형외과학회지
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• 제56권5호
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• pp.404-412
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• 2021

목적: 슬관절 내측 구획 골관절염으로 근위 경골 절골술 및 미세 골절술을 함께 시행한 환자 군에서 이차적 관절경 검사를 시행하여 연골 재생 정도를 평가하고 연골 재생에 영향을 미치는 요인을 규명하고자 한다. 또한 연골 재생의 정도와 기능적 결과가 연관성이 있는지 분석하고자 한다. 대상 및 방법: 2007년부터 2015년까지 근위 경골 절골술 및 미세 골절술을 함께 시행하였고, 최소 2년이 지나 금속판 제거술 및 이차 관절경 검사까지 시행 받은 81예를 대상으로 하였다. 술 전 대퇴부 연골 손상의 정도는 ICRS (International Cartilage Research Society) 분류를 이용하였고, 모두 grade III, IV 였다. 이차적 관절경 검사 이후에는 연골 재생이 양호한 그룹(grade I, II)과 불량한 그룹(grade III, IV)으로 분류하였다. 다변량 로지스틱 회기 분석을 통하여 연골 재생에 영향을 미치는 독립적인 요인을 파악하였다. 또한 두 그룹간의 수술 전후에 Knee Society score (KSS)와 Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC)를 이용하여 기능적 결과를 비교하였다. 결과: 연령, 성별, 체질량 지수, 술 전후 방사선학적 요인, 술 전 관절의 상태는 연골 재생의 정도에 유의한 영향을 끼치지 않았으며, 큰 연골 병변 범위(≥2.0 cm²) (p=0.011)와 키스 병변(kissing lesion)의 존재(p=0.027)는 불량한 연골 재생과 연관성이 있었다. KSS와 WOMAC 점수상에서는 연골의 재생이 양호한 그룹과 불량한 그룹 간의 유의한 차이는 없었다. 결론: 큰 연골 병변과 키스 병변의 존재는 근위 경골 절골술 및 미세 골절술 후 불량한 연골 재생과 관계가 있었다. 하지만 재생된 연골의 상태는 기능적 결과와 연관성을 보이지 않았다.

• 대한골관절종양학회지
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• 제6권2호
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• pp.106-111
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• 2000

국소적 섬유연골성 이형성증(FFCD)은 소아에서 일측성 경골 내반 소견을 보이는 드문 양성 질환이다. FFCD는 근위 경골 내측 골간단과 골간의 이행부에 오목한 방사선 투과 음영 소견을 보이는 전형적인 방사선 소견을 지니고 있다. 경골 내반이 병변 부위에서 발생한다. 내반의 교정과 골결손의 치유가 흔히 자발적으로 일어나기도 하지만 골교정술을 요하기도 한다. 저자들은 절제 조직 생검술로 진단하고 절골술 및 골이식술을 시행함으로써 치유한 FFCD에 의한 일측성 경골 내반 1예를 문헌고찰과 함께 보고하는 바이다.

• Archives of Reconstructive Microsurgery
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• 제6권1호
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• pp.63-72
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• 1997

We have evaluated the clinical results following the 46 cases of free vascularized osteocutaneous fibular flap transfer to the tibial defect combined with skin and soft tissue defect, which were performed from May 1982 to January 1997. Regarding to the operation, flap size, length of the grafted fibula, anastomosed vessels, ischemic time of the flap and total operation time were measured. After the operation, time to union of grafted fibula and the amount of hypertrophy of grafted fibula were periodically measured through the serial X-ray follow-up and also the complications and results of treatment were evaluated. In the 46 consecutive procedures of free vascularized osteocutaneous fibular flap transfer, initial bony union were obtained in the 43 grafted fibulas at average 3.75 months after the operation. There were 2 cases in delayed unions and 1 in nonunion. 44 cutaneous flaps among the 46 cases were survived but 2 cases were necrotized due to deep infection and venous insufficiency. One necrotized flap was treated with latissimus dorsi free flap transfer and the other was treated with soleus muscle rotational flap. Grafted fibulas have been hypertrophied during the follow-up periods. The fracture of grafted fibula(15 cases) was the most common complication and occurred at average 9.7 months after the operation. The fractured fibulas were treated with the cast immobilization or internal fixation with conventional cancellous bone graft. In the cases of tibia and fibula fracture at recipient site, the initial rigid fixation for the fibula fracture at recipient site could prevent the fracture of grafted fibula to the tibia.

• Journal of Periodontal and Implant Science
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• 제31권2호
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• pp.299-315
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• 2001

Application of membranes for guided tissue regeneration(GTR) have been confined to the subgingival barrier functions; however, many studies have provided evidence that some drugs, including tetracycline, initially can promote the growth of periodontal ligament or alveolar bone in peridontal therapy. Osseous regeneration in periodontal defects is increased by local administration of tetracycline due to its anti-collagenolytic effect, which enhances bone-forming ability via osteoblast cell chemotaxis and reduced bone resorption. The aim of this study was to evaluate effects of tetracycline loaded poly-L-lactide(PLLA) barrier membranes for guided bone regenerative potential. Tetracycline was incorporated into the PLLA membrane with the ratio 10% to PLLA by weight. Ability to guided bone regeneration of the membranes were tested by measuring new bone in the tibial defects($7{\times}10{\times}5\;mm^3$) of the beagle dog for 4,5, and 6 weeks. In control, drug-unloaded PLLA membranes were used in same size of defect. In histologic finding of the defect area, a few inflammatory cells were observed in both groups. These membrane were not perforated by connective tissue and maintained their mechanical integrity for the barrier function for 4-6 weeks. New bone formation was greater in defects covered by tetracycline-loaded membrane than in defects covered by drug- unloaded membranes. In bone regeneration guiding potential test, tetracycline-loaded membrane was more effective than drug- unloaded membranes(p<0.05). These results suggest that tetracycline-loaded PLLA membranes potentially enhance guided bone regenerative efficacy and might be a useful barrier for GTR in periodontal treatment.

• Investigative Magnetic Resonance Imaging
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• 제21권3호
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• pp.187-191
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• 2017

Bone marrow aspirates concentrate (BMAC) transplantation is a well-known technique for cartilage regeneration with good clinical outcomes for symptoms in patients with osteoarthritis (OA). Magnetic resonance imaging (MRI) has an important role in evaluating the degree of cartilage repair in cartilage regeneration therapy instead of a second assessment via an arthroscopy. We experienced a case of hypertrophic regeneration of the cartilage and a presumed simultaneous regeneration of the posterior horn of the lateral meniscus after BMAC transplantation for a cartilage defect at the lateral tibial and femoral condyle. This report provides the details of a case of an unusual treatment response after a BMAC transplant. This report is the first of its kind to demonstrate a MR image that displays the simultaneous regeneration of the cartilage and meniscus with a differentiation ability of the mesenchymal stem cell to the desired cell lineage.

• Archives of Reconstructive Microsurgery
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• 제17권1호
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• pp.7-13
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• 2008

Popliteal artery injury in blunt trauma of knee joint is not common but poses high rate of amputation due to anatomical characteristics or delayed diagnosis and treatment. The aim of the present study is to review the authors' experiences with this condition and identify factors contributing to disability. We reviewed 7 cases of popliteal artery injury in trauma around knee. Injury mechanism, type of vessel damage, associated injuries, mangled extremity severity scores (MESS), ischemic time and additional treatments were analyzed. Tibial fracture, distal femoral fracture and serious soft tissue defect were combined. Mean MESS was 9.9 point and mean time of revascularization was 7.1 hours. Transfemoral amputation was performed in 2 cases due to vascular insufficiency and devastating infection, and 4 patients were able to walk without any support at the last follow up. Age, the severity of soft tissue injury, ischemic time and MESS are thought to be related to prognosis, and young patients with short ischemic time show best results, but authors experienced one exceptional case. We have to consider multiple factors related to the prognosis in popliteal artery injury with fractures around knee, and careful decision is needed regarding to early amputation.

• 대한관절경학회지
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• 제7권2호
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• pp.183-188
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• 2003

목적 : 전방 십자 인대 재 재건술 시행시 자가 슬괵건을 이식건으로 사용하고 대퇴 및 경골 터널은 이중으로 고정하는 방법으로 시행하여 그 치료 결과를 보고하고자 한다. 대상 및 방법 : 2000년 5월부터 2002년 7월까지 슬괵건을 이용한 전방 십자 인대 재 재건술을 시행 받고 1년이상 추시가 가능하였던 6예를 대상으로 하였다. 6예 모두 남자였으며 평균 연령은 28.3세였다. 1차 재건술 후 재 재건술까지 기간은 평균 28.9개월이었으며 재 재건술 전까지 평균 수술 횟수는 1.7회였다. 슬괵건은 네 겹으로 준비하여 이용하였으며 기존 대퇴 터널이 재 재건술에 영향을 주는 경우 대퇴 터널을 40 mm 깊이로 만들고 횡고정 핀 고정후 흡수성 간섭 나사로 이중 고정하였다. 경골 터널은 Intrafix로 고정하였고 기존 터널의 영향이 있는 경우 screw-washe로 이중 고정하였다. 술후 평가는 Lysholm 점수, IKDC (International Knee Documentation Committee) 평가 기준, KT-2000 관절계를 이용하여 평가하였다. 결과 : 최종 추시상 Lysholm 점수는 술전 77.2점에서 술후 87.7점으로 호전되었고 IKDC 평가 기준상 술전 B 1예, C 4예, D 1예에서 술후 A 1예, B 4예, C 1예로 5예$(83\%)$에서 B이상의 결과를 보였다. KT-2000 관절계를 이용한 최대 도수 부하 검사상 술전 평균 4.5 mm에서 술후 1.8 mm로 호전되었다. 결론 : 전방 십자 인대 재 재건술시 슬괵건은 좋은 이식물로 사료되며, 수술시 기존 터널의 영향이 있는 경우 이중 고정 방법은 좋은 방법으로 사료된다.

• 한국임상수의학회지
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• 제19권1호
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• pp.66-72
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• 2002

Korean safflower seed has been known to have healing effects on both bone fracture and osteoporosis. On the base of such a notice, this experiment was carried out to explore the effects of safflower seed on bone formation and bone repair. The toxicity test and the effect of Korean safflower seed were evaluated with 60 rats, 3-month old. Forty Sprague-Dawley rats composed of 20 male and 20 female were underwent unilateral tibial defect and then fastened with unilateral fixators. The operated rats were divided into two groups depending on the composition of diet, such as positive control group fed normal diet(C-OP group) and safflower seed group fed 30% of safflower seed diet and 70% of normal diet(S-OP group). Another 20 rats without operation were maintained, each 10 rats were fed either normal diet or 30% of safflower seed diet and 70% of normal diet, and observed the toxicity of safflower seed by measuring weight and urine parameters. Postoperative radiography were taken once in 2 weeks to evaluate callus formation for operated groups and blood collection via heart puncture were carried out once in 3 weeks for 3 groups. The concentration of Ca and Pi in serum were measured using both auto Kit and $^{31}$ P Nuclear Magnetic Resonance(NMR). At present study, no toxic effect was observed from both weight increment and urine index after feeding the safflower seed diet. The comparison of the radiography between C-OP and S-OP group were showed that the safflower seed diet appeared to stimulate the formation of callus in the rat. The ratio of Ca/P in serum was low in S-OP group compared to C-OP group with the auto Kit, but there were no significant differences between two groups (p < 0.05). In addition, the variations of Pi values in NMR examination were also confirmed based on the result of auto Kit. In conclusion, this study implied that safflower seed might influence to bone formation and shorten the periods of remedy by stimulating the calcification of bone

• Archives of Reconstructive Microsurgery
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• 제7권1호
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• pp.54-61
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• 1998

Free vascularized fibular is the most usuful bony donor of the long bone reconstruction in reconstructive microsurgical field. It has many benifits such as very strong strut tubular bone, very reliable vascular anatomy with large vascular diameter with long pedicle, minimal donor site morbity too. In that situations of the huge long bone defects in distal femur or proximal tibia, the defective bony shape and strength of the transplanted fibular bone is not enough if only one strut of the fibula is transfered. The bony circulation of the fibula has two ways, one from nutrient artery via peroneal artery through nutrient foramen which makes endosteal arterial network inside of the fibula, another way is periosteal network through outside encircling vascular network of the bone which distributed in muscle sleeves of the fibular diaphysis. Authors modified free vascularized fibular bone graft with transverse osteotomy is made from the anterolateral aspect of the fibular shaft just distal to entry of the nutrient artery. This produces two vascularized bone struts that may be folded pararell to each other but that remain connected by the periosteum and muscle cuff surrounding the peroneal artery and veins. The proximal strut is vascularized by both a periosteal and endosteal blood supply, whereas the distal strut is vascularized by a periosteal blood supply alone. This procedure can call "doule barrel" free vascularized fibular graft. We performed 7 cases of doule barrel fashined fibular transplantation on distal femur and proximal tibial large defects. Average bone union time takes 7 months from that procedure. There were no significant bone union time differences between both proximal and distal struts. After solid union of the transfered double barrel fibular graft, there were no stress fracture in our series. We can propose double barrel free vascualized fibular graft is usuful method in that cases with very large bone defect on large long bones especially metaphyseal defects.

• Archives of Plastic Surgery
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• 제50권5호
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• pp.507-513
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• 2023

Background Free tissue transfer is considered the gold standard option for the reconstruction of distal leg defects. Free tissue transfer using recipient vessels in the contralateral leg (cross-leg bridge) is a potential option to supply the flap if there are no suitable recipient vessels in the injured leg. Most studies have described this technique using end-to-end anastomosis which sacrifices the main vessel in the uninjured leg. This study evaluated the use of a cross-leg free latissimus dorsi muscle flap for the reconstruction of defects in single-vessel legs, using end-to-side anastomosis to recipient vessels in the contralateral leg without sacrificing any vessel in the uninjured leg. Methods This is a retrospective study that included 22 consecutive patients with soft tissue defects over the lower leg. All the reconstructed legs had a single artery as documented by CT angiography. All patients underwent cross-leg free latissimus dorsi muscle flap using end-to-side anastomosis to the posterior tibial vessels of the contralateral leg. Results The age at surgery ranged from 12 to 31 years and the mean defect size was 86 cm². Complete flap survival occurred in 20 cases (91%). One patient had total flap ischemia. Another patient had distal flap ischemia. Conclusion Cross-leg free latissimus dorsi muscle flap is a reliable and safe technique for the reconstruction and salvage of mutilating leg injuries, especially in cases of leg injuries with a single artery. As far as preservation of the donor limb circulation is concerned, end-to-side anastomosis is a reasonable option as it maintains the continuity of the donor leg vessels.