• Journal of Chest Surgery
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• 제34권12호
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• pp.964-967
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• 2001

흉선 과증식증은 소아에서 아주 드물게 발생하는 질환으로써 우리나라에서는 아직 보고례가 없다. 환자는 2살된 남아로 잦은 기침과 객담을 주소로 입원 후 시행한 혈액검사상 림프구 수가 55%로 증가돼있는 소견외에는 정상이었으며 흉부 단순촬영 및 흉부 단층 촬영상 우측 전중격등에 5$\times$10cm 크기의 종괴가 발견되었다. 정중 흉골절개를 통한 종괴 적출술을 시행하였다. 적출된 종괴는 180mg이었고 조직검사상 정상 흉선구조를 유지하고 있는 등 흉선 과증식증에 합당한 소견을 보였다. 환자는 술후 별다른 합병증 없이 회복된후 2년이 지난 현재까지 정상생활을 영위하고 있다. 이에 저자들은 소아에서 발생하는 흉선 과증식증으로 문헌고찰과 함께 보고하는 바이다.

• 대한영상의학회지
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• 제83권1호
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• pp.212-217
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• 2022

An epidermoid cyst is a benign tumor found anywhere in the body. However, the occurrence of epidermoid cysts in the thymus is extremely rare, with only six cases reported worldwide. The correct diagnosis of thymic epidermoid cysts is often difficult due to the unusual location and nonspecific imaging findings. Herein, we present a case of a thymic epidermoid cyst in a 37-year-old female with clinical information and chest CT findings. Further, we have reviewed previous literature reports describing imaging findings of thymic epidermoid cysts.

• Tuberculosis and Respiratory Diseases
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• 제44권2호
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• pp.425-429
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• 1997

저자들은 68세 여자에서 전종격동에 발생한 흉선 유암종 1예를 광학 및 전자현미경소견들로 확진하였기에 문헌고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.771-774
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• 2016

Thymic tumors are the most common tumors in the anterior mediastinum. Total resection is the main treatment and predictor of longer survival. Adjuvant radiotherapy alone or in combination with chemotherapy is recommended with incomplete excision or advanced disease. Thirty seven patients with thymic tumors were included in this retrospective study from January 2001 till December 2012. They were studied regarding age, sex, performance status, tumor size and invasion, stage, pathology, treatment given, overall and progression free survival. Myasthenia gravis was present in 18.1% of the patients. Masaoka stage III was diagnosed in 40.5% of the cases followed by stage II in 24.3% and the other stages with lower percentages. Pathology type B3 was the most frequent followed by B2 and B1 with percentages of 27, 24.3 and 21.7 respectively. Complete resection was conducted in 11 cases (29.75%). Partial resection or debulking was done in 15 (40.5%) and a biopsy was taken in 11 cases (29.8%) Adjuvant chemotherapy was given to 14 patients (37.8%) and neoadjuvant to 13 (35.2%). Adjuvant radiotherapy was given to 17 patients (46%) and neoadjuvant to 14 (37.8%). The 5-year overall survival by was 83% for stage I, 71% for stage II, 60% for stage III, and 44% for stage IV (p=0.0426). Five year progression free survival was 71% for stage I, 62% stage II, 42% stage III, and 37% for stage IV (p=0.0532). In conclusion with the rare thymic tumors early stage and complete resection have the highest impact on overall and progression free survival.

• Applied Microscopy
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• 제27권1호
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• pp.31-46
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• 1997

Ultrastructure of mouse thymus was evaluated, following the administration of potassium dichromate and mercuric chloride, the heavy metals of evironmental pollutants. Potassium dichromate (20 mg/kg) or mercuric chloride solutions (10 mg/kg) were subcutanously injected to the mice. Six hours, three days and two weeks after the injections, animals were sacrificed. Thymic tissues were fixed in 2.5% glutaraldehyde-1.5% paraformaldehyde solutions. The procedure was followed by the fixation in 1% osmium tetroxide solutions. Washed and dehydrated tissue-blocks were embedded in the araldite mixture. Ultra-thin sections were stained with uranyl acetate-lead citrate solutions. Results observed were as follows: 1. In electron microscopy, cortical population of thymocytes in the thymus of experimental groups were reduced. especially in the outer cortex. Subcapsular cortices of potassium dichromate treated mice were filled with many epithelial reticular cells, whereas the similar area of mercuric chloride-treated mice exhibited large intercellular spaces. 2. In the thymus of mercuric chloride treated group, large intercellular spaces were formed by shrinkage of epithelial reticular cells, and the space was invaded by numerous cytoplasmic projections of macrophages. Thymocytes nuded out from the shrunken cytoplasm of epithelial reticular cells, presented numerous microvilli. 3. In the thymus of potassium dicromate treated group, many activated macrophages and plasma cells migrated into thymic cortices. 4. In the perivascular spaces of thymic cortices of potassium dichromate- and mercuric chloride-treated mice, activated macrophages. plasma cells, collagen fibrils, and flocculent substance of exudated materials were exhibited. From the above findifgs, it was concluded that potassium dichromate or mercuric chloride could disturb the normal differentiation or 'education' of T cells in the thymic cortex. In turn, these heavy metals may hurt the immunological defense mechanism.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2745-2748
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• 2012

Aims: To study KIT (CD117) expression in thymic epithelial tumors in China, and investigate diagnostic and clinical significance. Material and Methods: Thymic epithelial tumors (TETs) from 102 patients (3 type A, 29 type AB, 5 type B1, 22 type B2, 29 typeB3 and 16 thymic carcinomas) were examined. Immunohistochemical staining with an antic-kit monoclonal antibody was performed on a tissue microarray. Relationships between KIT positive expression and the TET clinical characteristics (WHO histologic classification and Masaoka stage system) were analysed. Results: The KIT positive expression rate was significantly higher in thymic carcinoma (60%, 9/16) than in thymoma (8%, 7/86), a strong correlation being found with the WHO classification, but not the Masaoka tumor stage. The overall survival for patients with KIT positive lesions was significantly worse. Conclusions: KIT is a good molecule marker to differentially diagnose thymic carcinoma from thymoma, while also serving as a predictor of prognosis for TETs. Further research into KIT mutations in Chinese TETs should be conducted to assess the efficacy of targeted therapy.

• Journal of Chest Surgery
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• 제52권6호
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• pp.420-424
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• 2019

Atypical thymic carcinoid is an extremely rare tumor with a poor prognosis. In addition to its known association with multiple endocrine neoplasia type 1, its hallmark characteristics include local invasion and early distant metastasis. In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome.

• Journal of Chest Surgery
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• 제39권10호
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• pp.795-798
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• 2006

쿠싱증후군과 연관된 흉선 carcinoid종양은 드문 질병으로 그 예후가 나쁜 것으로 알려져 있다. 그중 부신피질자극 호르몬 분비 촉진 호르몬을 생산하는 흉선 carcinoid 종양은 훨씬 더 드물다. 우리는 거대한 전방 종격동 종양을 갖고 있는 58세 여자 환자에 대해 보고하려고 한다. 환자는 흉선제거술 5개월 후 전반적인 부종과 호흡곤란으로 다시 입원하였다. 환자는 재발과 전이가 발견되었고 쿠싱증후군으로 진단 받았다.

• Journal of Chest Surgery
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• 제17권3호
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• pp.470-474
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• 1984

33-year old female was admitted chest surgery department for evaluation of mild chest pain. Chest plain film showed right anterior mediastinal mass and small metastatic daughter mass ipsilateral side. Exploratory thoracotomy was performed 24th Aug. 83 revealed that small nodular parenchymal mass at right middle lobe and large cystic mass at anterior mediastinum which was connected with anterior mediastinal fat. Histological examination confirmed diagnosis as pulmonary hamartoma and thymic cyst individually. We successfully treated these two masses by wedge resection and excision. Although postoperative course was uneventful, the cause and associated relationship between two tumor origin were obscure.

• Journal of Chest Surgery
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• 제23권3호
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• pp.561-565
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• 1990

We experienced thymolipoma which is a rare benign mediastinal tumor, an admixture of atrophic thymic tissue and matured adipose tissue. The patient was, 13 years old boy, admitted due to anterior mediastinal mass on routine chest X-ray and complained of mild exertional dyspnea. The physical examination revealed percussion dullness, decreased breathing sound at right anterior hemithorax. The chest PA and lateral views showed both paracardiac mass density and obliteration of retrosternal clear space. The chest CT Scan showed tubular structure containing of thymic tissue and enhanced fatty tissue, suggested thymolipoma. Operation was performed under the impression of thymolipoma. Through median sternotomy, the huge mass was resected. Grossly, the mass was yellowish fatty colored, measured 15X12X10cm, weighed 600gm. Light microscopic examination showed that thymic tissue containing of Hassal`s corpuscles were surrounded by matured adipose tissue, as the characteristic finding of thymolipoma. The postoperative course was uneventful.