• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.213-221
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• 2020

Salvianolic acid B (SAB) is an active phytocomponent of a popular Chinese herb called Radix Salvia militiorrhiza with numerous biological properties. The anti-psoriasis activity of SAB was examined by evaluating various psoriasis inflammatory and keratin markers against imiquimod (IMQ)-induced psoriasis on BALB/c mice. Totally 50 healthy BALB/c mice were evenly divided into 5 groups including control, drug control (SAB; 40 mg/kg), IMQ-induced psoriasis (5%), IMQ exposure and treated with SAB (40 mg/kg), or standard methotrexate (MTX; 1 mg/kg). Mice supplemented with either SAB or MTX significantly lowered the values of psoriasis area severity index (PASI), erythema, scaling, skin thickness, inflammatory markers (interleukin [IL]-22/23/17A/1β/6) and lipid peroxidation product (malondialdehyde). Also, IMQ exposed BALB/c mice treated with SAB or MTX display lesser histopathological changes with enhanced antioxidant activities (catalase, superoxide dismutase). Moreover, the protein expression of keratin markers (K16 and K17) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling proteins (pAkt/Akt and pPI3K/PI3K) were significantly downregulated after administration with SAB and MTX as compared with IMQ induced mice. Taking together, SAB and MTX significantly ameliorate psoriatic changes by inhibiting psoriatic inflammatory and keratin markers through abolishing PI3K/Akt signaling pathway. However, further studies (clinical trials) are needed to confirm the anti-psoriatic property of SAB before recommending to psoriasis patients.

• Journal of Magnetics
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• v.17 no.2
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• pp.86-95
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• 2012

This study investigated the effects of adding a third alloying element, Ni, to create $Fe_{70-x}Pd_{30}Ni_x$ (x = 2, 4, 6, 8 at.% Ni) ferromagnetic shape memory alloys (FSMAs). The Ni replaced a portion of the Fe. The $Fe_{70-x}Pd_{30}Ni_x$ alloys were homogenized through hot and cold forging to gain a ~38% reduction in thickness, next they were solution-treated (ST) with annealing recrystallization at $1100^{\circ}C$ for 8 h and quenched in ice brine, and then aged at $500^{\circ}C$ for 100 h. Investigation of the microstructures and magnetostriction indicated that the greater Ni amount in the $Fe_{70-x}Pd_{30}Ni_x$ alloys reduced saturation magnetostriction at room temperature (RT). It was also observed that it was more difficult to generate annealed recrystallization. However, with greater Ni addition into the $Fe_{70-x}Pd_{30}Ni_x$ (x = 6, 8 at.% Ni) alloys, the $L1_0+L1_m$ twin phase decomposition into stoichiometric $L1_0+L1_m+{\alpha}_{bct}$ structures was suppressed after the $500^{\circ}C$/100 h aging treatment. The result was that the $Fe_{70-x}Pd_{30}Ni_x$ (x = 6, 8 at.% Ni) alloys maintained a high magnetostriction and magnetostrictive susceptibility (${\Delta}{\lambda}{_\parallel}{^s}/{\Delta}H$) after the alloys were aged at $500^{\circ}C$ for 100 h. This magnetic property of the $Fe_{70-x}Pd_{30}Ni_x$ (x = 6, 8 at.% Ni) alloys make it suitable for application in a high temperature (T > $500^{\circ}C$) and high frequency environments.

• International Journal of Human Ecology
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• v.7 no.1
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• pp.37-52
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• 2006

This study was designed to analyze the three-dimensional shapes of Hanbok Chima made with various fabrics and to clarify the relationship between fabric properties as well as the objective and subjective evaluations of the 3D shape. For 3D shape data, a dress form (9A2 (N; nude)) was scanned with eight Chima garments made with the same number of fabrics. The scanner used was a non-contact three-dimensional human body measuring system belonging to Bunka Women's University in Japan. Data concerning the objective evaluation of the 3D shape was obtained from the measurements of the vertical and horizontal sections: those for subjective evaluation were through the sensory test after exposure to photographs from a front and side view. Four fabric factors were extracted from fabric physical properties: softness, extension, thickness of threads, and weight of fabric. Such factors as expansion (volume), sag of rear train, shape of nodes were influential in explaining the 3D shape of Hanbok Chima. From the analysis of the 3D shape, it can be deduced that with the constituent fabric stiffer, lighter, and less stretchable, the more expanded the 3D shape appeared to be. Multiple regression results showed that vertical shape factors have a greater effect on the evaluation of the 3D shape. It also implies that dependent variables of this study such as the subjective evaluation and 3D shape can be derived from regression equations on independent variables as fabric property factors or 3D shape factors. These results can enable the manufacturers to predict the 3D shape of the garment as well as the human subjective assessment to improve the efficacy of production. The investigation method proposed in this study can also be applicable to other garment items.

• Korean Journal of Oriental Medicine
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• v.14 no.3
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• pp.103-111
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• 2008

Recently, skin diagnosis has been suggested as a promising tool for discrimination of Sasang Constitution, reported by examining the skin characteristics such as thickness, stiffness, slip, and skin textures like wrinkles and furrows. However, the works had a limitation in that clinical decision on the skin characteristics was made by relying upon oriental medicine doctors' subjective sense of touch. In order to objectify the skin diagnosis and claim its efficacy on the discrimination of the Sasang Constitutions, it is necessary to demonstrate its discrimination capability by providing numerical values in terms of physical quantities obtained from measurements using today's sensors and equipment technologies, which motivated this work as a priliminary step towards objectification of skin diagnosis. The skin characteristics focused in this work is the slip property of the back-hand skin that has been exploited using the dynamic friction measurement system. First, curved geometric effects of the back-hand skin on the measured lateral/vertical force signals were estimated using the artificially designed silicon coated structures, which led to a suggestion on a quality controlled experimental design based upon a empirical analysis model. Second, the experimental design thus suggested has been applied to the measurement of dynamic friction coefficients for two healthy male subjects of Taeumin (TE) and Soyangin (SY), respectively. The result shows that the dynamic friction coefficient is less for the SY subject than for the TE subject around the area of the skin used for diagnosis by the oriental medicine doctor, implying the TE subject's skin is more slippery than the SE subject's that is consistent with the oriental medicine doctor's diagnosis. Hopefully, this work can provide guidelines for obtaining quality data in friction measurement to be collected for discussion on the efficacy of the skin diagnosis and its objectification through statistical analysis.

• Journal of Mechanical Science and Technology
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• v.18 no.1
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• pp.65-73
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• 2004

Composites are a material class for which nondestructive material property characterization is as important as flaw detection. Laminates of fiber reinforced composites often possess strong in-plane elastic anisotropy attributable to the specific fiber orientation and layup sequence when waves are propagating in the thickness direction of composite laminates. So the layup orientation greatly influences its properties in a composite laminate. It could result in the part being .ejected and discarded if the layup orientation of a ply is misaligned. A nondestructive technique would be very beneficial, which could be used to test the part after curing and requires less time than the optical test. Therefore a ply-by-ply vector decomposition model has been developed, simplified, and implemented for composite laminates fabricated from unidirectional plies. This model decomposes the transmission of a linearly polarized ultrasound wave into orthogonal components through each ply of a laminate. Also in order to develop these methods into practical inspection tools, motorized system have been developed for different measurement modalities for acquiring ultrasonic signals as a function of in-plane angle. It is found that high probability shows between the model and tests developed in characterizing cured layups of the laminates.

• Progress in Medical Physics
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• v.27 no.3
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• pp.125-130
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• 2016

Dual energy computed tomography (DECT) is used to classify two materials and quantify the mass density of each material in the human body. An energy modulation filter based DECT could acquire two images, which are generated by the low- and high-energy photon spectra, in one scan, with one tube and detector. In the case of DECT using the energy modulation filter, the filter should perform the optimization process for the type of materials and thicknesses for generating two photon spectra. In this study, Geant4 Monte-Carlo simulation toolkit was used to execute the optimization process for determining the property of the energy modulation filter. In the process, various materials used for the energy modulation filter are copper (Cu, $8.96g/cm^3$), niobium (Nb, $8.57g/cm^3$), stannum (Sn, $7.31g/cm^3$), gold (Au, $19.32g/cm^3$), and lead (Pb, $11.34g/cm^3$). The thickness of the modulation filter varied from 0.1 mm to 1.0 mm. To evaluate the overlap region of the low- and high-energy spectrum, Geant4 Monte-Carlo simulation is used. The variation of the photon flux and the mean energy of photon spectrum that passes through the energy modulation filter are evaluated. In the primary photon spectrum of 80 kVp, the optimal modulation filter is a 0.1 mm lead filter that can acquire the same mean energy of 140 kVp photon spectrum. The lead filter of 0.1 mm based dual energy CBCT is required to increase the tube current 4.37 times than the original tube current owing to the 77.1% attenuation in the filter.

• Journal of the Korean Wood Science and Technology
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• v.26 no.1
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• pp.76-86
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• 1998

Effects of processing variables and MAPP (maleic anhydride polypropylene) coupling agent on the properties of composite were discussed for turbulent-air-mixed woodfiber-polypropylenefiber composites. In this research, density, composition ratio, and mat moisture content were established as processing variables, and emulsified MAPP prepared by direct pressure method was incorporated as the coupling agent. And the turbulent air mixer, which was improved in function through alteration of our previous fiber mixer, was used to mix wood fibers and polypropylene fibers. At the addition level of 1% MAPP, based on oven-dried wood fiber weight, woodfiber-polypropylenefiber composites generally showed enhanced the physical and mechanical properties. And composites with low to medium densities of 0.6 to 0.8g/$cm^3$ greatly increased in these property values than with high densities of 1.0g/$cm^3$ or more by adding 1 % MAPP. Thus, MAPP addition was thought to be an effective way of enhancing properties for nonwoven web composites. At the mat moisture contents of 5 to 20%, however, the physical and mechanical properties were not enhanced by adding 1% MAPP. In the composites containing 15% polypropylene fibers, the lowest thickness swelling and water absorption values were observed at the 1% MAPP level. The addition of more than 1% MAPP had the adverse effect on the physical and mechanical properties of composites.

• Journal of the Korean Society for Heat Treatment
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• v.15 no.2
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• pp.57-64
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• 2002

The 22%Cr-5%Ni-3%Mo duplex and 18%Cr-8%Ni austenitic stainless steels have been nitrogen permeated under the $1Kg/cm^2$ nitrogen gas atmosphere at the temperature range of $1050^{\circ}C{\sim}1150^{\circ}C$. The nitrogen-permeated duplex and austenitic stainless steels showed the gradual decrease in hardness with increasing depth below surface. The duplex stainless steel showed nitrogen pearlite at the outmost surface and austenite single phase in the center after nitrogen permeation treatment, while the obvious microstructural change was not observed for the nitrogen-permeated austenitic stainless steel. After solution annealing the nitrogen-permeated stainless steels(NPSA treatment) at $1200^{\circ}C$ for 10 hours, the hardness of the duplex and austenitic stainless steels was constant through the 2 mm thickness of the specimen, and the ${\alpha}+{\gamma}$ phase of duplex stainless steel changed to austenite single phase. Tensile strengths and elongations of the NPSA-treated duplex stainless steel remarkably increased compared to those of solution annealed (SA) duplex stainless steel due to the solution strengthening effect of nitrogen and the phase change from a mixture of ferrite and austenite to austenite single phase, while the NP-treated austenitic stainless steel displayed the lowest value in elongation due to inhomogeneous deformation by the hardness difference between surface and interior.

• Journal of Powder Materials
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• v.21 no.3
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• pp.215-221
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• 2014

Translucent alumina is a potential candidate for high temperature application as a replacement of the glass or polymer. Recently, due to the increasing demand of high power light emitting diode (LED), there is a growing interest in the translucent alumina. Since the translucent property is very sensitive to the internal defect, such as voids inside or abnormal grain growth of sintered alumina, it is important to fabricate the defect-free product through the fabrication process. Powder injection molding (PIM) has been commonly applied for the fabrication of complex shaped products. Among the many parameters of PIM, the flowability of powder/binder mixture becomes more significant especially for the shape of the cavity with thin thickness. Two different positions of the gate were applied during PIM using the disc type of die. The binder was removed by solvent extraction method and the brown compact was sintered at $1750^{\circ}C$ for 3 hours in a vacuum. The flowability was also simulated using moldflow (MPI 6.0) with two different types of gate. The effect of the flowability of powder/binder mixture on the microstructure of the sintered specimen was studied with the analysis of the simulation result.

• Transactions of Materials Processing
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• v.11 no.8
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• pp.682-690
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• 2002

The formation of adiabatic shearband in tungsten heavy alloys(WHA) was studied in this investigation. Five prismatic specimens were loaded by high velocity impacts and treated as plane strain problems. To find out the effect of particle's volume ratio, specimens containing 81%, 93% and 97% volume percents of tungsten particles were used. Also the effects of particle's geometry and size on the formation of shearband were studied for 81% volume percent alloys by small size particle model, large size particle model and undulated particle models, and the results were discussed.be used to diagnose the causes of necking and fracture in industrial practice and to investigate whether these defects were caused by material property variation, changes in lubrication, or incorrect press settings. In non-axisymmetric deep drawing, three modes of forming regimes are found: draw, stretch, plane strain. The stretch mode for non-axisymmetric deep drawing could be defined when the major and minor strains are positive. The draw mode could be defined when the major strain is positive and minor strain is negative, and plane strain mode could be defined when the major strain is positive and minor strain is zero. Through experiments the draw mode was shown on the wall and flange are one of a drawn cup, while the plane strain and the stretch mode were on the punch head and the punch corner area respectively, We observed that the punch load of elliptical deep drawing was decreased according to increase of die corner radius and the thickness deformation of minor side was more large than major side.