• Journal of Ginseng Research
• /
• v.47 no.4
• /
• pp.552-560
• /
• 2023

Background: Ginseng Radix (Panax ginseng Meyer, Araliaceae) has been used medicinally to treat the brain and nervous system problems worldwide. Recent studies have revealed physiological effects that could potentially benefit cognitive performance or mood. The present study aimed to investigate the antidepressant effects of Korean red ginseng water extract (KGE) and its active component in an unpredictable chronic mild stress (UCMS)-induced animal model and elucidate the underlying mechanisms. Methods: The antidepressant potential of the UCMS model was evaluated using the sucrose preference test and open field tests. The behavioral findings were further corroborated by the assessment of neurotransmitters and their metabolites from the prefrontal cortex and hippocampus of rats. Three doses of KGE (50, 100, and 200 mg/kg) were orally administered during the experiment. Furthermore, the mechanism underlying the antidepressant-like action of KGE was examined by measuring the levels of brain-derived neurotrophic factor (BDNF)/CREB, nuclear factor erythroid 2-related factor 2 (Nrf2), and Kelch-like ECH-associated protein 1 (Keap1) proteins in the prefrontal cortex of UCMS-exposed rats. Results: KGE treatment normalized UCMS-induced depression-related behaviors. Neurotransmitter studies conducted after completing behavioral experiments demonstrated that KGE caused a reduction in the ratio of serotonin and dopamine, indicating a decrease in serotonin and dopamine turnover. Moreover, the expression of BDNF, Nrf2, Keap1 and AKT were markedly increased by KGE in the prefrontal cortex of depressed rats. Conclusion: Our results provide evidence that KGE and its constituents exert antidepressant effects that mediate the dopaminergic and serotonergic systems and expression of BDNF protein in an animal model.

• Communications for Statistical Applications and Methods
• /
• v.19 no.3
• /
• pp.495-500
• /
• 2012

We consider a Bayesian test of independence in a two-way contingency table that has some zero cells. To do this, we take a three-stage hierarchical Bayesian model under each hypothesis. For prior, we use Dirichlet density to model the marginal cell and each cell probabilities. Our method does not require complicated computation such as a Metropolis-Hastings algorithm to draw samples from each posterior density of parameters. We draw samples using a Gibbs sampler with a grid method. For complicated posterior formulas, we apply the Monte-Carlo integration and the sampling important resampling algorithm. We compare the values of the Bayes factor with the results of a chi-square test and the likelihood ratio test.

• Proceedings of the KSME Conference
• /
• 2004.11a
• /
• pp.1028-1033
• /
• 2004

The heat and flow characteristics in a single-phase parallel-flow heat exchanger was examined numerically to obtain its optimal shape. A response surface method was introduced to predict its performance approximately with respect to design parameters over design domain. Design parameters are inflow and outflow angle of the working fluid and horizontal and vertical location of inlet and outlet. The evaluation of the relative priority of the design parameters was performed to choose three important parameters in order to use a response surface method. A JF factor was used as an evaluation characteristic value to consider the heat transfer and the pressure drop simultaneously. The JF factor of the optimum model, compared to that of the base model, was increased by about 5.3%.

• International Journal of Concrete Structures and Materials
• /
• v.8 no.4
• /
• pp.269-278
• /
• 2014

When concrete is being transported through a pipe, the lubrication layer is formed at the interface between concrete and the pipe wall and is the major factor facilitating concrete pumping. A possible mechanism that illustrates to the formation of the layer is the shear-induced particle migration and determining the rheological parameters is a paramount factor to simulate the concrete flow in pipe. In this study, numerical simulations considering various rheological models in the shear-induced particle migration were conducted and compared with 170 m full-scale pumping tests. It was found that the multimodal viscosity model representing concrete as a three-phase suspension consisting of cement paste, sand and gravel can accurately simulate the lubrication layer. Moreover, considering the particle shape effects of concrete constituents with increased intrinsic viscosity can more exactly predict the pipe flow of pumped concrete.

• The Journal of Information Systems
• /
• v.15 no.2
• /
• pp.195-226
• /
• 2006

The purpose of this study is (1) to develop a conceptually integrated model of IT capability comprising hierarchically structured lower capabilities, and (2) to investigate the impacts of IT capability on firm performance. To do this, the study defined IT capability as a third-order factor model and identified three conceptual dimensions of IT capability IT resource integrating capability, IT infrastructure flexibility, and IT personnel expertise. The relationships between IT capability and firm performance are assessed with 243 firm level data using LISREL. The results of confirmatory factor analysis (CFA) demonstrated that the constructs is highly reliable and valid. Further, we found that IT capability not directly but indirectly affects firm performance through the impacts on business processes.

• Journal of Ocean Engineering and Technology
• /
• v.26 no.5
• /
• pp.55-62
• /
• 2012

In this paper, the rigid lid boundary condition is applied to simulate the influence of floating structures such as ships or pontoons, and the pressure term in both the momentum equations and continuity equation are modified. The pressure of a floating structure under the free surface is dependent on the draft of the structure, generally called a ship. If the free surface is covered by a floating structure, the free surface cannot move freely. The water level should be fixed, using a rigid lid boundary condition. This boundary condition is implemented by reducing the storage area of the grid cell with a factor between zero and one. The numerical model developed by Hong (2009) is verified through a comparison with experimental results, and the influence of the reduction factor is investigated using the verified numerical model.

• Journal of Applied Reliability
• /
• v.7 no.3
• /
• pp.127-136
• /
• 2007

The accelerated life tests(ALTs) and degradation characteristics of image intensifier assembly(KIT-7) under low illuminance and high temperature were investigated. The accelerated life tests were carried out at $5{\times}10^5\;fc-40^{\circ}C,\;10{\times}10^5\;fc-40^{\circ}C,\;5{\times}10^5\;fc-50^{\circ}C,\;10{\times}10^5\;fc-50^{\circ}C$ and relationship related to illuminance and temperature was used as an accelerated life test model. An ALTA program[6] was used to calculate an acceleration factor and the test of life distribution fit, and estimate three parameters of an life test model. To sum up, MTTF 10,000 h at $5{\times}10^{-5}\;fc-40^{\circ}C$ of image intensifier assembly was certificated.

• Computers and Concrete
• /
• v.4 no.3
• /
• pp.221-241
• /
• 2007

Based on the experiment results, the damage and fracture behavior of concrete at the ages of 1d, 2d, 7d and 28d, in three-point bending and uniaxial tensile tests, were simulated with a finite element program, ABAQUS. The critical stress intensity factor $K_{IC}^s$ and the critical crack tip opening displacement ($CTOD_C$) of concrete were calculated with effective-elastic crack approach for the three-point bending test of grade C30 concrete. Based on the crack band model, a bilinear strain-softening curve was derived to simulate the LOAD-CMOD curves and LOAD-Displacement curves. In numerical analysis of the uniaxial tension test of concrete of grade C40, the damage and fracture mechanics were combined. The smeared cracking model coupling with damaged variable was adopted to evaluate the onset and development of microcracking of uniaxial tensile specimen. The uniaxial tension test was simulated by invoking the damage plastic model which took both damage and plasticity as inner variables with user subroutines. All the numerical simulated results show good agreement with the experimental results.

• Journal of Korean Institute of Industrial Engineers
• /
• v.40 no.2
• /
• pp.172-183
• /
• 2014

This paper measures and compares the efficiency of national health technology R&D programs focused on translational research program increasing importance using data envelopment analysis (DEA). Three input variables and three output variables are selected for DEA. Inputs are funds, researchers, and project period and outputs are SCI (E) papers, applied and granted patents, and impact factor. This study uses a three-stage approach. In the first stage, output-based DEA model is applied to evaluate the efficiency of decision making unit (DMU). In the second stage, based on efficiency scores of target diseases high-efficiency group and low-efficiency group are classified. And then strategic portfolio matrix of translational research program is composed of four dimensions combining research types. Mann-Whitney U test is then run to compare average efficiency scores among four groups. In the final stage, Tobit regression model is used to estimate factors likely to influence the efficiency. The results are expected to provide policy implications for effectively establishing investment strategy and managing performance of R&D program.

• Journal of the Korean BIBLIA Society for library and Information Science
• /
• v.34 no.2
• /
• pp.115-136
• /
• 2023

The purpose of this study is to establish a weighting system for the diagnostic criteria of the KISTI Open Access Maturity Model. The maturity model consists of three dimensions, 12 sub-dimensions, and 28 measurement questions. Weighting was performed for the three dimensions and 12 sub-dimensions to determine their relative importance. The results showed that 'Institutionalization of OA' (48%) was the most important factor in the three dimensions. Among the sub-factors of "institutionalizing OA," "enacting and revising relevant regulations" (64%) was important, and "financing" (39%) was important for "OA sustainability. Submission and review (23%) and author rights (22%) were identified as important elements of "journal openness".