• 대한한방내과학회지
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• 제40권2호
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• pp.220-227
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• 2019

Objectives: Parkinson's disease is the neurodegenerative disease that affects both motor and non-motor function, including postural instability. Camptocormia is an abnormal condition in which the thoracolumbar spine bends forward during walking or standing. However, the treatment options are limited and often not effective. The purpose of this study was to report on the Korean medical treatment of a Parkinson's disease patient with postural instability who presented with camptocormia. Methods: We used Korean medical treatment including herbal medicine (Jemageopung-tang), acupuncture and pharmacopuncture therapy to the patient who was admitted to the hospital for 21 days. The clinical symptoms were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS) and walking time without assistance. Results: After treatment, the UPDRS Parts 2 and 3 scores were decreased from 5 to 3 and 20 to 9, respectively. Also, the walking time without assistance was improved. Conclusion: This study suggested that Korean medical treatment could be an effective option for treating Parkinson's disease with postural instability.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제27권3호
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• pp.158-167
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• 2024

Purpose: To evaluate the prevalence of vertebral fracture (VF) in children with chronic liver disease (CLD) with and without liver transplantation (LT) and to determine the associated factors. Methods: A cross-sectional study was conducted. Patients aged 3-21 years with CLD both before and after LT were enrolled in the study. Lateral thoracolumbar spine radiographs were obtained and assessed for VF using Mäkitie's method. Clinical and biochemical data were collected. Results: We enrolled 147 patients (80 females; median age 8.8 years [interquartile range 6.0-11.8]; 110 [74.8%] in the LT group and 37 [25.2%] in the non-LT group). VF was identified in 21 patients (14.3%): 17/110 (15.5%) in the LT group and 4/37 (10.8%) in the non-LT group (p=0.54). Back pain was noted in only three patients with VF. In the univariate analysis, a height z-score below -2.0 (p=0.010), pre-LT hepatopulmonary syndrome (p=0.014), elevated serum direct and total bilirubin levels (p=0.037 and p=0.049, respectively), and vitamin D deficiency at 1-year post-LT (p=0.048) were associated with VF in the LT group. In multivariate analysis, height z-score below -2.0 was the only significant associated factor (odds ratio, 5.94; 95% confidence interval, 1.49-23.76; p=0.012) for VF. All VFs in the non-LT group were reported in males. Conclusion: In children with CLD, VF is common before and after LT. Most patients with VF are asymptomatic. Screening for VF should be considered in patients with a height z-score below -2.0 after LT.

• 대한핵의학회지
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• 제32권4호
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• pp.354-364
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• 1998

목적: 단순골X-선검사와 골스캔은 다발성 골수종 병변의 조기검출에 많은 제한점을 가진다. 본 연구는 다발성 골수종에서 방사능 표지 항백혈구항체를 이용한 골수스캔의 유용성을 평가하기 위해 실시되었다. 대상 및 방법: 다발성 골수종 환자 22례의 경우 남녀비는 2.1:1이었고 중간연령은 57세였으며, Stage II는 3례, Stage III는 19례였다. 골수스캔은 $^{99m}Tc$으로 표지된 항백혈구 항체를 이용하여 전신상을 촬영하였고, 그 결과를 단순골X-선검사 및 골스캔과 부위별로 비교하였다. 결과: 단순골X-선검사는 14명(64%), 골스캔에서는 11명(50%)의 환자에서 병변을 검출한 반면, 골수스캔에서는 19명(86%)의 환자에서 국소결손병변을 검출하였다. 골수스캔은 Stage II에서는 33%의 환자(1/3)에서 병변을 검출하였고, Stage III에서는 90%의 환자(17/19)에서 병변을 검출하였다. 골수스캔에서 골수확장의 소견은 68% (15/22)에서 관찰되었다. 전체환자 22명에서 124개의 국소결손병변이 단순골X-선 검사, 골스캔, 골수스캔에서 검출되었는데, 단순골X-선검사는 58개 병변을, 골스캔은 40개 병변을 검출한 반면 골수스캔을 통해서는 92개 병변을 검출하였고, 단순골X-선검사나 골스캔에서는 검출하지 못한 국소결손병변을 51개나 더 검출할 수 있었으며, 이는 특히 새로운 흉요추 국소결손병변의 검출에 도움이 되었다. 결론: 골수스캔은 단순골X-선검사나 골스캔보다 높은 검출율을 보였고, 흉요추병변의 검출에 많은 도움을 줄 수 있는 것으로 생각된다. 또한 골수스캔은 진행한 병기에서 더 높은 검출율을 보여주어 골수스캔소견과 임상적 병기간에 상관성을 가지는 것으로 생각된다. 다발성 골수종에서의 골수스캔은 새로운 병변의 검출뿐만 아니라 병기정도의 평가에 도움이 될 것으로 판단된다.