• Title/Summary/Keyword: Thomas More

Search Result 186, Processing Time 0.027 seconds

Clinical Experience of Tapering Enteroplasty Using GIA Stapler in Jejunoileal Atresias (소장 무공증 환아에서 GIA stapler를 이용한 Tapering Enteroplasty 임상경험)

  • Song, Young-Tack
    • Advances in pediatric surgery
    • /
    • v.1 no.1
    • /
    • pp.27-32
    • /
    • 1995
  • Jejunal and ileal atresias are the most common cause of congenital intestinal obstruction and accounts for about 1/3 of all cases of intestinal obstruction in newborns. Despite the relative frequency of this anomaly, its survival rate was less than 10% up to 1950, more recently the survival rate has risen rapidly to 90% with the introduction of modern surgical techniques and the use of total parenteral nutrition. In 1969 Thomas described a tapering jejunoplasty to manage the discrepancy in the size of the proximal dilated lumen & contracted distal lumen, and to preserve absorptive surface when the dilated jejunum involved a long length, and Grosfeld et al.(1979) facilitated this method by using GIA staplers. Author have also used GIA stapler to resect the antimesenteric portion of the dilated proximal bowel in 8 cases of jejunoileal atresias with good results. The following results were obtained ; 1. There we 3 jejunal atresias & 5 ileal atresias, and male to female sex ratio was 5 : 3. 2. The type of atresia was as follows ; type IIIa was 3 cases, type IIIb was 4 cases, type IIIb+IV was 1 case. 3. In non-complication cases(5 cases), the mean hospital day was 16 days, and oral feeding was feasible from 6.2 days after operation. 4. The complications(anastomotic leakage, pneumonia) were frequently occurred in type IIIb cases and in low birth weight cases(75%). 5. Mortality rate was 25% including DAMA(discharge against medical advice) discharge case.

  • PDF

Second Primary Malignant Neoplasms: A Clinicopathological Analysis from a Cancer Centre in India

  • Hulikal, Narendra;Ray, Satadru;Thomas, Joseph;Fernandes, Donald J.
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.13 no.12
    • /
    • pp.6087-6091
    • /
    • 2012
  • Context: Patients diagnosed with a cancer have a life time risk of developing another de novo malignancy depending on various inherited, environmental and iatrogenic risk factors. Of late the detection of new primary has increased mainly due to refinement in both diagnostic and treatment modalities. Cancer victims are surviving longer and thus are more likely to develop a new metachronous malignancy. Aims: To report our observed trend of increase in prevalence of both synchronous and metachronous second malignant neoplasms among cancer victims and to review the relevant literature. Settings and Design: A hospital based retrospective collection of prospective data of patients diagnosed with second denovo malignancy. Materials and Method: The study was conducted over a 5 year period from July 2008 to June 2012. All patients diagnosed with a histologically proven second malignancy as per Warren Gate's criteria were included. Various details regarding sex, age at presentation, synchronous or metachronous, treatment and outcome were recorded. Conclusions: The occurrence of multiple primary malignancies is not rare. Awareness of the possibility alerts the clinician in evaluation of patients with a known malignancy presenting with unusual sites of metastasis. Individualizing the treatment according to the stages of the primaries will result in durable cancer control particularly in synchronous double malignancy.

Hybrid Imaging in Oncology

  • Fatima, Nosheen;uz Zaman, Maseeh;Gnanasegaran, Gopinath;Zaman, Unaiza;Shahid, Wajeeha;Zaman, Areeba;Tahseen, Rabia
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.16 no.14
    • /
    • pp.5599-5605
    • /
    • 2015
  • In oncology various imaging modalities play a crucial role in diagnosis, staging, restaging, treatment monitoring and follow up of various cancers. Stand-alone morphological imaging like computerized tomography (CT) and magnetic resonance imaging (MRI) provide a high magnitude of anatomical details about the tumor but are relatively dumb about tumor physiology. Stand-alone functional imaging like positron emission tomography (PET) and single photon emission tomography (SPECT) are rich in functional information but provide little insight into tumor morphology. Introduction of first hybrid modality PET/CT is the one of the most successful stories of current century which has revolutionized patient care in oncology due to its high diagnostic accuracy. Spurred on by this success, more hybrid imaging modalities like SPECT/CT and PET/MR were introduced. It is the time to explore the potential applications of the existing hybrid modalities, developing and implementing standardized imaging protocols and train users in nuclear medicine and radiology. In this review we discuss three existing hybrid modalities with emphasis on their technical aspects and clinical applications in oncology.

Prevalence of Local Recurrence of Colorectal Cancer at the Iranian Cancer Institute

  • Omranipour, Ramesh;Mahmoodzadeh, Habibollah;Safavi, Farinaz
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.20
    • /
    • pp.8587-8589
    • /
    • 2014
  • Background: Although a great deal of progress has been made in the management of colorectal cancer in terms of neoadjuvant modalities, surgical techniques and adjuvant therapies, the recurrence of tumors remains an enigmatic complication in patients. A better understanding of colorectal cancer and of factors that lead to recurrence of disease can provide helpful information for designing more effective screening and surveillance methods. Aim: To investigate the factors that may lead to local recurrence of colorectal cancers. Materials and Methods: The current retrospective case study evaluated 617 patients admitted to the Iranian Cancer Institute (the largest referral cancer center in the country) from 1995 to 2009 with confirmed colorectal cancer. Patients with distant metastasis, or with pathology other than adenocarcinoma and no follow-up, were excluded (175 patients). The remainder (442) included 294 (66.5%) with rectal cancer and 148 (33.5%) with colon cancer. The median duration of follow-up was 26 months. Results: The total rate of recurrence was 17.4%, comprising 19.6% and 16.3% recurrence rates in colon and rectal cancer, respectively. Conclusions: Recurrence of colorectal cancer was significantly correlated to tumor grade (p<0.008).

An Exploratory Research on the Implementation of Corporate Social Responsibility (CSR) in the Real Estate Sector of UAE: A Dyadic Perspective

  • THOMAS, Suja Sarah;POTLURI, Rajasekhara Mouly
    • Journal of Distribution Science
    • /
    • v.18 no.10
    • /
    • pp.101-110
    • /
    • 2020
  • Purpose: The study investigates the implementation of corporate social responsibility (CSR) in the real estate sector of the UAE by collecting the opinions of both the real estate companies and different tenants on the execution of CSR. Research design, data, and methodology: Using a sample of 300 different types of UAE real estate consumers and twenty real estate firms, the researchers collected the opinions of targeted subjects by administering two types of questionnaires. The Cronbach's Alpha and the Kaiser-Meyer-Olkin (KMO) tests were employed to check the internal consistency and validity of the questionnaires. The selected hypotheses were tested using the Kruskal-Wallis (K-W) hypothesis testing technique. Results: The findings revealed that all types of UAE real estate consumers expressed their discontentment over the implementation of socially responsible actions by the real estate companies. Whereas UAE real estate companies expressed their confidence in the ideal implementation of social actions towards all stakeholders in general and tenants. Conclusion: Even though more than 50 percent of realty customers are dissatisfied with the company's implementation of CSR, a little over 54.80 percent are willing to recommend the company to their family and friends. Implications have been provided for UAE real estate companies who wish to promote their business to all categories of UAE real estate consumers successfully.

Effect of Acaromyces Ingoldii Secondary Metabolites on the Growth of Brown-Rot (Gloeophyllum Trabeum) and White-Rot (Trametes Versicolor) Fungi

  • Olatinwo, Rabiu;So, Chi-Leung;Eberhardt, Thomas L.
    • Mycobiology
    • /
    • v.47 no.4
    • /
    • pp.506-511
    • /
    • 2019
  • We investigated the antifungal activities of an endophytic fungus identified as Acaromyces ingoldii, found on a loblolly (Pinus taeda L.) pine bolt in Louisiana during routine laboratory microbial isolations. The specific objectives were to determine the inhibitory properties of A. ingoldii secondary metabolites (crude extract) on the mycelial growth of a brown-rot fungus Gloeophyllum trabeum and a white-rot fungus Trametes versicolor, and to determine the effective concentration of A. ingoldii crude preparation against the two decay fungi in vitro. Results show the crude preparation of A. ingoldii from liquid culture possesses significant mycelial growth inhibitory properties that are concentration dependent against the brownrot and white-rot fungi evaluated. An increase in the concentration of A. ingoldii secondary metabolites significantly decreased the mycelial growth of both wood decay fungi. G. trabeum was more sensitive to the inhibitory effect of the secondary metabolites than T. versicolor. Identification of specific A. ingoldii secondary metabolites, and analysis of their efficacy/specificity warrants further study. Findings from this work may provide the first indication of useful roles for Acaromyces species in a forest environment, and perhaps a future potential in the development of biocontrol-based wood preservation systems.

Dynamic Analysis of Francis Runners - Experiment and Numerical Simulation

  • Lais, Stefan;Liang, Quanwei;Henggeler, Urs;Weiss, Thomas;Escaler, Xavier;Egusquiza, Eduard
    • International Journal of Fluid Machinery and Systems
    • /
    • v.2 no.4
    • /
    • pp.303-314
    • /
    • 2009
  • The present paper shows the results of numerical and experimental modal analyses of Francis runners, which were executed in air and in still water. In its first part this paper is focused on the numerical prediction of the model parameters by means of FEM and the validation of the FEM method. Influences of different geometries on modal parameters and frequency reduction ratio (FRR), which is the ratio of the natural frequencies in water and the corresponding natural frequencies in air, are investigated for two different runners, one prototype and one model runner. The results of the analyses indicate very good agreement between experiment and simulation. Particularly the frequency reduction ratios derived from simulation are found to agree very well with the values derived from experiment. In order to identify sensitivity of the structural properties several parameters such as material properties, different model scale and different hub geometries are numerically investigated. In its second part, a harmonic response analysis is shown for a Francis runner by applying the time dependent pressure distribution resulting from an unsteady CFD simulation to the mechanical structure. Thus, the data gained by modern CFD simulation are being fully utilized for the structural design based on life time analysis. With this new approach a more precise prediction of turbine loading and its effect on turbine life cycle is possible allowing better turbine designs to be developed.

Cytoprotection Against Oxidative Damage by Nrf2-regulated Genes

  • Kwak, Mi-Kyoung;Kensler, Thomas W.
    • Toxicological Research
    • /
    • v.23 no.3
    • /
    • pp.207-214
    • /
    • 2007
  • Chronic oxidative stress produced by exposure to environmental chemicals or pathophysiological states can lead animals to aging, carcinogenesis and degenerative diseases. Indirect antioxidative mechanisms, in which natural or synthetic agents are used to coordinately induce the expression of cellular antioxidant capacity, have been shown to protect cells and organisms from oxidative damages. Electrophile and free radical detoxifying enzymes, which were originally identified as the products of genes induced by cancer chemopreventive agents, are members of this protective system. The NFE2 family transcription factor Nrf2 was found to govern expression of these detoxifying enzymes, and screening for Nrf2-regulated genes has identified many gene categories involved in maintaining cellular redox potential and protection from oxidative damage as Nrf2 downstream genes. Further, studies using Nrf2-deficient mice revealed that these mutant mice showed more susceptible phenotypes towards exposure to environmental chemicals/carcinogens and in oxidative stress related disease models. With the finding that cancer chemopreventive efficacy of indirect antioxidants (enzyme inducers) is lost in the absence of Nrf2, a central role of Nrf2 in the antioxidative protective system has been firmly established. Promising results from cancer prevention clinical trials using enzyme inducers propose that pharmacological interventions that modulate Nrf2 can be an effective strategy to protect tissues from oxidative damage.

Kalman filter technique for defining solar regular geomagnetic variations

  • Martini, Daniel;Orispaa, Mikko;Ulich, Thomas;Lehtinen, Markku;Mursula, Kalevi;Lee, Dong-Hun
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.36 no.2
    • /
    • pp.81.2-81.2
    • /
    • 2011
  • Motivated by recent attempts to derive geomagnetic activity from hourly mean data in long term studies, we test the recursive Kalman filter method to obtain the regular solar variation curve of the geomagnetic field. Using a simple algorithm, we are able to assign a quiet day curve to every day separately, without the need for additional input parameter(s) to define the geomagnetically quiet days. We derive a digital counterpart AhK of the analog range index Ak at the subauroral Sodankyl$\ddot{a}$ station and compare it to the earlier digital estimate Ah and the local Ak index. We find that the new method outperforms the former estimate in every aspect studied and provides a robust, straightforward manner of estimating and verifying the manually scaled Ak index, based on readily available hourly values. The model is independent of sampling; thus, for shorter term studies where high-sampling data are available, more accurate estimates can also be obtained when needed. Therefore, in contrast to other recent approaches, we do not provide a method to quantify irregular activity directly but derive the actual quiet day curves in the traditional manner. In future applications the same algorithm may be used to define a wide variety of geomagnetic indices (such as Ak, Dst, or AE).

  • PDF

Analysis of Skills in Korean Middle School-Level Environmental Education Textbooks (제 7차 중학교 환경 교과서 내의 환경 기능 분석)

  • Noh, Kyung-Im;Marcinkowski, Thomas J.
    • Hwankyungkyoyuk
    • /
    • v.17 no.1
    • /
    • pp.12-24
    • /
    • 2004
  • The purpose of this study was to analyze and compare Korean middle school-level environmental education(EE) textbooks. More specifically, these analyses and comparisons were designed to explore the extent to which environmental investigation skills were addressed in these EE textbooks (i.e., curriculum inclusion), as well as the manner in which these skills were to be taught and learned (i.e., instructional approaches). To analyze EE textbooks, the researchers developed a 'Curriculum Analysis Chart' that include six skill clusters and four instructional strategies. This analytic chart permitted the researchers to determine which skills were featured in selected textbooks, as well as which skill-oriented instructional strategies accompanied each of those skills. The chart was revised several times through pilot analyses. Using the final version of this chart, the researchers analyzed and then compared the three textbooks. This analysis indicated that the Korean middle school-level EE textbooks were designed to support conceptual learning and understanding of environment and environmental problems/issues (i.e., content-oriented), and were designed to support skill learning to a moderate degree. On the basis of textbooks analysis, the researchers offered several recommendations for future research, and for educational practices in EE.

  • PDF