• The Journal of Korean Physical Therapy
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• 제26권1호
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• pp.27-32
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• 2014

Purpose: The purpose of the study was to comparison of trunk muscle activity during static standing position and standing position on therapeutic climbing wall of adult. Methods: Study subject is arbitrarily classified into 10 of experimental group and 10 control group among 20 of adult. Trunk activity measured as rectus abdominalis, external oblique, internal oblique, erector spinae. Control group maintains that center of gravity of trunk pass the front of shoulder, pelvis, knee and ankle on stable surface with putting legs apart more than shoulder width. Experimental group had static exercise on 4 by 3 meter, 90 degree of Therapeutic climbing wall. Starting position is that putting arms and legs apart more than shoulder width. In order to compare the effect of it between the groups, independent t-test was used. Results: According to the test result, significant difference between among rectus abdominalis, erector spinae the experimental groups. And external oblique, internal oblique muscle atvity is no significant difference experimental groups between among the control groups was observed. Conclusion: Trunk muscle activation is activated to standing position on the Therapeutic Climbing Wall more than static standing position.

• 한국생활과학회지
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• 제17권4호
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• pp.623-630
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• 2008

An educational program through therapeutic recreation was developed in order to analyze the effect of enhancement of ego integrity of the elderly. First of all, this study was designed to summarize the concepts of ego integrity and the effects of therapeutic recreation on the elderly and to identify elderly's educational needs of both educational methods and contents from the literature review. The above identified knowledge and information were applied to developing the educational program. The program was composed of 6 sessions with 17 old men and women focused on developing self acceptance using reminiscence on ego integrity through their whole life span and developing positive and active attitudes towards life. And enforcing and evaluation methods were also suggested. The results were as follows. This program showed the significant differences between post-test and pre-test scores in the scale of ego integrity of the elderly. In conclusion, educational program through therapeutic recreation employed for this study has significant effects of increasing ego integrity of the elderly.

• 대한한의학원전학회지
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• 제33권1호
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• pp.1-16
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• 2020

Objectives : This study aims to organize the genealogy of the Ministerial Fire Theory in relation to Wangbing's Dragon Fire discourse through examining how Wang's Dragon Fire content first mentioned in the annotation of 『Suwen』 was included into the discourse of the Ministerial Fire Theory in explaining the concept of Ministerial Fire and its therapeutic application. Methods :First to examine the inclusion and application of the Dragon Fire concept into the Ministerial Fire Theory, Zhudanxi's theory and critiques on him were studied. Next the concept of Dragon Fire within the Ministerial Fire Theory was analyzed, followed by comparison between generations of doctors's therapeutic application of Ministerial Fire and Wangbing's Dragon Fire application. Conclusions & Results : Wangbing's dragon fire concept held an important position in discussing its characteristic as fire within water, which was adopted and differentiated by later doctors in aspects of pathology, deficiency and excessiveness, influenced by various theoretical elements of later periods. In the midst of expansion of the concept from combination of dragon fire and ministerial fire, the therapeutic aspect of it was maintained from Wangbing's original mentioning. This tendency manifested in either awkward combination of Wang's therapeutic methods and the new theory or modification of Wangbing's methods.

• Radiation Oncology Journal
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• 제6권1호
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• pp.75-80
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• 1988

Twenty seven lesions of 25 patients with locally advanced malignant tumors were treated with combined hyperthermia introduced by microwave and ultrasound and radiotherapy. Most of all patients were failed with previous conventional therapeutic trial. Hyperthermia had been done immediately after radiotherapy, twice a week, $43^{\circ}C$ for one hour and radiotherapy had been done 5 fractions per week with fraction size of 2Gy upto 30 to 60Gy. Conclusions are as follows. 1. Total response rate (PR+PR) to thermoradiotherapy with microwave and ultrasound was $81\%$. 2. Tumor depth, minimum temperature of tumor center, number of heat fraction and radiation dose were statistically significant factors affecting response. 3. Hyperthermia with microwave and ultrasound can be used efficiently to control locally advanced malignant disease whether previously received near tolerance dose of radiotherapy or not.

• 한국전문물리치료학회지
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• 제6권3호
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• pp.94-109
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• 1999

The purposes of this study were to assess the effect of therapeutic exercise and to offer an approach to the physical therapy and rehabilitation procedure of the temporomandibular joint (TMJ) following surgery. In this research, 42 patients with TMJ surgery were assigned one of two groups. The experimental group included 21 patients who performed therapeutic exercise, and the control group included 21 patients who did not perform therapeutic exercise. Conservative therapy such as an ice pack, a hot pack, and pulsed ultrasound was applied to both groups. Treatment was applied twice a day during the admission period and, after discharge, everyday for six weeks. Visual analogue scale (VAS), incisal biting force, and joint ROM were measured before surgery and at 30 days after surgery. The results were as follows: VAS (p<0.05), mouth opening (p<0.01), lateral excursion to unaffected side (p<0.05), and protrusion (p<0.05) between experimental group and control group showed statistically significant differences. Incisal biting force and lateral excursion to affected side between experimental group and control group showed no statistically significant difference.

• BMB Reports
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• 제42권5호
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• pp.260-264
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• 2009

Tumor necrosis factor-$\alpha$ (TNF-$\alpha$) exhibits cytotoxicity towards various tumor cells in vitro and induces apoptotic necrosis in transplanted tumors in vivo. It also shows severe toxicity when used systemically for the treatment of cancer patients, hampering the development of TNF-$\alpha$ as a potential anticancer drug. In order to understand the structure-function relation of TNF-$\alpha$ with respect to receptor binding, we selected four regions on the bottom of the TNF-$\alpha$ trimer that are in close contact with the receptor and carried out mutagenesis studies and computational modeling. From the study, various TNF-$\alpha$ muteins with a high therapeutic index were identified. These results will provide a structural basis for the design of highly potent TNF-$\alpha$ for therapeutic purposes. By conjugating TNF-$\alpha$ muteins with a high therapeutic index to a fusion partner, which targets a marker of angiogenesis, it could be possible to develop TNF-$\alpha$ based anticancer drugs.

• 대한물리치료과학회지
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• 제19권4호
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• pp.27-34
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• 2012

The aim of study was to assess the effectiveness of dementia elderly persons on the cognitive function, Activities of Daily Living(ADL) and balance-performing ability the group therapeutic exercise programs. Fifteen community-dwelling subjects participated in this study. An 4-week group therapeutic exercise program, including strengthening and balance training, breathing and gait exercise, and recreation, consisted of activities related to daily living. The Mini-Mental State Examination-korean(MMSE-K), Modified Barthel Index(MBI), Berg Balance Scale(BBS), and Timed Up & Go (TUG) test were measured during before and after exercise points The results of this study were as follows : 1) After eight weeks, the MMSE-K and MBI total scores were significantly increased to more after than before(p<.05, p<.01). 2) in the MBI contents, personal hygiene, dressing, ambulation and chair, bed transfers scores were significant increased to after. 3) after BBS, TUG scores were statistically significant higher than the before scores(p<.05, p<.05, p<.01). These findings suggest that group therapeutic exercise program can be used to improve the cognitive function, ADL and balance-performing ability in dementia elderly persons.

• 생물정신의학
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• 제13권1호
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• pp.26-31
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• 2006

Object : To evaluate how the therapeutic factors affect post-discharge course of patients with schizophrenia, we analyzed relationship between each therapeutic factor and outcome of inpatients with schizophrenia in Hanyang University Hospital. Methods : This study is a retrospective report. Subjects were schizophrenic inpatients who were discharged from Hanyang University Hospital from January 1, 2003 through December 31, 2004. We obtained demographic and clinical data from review of inpatient and outpatient charts. Results : We analyzed the records of 104 patients with schizophrenia(44 males and 60 females). Patients who had longer first admission days have fewer number of readmission. There were no significant correlation between psychiatric rehabilitation and course of schizophrenia. Courses, such as duration of outpatient department follow-up and number and duration of rehospitalization, did not differ according to the existence of extrapyramidal symptoms or types of antipsychotics prescribed. Conclusion : Among the therapeutic factors, longer duration of the first admission only affected better post-discharge course of patients with schizophrenia.

• Radiation Oncology Journal
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• 제36권3호
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• pp.172-181
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• 2018

Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.

• Radiation Oncology Journal
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• 제10권1호
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• pp.121-123
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• 1992

판톰 산란 인자($S_{p}$) 측정을 위한 새로운 방법을 소개한다. 측정용 전리함을 가릴 수 있는 블럭을 이용하여 $S_{p}$인자를 구할 수 있음을 이론적으로 증명하였으며, 이의 검증을 위해 $^{60}Co$을 이용하여 실험하였다. 이론값과 실험값과의 차이는 1%를 넘지않았다. 이 새로운 방법을 이용하면 고에너지 광자선측정에서 문제로 대두되고 있는 공기중 측정이 필요 없으며, 작은 블럭 차폐물만을 이용하여 $S_{p}$인자를 구할 수 있음을 확인하였다.