• Advances in Traditional Medicine
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• 제5권4호
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• pp.272-282
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• 2005

Piper betle Linn. (PB), which belongs to the family Piperaceae, is used traditionally in many Asian countries for treatment of a variety of aliments. It has also been used in Ayurveda and Unani systems of medicine. PB leaves are also used as a masticatory in the form of quid. The basic preparation of PB leaves for chewing purposes (PB quid) is known as Paan in India. It is recommended in ancient scripture of Ayurveda and is closely associated with Indian culture. PB is reported to have several therapeutic potentials as well as to produce some untoward effects. The review deals with phytoconstituents present, therapeutic potentials and untoward effects of PB.

• Advances in Traditional Medicine
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• 제9권2호
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• pp.101-105
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• 2009

Morinda tinctoria Roxb. (Family: Rubiaceae) is commonly known as Indian mulberry or Aal in India. This plant is very well known for its therapeutic benefit in Indian systems of medicine including Ayurveda and Siddha and in other forms of traditional Medicine worldwide for the treatment of several ailments. Almost all parts of this plant have been explored for its medicinal uses. Several reports on the phytochemical and therapeutic benefits of this plant have been reported. In this article an attempt has been made to review the traditional uses, phytochemical profiles and therapeutic potentials of Indian mulberry.

• BMB Reports
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• 제44권10호
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• pp.619-634
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• 2011

Bone morphogenetic protein (BMP) signaling in diseases is the subject of an overwhelming array of studies. BMPs are excellent targets for treatment of various clinical disorders. Several BMPs have already been shown to be clinically beneficial in the treatment of a variety of conditions, including BMP-2 and BMP-7 that have been approved for clinical application in nonunion bone fractures and spinal fusions. With the use of BMPs increasingly accepted in spinal fusion surgeries, other therapeutic approaches targeting BMP signaling are emerging beyond applications to skeletal disorders. These approaches can further utilize next-generation therapeutic tools such as engineered BMPs and ex vivo-conditioned cell therapies. In this review, we focused to provide insights into such clinical potentials of BMPs in metabolic and vascular diseases, and in cancer.

• Advances in Traditional Medicine
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• 제7권1호
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• pp.1-10
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• 2007

Mangifera indica Linn. (MI) (Family: Anacardiaceae) is commonly known worldwide as mango and ‘Aam’ in India. MI shares an important place in treatment of several diseases in various ancient system of medicine like Ayurveda and other Indian System of Medicine and some other Traditional Medicines world wide. Almost all the parts of MI have been used in oriental medicine, so in this review attempt has being made to review the history, traditional uses, phytoconstituents and therapeutic potentials of mango.

• Biomolecules & Therapeutics
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• 제32권2호
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• pp.183-191
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• 2024

The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins, amplifying the ER's folding capacity, and eliminating slow-folding proteins. Prolonged ER stress and UPR irregularities have been linked to a range of neuropsychiatric disorders, including major depressive disorder, bipolar disorder, and schizophrenia. This review offers a comprehensive overview of the UPR pathway, delineating its activation mechanisms and its role in the pathophysiology of neuropsychiatric disorders. It highlights the intricate interplay within the UPR and its profound influence on brain function, synaptic perturbations, and neural developmental processes. Additionally, it explores evolving therapeutic strategies targeting the UPR within the context of these disorders, underscoring the necessity for precision and further research to effective treatments. The research findings presented in this work underscore the promising potential of UPR-focused therapeutic approaches to address the complex landscape of neuropsychiatric disorders, giving rise to optimism for improving outcomes for individuals facing these complex conditions.

• IMMUNE NETWORK
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• 제24권1호
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• pp.2.1-2.24
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• 2024

Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in the modulation of a wide range of immune responses. IL-17 serves as a critical defender against bacterial and fungal pathogens, while maintaining symbiotic relationships with commensal microbiota. However, alterations in its levels can lead to chronic inflammation and autoimmunity. IL-21, on the other hand, bridges the adaptive and innate immune responses, and its imbalance is implicated in autoimmune diseases and cancer, highlighting its important role in both health and disease. Delving into the intricacies of these cytokines not only opens new avenues for understanding the immune system, but also promises innovative advances in the development of therapeutic strategies for numerous diseases. In this review, we will discuss an updated view of the immunobiology and therapeutic potential of IL-17 and IL-21.

• BMB Reports
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• 제55권7호
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• pp.336-341
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• 2022

Narrowing of arteries supplying blood to the limbs provokes critical hindlimb ischemia (CLI). Although CLI results in irreversible sequelae, such as amputation, few therapeutic options induce the formation of new functional blood vessels. Based on the proangiogenic potentials of stem cells, in this study, it was examined whether a combination of dental pulp stem cells (DPSCs) and human umbilical vein endothelial cells (HUVECs) could result in enhanced therapeutic effects of stem cells for CLI compared with those of DPSCs or HUVECs alone. The DPSCs+ HUVECs combination therapy resulted in significantly higher blood flow and lower ischemia damage than DPSCs or HUVECs alone. The improved therapeutic effects in the DPSCs+ HUVECs group were accompanied by a significantly higher number of microvessels in the ischemic tissue than in the other groups. In vitro proliferation and tube formation assay showed that VEGF in the conditioned media of DPSCs induced proliferation and vessel-like tube formation of HUVECs. Altogether, our results demonstrated that the combination of DPSCs and HUVECs had significantly better therapeutic effects on CLI via VEGF-mediated crosstalk. This combinational strategy could be used to develop novel clinical protocols for CLI proangiogenic regenerative treatments.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.162-162
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• 2001

Phytoestrogens produced naturally by either plants or their seeds are three main classes of phytoestrogens: isoflavone, lignan and coumestan. Phytoestrogens can have both agonist and antagonist action of estrogenic activity. It is believed that phytoestrogens with agonist and antagonist action of estrogenic activity may reduce the risk of breast cancer, in addition to may reduce the risk of osteoporesis by therapeutic agent of breast cancer.(omitted)

• Toxicological Research
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• 제30권4호
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• pp.243-250
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• 2014

Mitochondrial integrity is critical for maintaining proper cellular functions. A key aspect of regulating mitochondrial homeostasis is removing damaged mitochondria through autophagy, a process called mitophagy. Autophagy dysfunction in various disease states can inactivate mitophagy and cause cell death, and defects in mitophagy are becoming increasingly recognized in a wide range of diseases from liver injuries to neurodegenerative diseases. Here we highlight our current knowledge on the mechanisms of mitophagy, and discuss how alterations in mitophagy contribute to disease pathogenesis. We also discuss mitochondrial dynamics and potential interactions between mitochondrial fusion, fission and mitophagy.

• BMB Reports
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• 제51권10호
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• pp.486-492
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• 2018

The CCN protein family is composed of six matricellular proteins, which serve regulatory roles rather than structural roles in the extracellular matrix. First identified as secreted proteins which are induced by oncogenes, the acronym CCN came from the names of the first three members: CYR61, CTGF, and NOV. All six members of the CCN family consist of four cysteine-rich modular domains. CCN proteins are known to regulate cell adhesion, proliferation, differentiation, and apoptosis. In addition, CCN proteins are associated with cardiovascular and skeletal development, injury repair, inflammation, and cancer. They function either through binding to integrin receptors or by regulating the expression and activity of growth factors and cytokines. Given their diverse roles related to the pathology of certain diseases such as fibrosis, arthritis, atherosclerosis, diabetic nephropathy, retinopathy, and cancer, there are many emerging studies targeting CCN protein signaling pathways in attempts to elucidate their potentials as therapeutic targets.