• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1823-1827
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• 2012

The gene encoding the Nin one binding (NOB1) protein which plays an essential role in protein degradation has been investigated for possible tumor promoting functions. The present study was focused on NOB1 as a possible therapeutic target for breast cancer treatment. Lentivirus mediated NOB1 siRNA transfection was used to silence the NOB1 gene in two established breast cancer cell lines, MCF-7 and MDA-MB-231, successful transfection being confirmed by fluorescence imaging. NOB1 deletion caused significant decline in cell proliferation was observed in both cell lines as investigated by MTT assay. Furthermore the number and size of the colonies formed were also significantly reduced in the absence of NOB1. Moreover NOB1 gene knockdown arrested the cell cycle and inhibited cell cycle related protein expression. Collectively these results indicate that NOB1 plays an essential role in breast cancer cell proliferation and its gene expression could be a therapeutic target.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5281-5285
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• 2016

Background: Brachytherapy is the most commonly used conservative treatment for the uveal melanoma. The aim of this study was to evaluate therapeutic results of Ruthenium-106 plaque brachytherapy in the management of localized uveal melanoma cases. Methods: We reviewed retrospectively the clinical records of all patients treated in our department for an uveal melanoma, undergoing Ruthenium-106 plaque brachytherapy, from January 1996 to December 2015. We focused on clinical features, therapeutic characteristics, local and distant tumor control and side effects. Results: Nineteen patients were enrolled in our study. Mean age was 56.2 years (28-79) and the sex ratio was 1.37:1 males to females. Diagnosis was made on the basis of ophthalmological clinical examination, angiography, ultrasound and/or magnetic resonance. Median tumor diameter was 9.7 mm (6-13) and median thickness 4.4 mm (2.5-8). The dose of Ruthenium-106 plaque brachytherapy prescribed to the apex of each tumor was 70 Gy in all cases. The median radiation dose to the sclera surface was 226.4 Gy (range: 179.6-342.3) and the median total application time 115.2 hours (range: 27 to 237). After a median follow-up of 61.5 months, local control was achieved in 17 patients (89%): 16 demonstrated a partial tumor response and 1 tumor stabilization. Two patients suffered local progression leading to enucleation, one dying of hepatic metastasis. Radiation-induced complications were cataracts in 3 cases and vitreal hemorrhage in 2. Conclusion: Ruthenium-106 plaque brachytherapy is an efficient treatment for localized uveal melanoma, offering good local control with low toxicity.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 1999년도 Japanese Journal of Medical Physics
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• pp.301-302
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• 1999

• Radiation Oncology Journal
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• 제9권2호
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• pp.319-324
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• 1991

여성 뇨도암은 극히 드문 종양으로 그 치료법에 대해서는 수술과 방사선 치료가 주종을 이룬다. 본원에서 micro Selectron ${I_r}-192$를 이용하여 원격조정 고선량 근접치료를 시행했는데 시술의 기술적인 측면을 소개하고 문헌고찰을 기술한다.

• 대한약침학회지
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• 제19권3호
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• pp.259-263
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• 2016

Lung cancer has a high mortality rate and is often diagnosed at the metastatic stage. Gefitinib is a targeted molecular therapeutic drug used to treat patients with non-small-cell lung cancer (NSCLC). Korean herbal medicines may also have therapeutic efficacy against lung cancer, reduce the side effects associated with chemotherapy, and improve patient quality of life (QOL). This case report describes the effects of a Korean herbal medicine regimen combined with gefitinib in a patient with NSCLC and bone metastasis. The Korean herbal medicine regimen included woohwanggeosa-dan, hwanggibujeong-dan and geonchilgyebok-jeong. The computed tomography (CT) findings showed that following combination treatment, the size of the tumor was markedly decreased without serious adverse events. Moreover, the Eastern Cooperative Oncology Group (ECOG) performance status was improved and cancer-related pain was decreased. These results suggest that a combination of Korean herbal medicines and gefitinib may be an effective therapeutic option for patients with advanced NSCLC and bone metastasis. Further studies are needed to examine the mechanism and the clinical efficacy of Korean herbal medicines against NSCLC.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 2009년도 춘계학술대회 논문집
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• pp.76-76
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• 2009

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 1999년도 Japanese Journal of Medical Physics
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• pp.28-32
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• 1999

• Radiation Oncology Journal
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• 제10권1호
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• pp.121-123
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• 1992

판톰 산란 인자($S_{p}$) 측정을 위한 새로운 방법을 소개한다. 측정용 전리함을 가릴 수 있는 블럭을 이용하여 $S_{p}$인자를 구할 수 있음을 이론적으로 증명하였으며, 이의 검증을 위해 $^{60}Co$을 이용하여 실험하였다. 이론값과 실험값과의 차이는 1%를 넘지않았다. 이 새로운 방법을 이용하면 고에너지 광자선측정에서 문제로 대두되고 있는 공기중 측정이 필요 없으며, 작은 블럭 차폐물만을 이용하여 $S_{p}$인자를 구할 수 있음을 확인하였다.

• 대한두경부종양학회지
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• 제1권1호
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• pp.81-86
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• 1985

A case of primary laryngeal non-Hodgkin's lymphoma is detailed with a review of the literature, on this rare site of presentation. Histologic findings and radio-therapeutic technique are included with longterm follow-up data. Local radiotherapy is a curative treatment of choice due to longterm NED survival with preservation of voice.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 1999년도 추계 학술대회
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• pp.262-263
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• 1999