• Therapeutic Science for Rehabilitation
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• v.6 no.2
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• pp.29-36
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• 2017

Introduction: Occupation based intervention is effective intervention of nervous system clients. So, this study investigated theoretical background, definition, and domain of occupation based intervention through literature reviews. And the study suggested neurological references to apply it in realistic occupation therapy area. Body: Occupation based intervention is performed in occupation based practice. Client's proper performance in natural environments is important. That is application of meaningful occupation in client's realistic environment is occupation based intervention. At this point, meaningful occupation is included client's motivation, selective task, and habituation of performance. Conclusion: Occupation based intervention were included motivation, habituation, and realistic environment of clients. The reviews identified that each factor is based on neurological basis. Therefore occupation based intervention need to use in realistic neurorehabilitation.

• Food Science and Biotechnology
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• v.17 no.5
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• pp.983-989
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• 2008

Two flavonoids, isorhamnetin 3-O-$\beta$-D-glucopyranoside (1) and quercetin 3-O-$\beta$-D-glucopyranoside (2), from slander glasswort (Salicornia herbacea, Korean name hamcho) were isolated. Antioxidative and matrix metalloproteinase-9(MMP-9) inhibitory effects of these compounds were investigated in HT 1080 cell lines. These compounds suppressed the electron spin resonance (ESR) signal intensity on generation of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical in a free-cellular system. Their scavenging effects on generation of intercellular reactive oxygen species (ROS) also exhibited similar trends with DPPH radical in the free cellular system. Also, a control group combined only with Fe(II)-$H_{2}O_2$ resulted in DNA apoptosis by oxidative stress, whereas treatments with these compounds suppressed radical-mediated DNA damage. Intracellular glutathione (GSH) levels were slightly increased in the presence of compound 1 and 2. Moreover, these compounds led to the reduction of the expression levels of MMP-9 without cytotoxic influence. These results suggest that these compounds have a potential as a valuable natural antioxidant and MMP inhibitor related to oxidative stress. Therefore, these compounds not only can be developed as a candidate for a therapeutic potential but also a source for use as ingredients of health foods or functional foods to prevent metastasis involving MMP-9, closely related to ROS.

• Journal of the Ergonomics Society of Korea
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• v.26 no.4
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• pp.25-31
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• 2007

The purpose of this study was to investigate the strength and endurance of the deep neck flexor muscles in individuals with work-related neck pain. Subjects consisted of two groups: twenty industrial workers with neck pain and twenty age-matched healthy subjects. To evaluate the strength and endurance of deep cervical flexors, maximum voluntary contractile strength (MVCS) and a sustained time at sub-maximal voluntary contractile strength (SMVCS) (80% and 50% of MVCS) were measured using a pressure biofeedback unit and a stop watch in supine. The MVCS of deep neck flexor muscles was 29.67${\pm}$4.56 in neck pain group and 54.27${\pm}$6.78㎜Hg in normal group. The sustained time at 80% SMVCS was 12.42${\pm}$2.64 seconds and 55.12${\pm}$12.76 seconds in the groups with and without neck pain. The sustained time at 50% SMVCS was 25.40±5.88 seconds and 109.70${\pm}$31.50 seconds in the groups with and without neck pain. The difference of the lower jaw position was 16.75${\pm}$3.57㎜ and 23.03${\pm}$2.51㎜. The MVCS, endurance at the two sub-maximal levels and the difference of the lower jaw position were significantly greater in the group without neck pain than with neck pain (p$<$0.05). The findings indicate that the maximal strength and endurance of the deep neck flexors were decreased in the workers with neck pain compared to those without neck pain. Therefore, it is necessary to include strengthening and endurance exercises of the deep neck flexor muscles in therapeutic program of work-related musculoskeletal disorders involving neck pain.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2115-2120
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• 2012

The presence of lung cancer cells in anoxic zones is a key cause od chemotherapeutic resistance. Thus, it is necessary to enhance the sensitivity of such lung cancer cells. However, loss of efficient gene therapeutic targeting and inefficient objective gene expression in the anoxic zone in lung cancer are dilemmas. In the present study, a eukaryotic expression plasmid pUC57-HRE-JAB1 driven by a hypoxia response elements promoter was constructed and introduced into lung cancer cell line A549. The cells were then exposed to a chemotherapeutic drug cis-diamminedichloroplatinum (C-DDP). qRT-PCR and western blotting were used to determine the mRNA and protein level and flow cytometry to examine the cell cycle and apoptosis of A549 transfected pUC57-HRE-JAB1. The results showed that JAB1 gene in the A549 was overexpressed after the transfection, cell proliferation being arrested in G1 phase and the apoptosis ratio significantly increased. Importantly, introduction of pUC57-HRE-JAB1 significantly increased the chemotherapeutic sensitivity of A549 in an anoxic environment. In conclusion, JAB1 overexpression might provide a novel strategy to overcome chemotherapeutic resistance in lung cancer.

• Journal of Korean Society of Forest Science
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• v.97 no.6
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• pp.634-640
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• 2008

The purpose of this study is to clarify the physiological effects of Shinrin-yoku (taking in the atmosphere of the forest of forest bathing). The subjects were twelve male university students ($21.6{\pm}2.1$ years old). On the first day, six subjects were sent to a forest area, and the others to a city area. On the second day, the subjects were sent to the opposite areas for a cross check. The subjects were seated on chairs and viewing the landscapes of their given areas for 15 minutes. HRV (Heart Rate Variability) and diastolic blood pressure were used as physiological indices. Diastolic blood pressure and LF/(LF+HF) components of HRV in the forest area were significantly lower than in the city area. And HF power components of HRV in the forest settings were significantly enhanced than in city settings. In conclusion, the results of the physiological measurements show that Shinrin-yoku was able to effectively relax people in both mind and body.

• Natural Product Sciences
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• v.26 no.1
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• pp.50-58
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• 2020

The study was conducted for quantitive determination of macronutrients, micronutrients and heavy metals present in Spilanthes acmella Hutch and Dalz, a traditionally used important medicinal plant. The results illustrated the presence of substantial amounts of essential nutrient elements in different parts of the plant. K and Mg were detected in the range between 36.35 ± 1.01 to 67.78 ± 1.33 g/kg and 2.17 ± 0.13 to 7.02 ± 0.84 g/kg of DWS respectively. While the essential micronutrients Fe, Na, Mn, Zn and Cu were detected in the range between 62.62 ± 12.72 to 856.95 ± 76.61 mg/kg, 365.47 ± 23.84 to 633.03 ± 38.12 mg/kg, 51.66 ± 7.77 to 186.33 ± 13.92 mg/kg, 41.87 ± 2.85 to 53.89 ± 3.79 mg/kg and 18.49 ± 2.07 to 48.71 ± 4.89 mg/kg of DWS respectively. Besides, heavy metals (Cd, Ni and Pb) detected in some of the plant samples were beyond the maximum permissible limit (MPL) of FAO/WHO for herbal medicines. The concentrations of the essential nutrient elements except zinc were significantly different in different parts of the plant (p < 0.001). Further variation in the concentrations of the elements in the plant was observed with respect to seasonal changes and geographical conditions. Nevertheless the findings corroborate ethnomedicinal significance of the plant and signify the possibilibity of utilizing its standardized products for preparation of food supplements as well as multidimensional therapeutic herbal medicines.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.2
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• pp.93-103
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• 2021

Purpose : This study aimed to investigate the effect of trunk postural stability maintained wearing a spiral elastic band on the upper extremity function of patients with stroke who undertook a functional activity program and to provide fundamental data useful for the application of therapeutic interventions in the clinical environment of occupational therapy. Methods : The research subjects included 16 patients with stroke who were evenly divided into an experimental group and a control group. The eight-week intervention consisted of a functional activity program aimed at improving the function of the affected-side upper extremity. The experimental group performed the functional activity program while maintaining a stable trunk posture by wearing a spiral elastic band. The control group followed the program without wearing the band. Upper extremity function was assessed before and after the intervention using a manual function test (MFT) and a motor activity log (MAL), and the effectiveness on the upper extremity function of the affected side was confirmed. Results : First, in the within-group comparison of the upper extremity function scores before and after the intervention, the experimental group showed a statistically significant difference in the MFT and MAL assessment(p<.05). The control group showed a statistically significant difference in the MAL assessment(p<.05). Second, in the between-group comparison of the change in scores after the intervention, a statistically significant difference was observed between the two groups in all assessments(p<.05). Conclusion : This study confirmed the positive effect on upper extremity function of trunk stabilization posture using a spiral elastic band. The results could be useful when implementing a task-oriented training program in the clinical environment of occupational therapy in the future, as application of the training while maintaining trunk postural stability by wearing a spiral elastic band could be more effective for improving the upper extremity function of patients with stroke.

• Journal of dental hygiene science
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• v.20 no.4
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• pp.213-220
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• 2020

Background: The leaves of Perilla frutescens, commonly called perilla and used for food in Korea, contain components with a variety of biological effects and potential therapeutic applications. The purpose of this study was to identify the components of 70% ethanol extracted Perilla frutescens (EEPF) and determine its inhibitory effects on oral microbial activity and production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharides (LPS)-stimulated Raw264.7 macrophages, consequently, to confirm the possibility of using EEPF as a functional component for improving the oral environment and preventing inflammation. Methods: One kg of P. frutescens leaves was extracted with 70% ethanol and dried at -70℃. EEPF was analyzed using high-performance liquid chromatography analysis, and antimicrobial activity against oral microorganisms was revealed using the disk diffusion test. Cell viability was elucidated using a methylthiazolydiphenyl-tetrazolium bromide assay, and the effect of EEPF on LPS-induced morphological variation was confirmed through microscopic observation. The effect of EEPF on LPS-induced production of pro-inflammatory mediators, NO and PGE2 was confirmed by the NO assay and PGE2 enzyme-linked immunosorbent assay. Results: The main component of EEPF was rosemarinic acid, and EEPF showed weak anti-bacterial and anti-fungal effects against microorganisms living in the oral cavity. EEPF did not show toxicity to Raw264.7 macrophages and had inhibitory effects on the morphological variations and production of pro-inflammatory mediators, NO and PGE2 in LPS-stimulated Raw264.7 macrophages. Conclusion: EEPF can be used as a functional material for improving the oral environment through the control of oral microorganisms and for modulating inflammation by inhibiting the production of inflammatory mediators.

• Journal of People, Plants, and Environment
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• v.23 no.5
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• pp.565-576
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• 2020

Background and objective: The elderly living in homeless living facilities for a long time suffer from various mental health problems. This study aims to determine the psychological, emotional, and social effects of a horticultural therapy program composed of gardening activities, which was designed based on the semantic structures of life for the homeless elderly living in the facilities for a long time. Methods: A total of 12 subjects (6 in the control group and 6 in the experimental group) participated in the study. The horticultural therapy program consisted mainly of gardening activities, and a total of 16 sessions were conducted once a week for 16 weeks, 60-90 minutes per session. The subjects were tested to evaluate their self-esteem, depression, and horticultural activities. The data were analyzed using the Mann-Whitney U test, Wilcoxon rank test, and Friedman test, which were nonparametric tests, conducted at a 95% significance level. Results: First, in the case of self-esteem, a significant difference was found between the groups, 20.00 points (SD = 5.69) in the control group, and 25.50 points (SD = 3.73) in the experimental group (p = .034). Second, in the case of depression, no statistically significant difference was found in the posttest. Finally, in the case of the horticultural activity evaluation, the scores of most variables gradually and significantly increased during the program [Verbal interaction during activity (p = .006), Self-concept and identity (p = .006), Need-drive adaptation (p < .001), Interpersonal and social relations (p < .001)]. Conclusion: These results support that the horticultural therapy program could help the elderly improve psychological relaxation, emotional stability, and social relationships. In order to generalize the results, it is suggested to increase the number of subjects or conduct additional repetitive experiments in further research.

• Korean Journal of Environment and Ecology
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• v.37 no.6
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• pp.464-472
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• 2023

Middle-aged women experience a lot of physical and mental stress during their developmental cycle. This stress reduces the quality of life because it leads to chronic pain and disease. Forest therapy is attracting attention as an alternative to this. Forest therapy refers to improving human health through the therapeutic elements of forests. Accordingly, this study was conducted to determine whether a sensory insight-based forest therapy program was effective in reducing stress in middle-aged women. For this purpose, middle-aged women who wanted to participate in the forest therapy program were recruited, 20 each were randomly assigned to an experimental group and a control group, and pre- and post-tests were conducted. The forest therapy program consisted of 8 sessions of 6 hours based on sense and insight. The forest therapy program was held at Saryeoni Forest in Jeju, and the measurement tools were compared by measuring perceived stress, leisure satisfaction, and stress index through pulse wave testing. The results of the study showed that the forest therapy program lowered stress and improved leisure satisfaction.