• 대한방사선치료학회지
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• 제2권1호
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• pp.87-92
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• 1987

The authors have intended to measure intrinsic dose distribution by Farmer dosimeter in irregularly shaped fields such as L, M, T,-shape model in order to determine dose inhomogeneity in those models. We made 2 off-axis points in each model and measured the depth dose at 1.5,5, and 9cm below surface. The results showed $1-3\%$ dose discrepancy between 2 points. We also measured the depth dose by geometric approximation and computer calculation in those models, and came to the conclusion that computer calculation using Clarkson's principle is simpler and the measurements are to the ideal data obtained by the experiment in those three models of irregularly shaped fields than those of geometric approximation method.

• International Journal of Computer Science & Network Security
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• 제22권10호
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• pp.155-164
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• 2022

The review of known decisions showed that currently there are no systems and technologies for supporting the decision about the possibility of concluding the civil law agreements for medical, therapeutic and dental services. The paper models the decision-making support process on the possibility of concluding the civil law agreements for medical, therapeutic and dental services, which is the theoretical basis for the development of rules, methods and system for supporting the decision about the possibility of concluding the civil law agreements for medical, therapeutic and dental services. The paper also developed the system for supporting the decision about the possibility of concluding the civil law agreements for medical, therapeutic and dental services, which automatically and free determines the possibility or impossibility of concluding the corresponding civil law agreement for the provision of a corresponding medical service. In the case of formation of a conclusion about the possibility of concluding the agreement, further conclusion and signing of the corresponding agreement takes place. In the case of forming a conclusion about the impossibility of concluding the agreement, a request is made for finalizing the relevant agreement for the provision of the relevant medical service, indicating the reasons for the impossibility of concluding the agreement - missing essential conditions in the agreement. After finalization, the agreement can be analyzed again by the developed system for supporting the decision.

• Radiation Oncology Journal
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• 제2권2호
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• pp.281-285
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• 1984

The authors have intended to measure intrinsic dose distribution by Farmer dosimeter in irregularly shaped fields such as L.M and T shape models in order to determine dose inhomogeneity in those models. We made 2 off·axis points in each model and measured the depth dose at 1.5, 5 and 9cm below surface. The results showed $l\~3\%$ dose discrepancy between 2 points. We also measured the depth dose by geometric approximation and computer calculation in those models, and came to the conclusion that computer calculation using Clarkson's principle is simpler and the measurements are closer to the ideal data obtained by the experiment in three models of irregularly shaped fields than those of geometric approximation method.

• BMB Reports
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• 제42권5호
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• pp.260-264
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• 2009

Tumor necrosis factor-$\alpha$ (TNF-$\alpha$) exhibits cytotoxicity towards various tumor cells in vitro and induces apoptotic necrosis in transplanted tumors in vivo. It also shows severe toxicity when used systemically for the treatment of cancer patients, hampering the development of TNF-$\alpha$ as a potential anticancer drug. In order to understand the structure-function relation of TNF-$\alpha$ with respect to receptor binding, we selected four regions on the bottom of the TNF-$\alpha$ trimer that are in close contact with the receptor and carried out mutagenesis studies and computational modeling. From the study, various TNF-$\alpha$ muteins with a high therapeutic index were identified. These results will provide a structural basis for the design of highly potent TNF-$\alpha$ for therapeutic purposes. By conjugating TNF-$\alpha$ muteins with a high therapeutic index to a fusion partner, which targets a marker of angiogenesis, it could be possible to develop TNF-$\alpha$ based anticancer drugs.

• International Journal of Contents
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• 제14권1호
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• pp.12-17
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• 2018

This study explored potential therapeutic mechanisms of playing preferred online games as predictors of therapeutic interventions for players' psychosocial factors (i.e., aggression, depression, and loneliness). Based on theories of catharsis, the generic model of psychotherapy, we took a therapeutic approach to integrate these perspectives. We created a path model describing how therapeutic catharsis-seeking, online game self-efficacy, and life self-efficacy were associated with psychosocial factors of aggression, depression, and loneliness, including generalized sub-constructs of each factor as multi-dimensional sources. We analyzed the path model using data of 1,227 online game players in Korea. Our results indicated that therapeutic catharsis-seeking could alleviate aggression via favorite game playing. Life self-efficacy was a primary predictor for alleviating depression and loneliness. However, online game self-efficacy was positively associated with depression and loneliness. Implications of these findings are discussed.

• Clinical Endoscopy
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• 제51권6호
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• pp.552-557
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• 2018

Although colonoscopy was originally a diagnostic imaging procedure, it has now expanded to include an increasing range of therapeutic interventions. These procedures require precise maneuvers of instruments, execution of force, efficient transmission of force from the operator to the point of application, and sufficient dexterity in the mobilization of endoscopic surgical instruments. The conventional endoscope is not designed to support technically demanding endoscopic procedures. In case of colonoscopy, the tortuous anatomy of the colon makes inserting, moving, and orientating the endoscope difficult. Exerting excessive pressure can cause looping of the endoscope, pain to the patient, and even perforation of the colon. To mitigate the technical constraints, numerous technically enhanced systems have been developed to enable better control of instruments and precise delivery of force in the execution of surgical tasks such as apposing, grasping, traction, counter-traction, and cutting of tissues. Among the recent developments are highly dexterous robotic master and slave systems, computer-assisted or robotically enhanced conventional endoscopes, and autonomously driven locomotion devices that can effortlessly traverse the colon. Developments in endoscopic instrumentations have overcome technical barriers and opened new horizons for further advancements in therapeutic interventions. This review describes examples of some of these systems in the context of their applications to advanced therapeutic colonoscopy.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2020년도 추계학술발표대회
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• pp.1036-1038
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• 2020

This paper proposes a novel automated liver segmentation using Multi-Dilated U-Nets. The proposed multidilation segmentation model has the advantage of considering both local and global shapes of the liver image. We use the CT images subject-wise, every 2D image is concatenated to 3D to calculate the IOU score and DICE score. The experimental results on Jeonbuk National University hospital dataset achieves better performance than the conventional U-Net.

• Radiation Oncology Journal
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• 제11권1호
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• pp.175-181
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• 1993

방사선수술을 시행하기 위해서는 종양의 위치결정, 흡수선량 계산, 그리고 치료를 위한 특수제작된 기구와 컴퓨터 프로그램이 요구된다. 본 연구의 목적은 선형가속기의 전반적인 기계적 정밀도를 확인하고 선형가속기를 이용한 방사선수술에 있어서의 선량계산 알고리즘을 개발하는 것이다. 치료기계의 정렬과 전반적인 치료체계의 성과에 대한 점검을 행하였고 백분율 심부선량, 중심축외 선량비, 그리고 출력인자와 같은 기본 계산자료를 측정하였다. 또한, 입체방사선수술을 위한 3차원적 치료계획 체계를 개발하였다. 선량분포를 계산하기 위하여 C-언어를 이용한 컴퓨터 프로그램을 작성하였고 하드웨어로는 IBM PS/2 (Intel 80386 SX, 24 MHz)를 사용하였다. 그 결과, 주 병원이 보유한 선형가속기의 겐트리와 테이블 회전에 따른 중심점에 대한 오차는 2 mm 이내로 방사선수술을 시행하기에 충분하였다. 팬톰실험에 따르면, 컴퓨터 단층촬영을 이용한 위치결정을 포함한 표적에의 빔의 일치도는 역시 2mm 이내였다. 끝으로, 본원에서 개발한 3차원적 치료계획의 정확도는 필름을 이용한 선량측정을 통하여 입증되었다.

• 한국컴퓨터정보학회논문지
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• 제28권12호
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• pp.155-166
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• 2023

이 연구는 치매안심센터 인지재활 프로그램의 현황 및 실태분석을 통한 활성화 방안과 다차원적 치료레크리에이션 프로그램에 대한 개발방향과 내용을 도출하고자 D시의 치매안심센타 인지재활 치료프로그램 참여 노인 각 50명씩(5개구)을 선정하였고, 9명을 전문가 집단 의견수렴 대상으로 선정하였다. 수집된 자료는 SPSS ver. 18.0 통계 프로그램을 이용하여 기술통계와 구성요소별 중요도 및 우선순위는 계층구조분석을 시행함으로써, 첫째, 현재 제공되고 있는 인지재활 지원 프로그램은 이용자의 요구와는 달리 지원프로그램이 충분하지 않아 경험이 상당히 낮게 나타났으며, 이에 대한 개선점으로는 돌봄이나 보호시설 확대와 이용자의 요구를 충족할 다양한 프로그램 개발이 중요하다고 나타났고, 둘째, 치료레크리에이션 구성요소별 중요도와 우선순위는 대분류(6개) 운동요법, 중분류(16개) 운동요법의 행동중심 접근법, 소분류(47개) 힘뇌체조, 실버건강체조가 가장 높게 나타났다. 이는 치료레크리에이션 프로그램 개발시 각 영역의 우선순위를 고려한 다차원적 프로그램 계획이 이루어져야 함을 보여주는 결과라 할 수 있다.

• Journal of Yeungnam Medical Science
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• 제5권2호
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• pp.31-36
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• 1988

회전조사시 회전각도에 따른 계산치와 측정치를 비교, 검토하여 마음과 같은 결과를 얻었다. $90^{\circ}$ 회전시에는 계산치와 측정치와는 4.5%의 차이를 나타내었고 $120^{\circ}$ 회전시에는 4.4%, $180^{\circ}$ 회전시에는 3.9%, $240^{\circ}$ 회전시에는 2.9%, $360^{\circ}$ 회전시에는 2.1%의 차이를 나타내어 회전각도가 클수록 계산치와 측정치와의 차이는 적은 것으로 나타났다. 또한 회전각도에 따라 최고선량지점이 상부로 이동하는 정도는 $90^{\circ}$에서 $240^{\circ}$까지 회전할 때 tumor depth가 4.5cm일 경우에 는 1.67cm에서 1.10cm 정도 상부로 이동하였으며, tumor depth가 8cm일 경우에는 2.45cm에서 1.40cm 정도 상부로 이동하는 것으로 나타났다.