• Journal of Neurocritical Care
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• v.11 no.2
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• pp.63-70
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• 2018

Management of mechanical ventilation is essential for patients with neuro-critical illnesses who may also have impairment of airways, lungs, respiratory muscles, and respiratory drive. However, balancing the approach to mechanical ventilation in the intensive care unit (ICU) with the need to prevent additional lung and brain injury, is challenging to intensivists. Lung protective ventilation strategies should be modified and applied to neuro-critically ill patients to maintain normocapnia and proper positive end expiratory pressure in the setting of neurological closed monitoring. Understanding the various parameters and graphic waveforms of the mechanical ventilator can provide information about the respiratory target, including appropriate tidal volume, airway pressure, and synchrony between patient and ventilator, especially in patients with neurological dysfunction due to irregularity of spontaneous respiration. Several types of asynchrony occur during mechanical ventilation, including trigger, flow, and termination asynchrony. This review aims to present the basic interpretation of mechanical ventilator waveforms and utilization of waveforms in various clinical situations in the neuro-ICU.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.171-177
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• 2022

ROS1 (c-ros oncogene) is one of the gene with mutation in NSCLC (non-small cell lung cancer). The increased expression of ROS1 is leading to the increase proliferation of cell, cell migration and survival. Crizotinib and Entrectinib are the drugs that have been approved by FDA against ROS1 protein, but recently patients started to develop resistance against Crizotinib and there is a need of new drug that could act as an effective drug against ROS1 for NSCLC. In this study, we have performed virtual screening, where compounds are taken from Zinc 15 dataset and molecular docking was performed. The top compounds were taken based upon their binding affinity and their interactions with the residues. The compounds stability and chemical reactivity was also studied through Density Functional theory and their properties. Further study of these compounds could reveal the required information of ROS1-inhibitor complex and in the discovery of potent inhibitors.

• Culinary science and hospitality research
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• v.24 no.3
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• pp.144-155
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• 2018

This study was conducted to explore the direction of culinary education based brain-based education with analysis of comprehensive research. Questionnaire was completed by frequency analysis, factor analysis, reliability analysis and regression analysis by using SPSS 21. The purpose of this study was to investigate the educational system for creative development through cooking sources and to develop brain-based learning theory, and thus to generate the characteristics and effects of the practice in culinary educational context. The basic principles of brain- based learning are brain plasticity, emotional brain, and ecological brain. Students need to be able to enrich their understanding of social interaction so that social brain's function will be activated through consistent and high-quality feedback. Likewise, students should be capable of collecting everything what they have learned. Defining main ideas and goal of the lesson, four factors were derived from development of competency, personality, application, and diversity. Regarding to the result of this study, the implications for the development of a brain-base program were suggested.

• Journal of the Korean Society of Safety
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• v.5 no.3
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• pp.51-55
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• 1990

This study describes the engineering approach adopted to investigate sprinkler head during the early stage of a fire when they are subjected to convective heating and low gas velocities. Comparions are made between the parameters derived using basic methods, ie. ramp test, for evaluating sprinkler parameters(time constant, response time index) is illustrated. Evidence is presented that the propotion of heat loss by conduction from a sprinkler element may very typically employed in the rate of rise test. This fact alone may justfy the precautionary need to perform a limited number of rate of rise tests to confirm a sprinklers capacity to function correctly in reasonably unfavourable yet realistic conditions. The work is aimed primarily at meeting the needs of sprinkler industry.

• Korean Journal of Head & Neck Oncology
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• v.33 no.1
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• pp.7-13
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• 2017

Despite improved treatment outcomes of locally advanced disease over the last 2 decades, the survival of patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains dismal. There is a clear need for development of novel therapeutic strategies for recurrent and/or metastatic HNSCC. Recent advances in understanding tumor immunology have been directly and rapidly translated into clinical success of T cell-directed immunotherapeutic approach in the treatment of several types of solid cancers. Among them, impact of immune checkpoint inhibition using neutralizing antibodies is the most striking. A variety of immunotherapeutic strategies targeting T cells have been also studied in HNSCC, especially in recurrent and/or metastatic setting even with significant survival benefit. The present article reviews the basic concept of T cell-directed immunotherapy and the current status of such approaches in the treatment of HNSCC.

• Proceedings of the KSR Conference
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• 2003.10b
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• pp.223-228
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• 2003

Risk Management does not mean accepting a risk but having a good grasp of, eliminating and controling the exact causes of known hazards. Good safety management plan or system for the safety of any systems need to include the procedures about standing safety goals, related technical information, time schedule, audit programs, etc at least. In this paper the summeries on general risk assessment techniques and the examples of risk assessment system and railway risk management strategies used in UK, Australia and Canada are introduced, and applicable establishment procedures for domestic railway industries are proposed.

• Journal of Families and Better Life
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• v.21 no.5
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• pp.155-170
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• 2003

This paper will provide a basic analysis of traditional wedding artifacts as they appear on museum websites and their value for scientific research. The results of this study are as follows: 1. There were a total of 115 wedding artifacts(72 written documents related to weddings, 43 marital items) on the website of a museum. Most of them were related to the latter half of Cho-sun Dynasty. From these artifacts, we may understand the culture surrounding wedding during the transitional period from the Cho-sun Dynasty to modem time. 2. By analyzing such wedding artifacts, we can supplement existing methods of study such as literature research and case histories. In this way, we may better understand the history and culture of weddings. 3. In order to gain a deeper understanding of the culture of weddings we need to adopt a more interdisciplinary approach of wedding artifacts.

• Korean Journal of Adult Nursing
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• v.21 no.6
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• pp.603-616
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• 2009

Purpose: The purpose of this study was to examine the subjective opinions of first-generation Korean-Americans about survival. Methods: The Q-methodology which provides a method of analyzing the subjectivity of each item was used. The 34 selected Q-statements from each of 38 subjects were classified into a shape of normal distribution using a 9 point scale. The collected data was analyzed using a QUANL/WIN program. Results: Four types of survival attitudes from 38 first-generation Korean-Americans were identified. Type I was a satisfaction type based on belief, Type II was an effort type based on purpose, Type III was an isolation type based on ethnicity, and Type IV was a compromise type based on adaptation. Results of this study indicate that approaches to a minority's survival strategies need to be differentiated taking this typology and various subject characteristics into account. Conclusion: This information may provide a basic understanding for healthcare providers who work with first-generation Korean-Americans.

• The Korean Journal of Health Service Management
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• v.10 no.1
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• pp.117-129
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• 2016

Objectives : This study investigated the prevalence of unmet health care needs among Korean adults and related factors. Methods : The study participants were adults over the age of 20 mental health experience from the Korea Health Panel in 2012(n=4,730). Statistical analysis methods used in this study were the ${\chi}^2$-test, Logistic Regression Analysis and other basic statistics such frequency-and percentage using SPSS version 22.0. Results : (1)Significant variables of stress: Factors were age, economic activity, subjective health status, and activity limitation. (2)Significant variables of depression: Factors were age, income class(low) and activity limitation. (3)Significant variables of suicidal impulse: Factors were age, chronic diseases, income class, and activity limitation. Conclusions : Stress, depression, and suicidal impulse can be unmet medical factors; therefore improvement measures and mental health counseling programs in response to suicide impulses, should be developed. Thus there is a need for a health sciences approach.

• Proceedings of the KIEE Conference
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• 1998.07c
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• pp.1150-1152
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• 1998

Recently, our electric industry confronts a structural change and high competiveness environment in the course of deregulation. Rapid growth in electricity demand, financial need for new power plant construction, and envionmental problems have led to search for more efficient energy production and energy conservation techmologies. Especially, residential and commercial buildings consumes 40% of electricity demands and building energies are increasing more and more in Korea. The purpose of this paper is to analyze the electricity use of commercial buildings by end-use. Also, we will use it as a basic informations of DSM potential evaluation and evaluation process based on different approach by sector and type of potential.