• 의료법학
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• 제7권2호
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• pp.331-364
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• 2006

Medical supplies have contradiction of efficacy and side effect to the various diseases together. Therefore, people have tried to reduce the side effects and also provide various methods to cope with any damages from the medicine quickly. In the case of accidents by medical supplies, the victim can be protected with advantage by the Product Liability Law rather than the Torts. The limit of Product Liability Law's application depends on whether medical supplies belong to the product or not. According to Product Liability Law, the product should be processed. Therefore, medical supplied should be processed to be the category of product. It can be said that the medical supplies in pharmacy, Chinese medicine, medical herbs, biological medicine manufactures, blood manufactured medicine, cord blood, hemopoietic progenitior cell and stem cell belongs to the manufactured products. The mixture by the prescription of doctor or preparation of pharmacist can be recognized as the product because prescription or preparation is a manufacturing act. Therefore, applying Product Liability Law to manufacturer, doctor or pharmacist would achieve the goal which is protecting the victims extensively.

• 대한한의학원전학회지
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• 제21권3호
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• pp.59-68
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• 2008

The reinforcement method for reducing fever prescribe sweet and warm drugs for reinforcing the middle heater and raising Yang(陽) and sweet and cold drugs for purging the pathogenic fire. Bojung-ikgitang(補中益氣湯) is representative prescription based on the reinforcement method for reducing fever. Therefore it is ought to be regarded as prescription for syndromes to show the impairment of Gi(氣), blood, fluids, and humors for pathogenic fire.

• 한국의사학회지
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• 제24권2호
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• pp.77-86
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• 2011

This paper aims to find out the unique Oriental Medical characteristics of the prescription Gami-Bojeongsan(加味普正散), which can only be found in "Cheong-gang Euigam(晴崗醫鑑)" and the records of diagnosis by Kim Yeong Hoon. First, clues regarding Gami-Bojeongsan (加味普正散) in "Cheong-gang Euigam(晴崗醫鑑)" and the records of diagnosis by Kim Yeong Hoon have been collected, and then the origin of Gami-Bojeongsan(加味普正散) has been studied. Moreover, changes of prescriptions for common cold in East Asian Medicine have been looked into from historical perspective, and their connection to Gami-Bojeongsan(加味普正散) has also been researched. Lastly, connection of prescriptions for common cold found in royal records of the Chosun Dynasty to Gami-Bojeongsan(加味普正散) has been confirmed. The results are as follow: 1) Gami-Bojeongsan(加味普正散) is a most frequently used prescription in the records of diagnosis by Kim Yeong Hoon, and was used mostly in winter. It includes various modified versions. 2) Prescriptions that adopt Cyperi Rhizoma(香附子) as the sovereign medicinal, such as Gami-Bojeongsan(加味普正散), include Hyangsosan(香蘇散) of "Hejijufang(和劑局方)" and Hyang-gal-tang (香葛湯) of "Dexiaofang(得效方)". Hyang-gal-tang(香葛湯) is thought to have adopted Korean characteristics through "Dong-Eui-Bo-Gam (東醫寶鑑)" and "Je-Jung-Shin-Pyeon(濟衆新編)", and have continued its existence until it reached Gami-Bojeongsan(加味普正散). 3) These characteristics can be found in the royal records of the Chosun Dynasty, and also in Shin-Su-Tae-Eul-San(神授太乙散) of "Euibang-Yuchui (醫方類聚)".

• 대한한의정보학회지
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• 제17권1호
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• pp.257-293
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• 2011

"Byun Jeung Rok(辨證錄)" written by Jinsatak(陳士鐸) is composed of 14 volumes. In relation to the contents, it is organized into 126 gates(門) and 770 remaining syndromes(餘證) where internal medicine, external medicine, pediatrics, gynecology(內科 外科 小兒 婦人), etc. are divided into sub-sections of cold damage, cold stroke, wind stroke(傷寒 中寒 中風), etc. He explained the symptom, cause of disease, method of treatment, prescription, construction of prescription, instruction of medicine and prognosis(症狀 病因 治法 處方 處方構成 服用法 預後) thoroughly. This study, as an inquiry of the sec 14 volume pediatrics(小兒), deals with febrile fit cacotrophy vomiting diarrhea(驚疳吐瀉), coprozoic parasite(便蟲), smallpox(痘瘡), eruption(疹症), eating mud(喫泥), fetal toxin(胎毒). It was written very logically so it is easy to understand. The analysis of the symptoms are brief and appropriate. Therefore, it is considered to have significant clinical value for future generations and is applied by them. Finally, this topic was studied in hopes of helping later pediatrics clinical treatment.

• 대한한의학방제학회지
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• 제12권2호
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• pp.163-173
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• 2004

Chelidonii Herba (CHE, Baek-gul-chae in Korean), which has its original description in Gu-Hwang-Bon-Cho, a classic book of oriental Herbal book, is widely used in the treatment of stomach cancer, jaundice, gasrtic ulcer, edema and stomach pain, in Korea, Japan and China. The present study was conducted to evaluate the effect of CHE on the nitric oxide (NO) production, iNOS and COX-2 expression in lipopolysaccharide - activated Raw 264.7 cells. After the treatment of CHE, NO production was monitored by measuring the nitrite content in culture medium, cell viability was measured by MIT assay. COX-2 and iNOS were determined by lmmunoblot analysis. The production of nitric oxide was significantly inhibited by pretreatment (1h) with CHE (0.1-0.3 mg／ml) on LPS-activated Raw264.7 cells. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) protein were up-regulated by LPS, but the increased levels of iNOS and COX-2 were inhibited by pretreatment of CHE (0.1-0.3 mg／ml), respectively. Thus, the present data suggest that CHE may play an important role in adjunctive therapy in Gram-negative bacterial infections.

• Journal of Acupuncture Research
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• 제22권4호
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• pp.197-204
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• 2005

Objectives : This survey was accomplished to find out how Korean medical doctors take acupuncture prescriptions for knee osteoarthritis in real clinical practice. Methods : The survey questions were developed by the consensus from 4 professors and 10 residents who major in acupuncture & moxibustion for developing clinical trial protocol on individualized acupuncture treatment for knee osteoarthritis. The questionnaires were distributed via e-mail to 3,306 members of Korea Oriental Medical Association from March 15th to March 23rd in 2005.84 members completed answers, and the computerized data were analyzed by ISP statistical program. Results : 1. 68 out of 84 Korean medical doctors used pattern diagnosis. 2. 61 out of 84 Korean medical doctors used both local and remote points, 20 doctors remote points only, and 3 doctors local acupuncture points only. 3. In case of doctors who use remote acupuncture points only, the acupuncture prescription principle was Saam or five element acupuncture (66%), along the meridian pathway (14%), Eight constitutional acupuncture (11%), Taegeuk acupuncture (2%), and miscellaneous (18%). Conclusion : In our e-mail survey, Korean medical doctors who experienced more than 10 year practice answered that they use five element acupuncture or Saam acupuncture according to meridian pathway theory as the most common principle of their acupuncture treatment prescription.

• 대한한의학방제학회지
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• 제16권2호
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• pp.11-29
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• 2008

Objective : The aim of this study was to analyse the latest trend of medical science articles about Bojungikki-Tang published in Japan. Methods : We searched medical science articles published from 2003 to 2008 in Japan on the web site, CiNii and then these articles were reviewed and classified according to experimental subject and method. Results : Fifty-two articles, related to Bojungikki-Tang were searched and these were classified into three classes, pharmacological signaling studies, clinical case studies and the others. As a result of classification, clinical case studies were most abundant by 38 cases, pharmacological signaling studies were 10 and the others were 4. This result suggested that the study of Bojungikki-Tang was mainly focused on clinical study rather than experimental study. Among the clinical case studies, clinical studies related to immune disease took the most greatest number and number of other clinical studies were evenly distributed over the various disease. Immune intensification effect of Bojungikki-Tang can be thought continuous with reinforce the middle Jiao Qi in company with improvement effect on growth hormone failure and male infertility. A fact that the one prescription, Bojungikki-Tang could be used to treat various diseases reflects a viewpoint of Oriental medicine that is based on the respect for and understanding of individual constitution and disposition while paying attention to the gender difference and individuality. The clinical usefulness of Bojungikki-Tang on obstructive sleep apnea syndrome and visceroptosis concerns with ascend Yang and treat Qi sinking. Pharmacological signaling studies were mainly focused on diseases that were treated Bojungikki-Tang in clinic, however, there was one study that experimented on changes of numerous gene expression according to the treatment of Bojungikki-Tang using DNA array. Conclusion : The therapeutic system of Oriental medicine is different in various aspects form that of Western medicine and appropriate harmonization of east and west is expected to improve the quality of medical care. In this regard, continuous investigation and analysis about herbal medical science papers in Japan can also be useful to make progress in Korean traditional medicine.

• 대한한의정보학회지
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• 제18권1호
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• pp.64-77
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• 2012

Donguibogam, Korea's cultural heritage and traditional Oriental medicine book listed in the World Heritage three years ago, is indeed great in its importance and value. Korea's posterity has sought treatment methods through the medical book and their researches on that book have continued. However, it is rare to make the concrete analysis on the medicines for prescriptions recorded in the book. In this study, we reviewed "Ears" in the Section "Bodily Appearance" among the five chapters of Donguibogam, and analyzed the 55 types of prescriptions for ear diseases, the medical characteristics, tastes, prime classification of medical herbs, and acupunctural effects, and the dosage forms depending on prescriptions. For insect-entering ear diseases and 20 kinds of a single-medicine prescription also, the treatments are presented in the book, but we presented the texts only and excluded them in the analysis. We also excluded overlapping prescriptions and adding and reducing prescriptions of the 55 prescriptions, and thus classified the left 42 proscriptions by dosage form. As a result: 1. With respect to medical characteristics, the medicine with warm characteristics reached 9 types(40.9%), the highest rate, followed by the medicine with cold characteristics 8 types (36.4%). 2. Concerning medical tastes, the medicine with bitter taste included 12 types (54.5%), the medicine with sour taste 10 types (45.5%), and the medicine with sweet taste 7 types (31.8%). It was unusual that of the 22 medicines used for multipurpose, no medicine with the taste was found. 3. For the acupunctural effects, the medicine with acupuncture effects for spleen medirian reached 12 types in total (54.5%). On the contrary, the medicine with the effects for pericardium meridian reached only one (4.5%) among the total of 22 medicines. 4. In the dosage form of 42 prescriptions, powder medicine was 15 types (35.7%), and decoction medicine was 14 (33.3%). Powder, dedoction, and pill medicines accounted for 90.4% of the total medicine type. It was found that in particular, for ear diseases powder medicine was used more frequently than decoction medicine.

• 동의생리병리학회지
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• 제17권2호
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• pp.560-567
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• 2003

Antimetastatic effects of Agaricus mixed prescription (AMP) were studied in the respect of blood-borne metastasis. For this aim, cytotoxicity against various cancer cells and normal cells, Chicken Chorioallantoic membrane (CAM) assay, cancer cell adhesion assay, platelet aggregation assay, pulmonary colonization, life span of S-180 implanted mice, and cytokine release assay were evaluated, respectively. The results were summarized as follows; AMP did not exert any cytotoxicity against all cell lines with IC50 of 25mg/ml on B16BL6. AMP disrupted formation of CAM at 1mg/ml. AMP was suppressive in adhesion assay of B16BL6. AMP also inhibited tumor induced platelet aggregation. In pulmonary colonization assay by B16BL6, the number of colonies in the lungs was significantly decreased in sample group than in control group. In animal study with S-180, the life span of AMP treated group was extended than that of control group. IL-12 was effectively increased in AMP treated group in cytokine release assay. Taken together, AMP can be possibly applied to cancer or metastasis.

• KSBB Journal
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• 제22권3호
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• pp.139-145
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• 2007

암에 효능을 보이는 생리활성소재의 탐색원을 발굴하기 위한 방법의 하나로 동양의학 데이터베이스의 처방정보를 활용하였다. 신동의약보감에 포함되어 있는 170건의 암 처방 천연약재의 처방빈도와 처방분량을 분석하였다. 처방순위와 처방 분량에 따라 마련된 점수표 (score table)를 기준으로 총처방점수 (total prescription score)를 작성하였다. 선행연구 결과들을 조사한 결과 총처방점수가 높은 약재들을 소재로 한 관련 보고들이 많은 것으로 나타났다. 결과적으로 당귀, 황기, 감초, 반하, 백출, 진피, 인삼, 백작약, 대황, 천궁, 지모, 천남성, 오미자, 형개, 흑축, 방기, 복령, 오수유 등이 암에 효과가 있으며 이들 약재를 이용한 항암 소재의 탐색이 제안되었다.