• 생약학회지
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• 제17권1호
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• pp.49-54
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• 1986

To explore the biological activities of Thalictrum alkaloids, a study was initiated to investigate the alkaloidal constituents from T. fauriei, a species indigenous to Taiwan. Extensive fractionation of the ethanolic extract provided three known aporphines, (+)-oconovine (Ia), (+)-isocorydine (Ib), and (+)-corydine (Ic) from nonphenolic tertiary base fraction. From quaternary base fraction two new protoberberinium salts, thalifaurine (IIa), dehydrodiscretine (IIb), in addition to magnoflorine (III), were isolated. The structure of both new compounds were confirmed by total syntheses. Fractionation of phenolic bases yielded a dihydromorphinandienone, (-)-ocobotrine (IV), as well as a novel aporphine-pavine dimer, tentatively named EP-10. The structure of EP-10 was established by means of 2D NMR studies. Preliminary study indicated a weak activity of lyzing Hela cells, in vitro, for EP-10.

• 생약학회지
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• 제9권2호
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• pp.57-72
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• 1978

The constituents of Ranunculaceae plants are summerized from more than one hundred of papers. Fifteen steroidal alkaloids, thirty two of terpenoids (diterpenes and triterpenes), fifty four isoquinoline alkaloids are recorded. Thirty three papaverines, eighteen berberines, and three hydrastines belong to isoquinoline group. Besides, of alkaloids a number of glycosides are also found. Adonis glycoside, famous cardiotonics, from Adonis and cyanogenin glycoside and calthoside D were identified from the leaves of Thalictrum aquilegifolium and Caltha silvestris. Anemonin, the irritating substance, found in Pulsatilla grandiz $W_{ENDER}$. Kaempf-erol and dihydrokaempferol were isolated and identified from the leaves of Clematis brachyura ^M_{AXIMOWICZ}$ by author in 1968.

• 생약학회지
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• 제13권3호
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• pp.132-135
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• 1982

Three phenolic alkaloid compounds (A,B,C) were isolated from the roots of Thalictrum uchiyamai Nakai (Ranunculaceae). Compound A, a colorless crystalline substance $mp168^{\circ}$, $C_{11}H_{15}NO_2$ was identified to be corypalline (6-methoxy-7-hydroxy-N-methyl-1, 2, 3, 4-tetrahydroisoquinoline) which has been reported by Wu from Thalictrum rugosum. Compound B, $mp166^{\circ}$ and Compound C, $mp164^{\circ}$ were shown aromatic rings by UV, IR spectra and chiral center by CD.

• 약학회지
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• 제28권3호
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• pp.185-190
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• 1984

Protothalipine colorless needle crystal, mp $195-6^{\circ}$, $C_{21}H_{25}NO_{5}$) and jatrorrhizine chloride (Base A, orange needle crystal, mp $198^{\circ}$) are identified by chemical, spectral analysis, and comparison with authentic sample. Base B (reddish crystal, mp $192-4^{\circ}$) might be a artifact substance, which was changed from the jatrorrhizine chloride. Base C (yellowish needle crystal, mp $228~230^{\circ}$) and Base D (reddish needle crystal, mp $211~213^{\circ}$) were assumed to be thalifendine chloride, desoxythalidastine chloride by phytochemical and spectral analysis respectively.