• Title/Summary/Keyword: Th2 responses

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A Mixed-Methodological Study of Dietitians' Perception and Behavioral Intention towards Sustainable Institutional Foodservice: Focus on Contract Business-and-Industry Foodservice (통합연구방법을 이용한 지속가능한 급식에 대한 영양사 인식 및 실천의도 조사: 산업체 위탁 급식소를 중심으로)

  • Kim, Soyoung;Yoon, Jihyun
    • Journal of the Korean Dietetic Association
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    • v.21 no.2
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    • pp.140-153
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    • 2015
  • Considering the importance of institutional foodservice in modern dietary life and its influence on the environment, sustainable development in institutional foodservice industry carries great significance. The current study was conducted to investigate dietitians' perceptions of sustainable business-and-industry foodservice and their intentions to perform sustainable practices by applying a mixed methodology. For the quantitative study, an online survey was conducted on 362 dietitians who had worked at a contact foodservice company for more than 1 year. The survey was performed from December 15th, 2011 to January 30th, 2012, and 202 responses were used for the analysis. For the qualitative a study, a focus group interview was conducted during May, 2012 with representative employees of the company. According to the results, dietitians seemed to be unfamiliar with the terms "sustainability" or "sustainable development," whereas they understood related contents and practices. Dietitians' awareness and perceived need in terms of sustainable business-and-industry foodservice were not significantly different across general characteristics. Dietitians seemed to be highly aware of the impacts of business-and-industry foodservice on economy, whereas they appeared to lack understanding of its impacts on society and environment. Cost increase and levy on work in daily operations were considered as main obstacles hampering dietitians' intentions to perform sustainable practices. A total of 88.1% of responding dietitians expected that the meal price at a sustainable business-and-industry foodservice should be higher than the supposed standard price of 4,000 won, with an average reaching 5,270 won. Findings from this study could be used as baseline information for vitalizing sustainable business-and-industry foodservice in Korea.

Identification of Hepatitis C Virus Core Domain Inducing Suppression of Allostimulatory Capacity of Dendritic Cells

  • Kim, Ho-Sang;Lee, Jae-Kwon;Yang, In-Ho;Ahn, Jeong-Keun;Oh, Yoon-I;Kim, Chul-Joong;Kim, Young-Sang;Lee, Chong-Kil
    • Archives of Pharmacal Research
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    • v.25 no.3
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    • pp.364-369
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    • 2002
  • Hepatitis C virus (HCV) is remarkably efficient at establishing chronic infection. One of the reasons for this appears to be the suppression of the accessory cell function of professional antigen presenting cells. In the present study, the immunosuppressive activity of HCV protein was examined on dendritic cells (DCs) generated from mouse bone marrow progenitor cells in vitro. We found that the DCs forced to express HCV protein have defective allostimulatory ability. DCs expressing HCV protein were phenotypically indistinguishable from normal DCs. However, they were unable to produce IL-12 effectively when stimulated with lipopolysaccharide. The functional domain of the HCV protein essential for immunosuppression was determined using a series of ${NH_2}-and$ C-terminal deletion mutants of HCV core protein. We found that amino acid residues residing between the 21 st and the 40th residues from the ${NH_2}-terminus$ of HCV core protein are required for immunosuppression. These findings suggest that HCV core protein suppresses the elicitation of protective Th1 responses by the inhibition of IL-12 production by DCs.

The Immune-Enhancing Effect of Mountain Gown ginseng, Mountain Cultivated ginseng, and Panax ginseng (산삼(山蔘), 장뇌삼(長腦蔘), 인삼(人蔘)의 면역증강(免疫增强)효과 비교연구)

  • Chung, Dae-Kyoo;Kwon, Soon-Joo
    • Journal of Oriental Neuropsychiatry
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    • v.15 no.2
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    • pp.89-101
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    • 2004
  • Objective : The present experiments were designed to study on the immune-enhancing effect of Mountain grown ginseng, Mountain cultivated ginseng, and Panax ginseng Method : In order to compare the immune-enhancing effect of moutain grown ginseng, moutain cultivated ginseng and Panax ginseng, the study was done through the forced swimming test (FST), measurement of T helper Th1, Th2 cytokines and fatigue related factors. Result : Moutain grown ginseng and panax ginseng decreased the immobility time in the FST compared to the control. Glucose, blood urea nitrogen (BUN), creatinine, lactate dehydrogenase (LDH) and Total-protein (T-protein) in serum were investigated. The serum achieved from ginseng administered mouse showed higher BUN, T-protein than the control. moutain grown ginseng administered group showed lower LDH than the control group. moutain grown ginseng administered mouse showed higher glucose than the control. Creatinine was same in either experimental or control group. Ginseng-induced cytokine production in human T-cell line, MOLT-4 cells and mouse peritoneal macrophages were compared. Moutain cultivated ginseng (10-4 dilution) and panax ginseng (10-3 dilution) were increased the interferon $IFN-{\gamma}$ production compared with media control (about 1.6-fold P<0.05) at 48 h. Moutain grown ginseng (10-4 dilution) was increased the $IFN-{\gamma}$ and interleukin IL-4 production compared with media control (about l.4-fold for $IFN-{\gamma}$ and 1.6-fold for IL-4 P<0.05) at 48 h. Moutain grown ginseng (10-3 dilution) and moutain cultivated ginseng (10-4 dilution) were increased the turmor necrosis factor $TNF-{\alpha}$ production compared with $rIFN-{\gamma}$ treated cells (about 1.9-fold for $TNF-{\alpha}$ P<0.05), respectively. Moutain cultivated ginseng (10-3 dilution) was increased the IL-12 production compared with $rIFN-{\gamma}$ treated cell (about 1.7-fold for IL-12 P<0.05). Conclusion : These data suggest that three different three kinds of ginseng act on immune responses in different aspects.

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A study of Elementary Students' Satisfaction in School Food Service and Their Dietary Behaviors in Gunsan City (군산지역 일부 초등학교 학생의 학교급식에 대한 만족도 및 식행동 조사)

  • Chang, Hye-Soon;Park, Hyo-Jung
    • Korean Journal of Human Ecology
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    • v.18 no.2
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    • pp.477-489
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    • 2009
  • In this study, elementary school students' satisfaction in school food service and their dietary behaviors were investigated, based on survey performed on 453 elementary school students (233 boy and 221 girl students) in the range of 4th grade to 6th grade. 85.7% of the students had agreed to the necessity of school food service. The point of overall satisfaction in school food service was $3.53{\pm}0.83$. The highest satisfactory factor was menu of school food service$(3.64{\pm}0.77)$, while the lowest satisfactory was service$(3.41{\pm}0.85)$. The point of boy students' satisfaction in menu(p<0.05), sanitation & facility(p<0.001), and service(p<0.05) of school food service was higher than girl students'. The students' responses indicate that: 36.9% of the students wash their hands before meal; 19.9% of the students brush their teeth after meal; 36.1% of the students arrange their table after meal; 22.1% of the students do not disturb others during their meal. 46.5% of the students always have meals pleasantly, while 22.8% of the students have meals without any particular feelings. 74.6% of the students always eat proper amount. 51.3% of the students turned out to eat snacks between meals out of hunger (50.7%) once a day with their friends(59.8%). 61.8% of the students believe that their tastes are affected by their parents and 57.8% of the students are aware of their unbalanced diet to be corrected. In summary, to provide satisfactory school food service for students, the improvements in the facilities and hygienic standard and the taste and nutrition have to be preceded, and the students have to be advised about the healthy dietary habits and the hazard of biased diet.

The EFFECTS OF DENTAL LASER ON PULP FIBROBLAST IN VITRO (치과용 레이저 조사가 배양 치수 섬유모세포에 미치는 영향에 관한 연구)

  • Jeong, Hye-Jeon;Min, Byung-Soon
    • Restorative Dentistry and Endodontics
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    • v.22 no.2
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    • pp.519-535
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    • 1997
  • The responses of human pulp fibroblastic cells to Ga-As Semi-Conductor-Dens-Bio Laser (Frequency: 5 Hz~10,000 Hz Model: SD-101A RCA, U.SA)) were examined in vitro using pulp fibroblastic cells obtained from the pulp tissue of human tooth. The mitogenic effect of soft laser was assessed by measuring the MTT assay. The morphologic effect for soft laser showed under the scanning and transmission electron microscopy. The results as follows; 1. The mitogenic response of the soft laser was not observed until 4th time of radiation, while the mitogenic response at 4th time increased mitogenic effect by as much as 1.7 fold compared to the control value. 2. The mitogenic response of the soft laser on pulp fibroblast differ from the mitogenic response on other fibroblasts. 3. In scanning electron microscopic study, The microvilli of cell surface increased gradually with width and length after laser radiation, it demonstrate that development of microvilli have close connection with differentiation of cells. 4. Under the transmission electron microscope, The laser-treated cells maintained their elongated shape and a high degree of cellular polarization. The large cell body containing a well developed Golgi complex, a large number of profiles of rough endoplasmic reticulum, and great numbers of mitochondria. 5. The laser-treated cells maintained the long straight bundles of closely apposed microfilaments or individual filaments forming a cross-linked network. These findings suggest that the laser may have important roles in promotion of pulp healing and consequently may be useful for clinical application in pulp regenerative procedures.

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The Influence of Stress of Children on Game Addiction -Focused on Moderating Effect of Family Support- (아동의 스트레스가 게임중독에 미치는 영향 -가족지지의 조절효과를 중심으로-)

  • Kim, Na-Ye
    • Journal of the Korea Society of Computer and Information
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    • v.20 no.2
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    • pp.209-219
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    • 2015
  • The aim of this study is to identify whether the stress of children has an impact on their game addiction and to verify the moderating effect of family support. The survey was conducted to the children who were 5th and 6th graders in Gwangju and Jeonnam. The responses from 564 subjects contacted subjects were analyzed. In accordance with the verification on the impact game addiction, Children's stress has a impact on their game addiction. In other words, higer stress was related to higer game addiction. The impact family support on their game addiction was analyzed. In accordance with the results, the family support had positive impact on their game addiction. It suggested that higher family support meant lower game addiction. The moderated effect of family support was analyzed. The family support had the control effect to reduce the negative effect of stress of children in to their game addiction. Implication of the study findings is discussed.

Inhibitory Effects of Trichosanthis Radix in the Activity and Proliferation of Th2 T Cells and Eosinophils in vitro : Implications on its Regulatory Roles for Asthma (과루근(瓜蔞根)이 Th2 T 세포와 호산구에 대한 활성 및 증식 억제에 미치는 영향)

  • Roh, Seong-Soo
    • The Korea Journal of Herbology
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    • v.24 no.3
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    • pp.29-37
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    • 2009
  • Objectives : The present study was carried out to investigate the effect of Trichosanthis Radix extract (TRE) on the proliferation and activation of eosinophils which were prepared from lung cells of asthma-induced mice by ovalbumin (OVA) treatment. Methods : C57BL/6 mouse was exposed to OVA three times a week for 6 weeks. The mouse lung tissues were dissected out, chopped and dossiciated with collagenase (1 $\mu$g/ml). Eosinophils were activated by rmIL-3/rmIL-5 co-treatments. The lung cells were treated with TRE, incubated for 48 hr at 37$^{\circ}C$, and analyzed by flow cytometer, ELISA and RT-PCR methods Results : To measure cytotoxicity, mouse lung fibroblast cells (mLFCs) were pretreated with various concentrations of TRE. TRE at 100 $\mu$g/ml, the highest concentration, examined did not have any cytotoxic effects on mLFCs. In FACS analysis, number of granulocyte/lymphocyte, CD3e-/CCR3+, CD3e+/CD69+, CD4+/CD8+ T cells in asthma-induced lung cells were significantly decreased by TRE treatment compared to the control group. But CD4+/CD25+ T cells were not examined significant change in lung cells treated with TRE. In ELISA analysis, production levels of IL-3, IL-5, IL-13 and histamine in asthma-induced lung cells, which were induced by rIL-3 plus rmIL-5 co-treatment, were significantly decreased by TRE treatment. Conclusions : The present data suggested that Trichosanthis Radix on the inhibition of parameters associated with asthma responses in eosinpophils, and thus implicate the possibility for the clinical application of Trichosanthis Radix.

Trade-offs Between the Ripple and the Transition Band for the Chebyshev BPF and the Cascading Chebyshev BPF (Chebyshev BPF와 종속 Chebyshev BPF의 리플-천이대역 Trade-offs)

  • Shin, Seung-Sik;You, Chi-hyung
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.67 no.2
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    • pp.255-260
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    • 2018
  • This study is focusing on the trade-offs between the passband ripples and transition bands of the Chebyshev BPF, which is converted by using the Chebyshev LPF that is well known as a proto-type analog filter. It is also focusing on the trade-offs between the passband ripples and transition bands of the cascading Chebyshev BPF, as well as, the trade-offs between the two BPFs. The study finds the frequency responses of the proto-type analog LPF, the Chebyshev BPF and the cascading Chebyshev BPF. The study shows the results as comparative analysis tables. The study designs the 10th Chebyshev BPF in order to analyze it easily. The simulation results show that the Chebyshev BPF decreases about 55% of the transition band for the -2.5[dB] passband ripple comparing to the -0.5[dB] passband ripple. This study shows the effectiveness and economic feasibility in the restricted frequency communication environment for the decrease of the transition band as providing the passband ripple margin.

The inhibitory effects of Gami-Phedoc-San on TNF-α, IL-1β and IFN-γ secretion from human monocytes

  • Kim Mi-Sun;Lee Eun-Hee;Choung Se-Young
    • Advances in Traditional Medicine
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    • v.2 no.1
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    • pp.41-46
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    • 2002
  • In our study, the several cytokines were determined in phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) of Adamantiades-Behcets patients. Adamantiades-Behcets disease (ABD) is a systemic inflammatory disorder and might involve immune dysfunction. High levels of $TNF-\alpha,\;IL-1\beta$ and $IFN-{\gamma}$ indicate the activation of inflammatory reactions and immune system in ABD. Gami-Phedoc-San (GPS) is an Oriental herbal medication, which has been used in Korea for the treatment of ABD. GPS (1 mg/ ml) significantly inhibited the secretion of proinflammatory cytokines, $TNF-\alpha\;and\;IL-1\beta$, compared to absence of GPS (by $50.5{\pm}1.9%$ inhibition for $TNF-\alpha$ and $106.9{\pm}16.8%$ for $IL-1\beta$). GPS also inhibited the production of $IFN-\gamma$, immunoregulatory Th1 cytokine, by $78.4{\pm}2.8%$. The inhibitory effects of GPS on cytokine secretion showed dose-dependent manner, and the pre-treatment of 1 mg/ml GPS had better effects than immunosuppressive drug for treatment of ABD, cyclosporin A. Our results suggest that GPS treatment for ABD patients might have pharmacological activity of immune and inflammatory responses through the cytokine modulation.

Acute Temporary Visual Loss after General Anesthesia in a Cat (전신 마취 후 발생한 고양이의 일시적인 급성 시력상실 1례)

  • Son, Won-Gyun;Jung, Bo-Young;Kwon, Tae-Eog;Seo, Kang-Moon;Lee, In-Hyung
    • Journal of Veterinary Clinics
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    • v.26 no.5
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    • pp.480-482
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    • 2009
  • A 2-year-old, castrated male, Scottish fold cat was referred to Veterinary Medical Teaching Hospital of Seoul National University (VMTH-SNU) for evaluation of acute bilateral blindness after general anesthesia. For dental prophylaxis in local animal hospital, general anesthesia had been induced with intravenous acepromazine and ketamine, and maintained with isoflurane after intubation. At VMTH-SNU on next day, complete blood count, electrolytes and serum chemistry values were within normal ranges. On neurologic examination, visual placing and postural reactions like as hopping, hemiwalking and wheelborrowing were reduced on right hindlimb. On ophthalmic examination, menace responses were absent on both eyes and pupillary light reflex (PLR) reduced on right eye, but other reflex and fundus were normal. Prednisolone (2 mg/kg sid for 3 days) was administrated orally and tapered. Visual placing was possible on 2nd day, and postural reactions were recovered on 4th day after dental prophylaxis. Based on the process and recovery, this case was considered as postoperative visual loss (POVL) after general anesthesia.