• 해양환경안전학회지
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• 제14권3호
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• pp.241-245
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• 2008

본 논문은 해난사고에 의해 빈번하게 발생하는 저체온증으로 인한 인명손실을 최소화하기 위하여 개발된 발열구명동의의 열적특성을 수치해석을 통해 조사한 것으로, 계산에 이용된 주된 파라메터는 계절에 따른 수온, 구명동의의 발열량 및 발열시간이다. 이산화 및 차분방정식은 유한차분법을 이용하였으며, 컴퓨터를 이용한 계산을 위하여 매스캐드를 이용하여 프로그래밍을 작성하였다. 또한 본 논문은 서로 다른 물질들이 경계를 이루고 있는 복잡한 형태의 모델에 해당함으로 경계에 해당하는 부분의 열전도율은 열저항의 모델을 응용하여 인접한 셀들의 열전도값을 이용하여 계산하였다. 본 연구를 통하여 발열구명동의의 열발생으로 인체의 온도를 높게 유지할 수 있음을 알았고, 겨울철을 제외하고 저체온증의 우려가 없음을 알았다. 또한 해난사고시 생존율을 높일 수 있을 것으로 기대된다.

• 약학회지
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• 제39권5호
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• pp.471-479
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• 1995

The recombinant human epidermal growth factor(DWP 401) was investigated on the pharrnacological actions. DWP 401 had no effects on the hexobarbital-induced sleeping time, locomotor activity, rotarod test, body temperature, analgesic action and anticonvulsant action in mice. It also had no influences on the isolated tracheal muscle and ileum of guinea-pig, isolated uterus and fundus strip of rats. Slight hypotensive action with effect on respiration was revealed at a dose of 8 g/kg i.v. of DWP 401 in rabbits. DWP 401 exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats at .a concentration of 160 g,/kg, and produced a significant inhibitory effect on leucocyte migration in CMC-pouch of rats at a concentration of 32 g/rat. Furthermore, DWP 401 showed a significant decrease on gastric juice volume and acidity. However. DWP 401 had no intestinal propulsion rate and influence on urine excretion.

• 약학회지
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• 제36권1호
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• pp.17-25
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• 1992

The general and some other pharmacological actions of growth hormone without N-terminal methionine(rhGH) were investigated in animals. The hormone had no influences on the central nervous system and on body temperature at a high oral dose of 40 IU/kg in animals. It had neither analgesic nor antiepileptic actions at the high doses. In the isolated ileum and trachea of guinea-pig and isolated stomach fundus and uterus of rat, it showed neither contractive nor relaxing effects at a concentration of $1{\times}10^{-3}\;IU/ml$ in bath, and no inhibitory action at a dose of $1{\times}10^{-3}\;IU/ml$ against the contractions produced by histamine ($5{\times}10^{-5}\;g/ml$), serotonin($1{\times}10^{-5}\;g/ml$), acetylcholine($1{\times}10^{-5}\;g/ml$) and oxytocin($5{\times}10^{-3}\;IU/ml$). Furthermore, the intravenous injection of 20 IU/kg rhGH had no influences on the normal blood pressure and respiration in rabbits. These negative results in pharmacological profile are thought that the hormone may not elicit serious side effects. On the other hand, the rhGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration of 80 IU/kg, and showed a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.