• 제목/요약/키워드: Technology Fusion

검색결과 2,906건 처리시간 0.028초

Multi-Attribute Data Fusion for Energy Equilibrium Routing in Wireless Sensor Networks

  • Lin, Kai;Wang, Lei;Li, Keqiu;Shu, Lei
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제4권1호
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    • pp.5-24
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    • 2010
  • Data fusion is an attractive technology because it allows various trade-offs related to performance metrics, e.g., energy, latency, accuracy, fault-tolerance and security in wireless sensor networks (WSNs). Under a complicated environment, each sensor node must be equipped with more than one type of sensor module to monitor multi-targets, so that the complexity for the fusion process is increased due to the existence of various physical attributes. In this paper, we first investigate the process and performance of multi-attribute fusion in data gathering of WSNs, and then propose a self-adaptive threshold method to balance the different change rates of each attributive data. Furthermore, we present a method to measure the energy-conservation efficiency of multi-attribute fusion. Based on our proposed methods, we design a novel energy equilibrium routing method for WSNs, viz., multi-attribute fusion tree (MAFT). Simulation results demonstrate that MAFT achieves very good performance in terms of the network lifetime.

Novel function of stabilin-2 in myoblast fusion: the recognition of extracellular phosphatidylserine as a "fuse-me" signal

  • Kim, Go-Woon;Park, Seung-Yoon;Kim, In-San
    • BMB Reports
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    • 제49권6호
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    • pp.303-304
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    • 2016
  • Myoblast fusion is important for skeletal muscle formation. Even though the knowledge of myoblast fusion mechanism has accumulated over the years, the initial signal of fusion is yet to be elucidated. Our study reveals the novel function of a phosphatidylserine (PS) receptor, stabilin-2 (Stab2), in the modulation of myoblast fusion, through the recognition of PS exposed on myoblasts. During differentiation of myoblasts, Stab2 expression is higher than other PS receptors and is controlled by calcineurin/NFAT signaling on myoblasts. The forced expression of Stab2 results in an increase in myoblast fusion; genetic ablation of Stab2 in mice causes a reduction in muscle size, as a result of impaired myoblast fusion. After muscle injury, muscle regeneration is impaired in Stab2-deficient mice, resulting in small myofibers with fewer nuclei, which is due to reduction of fusion rather than defection of myoblast differentiation. The fusion-promoting role of Stab2 is dependent on its PS-binding motif, and the blocking of PS-Stab2 binding impairs cell-cell fusion on myoblasts. Given our previous finding that Stab2 recognizes PS exposed on apoptotic cells for sensing as an "eat-me" signal, we propose that PS-Stab2 binding is required for sensing of a "fuse-me" signal as the initial signal of myoblast fusion.

Molecular Effect of PVP on The Release Property of Carvedilol Solid Dispersion

  • Oh, Myeong-Jun;Shim, Jung-Bo;Lee, Eun-Yong;Yoo, Han-Na;Cho, Won-Hyung;Lim, Dong-Kyun;Lee, Dong-Won;Khang, Gil-Son
    • Journal of Pharmaceutical Investigation
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    • 제41권3호
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    • pp.179-184
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    • 2011
  • This study aimed to confirm the effect of molecular weight (MW) in solid dispersion of carvedilol with poly-vinylpyrrolidone (PVP) of various MW. Solid dispersion of carvedilol with PVP was prepared by spray-drying method. Scanning electron microscopy (SEM) was used to analyze the surface of solid dispersion samples. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystalline of solid dispersion. Fourier transform infrared spectroscopy (FT-IR) was used to analyze the change of chemical structure characteristic of solid dispersion. DSC and XRD show that drug crystalline was changed. FT-IR revealed that chemical structure of solid dispersion comparing the chemical structure of drug was changed. The dissolution studies of solid dispersion presented at simulated gastric juice (pH 1.2). The dissolution rate of solid dispersion was dramatically enhanced than pure drug and the MW of PVP has an effect on the release property of carvedilol in solid dispersion. In conclusion, the present study has confirmed the effect of MW of PVP on release property of solid dispersion formulation of carvedilol with PVP.

건설 산업에서의 첨단융합기술 동향 분석에 관한 연구 (A Trend Analysis of Advanced Fusion Technology in the Construction Industry)

  • 손효주;김태우;김창완;김형관;한승헌;김상범;김문겸
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 2007년도 정기 학술대회 논문집
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    • pp.188-192
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    • 2007
  • This paper presents a current perspective on advanced fusion research trends in the construction industry as reflected in the proceedings of International Symposium on Automation and Robotics in Construction (ISARC) which has focused on advanced fusion technology in last decades. The paper reports the results of a 7-year analysis of papers between 2000 and 2006. The analysis focused on such data as research topics of the proceedings. The paper summarizes the data extracted from the paper and uses it to analyze advanced fusion research trends. The research result shows that the top research topics in advanced fusion research areas are construction robots and automation and intelligent construction management. The research also found that research related to advanced fusion technology is increasing throughout the world and topics are changing as current needs change.

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Topomer-CoMFA Study of Tricyclic Azepine Derivatives-EGFR Inhibitors

  • Chung, Jae-Yoon;Pasha, F.A.;Chung, Hwan-Won;Yang, Beom-Seok;Lee, Cheol-Ju;Oh, Jung-Soo;Moon, Myoung-Woon;Cho, Seung-Joo;Cho, Art E.
    • Molecular & Cellular Toxicology
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    • 제4권1호
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    • pp.78-84
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    • 2008
  • EGFR has been intensively investigated as a target to block the signal transduction pathway which stimulates cancer growth and metastasis. Studies about structure-activity relationship for tricyclic azepine derivatives were performed with topomer-CoMFA. The derived topomer-CoMFA model with steric and electrostatic field parameters based on fragment units gave reasonable statistics ($q^2$=0.561, $r^2$=0.679). The model explains why a halogen atom at the meta position of aniline is important to increases inhibitory activity. This comes from an electrostatically negative groups are favored near this region. The model also shows that there are sterically favored regions around methoxy group extended from oxazepine derivatives. The findings about steric and electrostatic effects can be utilized for designing new inhibitors.