• Journal of Technology Innovation
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• v.20 no.2
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• pp.135-159
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• 2012

To the analysis and discussion whether to conceptualization between the basis and LCM(Life cycle management) of patentability decisions and evergreening through research on patent application strategies and litigation cases. The Stakeholders have said that the LCM and evergreening strategies are an innovative effort to develop new pharmaceuticals, while others say that it is an effort to block generic pharmaceuticals from entering the market and permanently dominate the market by generic pharmaceuticals manufacturers or health economic perspectives. To achieve the goal of research, to discuss for conceptualization LCM and Evergreening strategies through patent application strategies for 14 pharmaceuticals for APIs and case studies for litigations. As a results, the LCM is getting patent rights for the results of research at the initial R&D stage and as such this shall be regarded as part of an effort for technology innovation. However, Evergreening is granting patent rights for the results by making high permission barrier to prevent the market entry of generic pharmaceuticals in the late development period during the pharmaceuticals development process or after their launch. This may lead to the problem of getting weak in health economic aspects and consumer welfare aspects by lowering the market accessibility of cheap generic pharmaceuticals.

• Agribusiness and Information Management
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• v.4 no.2
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• pp.42-49
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• 2012

This study introduces cases of individual feeding systems for sow and the sow sorters which are the subparts of an eco-friendly feeding and management system based on a u-IT program using the hog feeding and management information system. The purpose of this study is to conduct an analysis of economic feasibility on cases of the improvement of the system using the u-IT and to provide information on the positive effects of an introduction of an eco-friendly pigsty and hog feeding and management system to hog raisers and government officials. The literature review and background section examine the effects of the introduction of u-IT technology into the field of livestock raising, hog feeding and management information system, and the eco-friendly feeding and management system based on the u-IT. This paper will present the results of the analysis on the effects and the economic feasibility of the individual feeding system for sow and the sow sorter utilizing the u-IT technology and information systems. The results of this study will contribute to the sustainable development of the hog raising industry by showing that the new feeding and management system utilizing the u-IT can not only increase the efficiency and productivity of farm management but also contribute to efficient, eco-friendly hog feeding and management.

• Journal of the Korean Applied Science and Technology
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• v.40 no.4
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• pp.631-641
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• 2023

This study conducted an empirical analysis through a survey to analyze the effect of social risk perception caused by COVID-19 on college students' cosmetics purchase behavior. Factors were extracted through factor analysis, and Pearson's correlation analysis and multiple regression analysis were used to analyze the correlation of each factor and the impact of variables. To this end, a statistical analysis was conducted using 320 copies of the questionnaire as a sample. Studies have shown that the higher the fear of COVID-19, the higher the fear of infection, changes in life, and awareness of the economic crisis, and the higher the tendency to buy ostentatiously, habitually, and reasonably. The more changes in life, the higher the awareness of the economic crisis, and the higher the trademark habitual purchase and rational purchase behavior. Fear of infection has been shown to affect trademark habitual purchases, and fear of infection and changes in life have been shown to have a significant impact on rational purchase behavior.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2003.10a
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• pp.100-105
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• 2003

With the recent development of machining technology, high speed machining process is widely used for-the mold and difficult-to -cut-materials machining since it allows achieving high productivity and surface quality. However, during the high speed machining process, high cutting speed and feed rate can cause abrupt tool life decrease due to rapid rising of the cutting tool temperature. Such situation may cause increase of machining cost. Thus, in this study, developed optimization algorithm is applied to determine optimal machining variables for multiple high speed machining. The R-T characteristic curve for machining economics problems with a linear-lorarithmic tool life model is determined by applying sensitivity analysis. finally, a series of high speed machining experiments are performed to determine the desired optimal machining variables, and the results are analyzed.

• Journal of Animal Science and Technology
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• v.59 no.7
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• pp.19.1-19.10
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• 2017

Background: To reduce use of main feed ingredient like corn, soy bean meal (SBM) and wheat, alternative ingredients has been studied like copra meal (CM). Production amount of CM which has been high makes CM to be an alternative feed stuff. However, low digestibility on AA and low energy content by high fiber content can be an obstacle for using CM. This experiment was conducted to evaluate the effects of CM supplementation with ${\beta}$-mannanase on growth performance, blood profile, nutrient digestibility, pork quality and economic analysis in growing-finishing pigs. Methods: A total of 100 growing pigs ([Yorkshire ${\times}$ Landrace] ${\times}$ Duroc) averaging $31.22{\pm}2.04kg$ body weight were allotted to 5 different treatments by weight and sex in a randomized complete block (RCB) design in 5 replicate with 4 pigs per pen. Treatments were 1) Control (corn-SBM based diet + 0.1% of ${\beta}$-mannanase (800 IU)), 2) CM10 (10% copra meal + 0.1% ${\beta}$-mannanase (800 IU)), 3) CM15 (15% copra meal + 0.1% ${\beta}$-mannanase (800 IU)), 4) CM20 (20% copra meal + 0.1% ${\beta}$-mannanase (800 IU)) and 5) CM25 (25% copra meal + 0.1% ${\beta}$-mannanase (800 IU)). Four phase feeding program was used: growing I (week 1-3), growing II (week 4-6), finishing I (week 7-9) and finishing II (week 10-12). Results: In growth performance, there was no significant difference among treatments during whole experimental period. In growingI phase, G:F ratio tended to increase when CM was increased (P = 0.05), but ADG and ADFI tended to decrease in finishingII phase (linear, P = 0.08). Also, increasing CM reduced ADG (linear, P = 0.02) and feed efficiency (linear, P = 0.08) during the whole finishing period. In blood profiles, BUN was linearly increased as CM increased (linear, P = 0.02) at growingII period. In digestibility trial, there was no significant difference in dry matter, crude fat, crude ash and nitrogen digestibility. However, crude protein digestibility was decreased linearly (linear, P = 0.02). In economic analysis, feed cost per weight gain and total feed cost per pig were reduced in overall period when CM was provided by 25% (linear, P = 0.02). Conclusion: CM with 0.1% of ${\beta}$-mannanase (800 IU) could be supplemented instead of corn and SBM up to 25% without detrimental effects on growth performance and pork quality of growing-finishing pigs.

• Journal of Veterinary Science
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• v.22 no.1
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• pp.8.1-8.11
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• 2021

Background: Porcine circovirus type 2 (PCV2) is an important infectious pathogen implicated in porcine circovirus-associated diseases (PCVAD), which has caused significant economic losses in the pig industry worldwide. Objectives: A suitable viral vector-mediated gene transfer platform for the expression of the capsid protein (Cap) is an attractive strategy. Methods: In the present study, a recombinant adeno-associated virus 8 (rAAV8) vector was constructed to encode Cap (Cap-rAAV) in vitro and in vivo after gene transfer. Results: The obtained results showed that Cap could be expressed in HEK293T cells and BABL/c mice. The results of lymphocytes proliferative, as well as immunoglobulin G (IgG) 2a and interferon-γ showed strong cellular immune responses induced by Cap-rAAV. The enzyme-linked immunosorbent assay titers obtained and the IgG1 and interleukin-4 levels showed that humoral immune responses were also induced by Cap-rAAV. Altogether, these results demonstrated that the rAAV8 vaccine Cap-rAAV can induce strong cellular and humoral immune responses, indicating a potential rAAV8 vaccine against PCV2. Conclusions: The injection of rAAV8 encoding PCV2 Cap genes into muscle tissue can ensure long-term, continuous, and systemic expression.

• Journal of the Korean housing association
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• v.14 no.5
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• pp.65-74
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• 2003

Recently, the environmental conservation has been emphasized over the world. Building industry should carefully reflected the development focused on the economic aspect as well as the environmental considerations. Therefore, it requires the technology development to mitigate the environmental pollution through the reducement of the energy and resources usage amount over the building life cycle. For these, it should be required to set up the analysis methodology to grasp the amount of the environmental pollution and energy and resources in each step of building life cycle. In this paper, it aimed at preparing the analysis process and analyzing the embodied energy and $CO_2$ and $SO_x$ emission according to the building work, field work, mechanical and electrical work on the new building and remodelling, utilizing the inventory analysis which is one of the LCA process.

• Journal of Advanced Marine Engineering and Technology
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• v.32 no.1
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• pp.66-72
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• 2008

In this study, the ground source heat pump was installed at a research center in Jeju Island to verify the performance of the system and to give an information for a economic feasibility. The performance test was conducted until the heat storage tank temperature reached at $5^{\circ}C$ from $50^{\circ}C$ in the cooling operation, and until the storage temperature goes up to $50^{\circ}C$ from $10^{\circ}C$ in the heating mode. As results, the system performance shows that $2.2{\sim}3.5$ for the cooling operation and $2.5{\sim}3.5$ for heating operation. It is found that the underground is good heat source for the heat pump with $3{\sim}10^{\circ}C$ variation range. The ground source heat pump could be connected one of air conditioning system without any problem in system performance. Based on the economic analysis, the initial cost for the ground source heat pump will be compensated after 4 years operation. If the system runs 20 years, approximately 300 million Won will be saved when the air conditioning system adapt the ground source heat pump based on Life Cycle Cost analysis.

• Journal of the Korean housing association
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• v.14 no.6
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• pp.69-77
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• 2003

The environmental problems aren't only restricted in single area or country, but also related in all around the world. Various approaches have been tried to protect and utilize properly the environment. Especially, building area has been attempted to provide the model which could explain the degree of environmental influence and technology development criteria to lessen the environmental impact in building life cycle. The environmental impact in the building life cycle can be overally explained with sustainability. Sustainability can be utilized to establish the target level of building to environmental influence. This paper aimed at extracting items to evaluate the building sustainability, divided into social, economic and environmental aspects. First, 93-items is extracted from 3 areas through existing literature review. Second, the 93-items would be controlled and reviewed into 21 items, which are five social aspect items, two economic aspect items and twelve environmental items, because 93 items can not properly be applied and evaluated. And, it provided the model to combine the extracted items of each area. In social aspect, the outdoor noise is more affect than any other items. In environmental aspect, the item of surface-to-volume is more affect than any other items.

• Journal of Korea Water Resources Association
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• v.40 no.7
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• pp.503-510
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• 2007

In the area of such a nature-friendly stream improvement, it is not established yet which engineering method is suitable for stream environment, due to lack of technology. Therefore, although nature-friendly stream improvement was done with expensive engineering method, the effect has not been fully confirmed, which results from the absence of overall valuation tool of stream improvement. In this regard, it is necessary to develop and apply comprehensive and diverse valuation methods covering stream functions to the analysis of stream improvement. In this study, we collected data from years' of monitoring on the Gyeongcheon river, which is located in Sunchang-eup, Jeollabuk-do and recently underwent an nature-friendly stream improvement work. Based on the data, we developed a series of valuation methods such as stream naturalness evaluation, life cycle evaluation, amenity evaluation, and economic benefit analysis to consider the environmental function of stream from a comprehensive perspective. Stream naturalness evaluation is a quantitative analysis of how natural a stream is, and includes additional valuation items such as ecosystem and water quality for the purpose of overall valuation, unlike existing research focusing on physical elements and structural characteristics of a stream. We developed a method of stream valuation with life cycle assessment to river reorganization project. Amenity evaluation method was developed as a means to analyze residents' satisfaction with stream improvement through questionnaires. Economic benefit analysis was developed as a means to determine the attributes of environmental water supply, ecosystem, river maintenance, and water quality and predict economic benefits using contingent valuation method (CVM) and multi-attribute utility analysis (MAUA) method in order to analyze economic benefits brought in by stream improvement. It is considered that the four methods developed in this study make possible to conduct an overall and quantitative analysis of stream improvement.