• The Korean Journal of Nuclear Medicine
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• v.38 no.6
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• pp.492-497
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• 2004

Purpose: it is very important to differentiate breast cancer from benign mass. There are many reports to evaluate the differential diagnosis under the several diagnostic tools. We evaluated the usefulness of mammography and Tc-99m MIBI scintimammography in the differential diagnosis of breast mass and correlated with pathologic findings. Materials and Methods: This study included 80 patients (a8e: 24-72, mean: 48.4) who underwent mammography and Tc-99m MIBI scintimammography for breast masses. Scintimammographies (anterior-posterior and lateral projections) were acquired in 10 minutes and 2 hours after intravenous injection of Tc-99m MIBI. four specialists in diagnostic radioloay and nuclear medicine evaluated the findings of breast masses under the mammography and Tc-99m MIBI scintimammography, and calculated the tumor to background (T/B) ratio. The pathologic results were obtained and we statistically analyzed the correlations between pathologic results and imaging findings under the mammography and Tc-99m MIBI scintimammography by chi-square and correlation test. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of mammography for detection of breast cancer were 87.5%, 56.3%, 75.0%), and 75.0% respectively. 45 cases of 80 patients were suspicious for breast cancer under the Tc-99m MIBI scintimammography. 41 cases of 45 patients were confirmed as breast cancer and the remaining 4 cases were confirmed as benign masses. The sensitivity, specificity, positive predictive value and negative predictive value of Tc-99m MIBI scintimammography for detection of breast cancer were 85.4%, 87.5%, 91.1%, and 80.8% respectively. The sensitivity of scintimammography was lower than that of mammography for detection of breast cancer, however the specificity, positive predictive value, and negative predictive value were higher. In the benign mass, the mean T/B ratio in 10 minutes was $1.409{\pm}0.30$, and that in 2 hours was $1.267{\pm}0.42$. The maximal T/B ratio of benign mass in 10 minutes was $1.604{\pm}0.42$, and that in 2 hours was $1.476{\pm}0.50$. In the malignant mass, the mean T/B ratio in 10 minutes was $2.220{\pm}1.07$, and that in 2 hours was $1.842{\pm}0.75$. The maximal T/B ratio of malignant mass was $2.993{\pm}1.94$, and that in 2 hours was $2.480{\pm}1.34$. And the T/B ratio under the early and delayed images were meaningful. Conclusion: The scintimammography is useful diagnostic tool to differentiate breast cancer from benign mass, although the sensitivity of mammography for detection of breast mass is high. Especially, the use of the T/B ratio is helpful to diagnose breast cancer.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.6B
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• pp.1068-1073
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• 2000

In this paper, we propose a serially concatenated turbo bode/turbo equalizer scheme for optical storage systems. Without modulation coding, a random data sequence is directly passed through the optical channel. In simulation, the channel includes jitter of 15% and AWGN. The densities of the channel are S=4.6 and S=7.0. The code rates of turbo code are 4/5, 8/9 and 16/17. All code rates, the bit error probability is less than 10-5 at 24dB when we and jitter of 15%.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7251-7255
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• 2014

MicroRNAs (miRNAs) act as tumor suppressors or promoters in neoplasia by regulating relative geneexpression. The association between a single nucleotide polymorphism (SNP) rs4938723 in miR-34b/c and susceptibility to cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed, Web of Science and Embase to identify all relevant studies in this meta-analysis with 6,036 cases and 6,204 controls. We found that the miR-34b/c rs4938723 polymorphism was significantly associated with increased risk of cancers in the heterozygous model (TC versus TT, OR=1.09, 95% CI=1.01-1.18, P=0.02). Subgroup analysis also revealed increased risk for Asian ethnicity in the heterozygous model (TC versus TT, OR=1.12, 95% CI=1.02-1.22, P=0.02), but decreased risk of colorectal cancer in homozygote model (CC versus TT, OR=0.66, 95% CI=0.47-0.92, P=0.02) and in the recessive model (CC versus TC+TT, OR=0.67, 95% CI=0.48-0.93, P=0.02) by cancer type. The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer. Well-designed studies with larger sample size are required to further validate the results.

• Journal of Nutrition and Health
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• v.32 no.2
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• pp.197-203
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• 1999

A total of 216 women of natural menopause over 40 years were interviewed to find the relationships among general environmental fctors, anthropometric measurements, daily nutrient intake, and BMD. The average age of the subjects was 54.0 years. Average ages of menarche and menopause were 16.7 years and 47.7 years, respectively. In general, energy and nutrients intake of the subjects were relatively low compared to the Korean recommended dietary allowances(RDA). Specifically, intakes of energy, protein, clcium, iron, and vitamin A were lower than Korean RDA, BMD levels of lumbar spin (LS), femoral neck(FN), ward's triangle(WT), and trochanter(TC) were significantly decreased wit age in descending order of LS, FN, TC, and WT BMD, accordingly. BMD levels of FN and TC of the subjects were higher compared to those of the same age but BMD levels of LS and WT were lower than those of the same age from the general population. For factors related to BMD levels, hight, weight, BMI, and hip circumference had positive correlations with BMD. On the other hand, menarche, and WHR had negative correlations with BMD. Protein, lipid, iron, vitamin B1, vitamin B2, and niacin intake among factors related nutrient intakes were positively correlated with BMD levels. Based on the stepwise regression analysis, the factors and vitamin B1 intakes. Overall, BMD was decreased with age as can be expected. For those being tall, moderately weighed, and smaller waist circumference, BMD levels were high when the relationships of body characteristics and BMD levels were considered. The higher BMD levels were found for those with high intake of protein and vitamin B1. From the findings, it is suggested that the women after menopause keep the optimum body weight and good eating habits. Specially intakes of good quality protein, vitamin B1 seemed to be important.

• The Korean Journal of Nuclear Medicine
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• v.35 no.5
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• pp.313-323
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• 2001

Purpose: The purpose of this study was to search activated genes that could be related to radiation adaptive response (RAR) induced by low-level radiation from $^{99m}Tc$ in human cell lines. Methods: We used gene discovery array (GDA) and representational difference analysis (RDA) methods. $^{99m}Tc$-pertechnetate was added to $2{\times}106/mL$ NC-37 cells (human lymphoblastic cells) to make concentrations ranging from 148 MBq/mL to 148 Bq/mL by serial 10 fold dilutions. After 44 hours, 2 Gy gamma irradiation was given to them using a Cs-137 cell irradiator. Results: As compared to the control (Con) group to which no $^{99m}Tc$ was added, those cells to which 148 and 14.8 KBq of $^{99m}Tc$ were added showed significantly lower damage to chromosomes, which was evaluated by metaphase analysis. Cells with 148 KBq $^{99m}Tc$ (T148 group) showed most significant protection. Activated genes in the T148 group as compared to Con group were evaluated by GDA and GDA methods. GDA revealed genes of casein kinase 2 (CK2) beta chain, immunoglobulins (lg), human leukocyte antigen (HLA)-B, and two novel genes. Twenty RAR related clones were selected by RDA method. The size of those genes was from 234 to 603 base pairs. Conclusions: RAR was induced by low dose irradiation from $^{99m}Tc$ in NC-37 cell lines. Genes related to the response included CK2, lg, HLA-B in human lymphoblastic cell lines.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.1B
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• pp.153-160
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• 2008

To estimate microbial contaminant loading discharged from diffuse sources, rainfall runoff of six rainfall events were monitored at three study watersheds of forestry and agricultural land use. Monitored indicator microorganism constituents were total coliform (TC), fecal coliform (FC), Escherichia coli (EC), and fecal streptococcus (FS). Soil loss during elevated flow rate caused higher suspended solid concentrations. Indicator microorganism concentrations were closely related with flow rate. TC event mean concentration (EMC) from unpolluted forestry was $5.3{\times}10^3CFU/100ml$, FC EMC was $1.4{\times}10^3CFU/100ml$, EC EMC was $1.1{\times}10^3CFU/100ml$, and FS EMC was $2.9{\times}10^2CFU/100ml$. From a watershed with agricultural-forestry land use, TC EMC was $1.7{\times}10^5CFU/100ml$, FC EMC was $8.5{\times}10^4CFU/100ml$, EC EMC was $8.9{\times}10^4CFU/100ml$, and FS EMC was $3.4{\times}10^4CFU/100ml$. Mixed land use of agricultural-forestry with bigger area, TC EMC was $1.9{\times}10^5CFU/100ml$, FC EMC was $9.6{\times}10^4CFU/100ml$, EC EMC was $7.0{\times}10^4CFU/100ml$, and FS EMC was $5.1{\times}10^4CFU/100ml$.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.1
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• pp.44-50
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• 2002

• Korean Journal of Materials Research
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• v.2 no.4
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• pp.293-297
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• 1992

The magnetic properties of the amorphous Fe/sub 32/Ni/sub 36/Cr/sub 14/P/sub 12/B/sub 6/ has been studied by Mossbauer spectroscopy in the temperature range of 88-400K. The analysis of the spectrum of B8K, the magnetic hyperfine field and quadrupole splitting are found to be 140.5kOe and almost zero, which means that the magnetic hyperfine field is randomly oriented with respect to the principal axes of the electric field gradient, respectively. The values of quadrupole splitting in paramagnetic phase with Tc=280K are independent on the changes of temperature. Debye temperature is found to be about 288k from the analysis of recoilless fraction.

• Korean Journal of Poultry Science
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• v.32 no.1
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• pp.29-34
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• 2005

This study was conducted to estimate the effects of genotype for chicken major histocompatibility complex (MHC) B-LB genes on economic traits. To detect polymorphism, 400 bp fragments of MHC B-LB genes were obtained and sequenced. After digestions using restriction enzyme Hea III, two restriction enzyme sites were observed. There were two mutations at position 427 and 651 those were decided as Type I and Type II, respectively. Using RFLP analyses, type I were genotyped to TT, TC and CC, and type II to MM, Mm and mm. The relatively higher TC genotype frequencies (0.8) of Type I and Mm genotype frequencies (0.88) of Type II were observed in Korean native chickens. The effects of the genotype on 150 days body weight trait were investigated by the associations of CC and Mm genotypes (P<0.05) in Korean native chickens. This result suggests that a significant association exists between the SNP and 150 days body weight.

• Journal of the Korean Mathematical Society
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• v.47 no.5
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• pp.967-983
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• 2010

Let M be an n-dimensional complete simply connected Riemannian manifold with sectional curvature bounded above by a nonpositive constant $-{\kappa}^2$. Using the cone total curvature TC($\Gamma$) of a graph $\Gamma$ which was introduced by Gulliver and Yamada [8], we prove that the density at any point of a soap film-like surface $\Sigma$ spanning a graph $\Gamma\;\subset\;M$ is less than or equal to $\frac{1}{2\pi}\{TC(\Gamma)-{\kappa}^2Area(p{\times}\Gamma)\}$. From this density estimate we obtain the regularity theorems for soap film-like surfaces spanning graphs with small total curvature. In particular, when n = 3, this density estimate implies that if $TC(\Gamma)$ < $3.649{\pi}\;+\;{\kappa}^2\inf\limits_{p{\in}F}Area(p{\times}{\Gamma})$, then the only possible singularities of a piecewise smooth (M, 0, $\delta$)-minimizing set $\Sigma$ are the Y-singularity cone. In a manifold with sectional curvature bounded above by $b^2$ and diameter bounded by $\pi$/b, we obtain similar results for any soap film-like surfaces spanning a graph with the corresponding bound on cone total curvature.