• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2011년도 한국컴퓨터종합학술대회논문집 Vol.38 No.1(C)
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• pp.393-396
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• 2011

In this paper, we propose a constrained alternating least squares nonnegative matrix factorization algorithm (cALSNMF) to detect active brain regions from single subject's task-related fMRI data. In cALSNMF, we define a new cost function which considers the uncorrelation and noisy problems of fMRI data by adding decorrelation and smoothing constraints in original Euclidean distance cost function. We also generate a novel training procedure by modifying the update rules and combining with optimal brain surgeon (OBS) algorithm. The experimental results on visuomotor task fMRI data show that our cALSNMF fits fMRI data better than original ALSNMF in detecting task-related brain activation from single subject's fMRI data.

• Investigative Magnetic Resonance Imaging
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• 제21권2호
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• pp.91-96
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• 2017

Purpose: To describe technical methods for functional magnetic resonance imaging (fMRI) study with arterial spin labeling (ASL) compared to blood oxygenation level-dependent (BOLD) technique and discuss the potential of ASL for research and clinical practice. Materials and Methods: Task-based (n = 1) and resting-state fMRI (rs-fMRI) (n = 20) were performed using ASL and BOLD techniques. Results of both techniques were compared. Results: For task-based fMRI with finger-tapping, the primary motor cortex of the contralateral frontal lobe and the ipsilateral cerebellum were activated by both BOLD and ASL fMRI. For rs-fMRI of sensorimotor network, functional connectivity showed similar results between BOLD and ASL. Conclusion: ASL technique has potential application in clinical and research fields because all brain perfusion imaging, CBF measurement, and rs-fMRI study can be performed in a single acquisition.

• Investigative Magnetic Resonance Imaging
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• 제6권1호
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• pp.28-34
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• 2002

목적 : Event-related fMRl를 위한 통계학적 자극설계에서 최소 자극간격(Minimum Stimulus Onset Asynchronoy: SOAmin)은 중요한 요소로 알려져 있다. 본 연구에서는 통계학적 자극설계를 이용한 event-related fMRI에서 언어과제와 운동과제의 보다 큰 활성화 신호를 얻기 위한 치적의 SOAmin을 알아보고자 하였다. 대상 및 방법 : 4명의 오른손잡이 정상 자원자를 대상으로 운동과 언어의 event-related fMRI를 얻었다. 기능적 자기공명영상은 1.5T기기에서 EPI-BOLD시퀀스를 사용하였다. 각 과제에서 SOAmin을 2, 3, 4, 6초로 달리한 4회의 자극을 이용하여 활성화를 유도하였다. 영상 후 처리는 SPM99를 이용하였으며 활성화 신호의 유의수준은 p<0.05를 기준으로 하였다. 각 과제에서 나타난 활성화 신호를 Z값, 활성화된 화소수와 군집성을 기준으로 비교하였다. 결과 : 운동과제에서는 중심구(1차 운동영역)와 내전두엽(2차 운동영역)에서 활성화 신호가 나타났고, 언어과제에서는 좌측 하전두회 (Broca영역)에서 일정한 활성화 신호가 나타났다. 운동과 언어과제에서 활성화 신호는 SOAmin이 작아질 수록 커지는 경향을 나타내었다. 운동과제에서 1차 운동영역의 활성화 신호는 3초, 2차 운동영역에서는 2초의 SOAmin을 적용한 경우 가장 큰 활성화 신호가 나타났고, 언어과제에서는 2초의 SOAmin을 적용한 경우 가장 큰 활성화 신호가 나타났다. 결론 : 통계학적 자극설계를 이용한 event-related URI로 운동과 언어의 기능적 자기공명영상을 얻기 위해서는 2초 또는 3초의 짧은 SOAmin이 효과적이었다.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 1부
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• pp.728-732
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• 2008

본 연구는 운동 표상에 관한 뇌 메커니즘의 이해를 위해 fMRI를 이용한 측정 시스템을 개발하였다. 개발된 시스템의 검증을 위해 예비 실험을 시행하였다. fMRI task는 visual feedback을 제공하는 task와 차단하는 task 두 가지의 task로 구성되었다. 실험 결과 visual feedback이 제공되었을 때는 left superior orbital gyrus, bilateral precentral gyrus, left superior occipital gyrus, left supplementary motor area, right thalamus, right postcentral gyrus 그리고 right superior parietal lobule 같은 영역들이 활성화 되었다. Visual feedback이 차단되었을 때는 left precuneus, right middle temporal gyrus, bilateral supplementary motor area, right anterior cingulate cortex, left Inferior temporal gyrus, left insula lobe, right superior parietal lobule, bilateral postcentral gyrus 그리고 left precentral gyrus 같은 영역들이 활성화 되었다. 개발된 시스템을 통해서 visual feedback이 차단되었을 경우 운동 표상에 관한 뇌 메커니즘을 알아 볼 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제28권1호
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• pp.139-147
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• 2007

The aim of this study was to evaluate effects of short-tenn repetitive-bilateral excercise on the activation of motor network using functional magnetic resonance imaging (fMRI). The training program was performed at 1 hr/day, 5 days/week during 6 weeks. Fugl-Meyer Assessments (FMA) were performed every two weeks during the training. We compared cerebral and cerebellar cortical activations in two different tasks before and after the training program: (1) the only unaffected hand movement (Task 1); and (2) passive movements of affected hand by the active movement of unaffected hand (Task 2). fMRI was performed at 3T with wrist flexion-extension movement at 1 Hz during the motor tasks. All patients showed significant improvements of FMA scores in their paretic limbs after training. fMRI studies in Task 1 showed that cortical activations decreased in ipsilateral sensorimotor cortex but increased in contralateral sensorimotor cortex and ipsilateral cerebellum. Task 2 showed cortical reorganizations in bilateral sensorimotor cortex, premotor area, supplemetary motor area and cerebellum. Therefore, this study demonstrated that plastic changes of motor network occurred as a neural basis of the improvement subsequent to repetitive-bilateral excercise using the symmetrical upper-limb ann motion trainer.

• The Journal of Korean Physical Therapy
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• 제21권1호
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• pp.81-87
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• 2009

Purpose: Human brain was lateralized to dominant or non-dominant hemisphere, and could be reorganized by the processing of the motor learning. We reported four cases which showed the changes of the cortical activation patterns resulting from two weeks of training with the serial reaction time task. Methods: Four right-handed healthy subjects were recruited, who was equally divided to two training conditions (right hand training or left hand training). They were assigned to train the serial reaction time task for two weeks, which should press the corresponding four colored buttons as fast as accurately as possible when visual stimulus was presented. Before and after two weeks of training, reaction time and function magnetic resonance image (fMRI) was acquired during the performance of the same serial reaction time task as the training. Results: The reaction time was significantly decreased in all of subjects after training. Our fMRI result showed that widespread bilateral activation at the pre scanning was shifted toward the focused activation on the contralateral hemisphere with progressive motor learning. However, the bilateral activation was still remained during the performance of the non-dominant hand. Conclusion: These findings showed that the repetitive practice of the serial reaction time task led to increase the movement speed and accuracy, as described by motor learning. Such motor learning induced to change the cortical activation pattern. And, the changed pattern of the cortical activation resulting from motor learning was different each other in accordance with the hand dominance.

• Investigative Magnetic Resonance Imaging
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• 제21권4호
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• pp.199-209
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• 2017

Purpose: Caffeine is the most widely consumed psychostimulant. It is often adopted as a tool to modulate brain activations in fMRI studies. However, its pharmaceutical effect on task-induced deactivation has not been fully examined in fMRI. Therefore, the purpose of this study was to examine the effect of caffeine on both activation and deactivation under sustained attention. Materials and Methods: Task fMRI was acquired from 26 caffeine naive healthy volunteers before and after taking caffeine pill (200 mg). Results: Statistical analysis showed an increase in cognition-load dependent task activation but a decrease in load dependent de-activation after caffeine ingestion. Increase of attention and memory task activation and its load-dependence suggest a beneficial effect of caffeine on the brain even though it has no overt behavior improvement. The reduction of deactivation by caffeine and its load-dependence indicate reduced facilitation from task-negative networks. Conclusion: Caffeine affects brain activity in a load-dependent manner accompanied by a disassociation between task-positive network and task-negative network.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2001년도 추계학술대회 학술발표 논문집
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• pp.251-254
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• 2001

본 논문에서는 Self Organizing Map을 이용하여 fMRI data를 분석해 보았다. fMRl (functional Magnetic Resonance Imaging)는 인간의 뇌에 대한 비 침투적 연구 방법 중 최근에 각광받고 있는 것이다. Motor task를 수행하고 있는 피험자로부터 image data를 얻어내어 SOM을 적용하여 clustering한 결과 motor cortex 영역이 뚜렷하게 clustering 되었음을 알 수 있었다.

• 인지과학
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• 제19권4호
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• pp.397-417
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• 2008

본 연구에서는 기능적 자기공명영상 기법을 이용하여, 정상 성인이 한국어 틀린 믿음 과제를 수행하는 동안 활성화되는 뇌 영역을 알아보고자 하였다. 실험 1에서 일차 틀린 믿음 과제를 수행하는 동안 양측 설전소엽과 측두-두정 인접부, 좌반구의 하두정소엽, 후측 대상회, 중전두회 등의 뇌 활성화가 관찰되었다. 실험 2에서 이차 틀린 믿음 과제를 수행하는 동안에는 좌반구의 중전두회와 내전두회와 우반구의 설전소엽, 중전두회, 측두-두정 인접부 영역이 활성화되었다. 이런 결과는 성인이 마음이론 이야기를 이해하는 방식은 보편적임을 시사하는 것이다.

• 대한의용생체공학회:의공학회지
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• 제27권6호
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• pp.318-322
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• 2006

The purpose of this study is to examine differences between 20s and 40s in visuospatial performance and brain activation areas using functional Magnetic Resonance Imaging (fMRI). Eight male college students in their twenties ($21.5{\pm}2.3$ years old) and six male adults in their forties ($45.7{\pm}2.6$ years old) who were graduated from college participated in the study. A visuospatial task was presented while brain images were acquired by a 3T fMRI system. Compared to the 20s the 40s showed lower visuospatial performance. There were more activations observed at the parietal and superior frontal areas at 20s compared to 40s. There were more activations observed at the middle frontal and occipital areas at 40s compared to 20s. The results of this study show that the lowering of visuospatial performance with aging was correlated to the decrease of activation area at the parietal lobe and the change of activation area at the frontal lobe.