• BMB Reports
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• v.44 no.6
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• pp.359-368
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• 2011

Polycystic kidney disease (PKD) is a common genetic disorder in which extensive epithelial-lined cysts develop in the kidneys. In previous studies, abnormalities of polycystin protein and its interacting proteins, as well as primary cilia, have been suggested to play critical roles in the development of renal cysts. However, although several therapeutic targets for PKD have been suggested, no early diagnosis or effective treatments are currently available. Current developments are active for treatment of PKD including inhibitors or antagonists of PPAR-${\gamma}$, TNF-${\alpha}$, CDK and VEGF. These drugs are potential therapeutic targets in PKD, and need to be determined about pathological functions in human PKD. It has recently been reported that the alteration of epigenetic regulation, as well as gene mutations, may affect the pathogenesis of PKD. In this review, we will discuss recent approaches to PKD therapy. It provides important information regarding potential targets for PKD.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.14 no.4
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• pp.13-21
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• 2005

The affected factors for an accuracy of theodolite system are not only the measurement environment of temperature, illumination, etc. but also the measurement processes of the distance between two theodolites, the distance from theodolite system to scale bar and the distance from theodolite system to targets. We have known that the best collimation distance between two theodolites and the best distance from theodolite system to scale bar is $3{\sim}4m$. This study was performed for searching the best distance from theodolite system to targets on above measurement configuration. And, we could know that the best distance from theodolite system to targets is $2{\sim}6m$ and the system accuracy could be within ${\pm}0.025mm$.

• Nuclear Engineering and Technology
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• v.45 no.7
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• pp.979-986
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• 2013

Uranium metal particle dispersion plates have been proposed as targets for Molybdenum-99 (Mo-99) production to improve the radioisotope production efficiency of conventional low enriched uranium targets. In this study, uranium powder was produced by centrifugal atomization, and miniature target plates containing uranium particles in an aluminum matrix with uranium densities up to 9 $g-U/cm^3$ were fabricated. Additional heat treatment was applied to convert the uranium particles into UAlx compounds by a chemical reaction of the uranium particles and aluminum matrix. Thus, these target plates can be treated with the same alkaline dissolution process that is used for conventional $UAl_x$ dispersion targets, while increasing the uranium density in the target plates.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.07a
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• pp.464-466
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• 2000

AIN thin films have been prepared by reactive sputtering method, using facing targets sputtering system with a DC power supply which can deposit a high quality thin film and control deposition condition in all range of nitrogen. The crystallographic characteristics of AIN thin films on N$_2$/Ar ratio was investigated by alpha-step and X-ray diffraction. As a result, the AIN film deposited at the pressure ratio of the nitrogen of 30% revealed strong X-ray diffraction intensity under substrate temperature 25$^{\circ}C$ and applied current 0.4A.

• Journal of electromagnetic engineering and science
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• v.15 no.1
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• pp.37-43
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• 2015

We implemented a real-time radar system for an unmanned ground vehicle designed to run on unpaved or bumpy roads. The system must be able to detect slow targets in a cluttered environment and cover wide angular sections with high resolution at the same time. The system consists of array antennas, preprocessors for digital beam forming, and digital signal processors for the detection process which uses sawtooth waveforms and high-resolution estimation, and is called forward/backward spatial smoothing beamspace multiple signal classification (FBSS BS-MUSIC). We show that the sawtooth waveforms enhance the angular estimation capability of FBSS BS-MUSIC in addition to their well-known advantages of removing the ambiguity of targets and detecting slow targets with improved velocity resolution.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.1 no.2
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• pp.183-191
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• 1997

A neural network-based algorithm for the static weapon-target assignment (WTA) problem is Presented in this paper. An optimal WTA is one which allocates targets to weapon systems such that the total expected leakage value of targets surviving the defense is minimized. The proposed algorithm is based on a Hopfield and Tank's neural network model, and uses K x M processing elements called binary neuron, where M is the number of weapon platforms and K is the number of targets. From the software simulation results of example battle scenarios, it is shown that the proposed method has better performance in convergence speed than other method when the optimal initial values are used.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.11a
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• pp.525-528
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• 2001

ZnO:Al thin film can be used as a transparent conducting oxide(TCO) which has low electric resistivity and high optical transmittance for the front electrode of amorphous silicon solar cells and display devices. This study of electrical, crystallographic and optical properties of Al doped ZnO thin films prepared by Facing Targets Sputtering (FTS), where strong internal magnets were contained in target holders to confine the plasma between the targets, is described. Optimal transmittance and resistivity was obtained by controlling flow rate of O$_2$ gas and substrate temperature. When the of gas rate of 0.3 and substrate temperature 200$^{\circ}C$ , ZnO:Al thin film had strongly oriented c-axis and lower resistivity(<10$\^$-4/Ω-cm).

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.50 no.5
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• pp.216-220
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• 2001

Piezoelectric ZnO thin films by Facing Targets Sputtering(FTS) method were deposited on slide glass. The Facing Targets Sputtering system can deposit thin film at plasma-free condition and change the deposition condition in wide range. The characteristics of ZnO thin films changed with power, working pressure and substrate temperature were investigated by XRD(x-ray diffractometer), alpha-step(Tencor) and SEM(Scanning Electron Microscopy) analyses. In the results, we suggest that FTS system is very suitable for the preparation of high quality ZnO thin films with good c-axis orientation.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.11a
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• pp.324-327
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• 2000

ZnO(Zinc Oxide) thin films were deposited on glass substrate by Facing Targets Sputtering. Facing Targets Sputtering system can deposit thin films in plasma-free situation and change the sputtering conditions in wide range. The characteristics of ZnO thin films deposited at variation of sputtering conditions films thickness, power and substrate temperature were evaluated by XRD(x-ray diffractometer), ${\alpha}$-step (Tencor). The excellently c-axis oriented ZnO thin films were obtained at sputter pressure ImTorr, power 150W, substrate temperature 200$^{\circ}C$. In these conditions, the rocking curve of ZnO thin films deposited on glass was 3.3$^{\circ}$.

• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.1
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• pp.115-121
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• 2014

In this paper, we propose a robust background removal integral projection(BRIP) method which can detect close surface targets in coastal environment for IRST. Row pixels of background region from coastal infrared image show similar response. Thus, the proposed BRIP is calculated after horizontal and vertical background estimations and removals are performed sequentially. Finally, surface large targets can be detected using the results of the BRIP. Experimental results on a set of real infrared image sequence show that the proposed method could fully detect ships in every frame.