• 대한작업치료학회지
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• 제26권4호
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• pp.43-55
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• 2018

목적 : 본 연구는 피젯 스피너를 활용하여 초등학교 저학년 아동의 손 기능과 글씨쓰기 명료도에 미치는 영향을 알아보고자 하였다. 연구방법 : 본 연구는 일반아동 중 우세손이 우측인 1~2학년(만 7~8세) 아동 24명을 대상으로 실험군 12명, 대조군 12명으로 무작위 분류하여 실시하였다. 연구 설계는 사전-사후 설계이다. 중재는 실험군 아동들에게만 실시하였으며, 5주간, 주 2회, 1회 당 40분씩 총 10회기로 진행하였다. 측정도구로는 중재 전, 후의 손 기능과 글씨쓰기 명료도의 비교를 위하여 젭슨-테일러 손 기능 검사(Jebsen-Taylor Hand Function Test; JHFT)와 장악력 검사(Grip Strength Test; GST) 그리고 명료도 검사(Legibility Test; LT)를 사용하였다. 자료 분석은 Wilcoxon signed rank 검정과 Mann-Whitney U 검정, 그리고 교차분석의 카이제곱 검정을 사용하였다. 결과 : 피젯 스피너 훈련은 실험군의 손 기능과 장악력, 글씨쓰기 명료도에 유의한 향상을 보였으며, 실험군과 대조군 사이의 유의한 차이를 보였다. 결론 : 본 연구는 초등학교 저학년 아동의 손 기능과 글씨쓰기 명료도를 효과적으로 향상시키는 도구로써 피젯 스피너의 가치 및 효용성을 확인하였다. 이에 향후 연구에서는 본 연구를 토대로 피젯 스피너 훈련의 효과를 검증하는 다양한 연구가 이어지길 기대한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1693-1698
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• 2015

The heterogeneous nature of lung cancer has become increasingly apparent since introduction of molecular classification. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. Activating alterations in several potential driver oncogenic genes have been identified, including EGFR, ROS1 and ALK and understanding of their molecular mechanisms underlying development, progression, and survival of lung cancer has led to the design of personalized treatments that have produced superior clinical outcomes in tumours harbouring these mutations. In light of the tsunami of new biomarkers and targeted agents, next generation sequencing testing strategies will be more appropriate in identifying the patients for each therapy and enabling personalized patients care. The challenge now is how best to interpret the results of these genomic tests, in the context of other clinical data, to optimize treatment choices. In genomic era of cancer treatment, the traditional one-size-fits-all paradigm is being replaced with more effective, personalized oncologic care. This review provides an overview of lung cancer genomics and personalized treatment.

• 생물정신의학
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• 제1권1호
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• pp.7-16
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• 1994

I will try to serve as the basis for the development of a clinical therapeutic guideline of antipsychotic drugs. Knowing that many patients fail standard treatment recommendations, either because of insufficient efficacy or intolerance to adverse effects, led us to emphasize the importance of the guideline. The clinicians continually assimilate new information about recent advances, including : novel agents targeted to impact specific components of various neurotransmitter systems ; combination strategies ; alternative uses of existing agents ; and specialized requirements of a growing number of identified diagnostic subtypes. The cost to benefit ratio must always be considered when developing a therapeutic guideline.

• 대한통합의학회지
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• 제5권1호
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• pp.35-42
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• 2017

Purpose : This study examined the symptoms and body flexibility according to physical change of the female college students who like to wear skinny jeans. Methods : This study targeted 39 female college students and conducted a questionnaire survey on physical change and disease, and measured waist flexibility and hip joint working range. Result : The study subjects showed much fatigue, subjective symptoms, and the highest varicose veins. As for comparison before and after waist flexibility measurement, the mean value of the waist flexibility was 17.97 before the experiment, and the mean value after the experiment was 17.63. Therefore there was a significant difference (P<.5). Conclusion : As a result of this study, the female college students revealed fatigue, varicose veins, and numbness, as well as waist flexibility and hip joint limitations even with a little walk.

• Mycobiology
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• 제48권1호
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• pp.1-8
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• 2020

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially Aspergillus. Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA.

• 대한치과의사협회지
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• 제48권8호
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• pp.576-586
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• 2010

Recent advancement in molocular biology enhanced further understanding of the carcinogenesis of oral cancer and its relation with various genetic backgrounds. Familial risk factors includes similar habits of the family and polymorphic variations of the genes. Recently, human papilloma virus has been suggested to be linked with oral cancer progression. Enhancement of understanding of the damage or alteration in molecular pathway in various cellular response of oral cancer progression would lead the targeted therapy or precise early diagnosis of the oral cancer.

• Clinical and Experimental Pediatrics
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• 제61권4호
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• pp.101-107
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• 2018

Recent advances in genetics have determined that a number of epilepsy syndromes that occur in the first year of life are associated with genetic etiologies. These syndromes range from benign familial epilepsy syndromes to early-onset epileptic encephalopathies that lead to poor prognoses and severe psychomotor retardation. An early genetic diagnosis can save time and overall cost by reducing the amount of time and resources expended to reach a diagnosis. Furthermore, a genetic diagnosis can provide accurate prognostic information and, in certain cases, enable targeted therapy. Here, several early infantile epilepsy syndromes with strong genetic associations are briefly reviewed, and their genotype-phenotype correlations are summarized. Because the clinical presentations of these disorders frequently overlap and have heterogeneous genetic causes, next-generation sequencing (NGS)-based gene panel testing represents a more powerful diagnostic tool than single gene testing. As genetic information accumulates, genetic testing will likely play an increasingly important role in diagnosing pediatric epilepsy. However, the efforts of clinicians to classify phenotypes in nondiagnosed patients and improve their ability to interpret genetic variants remain important in the NGS era.

• 생물정신의학
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• 제23권3호
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• pp.89-101
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• 2016

Transcranial magnetic stimulation (TMS) is a safe, noninvasive and useful technique for exploring brain function. Especially, for the study of cognition, the technique can modulate a cognitive performance if the targeted area is engaged, because TMS has an effect on cortical network. The effect of TMS can vary depending on the frequency, intensity, and timing of stimulation. In this paper, we review the studies with TMS targeting various regions for evaluation of cognitive function. Cognitive functions, such as attention, working memory, semantic decision, discrimination and social cognition can be improved or deteriorated according to TMS stimulation protocols. Furthermore, potential therapeutic applications of TMS, including therapy in a variety of illness and research into cortical localization, are discussed.

• Molecules and Cells
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• 제41권11호
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• pp.943-952
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• 2018

The discovery and mechanistic understanding of target-specific genome engineering technologies has led to extremely effective and specific genome editing in higher organisms. Target-specific genetic modification technology is expected to have a leading position in future gene therapy development, and has a ripple effect on various basic and applied studies. However, several problems remain and hinder efficient and specific editing of target genomic loci. The issues are particularly critical in precise targeted insertion of external DNA sequences into genomes. Here, we discuss some recent efforts to overcome such problems and present a perspective of future genome editing technologies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3577-3581
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• 2012

Small cell lung cancer (SCLC) is characterized by a short cell doubling time, rapid progression and early occurrence of blood-borne and lymph metastasis. The malignancy is the highest of all lung cancer types. Although SCLC has a relatively good initial response to chemotherapy as well as radiotherapy, relapse or disease progression may occur quickly after the initial treatment. Drug resistance, especially multi-drug resistance, is the most important cause of failure of SCLC chemotherapy. This article provides a brief update of research on mechanisms of drug resistance in SCLC and reversal strategies.