• Genomics & Informatics
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• 제8권4호
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• pp.177-184
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• 2010

The target of rapamycin (TOR) signaling pathway is a conserved pathway that regulates eukaryotic cell growth in response to environmental cues. Chemical genomic approaches that profile rapamycin sensitivity of yeast deletion strains have given insights into the function of TOR signaling pathway. In the present study, we analyzed the rapamycin sensitivity of yeast deletion library strains on synthetic medium. As a result, we identified 130 strains that are hypersensitive or resistant to rapamycin compared with wild-type cells. Among them, 36 genes are newly identified to be related to rapamycin sensitivity. Moreover, we found 16 strains that show alteration in rapamycin sensitivity between complex and synthetic media. We suggest that these genes may be involved in part of TOR signaling activities that is differentially regulated by media composition.

• Water Engineering Research
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• 제6권2호
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• pp.73-89
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• 2005

Two kinds of high resolution GCMs with the same spatial resolutions but with different schemes run by domestic and foreign agencies are used to clarify the usefulness and sensitivity of GCM for water resources applications for Korea. One is AMIP-II (Atmospheric Model Intercomparison Project-II) type GCM simulation results done by ECMWF (European Centre for Medium-Range Weather Forecasts) and the other one is AMIP-I type GCM simulation results done by METRI (Korean Meteorological Research Institute). Observed mean areal precipitation, temperature, and discharge values on 7 major river basins were used for target variables. Monte Carlo simulation was used to establish the significance of the estimator values. Sensitivity analyses were done in accordance with the proposed ways. Through the various tests, discrimination condition is sensitive for the distribution of the data. Window size is sensitive for the data variation and the area of the basins. Discrimination abilities of each nodal value affects on the correct association. In addition to theses sensitivity analyses results, we also noticed some characteristics of each GCM. For Korean water resources, monthly and small window setting analyses are recommended using GCMs.

• 한국광학회지
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• 제15권5호
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• pp.461-468
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• 2004

본 논문에서 연구된 정밀모형안은 정시안에서 1.2 시력의 적정한 수차를 가진 모형안임을 확인하였다. 망막의 특성을 생략한 안광학계에 광전달함수를 사용하여 망막에서의 광세기 분포를 조사하여 자각식으로 측정한 임상자료와 비교하였다. 망막의 광학적 특성을 나타내는 안구의 수차, 회절, 망막 대비감도, Stiles-Crawford 효과, 동공크기를 포함한 대비감도함수를 계산하였다. 모형안에 동공직경 1 mm와 8 mm의 범위에서 정시안과 비정시안에 대해 대비감도함수와 변조전달함수를 비교하여 시력을 예측하였다.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2004년도 춘계학술대회 논문집
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• pp.453-458
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• 2004

A capacitate sensor is a proper device for measuring high small displacement. General design parameters and procedure are discussed and a test sensor was built to have a measuring range of 100$\mu\textrm{m}$ and a sensitivity about 30nm. This sensor has too opposing electrode of comparably large area and has nominal gap distance about 150$\mu\textrm{m}$. So as to achieve a nano order displacement sensitivity, both sensor and target system have to be considered. This is important for the sensitivity can be achieved by minimizing a system total noise level in electronic type sensor application. Typical performance of the developed sensor is demonstrated in precision moving stage having 0.1$\mu\textrm{m}$ moving resolution.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.474-478
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• 2008

In this paper, the technique to reinforce the structure using the sensitivity information is proposed. Design variables related to the geometry of structure at fatigue fracture points are determined and sensitivities of fatigue life at fracture points with respect to the variation of design variables are calculated. Then the vector composed of gaps between the target life and initial life cycles at fracture points is calculated. The linear algebraic equation to solve the variation of design variables is composed. From the equation, the design variables for reinforced structure are determined.

• 한국소음진동공학회논문집
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• 제11권7호
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• pp.287-294
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• 2001

The identification of connection stiffnesses of bolted structures is presented using FRT-based substructural sensitivity analysis. The substructural design sensitivity formula is derived and plugged into the optimization module of MATLAB to identify connection stiffnesses of an air-conditioner compressor or passenger Car. The air-conditioner composed of a compressor and a bracket, is analysed by using the FRT-based substructural(FBS) method to obtain FTRs an FE model is generated for the bracket, and the impact hammer test is performed for the compressor, Obtained FRTs are combined to calculate the reaction force at the connection point and the system response. By minimizing the difference between a target FRT and calculated one the connection element properties of the air-conditioner syste are identified It is shown that the proposed identification method is effective for a real problem.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2002년도 추계학술대회논문집
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• pp.128-133
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• 2002

The main obstacle to high track density in HDD is the structural resonances of the suspension. The most critical mode is sway mode and second torsion mode, when a data is read and written. It is common fact that the effect of two modes is smaller when a thickness is bulky. But the stiffness of suspension is smaller, the slider can follow a disk better. Because these two fact are reciprocal, a compromise is needed. So we investigated another method to improve band width without changing of the thickness of suspension but with changing of the shape. In this paper, we use two method - Sensitivity analysis and SIP using ADS. And we obtained the optimized value close to target value.

• 대한기계학회논문집A
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• 제21권5호
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• pp.859-869
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• 1997

In this paper, the robust design and tolerancing of the stabilized mirror is performed to increase its stabilization performance under vehicle vibration. Based on the sensitivity analysis, the seven important control factors are first identified, and then the optimal as well as robust values in the sense of Taguchi method are obtained. Finally, the tolerances associated with each design variables are determined based on a successive sensitivity analysis of the simulated system response so that the deviation in the response from the target value meets the specification requirements. The proposed tolerancing method features that it is a robust but conservative design method and that the computational effort is much less than the Monte Carlo simulation method.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.859-863
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• 2004

Structural Dynamics Modification is very effective technique to improve structure's dynamic characteristics by adding or removing auxiliary structures, changing material property, changing shape of structure. In this research, using the surface grooving technique, shape of base structure was changed to improve its first natural frequency. Utilizing the result of sensitivity analysis, groove shape was formed gathering the many small embossing elements. For this process, Sensitivity Criterion Factor was introduced. To reduce its amount of calculation, the range of target area was restricted to their neighboring area and that result was very successful.

• International journal of advanced smart convergence
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• 제2권1호
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• pp.21-23
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• 2013

The antenna pattern in this case has a main beam pointed in the desired signal direction, and has a null in the direction of the interference.The conventional antenna pattern concepts of beam width, side lobes, and main beams are not used, as the antenna weights are designed to achieve a set performance criterion such as maximization of the output SNR.A new direction of arrival estimation method using effects of model errors and sensitivity analysis is proposed. Two subspaces are used to form a signal space whose phase shift between the reference signal and its effects of model error signal. Through simulation, the performance showed that the proposed method leads to increased resolution and improved accuracy of DOA estimation relative to those achieved with existing method. Since a desired signal is obtained after interference rejection through correction effects of model error, the effect of channel interference on the estimation is significantly reduced.