• Journal of Chest Surgery
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• v.54 no.2
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• pp.117-126
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• 2021

Background: Several factors, such as the degree of target vessel stenosis, are known to be associated with radial artery (RA) graft patency in coronary artery bypass grafting (CABG). There is a lack of data regarding the effect of the RA proximal configuration (aortic anastomosis versus T-anastomosis). This study evaluated the effects of the RA proximal configuration on the patency rate and clinical outcomes after CABG. Methods: We conducted a retrospective study, analyzing 328 patients who had undergone CABG with an RA graft. We divided the patients into 2 groups. The primary endpoint was RA patency and the secondary endpoints were overall mortality and major adverse cardiac and cerebrovascular events (MACCE). We performed a propensity score-matched comparison. Results: Aorta-RA anastomosis was performed in 275 patients, whereas the rest of the 53 patients received T-RA anastomosis. The mean age was 67.3±8.7 years in the T-RA anastomosis group and 63.8±9.5 years in the aorta-RA anastomosis group (p=0.02). The mean follow-up duration was 5.13±3.07 years. Target vessel stenosis ≥70% (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.20-0.91; p=0.03) and T-RA anastomosis configuration (HR, 2.34; 95% CI, 1.01-5.19; p=0.04) were significantly associated with RA occlusion in the multivariable analysis. However, T-RA anastomosis was not associated with higher risks of overall mortality and MACCE following CABG (p=0.30 and p=0.07 in the matched group, respectively). Conclusion: Aorta-RA anastomosis showed a superior patency rate compared to T-RA anastomosis. However, the RA proximal anastomosis configuration was not associated with mortality or MACCE.

• Journal of Navigation and Port Research
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• v.43 no.4
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• pp.250-255
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• 2019

The objective of this study was to analyze the risk of collision accidents to the VTSOs (Vessel Traffic Service Operators) as small ferries and fishing boats are expanded for monitoring targets. The VTSOs was surveyed, the scale of the small vessels defined and the course of general cargo vessels and small vessels along the Busan VTS area investigated for three days. From calculating the risk with CoRI, patterns of increased or decreased risk due to course deviation were similar, and there was no significant difference between the maximum values and the minimum values. In addition, most VTSOs responded that the minimum time required was approximately three minutes to safely instruct in encounter situation, however, the collision risk with a small vessel is very rapidly changing within the three minutes, which is likely to increase the workload and decrease the concentration of the VTSOs. The objective of this study was to investigate the effect on VTSOs with respect to the expansion of small vessels as collision risk, it is expected that it will contribute to the establishment of a suitable scale for the target vessels for VTS through the analysis of each index of the CoRI model and various case studies.

• Ocean and Polar Research
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• v.33 no.4
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• pp.473-483
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• 2011

In the recent WTO/DDA negotiations, discussions are progressing to forbid fishery subsidies which have negative effect on the natural environment and the fishery resources and to lower or to eliminate the tariff/non-tariff barriers that distort trade liberalization. As a result, linking to the weak structural environment of Korea's fishing villages; such a scheme has jeopardized the livelihood of fishermen who settle down in local fishing harbors. Against this backdrop, the government is attempting to positively respond to changes in the fishing environment in a number of different ways: promotion of fishing tourism, fishing harbor reinforcement in function, developing fishing villages, and harbors. With respect to investment by priority in fishing harbor development, it is very important to appropriately select investment targets based on objective criteria. A small number of harbors are chosen and investment plans by harbor are systematically devised, economic feasibility and the effects of investment are analyzed and reviewed in relation to each target harbor. This paper is designed to review and assess objective evaluation methods and the degree of importance for the designation of target harbors, dealing with local harbors in Chung Nam Do as a model. Each local government has tried to reorganize existing harbors and develop new harbors, considering a fall in the number of fishing vessels and the expansion of maritime leisure activities. In order to overcome the limit of existing harbors in function, to raise the income of fishermen, and to activate tourism, they have shifted their focus from simple functions such as vessel evacuation and anchoring to harbor beautification, which can work as a basis for fishing tourism. This paper points out that the AHP analysis method for prioritizing local harbors in Chung Nam Do should help to be chosen target harbors in other cities and provinces. Each local government has attempted to reorganize existing harbors and to develop new harbors, taking into consideration the decline in the number of fishing vessels and the expansion of maritime leisure activities. In order to overcome the limited number of functional harbors, to raise the income of fishermen, and to boost tourism, they have shifted their focus from simple functions, such as vessel evacuation and anchoring, to harbor beautification, which can work as a basis for fishing tourism. This paper shows that the AHP analysis method for prioritizing local harbors in Chungcheongnam-do could aid in the effective selection of target harbors in other cities and provinces.

• The Journal of the Acoustical Society of Korea
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• v.32 no.6
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• pp.472-483
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• 2013

Actual maritime exercise for improving the capability of submarine sonar operator leads to a lot of cost and constraints. Sonar simulator maximizes the capability of sonar operator and training effect by solving these problems and simulating a realistic battlefield environment. In this study, a passive sonar simulator algorithm is suggested, where the simulator is divided into three modules: maneuvering module, noise source module, and sound propagation module. Maneuvering module is implemented in three-dimensional coordinate system and time interval is set as the rate of vessel changing course. Noise source module consists of target noise, ocean ambient noise, and self noise. Target noise is divided into modulated/unmodulated and narrowband/broadband signals as their frequency characteristics, and they are applied to ship radiated noise level depending on the vessel tonnage and velocity. Ocean ambient noise is simulated depending on the wind noise considering the waveguide effect and other ambient noise. Self noise is also simulated for flow noise and insertion loss of sonar-dome. The sound propagation module is based on ray propagation, where summation of amplitude, phase, and time delay for each eigen-ray is multiplied by target noise in the frequency domain. Finally, simulated results based on various scenarios are in good agreement with generated noise in the real ocean.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.8 no.2
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• pp.91-97
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• 2010

As nuclear power plants are getting older, interests on a decontaminating process are increasingly attracting more attention. Chemical decontamination is crucial to lower the production of radioactive waste and radiation dose rate. Prior to this, oxidizers and detergents for target material should be chosen so as to decontaminate major systems and components of a nuclear power plant chemically. In order to decontaminate it properly, it is crucial to have information about the chemical composition and crystalline structure of CRUD, analyzing its samples from the target or the decontamination system with components. However, there is no program which enables the extraction of samples directly from the object or the decontamination system with components carrying genuine radioactivity. Therefore, it is limited to samples from corrosion products carrying partial radioactivity as a resource. The composition of CRUD varies considerably depending on refueling cycle because it is closely related to the constituent of basic material. After settling a target, it is crucial to analyze and obtain analytical information about CRUD as a decontamination target. In this paper, various technologies for manufacturing simulated CRUD are introduced as alternatives to unattained samples. A metal oxide or metal hydroxide was used to synthesize simulated cruds having chemical compositions and crystalline stricture similar to the actual one by 12 different methods. CRUD 4(metal oxides in the autoclave vessel) and CRUD 10(metal oxides in a crucible after hydrazing pretreatment)were chosen as the best method for Type 1 and Type 2.respectively. As these CRUD can be synthesized easily without using any specialized equipment or reagents in a short time and in large quantities, they are expected to stimulate the development of decontaminating agents and processes.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.32 no.1
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• pp.1-8
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• 2010

Background and Purpose: Vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 are involved in tumor lymphangiogenesis. Oral mucosal squamous cell carcinoma (OMSCC) preferentially metastasizes to cervical lymph nodes, so we investigated the expression and distribution of VEGFR-3 signaling proteins in OMSCC. Materials and Methods: Tissue samples of 18 OMSCC, 10 oral mucosal leukoplakia, and 3 normal oral mucosa were evaluated for expression of VEGF-C, VEGF-D, and VEGFR-3 by immunohistochemical staining. The presence of lymphatic vessels was determined using D2-40 staining, by which we also measured lymphatic vessel density (LVD). Results: 72% (13/18) and 56% (10/18) of tissue samples showed VEGF-C and VEGF-D immunopositivity in tumor cells and tumor-associated endothelial cells. VEGFR-3 was also expressed in most of OMSCC, which was up-regulated when compared with normal mucosa or with leukoplakia. Furthermore, LVD was higher in OMSCC than in leukoplakia. Conclusion: Taken together, our results suggest that autocrine activation of lymphatic endothelial cell via VEGFR-3 by VEGF-C and/or VEGF-D could be involved in progression of OMSCC. Therefore, VEGF-C/VEGFR-3 signaling pathway can be a molecular target for anti-metastatic therapy in OMSCC.

• Journal of the Korean Society of Safety
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• v.21 no.3 s.75
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• pp.38-44
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• 2006

The majority of both small and large-scale experiments on gas explosion have been carried out in the explosion instruments with cylindrical tubes of a high length/diameter ratio and vessels of a high height/length ratio, focusing on investigating the interaction between propagating flame and obstacles inside the tubes or vessels. The results revealed that there is a strong interaction between the propagating flame and turbulence formed after the flame passes the obstacle. However this paper focuses on analyzing the pressure impact or profile outside the vent in vented gas explosion in a partially confined chamber by performing gas explosion experiments in a reduced-scale experimental assembly properly constructed. This study has considered eight different cases in gas explosion based on variation of three kinds of parameters such as height of vessel, shape of the vent and vent size, and reveals that the large vessel with big size circle vent is more danger to the target than others because the overpressure is spread out faraway horizontally and vertically.

• International Journal of Naval Architecture and Ocean Engineering
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• v.8 no.6
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• pp.537-553
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• 2016

This paper addresses the safety of two-row tank design by performing the extensive sloshing model tests. Owing to the uncertainties entangled with the scale law transforming the measured impact pressure up to the full scale one, so called comparative approach was taken to derive the design sloshing load. The target design vessel was chosen as 230 K LNG-FPSO with tow-row tank arrangement and the reference vessel as 138 K conventional LNG carrier, which has past track record without any significant failure due to sloshing loads. Starting with the site-specific metocean data, ship motion analysis was carried out with 3D diffraction-radiation program, then the obtained ship motion data was used as 6DOF tank excitation for subsequent sloshing model test and analysis. The statistical analysis was carried out with obtained peak data and the long-term sloshing load was determined out of it. It was concluded that the normalized sloshing impact pressure on 230 K LNG-FPSO with two-row tank arrangement is higher than that of convectional LNG carrier, hence requires the use of reinforced cargo containment system for the sake of failure-free operation without filling limitation.

• Journal of Sensor Science and Technology
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• v.32 no.6
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• pp.418-424
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• 2023

Natural killer (NK) cells play a crucial role in combating infections and tumors. However, their therapeutic application in solid tumors is hindered by challenges, such as limited lifespan, tumor penetration, and delivery precision. Our research introduces a novel ultrasonic actuation technique to navigate NK cells more effectively in the vascular system, particularly at vessel bifurcations where targeted delivery is most problematic. We use a hemispherical ultrasonic transducer array that generates phase-modulated traveling waves, focusing on an ultrasound beam to steer NK cells using blood-flow dynamics and a focused acoustic field. This method enables the precise obstruction of non-target vessels and efficiently directs NK cells toward the tumor site. The simulation results offer insights into the behavior of NK cells under various conditions of cell size, radiation pressure, and fluid velocity, which inform the optimization of their trajectories and increase targeting efficiency. The experimental results demonstrate the feasibility of this ultrasonic approach for enhancing NK cell targeting, suggesting a potential leap forward in solid tumor immunotherapy. This study represents a significant step in NK cell therapeutic strategies, offering a viable solution to the existing limitations and promising enhancement of the efficacy of cancer treatments.

• Journal of Ocean Engineering and Technology
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• v.28 no.5
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• pp.387-395
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• 2014

In this paper, a numerical analysis for an internal turret moored vessel located at a 400-m water depth is conducted. The target vessel has an internal turret that is located at the 0.2 Lpp position from the fore-side, with $3{\times}4$ complex mooring lines installed around the turret circumference. To investigate the motion response of the vessel and the structural reliability of the lines, model tests were conducted. The KRISO ocean basin has a water depth of 3.2 m, which represents 192m using a scaling of 1:60. In order to precisely represent the real-scale condition, equivalent mooring lines needed to be designed. Truncated mooring lines were designed to supplement the restriction of the flume's water depth and increase the reliability of the model testing. These truncated mooring lines were composed of two different chains in order to match the pre-tension, simultaneously restoring the curve and variation in the effective line tension. The static similarities were compared using a static pull-out test and free decaying test, and the dynamic similarities were matched via a regular wave test and combined environments test. Consequently, the designed truncated mooring system could represent the prototype mooring system relatively well in the aspects of kinematics and dynamics.