• 한국정보시스템학회지:정보시스템연구
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• 제24권1호
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• pp.45-66
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• 2015

This study empirically investigated the relationships among organizational culture, target costing, knowledge management activities, and corporate innovations. The results of this study showed that innovative and supportive culture positively affects the adoption degrees of target costing. According to the results, it was observed that target costing as well as innovative and supportive culture have a positive impact on levels of knowledge management activities(i.e., knowledge creation, sharing, storage, and application). It was also demonstrated that organizational culture has an indirect effect on activation of knowledge management activities through target costing. Thus, to enhance knowledge management activities, target costing must be aligned with appropriate types of organizational culture. In examining the impact of knowledge management activities on the frequencies of product and process innovations, no significant effect was found. Additional analyses that compare across three groups(i.e., low level group, middle level group and high level group in knowledge management activities) and between two groups(i.e., between high level group and middle level group or between high level group and low level group) were performed. The results of comparison showed that the degrees of product and process innovations are highest in high level group, but no significant differences are found in the degrees of innovations between middle level group and low level group.

• Genomics & Informatics
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• 제6권2호
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• pp.84-86
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• 2008

The Tetrahymena group I intron has been shown to employ a trans-splicing reaction and has been modified to specifically target and replace human telomerase reverse transcriptase (hTERT) RNA with a suicide gene transcript, resulting in the induction of selective cytotoxicity in cancer cells that express the target RNA, in animal models as well as in cell cultures. In this study, we evaluated the target RNA specificity of trans-splicing phenomena by the group I intron in mice that were intraperitoneally inoculated with hTERT-expressing human cancer cells to validate the anti-cancer therapeutic applicability of the group I intron. To this end, an adenoviral vector that encoded for the hTERT-targeting group I intron was constructed and systemically injected into the animal. 5'-end RACE-PCR and sequencing analyses of the trans-spliced cDNA clones revealed that all of the analyzed products in the tumor tissue of the virus-infected mice resulted from reactions that were generated only with the targeted hTERT RNA. This study implies the in vivo target specificity of the trans-splicing group I intron and hence suggests that RNA replacement via a trans-splicing reaction by the group I intron is a potent anti-cancer genetic approach.

• 대한물리치료과학회지
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• 제17권1_2호
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• pp.33-39
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• 2010

Purpose: The purpose of this study was to analyze the effects of a balance training program using the TARGET Balance Trainer(TBT), which utilizes a visual target, on the balancing ability of normal, healthy individuals. Methods: Twelve healthy female students with an average of 20.7 years(SD=0.25), were participated in this study. They were randomly divided into two groups(6 subjects in each group); experimental group, control group. The experimental group underwent a 3-week training program using the TBT, while the control group trained using only a dynamic air cushion(DAC). Results: Compared to those who trained using only the DAC, participants who trained with the TBT had a smaller difference between the weights distributed(N) to their left and right foot while normal standing with their eyes open. The TBT group also showed a smaller discrepancy between the weights distributed(N) to their left and right sides while standing on one leg with their eyes open, and also with their eyes closed by eye band. Conclusions: TBT is effective to reduce the degree of weight shifting between left and right side in each group. This study is expected to provide a model for future clinical studies.

• 한국조경학회지
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• 제32권3호
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• pp.18-31
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• 2004

Ecological network can solve the ecological problems such as habitat cutting and fragmentation that are resulted from urbanization. Recently, rooftop biotope construction has been appeared as a usefull method for ecological networking in urban area. The objective of this study is to seek the possibility of rooftop greening introduction as well as to select target species for rooftop greening construction from the urban ecological network point of view. In order to select target species, we monitored two adjacent rooftop greening sites, where we found 22 species of birds and insects and 33 species of plants. We set criteria to select target species through documents research, and gave marks species according to the criteria with the help of specialists. We divided the target species into 5 groups on the basis of the 12 selecting criteria. In those two monitored rooftop greening sites, we did not find any species belong to group A, which is the best target species, but we found species belong to the other groups. Orthetrum albistylum, Sympetrum dawinianum belong to group B, which is the priority target species, 7 species besides Passer montanus, Coccinella axyridis, Agrionidae to group C, which is the possible target species, 6 species besides Atractomorpha lata to group D, which is the potential target species, and the others were found to be inadequate to the target species. We found Orthetrum albistylum, Sympetrum dawi-nianum to be the best appropriate target species in the two sites. According to the result of this study, the method of ecological network construction from the dra-gonfly habitat network point of view through the construction of rooftop habitat is ideal for Orthetrum albistylum, and Sympetrum dawinianum. For successful urban ecological network construction, selection criteria and construction techniqes & methods for rooftop habitat should be developed through future research.

• Journal of Communications and Networks
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• 제15권2호
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• pp.164-172
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• 2013

We consider the problem of secure and robust clustering for quantized target tracking in wireless sensor networks (WSN) where the observed system is assumed to evolve according to a probabilistic state space model. We propose a new method for jointly activating the best group of candidate sensors that participate in data aggregation, detecting the malicious sensors and estimating the target position. Firstly, we select the appropriate group in order to balance the energy dissipation and to provide the required data of the target in the WSN. This selection is also based on the transmission power between a sensor node and a cluster head. Secondly, we detect the malicious sensor nodes based on the information relevance of their measurements. Then, we estimate the target position using quantized variational filtering (QVF) algorithm. The selection of the candidate sensors group is based on multi-criteria function, which is computed by using the predicted target position provided by the QVF algorithm, while the malicious sensor nodes detection is based on Kullback-Leibler distance between the current target position distribution and the predicted sensor observation. The performance of the proposed method is validated by simulation results in target tracking for WSN.

• 대한치과마취과학회지
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• 제14권4호
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• pp.213-219
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• 2014

Background: Clinical use of propofol along with remifentanil for intravenous sedation is increasing in these days, but there are not enough researches to evaluate proper target concentration when these drugs are infused by using target controlled infusion (TCI) pump in dental treatment cases. In this study, we compared efficacy of TCI conscious sedation and target concentration of propofol when it used with or without remifentanil during conscious sedation with the help of a TCI for the surgical extraction of impacted teeth. Methods: After IRB approval, all the charts of patients who had undergone surgical extraction of impacted teeth under propofol TCI sedation for 6 months were selected and reviewed for this study. After reviewal of charts, we could divide patients in two groups. In one group (group 1), only propofol was selected for sedation and initial effect site concentration of propofol was $1{\mu}g/ml$ (n = 33), and in another group (group 2), both propofol and remifentanil was infused and initial effect site concentration of each drug was $0.6{\mu}g/ml$ and 1 ng/ml respectively (n = 25). For each group, average propofol target concentration was measured. In addition, we compared heart rate, respiratory rate, and systolic and diastolic blood pressure as well as oxygen saturation. Besides, BIS, sedation scores (OAAS/S), and subjective satisfaction scores were compared. Results: Between group 1 and 2, there were no significant differences in demographics (age, weight and height), and total sedation time. However, total infused dose and the effect site target concentration of propofol was $163.8{\pm}74.5mg$ and $1.13{\pm}0.21{\mu}g/ml$ in group 1, and $104.3{\pm}46.5mg$ and $0.72{\pm}0.26{\mu}g/ml$ in the group 2 with $1.02{\pm}0.21ng/l$ of the effect site target concentration of remifentanil, respectively. During sedation, there were no differences between overall vital sign, BIS and OAAS/S in 2 groups (P > 0.05). However, we figured out patients in group 2 had decreased pain sensation during sedation. Conclusions: Co-administration of propofol along with remifentanil via a TCI for the surgical extraction of impacted teeth may be safe and effective compared to propofol only administration.

• Translational and Clinical Pharmacology
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• 제26권4호
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• pp.150-154
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• 2018

This tutorial reviews the principles of dose individualisation with an emphasis on target concentration intervention (TCI). Once a target effect is chosen then pharmacodynamics can predict the target concentration and pharmacokinetics can predict the target dose to achieve the required response. Dose individualisation can be considered at three levels: population, group and individual. Population dosing, also known as fixed dosing or "one size fits all" is often used but is poor clinical pharmacology; group dosing uses patient features such as weight, organ function and comedication to adjust the dose for a typical patient; individual dosing uses observations of patient response to inform about pharmacokinetic and pharmacodynamics in the individual and use these individual differences to individualise dose.

• 대한수의학회지
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• 제36권1호
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• pp.101-108
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• 1996

This study was desinged to investigate the effect of estrogen(Est) on the proliferating of progesterone(Prog) target cells. The spayed 13 rats(Wistar, approximately 300gm) were randomly alloted into 3 groups. One group was the control group and another Prog-treated group was injected with 1mg of Prog/rat/day for 2 consecutive days, and Estand Prog-treated group was injected intramuscularly with $17{\beta}$-estradiol $20{\mu}g/rat/day$ for 3 consecutive days and then with Prog for 2 days as above from 4th day. Rats were administrated intraperitoneally with bromodeoxyuridinc(Brdur,0.2mg/BW once) befero 2 hours of exanguination. In gross finding, the groups with more level of dimension and weight on the uterus were ordered as Est- and Prog-treated group, Prog-treated group and control group. The investigation by immunohistochemical methods using paraffin sections of the uteri was performed by using anti-Brdur antibody for labeling proliferating cells of Prog target cells. The groups with higher labeling index(LI) were ordered as Prog-treated grop, Est- and Prog- treated group and control group. The number of proliferating cells from Prog target cells in the rats were rather deceased by Prog injection following Est injection than prog injection only. The cell types with higher LI in the wall layers of all 3 groups were ordered as endometrial stromal cells, glandular epithelial cells, luminal epithelial cells, myometrial muscle cells and serosa methodelial cells, and the region with highest LI was functional zone of the endometrium and the region with lower LI was muscular layer and then those with lowest LI was serosa and also the considerable different LI from individual rat were observed.

• International Journal of Aeronautical and Space Sciences
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• 제9권2호
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• pp.114-120
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• 2008

In the vision-based recovery phase, a terminal guidance for the blended-wing UAV requires visual information of high accuracy. This paper presents the light source target design and detection algorithm for vision-based UAV recovery. We propose a recovery target design with red and green LEDs. This frame provides the relative position between the target and the UAV. The target detection algorithm includes HSV-based segmentation, morphology, and blob processing. These techniques are employed to give efficient detection results in day and night net recovery operations. The performance of the proposed target design and detection algorithm are evaluated through ground-based experiments.

• 예술인문사회 융합 멀티미디어 논문지
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• 제7권12호
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• pp.371-380
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• 2017

본 연구는 대학 교양영어 교육에서 영어학습 부진아 학생들을 대상으로 목표어의 유창성과 정확성을 모두 얻기 위해서 언어의 형식적인 특성을 체계적으로 지도해야 할 필요성을 느끼고 기능 중심의 교양영어 교육을 하면서 기본적인 언어 요소인 문법과 어휘를 강화시키는 방법인 'focus on form'(FnF)를 투입하여 그 효과성을 알아보고자 하였다. 동질성이 검증된 3개 집단을 선정하여 의미중심의 의사소통 수업의 비교반과 FnF의 입력 강화 과제 방식 수업의 실험 A반, FnF의 출력 강화 수업의 실험 B반으로 구성하여 13주 실험을 실시하였다. 그 결과, 입력 강화의 실험 A반은 비교반에 비해 문법 습득에 유의한 효과가 있었고, 출력 강화의 실험 B반은 비교반에 비해 어휘 습득에 유의한 효과가 있었다. 그러나 어휘와 문법 습득에서 FnF의 두 방식의 통계적 차이는 나타나지 않았다. 따라서 교양영어수업에서 부진아 학생들에게 문법 항목과 관련해서는 인지적 부담이 낮은 입력 강화를 적용한 수업을 하고, 어휘 항목은 출력 강화를 적용한 FnF수업을 섞어서 할 필요가 있다는 것을 본 연구의 결과가 시사한다.