• Journal of Gastric Cancer
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• v.13 no.3
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• pp.129-135
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• 2013

Gastric cancer is the second leading cause of cancer-related deaths worldwide. In advanced and metastatic gastric cancer, the conventional chemotherapy with limited efficacy shows an overall survival period of about 10 months. Patient specific and effective treatments known as personalized cancer therapy is of significant importance. Advances in high-throughput technologies such as microarray and next generation sequencing for genes, protein expression profiles and oncogenic signaling pathways have reinforced the discovery of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discoveries to practical clinical benefits. Although there is a flood of biomarkers and target agents, only a minority of patients are tested and treated accordingly. Numerous molecular target agents have been under investigation for gastric cancer. Currently, targets for gastric cancer include the epidermal growth factor receptor family, mesenchymal-epithelial transition factor axis, and the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathways. Deeper insights of molecular characteristics for gastric cancer has enabled the molecular classification of gastric cancer, the diagnosis of gastric cancer, the prediction of prognosis, the recognition of gastric cancer driver genes, and the discovery of potential therapeutic targets. Not only have we deeper insights for the molecular diversity of gastric cancer, but we have also prospected both affirmative potentials and hurdles to molecular diagnostics. New paradigm of transdisciplinary team science, which is composed of innovative explorations and clinical investigations of oncologists, geneticists, pathologists, biologists, and bio-informaticians, is mandatory to recognize personalized target therapy.

• Journal of Cancer Prevention
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• v.22 no.4
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• pp.203-210
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• 2017

After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA binding domains. In development and progression of carcinogenesis, RBPs are aberrantly dysregulated in many human cancers with various mechanisms, such as genetic alteration, epigenetic change, noncoding RNA-mediated regulation, and post-translational modifications. Upon deregulation in cancers, RBPs influence every step in the development and progression of cancer, including sustained cell proliferation, evasion of apoptosis, avoiding immune surveillance, inducing angiogenesis, and activating metastasis. To develop therapeutic strategies targeting RBPs, RNA interference-based oligonucleotides or small molecule inhibitors have been screened based on reduced RBP-RNA interaction and changed level of target RNAs. Identification of binding RNAs with high-throughput techniques and integral analysis of multiple datasets will help us develop new therapeutic drugs or prognostic biomarkers for human cancers.

• Korean Management Science Review
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• v.32 no.4
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• pp.69-80
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• 2015

The semiconductor industry is one of those in which the most intricate processes are involved and there are many critical factors that are controlled with precision in those processes. Naturally production scheduling in the semiconductor industry is also very complex and studied by the industry and academia for many years; however, still there are many issues left unclear in the problem. This paper proposes an multi-objective optimization-based scheduling method for semiconductor fabrication(fab). Two main objectives are throughput maximization and meeting target production quantities. The first objective aims to reduce production cost, especially the fixed cost incurred by a large investment constructing a new fab facility. The other is meeting customer orders on time and also helps a fab maintain stable throughput through controlled WIP balancing in the long run. The paper shows a trade-off structure between the two objectives through experimental studies, which provides industrial practitioners with useful references.

• Journal of KIISE:Information Networking
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• v.28 no.2
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• pp.242-250
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• 2001

This paper deals with the TCP bandwidth guarantee problem in a differentiated serviccs(Diffserv) network. The Diffserv assured s<:rvice differentiates packet drop probabilities to guarantee the promised bandwidth even under network congestion. However a token buffer marker fails to show adequate performance because TCI' generates packets according to the unique Tel' congestion control mechanism. We propose a marker that uses a data buffer as well as a token buffer. The marker with a data buffer works well with the assured service mechanism because it smooths Tel' traffic. We showed that the marker with a data buffer achieves the target throughput better than a marker with a token buffer only. We also showed that the optimal buffer size is proportional to reserved throughput and HTT.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.6A
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• pp.666-675
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• 2008

The IEEE 802.22 standard is being developed with the target of improving the efficiency of spectrum utilization and importing the new wireless communication service. The WRAN standard based on Cognitive Radio is being processed for sharing TV bands. In this paper, the efficient spectrum allocation scheme and the optimal power allocation scheme, Partial Constant Power Water Filling (PCPWF), are proposed to maximize the channel capacity and spectrum efficiency and minimize the interference between adjacent cells. And we maximize the system throughput and fairness by using proposed dynamic cell plan that efficiently allocates channel. The results of the simulations are presented to verify the utilization of our proposed scheme.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.8
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• pp.2648-2665
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• 2022

Device-to-device (D2D) multicast has become a promising technology to provide specific services within a small geographical region with a high data rate, low delay and low energy consumption. However, D2D multicast communications are allowed to reuse the same channels with cellular uplinks and result in mutual interference in a cell. In this paper, an intelligent channel assignment algorithm is designed in D2D underlaid cellular networks with the target of maximizing network throughput. We first model the channel assignment problem to be a throughput maximizing problem which is NP-hard. To solve the problem in a feasible way, a novel channel assignment algorithm is proposed. The key idea is to find the appropriate cellular communications and D2D multicast groups to share a channel without causing critical interference, i.e., finding a channel for a D2D multicast group which generates the least interference to network based on current channel assignment status. In order to show the efficacy and effectiveness of our proposed algorithm, a novel search algorithm is proposed to find the near-optimal solution as the baseline for comparisons. Simulation results show that the proposed algorithm improves the network throughput.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 1999.11b
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• pp.255-260
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• 1999

This paper shows the design of a high throughput 512-point FFT processor. The performance target of the 512-point FFT processor is to achieve data symbol rate required for OFDM systems. The memory requirement of the 512-point FFT processor is minimized by adopting shuffle memory system. The hardware cost of the 512-point in processor is further reduced by using a complex multiplier with a new strength reduction method.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.4 no.6
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• pp.1116-1132
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• 2010

In this paper, a new forward error correction (FEC) protocol is proposed for point-to-multipoint satellite links. Link-layer error control protocols in point-to-multipoint satellite links impose several problems such as unreliability and receiver-heterogeneity. To resolve the problem of heterogeneous error rates at different receivers, the proposed scheme exploits multiple multicast channels to which each receiver tunes. The more channels a receiver tunes to, the more powerful error correcting capability it achieves. Based on its own channel condition, each receiver tunes to as many channels as it needs, which prevents from receiving unwanted parities. Furthermore, each receiver saves the decoding time, processing overhead, and processing energy. Performance evaluation shows that the proposed scheme guarantees the target PER while saving energy. The proposed technique is highly adaptive to the channel variation with respect to the throughput efficiency, and provides scalable PER and throughput efficiency.

• Journal of the Korea Institute of Military Science and Technology
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• v.10 no.2
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• pp.115-125
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• 2007

The ubiquitous embedded computers are firmly established as the basic electronic component of design that control military systems. Such applications can be found everywhere in the field of military system. A embedded computer is required to redesign when system needs performance upgrade or production-state of processor is NRND or EOL. This paper describes a scheme about impact analysis of designing processor alteration on embedded computer. In this case, hardware architecture and interrupt source of target system must be considered. Also, performance and throughput of that must be analyzed.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.4
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• pp.335-342
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• 2021

By using HLS when developing a communication system FPGA, HDL code can be automatically generated from a little modified C/C++ source code used for performance verification, which has the advantage of shortening the development period. In this paper, a method of designing a telemetry standard 106-17 LDPC decoder in C language is proposed using Xilinx's Vivado HLS, and by synthesizing Spartan-7 and Kintex-7 as target devices, throughput and FPGA utilization rate was compared.