• Title/Summary/Keyword: Tapering

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Pulmonary thromboembolism combined with intracardiac thrombus occurred during the steroid reduction in nephrotic syndrome patient (미세변화신증에서 스테로이드 감량 중 발생한 심장내 혈전을 동반한 폐색전증)

  • Lee, Se Jin;Park, Ji Young;Ryu, Sung Kee;Choi, Jae Woong;Chae, Won Young;Ryu, Hee Yun;Yoo, Min Seok;Bak, Yoon Suk
    • Journal of Yeungnam Medical Science
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    • v.33 no.1
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    • pp.25-28
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    • 2016
  • Nephrotic syndrome is associated with a hypercoagulable state, which results in thromboembolism as one of its main complications. Various pathogenetic factors that cause the hypercoagulable state in nephrotic syndrome have been recognized. We report on a 19-year-old female with a minimal-change disease who developed pulmonary thromboembolism combined with intracardiac thrombus while on tapering steroid. Our patient showed hypoalbuminemia with an episode of shock, and was successfully treated with thrombolysis and anticoagulation therapy.

Buckling analysis of tapered BDFGM nano-beam under variable axial compression resting on elastic medium

  • Heydari, Abbas;Shariati, Mahdi
    • Structural Engineering and Mechanics
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    • v.66 no.6
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    • pp.737-748
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    • 2018
  • The current study presents a new technique in the framework of the nonlocal elasticity theory for a comprehensive buckling analysis of Euler-Bernoulli nano-beams made up of bidirectional functionally graded material (BDFGM). The mechanical properties are considered by exponential and arbitrary variations for axial and transverse directions, respectively. The various circumstances including tapering, resting on two-parameter elastic foundation, step-wise or continuous variations of axial loading, various shapes of sections with various distribution laws of mechanical properties and various boundary conditions like the multi-span beams are taken into account. As far as we know, for the first time in the current work, the buckling analyses of BDFGM nano-beams are carried out under mentioned circumstances. The critical buckling loads and mode shapes are calculated by using energy method and a new technique based on calculus of variations and collocation method. Fast convergence and excellent agreement with the known data in literature, wherever possible, presents the efficiency of proposed technique. The effects of boundary conditions, material and taper constants, foundation moduli, variable axial compression and small-scale of nano-beam on the buckling loads and mode shapes are investigated. Moreover the analytical solutions, for the simpler cases are provided in appendices.

A case of Behcet's Disease with CNS Manifestations (중추 신경계 증상이 동반된 Behcet,씨 병 1예)

  • Shin, Dong-Gu;Ko, Myung-Ku;Yoon, Kyung-Woo;Kim, Chong-Suhl
    • Journal of Yeungnam Medical Science
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    • v.3 no.1
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    • pp.307-311
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    • 1986
  • Beh,cet's disease was originally described as a triple symptom complex of oral aphthous ulceration, genital ulceration, and hypopyon iritis. It is now known to have a wide systemic manifestations. Among them, the central nervous system involvement should be diagnosed earlier because of it's lethal potential. Recently the authors experienced a case of Behcet's disease with CNS involvement. A 51-year-old female patient was admitted due to deterioration of mentality and generalized ache since 2 years prior to admission. The findings on physical examination were compatible with Behcet's disease, but without cerebrospinal pleocytosis. The manifestations were improved with medications of prednisolone, chlorambucil, colchicine, but relapsed 2 months later during subsequent tapering of prednisolone and chlorambucil. The patient is now on medication again. A case of Beh,cet's disease with CNS manifestations is reported with review of literature.

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The Treatment of Hemangioma in Lower Lip (하순에 발생한 혈관종 환자의 치험례)

  • Lee, Eun-Young;Kim, Kyoung-Won;Lee, Ji-Yeoun
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.32 no.4
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    • pp.373-377
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    • 2010
  • Vascular anomalies are common birthmarks. A eight-month-old male infant had a small size, bright red swelling on the lower lip since birth. On cutaneous examination there was a small brightly erythematous, lobulated, soft plaque on the left side of the lower lip of $10{\times}8{\times}5$ mm. Ultrasonogram examination revealed the lesion and confirmed the diagnosis of capillary hemangioma. The decision to initiate treatment is based on many factors, including size, location and risks and benefits of the proposal therapy. Systemic corticosteroids are decided to prevent the scarring and deforming. Prednisolone was given at a dose of 2 mg/kg/day for 2 weeks followed by tapering for 6 weeks for treatment. After eight weeks there was 80% reduction in the size of the lesion and the left lower lip almost completely cleared without intraoral bleeding. Furthermore, intervention by way of systemic steroids, laser therapy or surgical debulking is appropriate and safe in a select group of patients presenting with a proliferating hemangioma. This report describes a case that was sucessfully treated by systemic steroid therapy for hemangima in intraoral region.

Skin Graft-versus-host Disease Following Autologous Stem Cell Transplantation for Multiple Myeloma

  • Lee, Sung-Eun;Yoon, Jae-Ho;Shin, Seung-Hwan;Park, Gyeongsin;Min, Chang-Ki
    • IMMUNE NETWORK
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    • v.13 no.3
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    • pp.107-110
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    • 2013
  • Graft-versus-host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). However, a similar syndrome has been reported in autologous stem cell transplantation (ASCT) as well. The target organs of GVHD in ASCT are the skin, liver and gastrointestinal (GI) tract, which are consistent with those in allo-SCT. Histologic findings from the skin and the mucosa of the GI tract also show similar features. Here we describe a case of autologous GVHD involving the skin of a patient who underwent ASCT for multiple myeloma. In this patient, the response to a total prednisone dose of 0.5 mg/kg/day was unsatisfactory, and the patient required more intensive and prolonged immunosuppressive therapy with slow tapering.

Elastic distortional buckling of tapered composite beams

  • Bradford, M.A.;Ronagh, H.R.
    • Structural Engineering and Mechanics
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    • v.5 no.3
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    • pp.269-281
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    • 1997
  • The overall buckling mode in a composite steel-concrete beam over an internal support is necessarily lateral-distortional, in which the bottom compressive range displaces laterally and twists, since the top flange is restrained by the nearly rigid concrete slab. An efficient finite element method is used to study elastic lateral-distortional buckling in composite beams whose steel portion is tapered. The simplified model for a continuous beam that is presented herein is a fixed ended cantilever whose steel portion is tapered, and is subjected to moment gradient. This is intended to give an insight into distortion in a continuous beam that occurs in the negative bending region, and the differences between the cantilever representation and the continuous beam are highlighted. An eigenproblem is established, and the buckling modes and loads are determined in the elastic range of structural response. It is found from the finite element study that the buckling moment may be enhanced significantly by using a vertical stiffener in the region where the lateral movement of the bottom range is greatest. This enhancement is quantified in the paper.

Diagrid Systems for Structural Design of Complex-Shaped Tall Buildings

  • Moon, Kyoung Sun
    • International Journal of High-Rise Buildings
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    • v.5 no.4
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    • pp.243-250
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    • 2016
  • Today's architectural design trend based on the recognition of pluralism has led to multiple design directions for all building types including tall buildings. This contemporary design trend has produced many complex-shaped tall buildings, such as twisted, tilted, tapered and freeform towers. Among many different structural systems developed for tall buildings, the diagrid system, with its powerful structural rationale and distinguished aesthetic potential, is one of the most widely used systems for today's tall buildings. This paper studies structural performance of diagrid systems employed for complex-shaped tall buildings. Twisted, tilted, tapered and freeform tall buildings are designed with diagrid structures, and their structural performances are investigated. For the twisted diagrid study, the buildings are twisted up to 3 degrees per floor. In the tilted diagrid study, the angles of tilting range from 0 to 13 degrees. The impact of eccentricity is investigated for gravity as well as lateral loads in tilted towers. In the study of tapered diagrid structures, the angles of tapering range from 0 to 3 degrees. In the study of freeform diagrid structures, lateral stiffness of freeform diagrids is evaluated depending on the degree of fluctuation of free form. The freeform floor plans fluctuate from plus/minus 1.5 meter to plus/minus 4.5 meter boundaries of the original square floor plan. Parametric structural models are generated using appropriate computer programs and the models are exported to structural engineering software for design, analyses and comparative studies.

Designs on CPW-FED aperture antenna for uwb applications (UWB용 CPW-FED APERTURE 안테나 설계)

  • Jo, Sung-Sik;Park, Chang-Hyun;Park, Jung-Ah;Kim, Kab-Ki
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2008.10a
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    • pp.303-307
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    • 2008
  • In this paper, a new co-planar waveguide ultra-wideband aperture is designed. The designed antenna consists of a rectangular aperture on a determined ground plane and a mushroom shaped stub. The mushroom-shaped stub, which is simple, convenient to analyze and optimise, has less parameter. This antenna has compact aperture size $21.1{\times}8.1mm^2$, designed on FR-4 substrate with dielectric constant of 4.3, thickness of l.5mm. CPW fed planar antenna has the advantages of wide-bandwidth, low-cost and easy interaction with the radio frequency front end circuitry.

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Early Experience of Laparoscopic Adhesiolysis in Children with Postoperative Intestinal Obstruction (소아에서 수술 후 발생한 장폐색에 대한 복강경 유착박리술의 초기 경험)

  • Lee, Jeongwoo;Jung, Eunyoung;Park, Woo-Hyun;Choi, Soon-Ok
    • Advances in pediatric surgery
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    • v.19 no.1
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    • pp.32-38
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    • 2013
  • The purpose of this study is to analyze the early experience of the laparoscopic adhesiolysis for the intestinal obstruction due to postoperative adhesion. Seven patients were included in this study. The median age of those patients was 13, and there were 3 males and 4 females. Previous diagnosis and surgical procedure were various in seven cases, including small bowel resection with tapering enteroplasty, Boix-Ochoa fundoplication, Ladd's procedure with appendectomy, mesenteric tumor resection with small bowel anastomosis, ileocecal resection and anastomosis, primary gastric repair, and both high ligation. A successful laparoscopic adhesiolysis was performed in one who had high ligation for inguinal hernia and had a single band adhesion. Six out of 7 (86%) cases needed to convert open surgery due to multiple and dense type of adhesion. In conclusion, laparoscopic approach with postoperative small bowel adhesion seems safe. However, it might be prudently considered because of high rates of conversion in children.

Respiratory Reviews in Asthma 2013

  • Kim, Tae-Hyung
    • Tuberculosis and Respiratory Diseases
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    • v.76 no.3
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    • pp.105-113
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    • 2014
  • From January 2012 up until March 2013, many articles with huge clinical importance in asthma were published based on large numbered clinical trials or meta-analysis. The main subjects of these studies were the new therapeutic plan based on the asthma phenotype or efficacy along with the safety issues regarding the current treatment guidelines. For efficacy and safety issues, inhaled corticosteroid tapering strategy or continued long-acting beta agonists use was the major concern. As new therapeutic trials, monoclonal antibodies or macrolide antibiotics based on inflammatory phenotypes have been under investigation, with promising preliminary results. There were other issues on the disease susceptibility or genetic background of asthma, particularly for the "severe asthma" phenotype. In the era of genome and pharmacogenetics, there have been extensive studies to identify susceptible candidate genes based on the results of genome wide association studies (GWAS). However, for severe asthma, which is where most of the mortality or medical costs develop, it is very unclear. Moreover, there have been some efforts to find important genetic information in order to predict the possible disease progression, but with few significant results up until now. In conclusion, there are new on-going aspects in the phenotypic classification of asthma and therapeutic strategy according to the phenotypic variations. With more pharmacogenomic information and clear identification of the "severe asthma" group even before disease progression from GWAS data, more adequate and individualized therapeutic strategy could be realized in the future.