• The Journal of Korean Medicine
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• v.32 no.4
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• pp.1-24
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• 2011

Backgrounds: Danggui, one of the major herbs in Korean traditional medicine consists of three species: Angelica gigas of Korea, Angelica sinensis of China, and Angelica acutiloba of Japan. Despite its importance in Korean traditional medicine, recognition of the clinical differences between its three species is insufficient. Objectives: The purpose of the present review is to suggest evidence in using Angelica gigas, Angelica sinensis, and Angelica acutiloba distinctively in clinic, by comparing their pharmacological effects and bioactive compounds. Methods: We searched articles published from 2000 to 2009 in Pubmed, EMbase, and RISS. The search keywords were "Angelica gigas", "Angelica sinensis", "Angelica acutiloba", "dongquei", "toki", "Angelicae Radix", "Archangelica officinalis Hoffm.", "Garden Angelica", "Chinese angelica root", "tangkuei", and "danggui". 861 articles were searched. Among them, we selected 143 articles which met our inclusion criteria. Results: This review summarizes active constituents, experimental studies, clinical studies, pharmacokinetics, side effects and toxicity, drug interaction, and industrial use of Angelica gigas, Angelica sinensis, and Angelica acutiloba. Conclusions: While Angelica sinensis and Angelica acutiloba are relatively similar, Angelica gigas is quite different from the others in main active constituents and genetic form. The main experimental studies of Danggui are cardiovascular studies, central nervous system studies and anti-cancer activity. Even though there were cases in which the three species show similar pharmacological effects, the mechanism was not always shared. Therefore, distinguished use of Angelica gigas, Angelica sinensis and Angelica acutiloba is needed.

• Korean Journal of Medicinal Crop Science
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• v.11 no.5
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• pp.392-396
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• 2003

This study was carried out to determine plant growth and bolting characteristics of Angelica gigas. Three varieties and/or lines Manchu bolting resistant variety, AGJ90-1 medium type line, and bolting Jinbu local were used for field trial in Suwon. FIve different transplanting times were applied on March 25, April 5, April 15, April 25, and May 5th. Survival rate was decreased by the delayed transplantation and it affected after April 25th respectively. Plant growth by the early transplantation showed the best growth during the beginning stage and recognized signifiquence but not by the late transplantation. Bolting rate revealed severe different by the variety and line, it ranged from $10{\sim}8.1%$ of Manchu, $5.9{\sim}20.3%$ of AGJ90-1, and $58.5{\sim}74.6%$ of Jinbu local clearly. By the treatment of transplantation time bolting rate was different, early plantation showed high bolting rate compare to the late plantation from the all of tested variety and lines. Bolting response according to the transplanting time, bolting resistant variety showed insensibility and boling line showed sensitive response. In Manchu root yield was best when planted on April 5th as 389 kg /10a, in case of AGJ90-1 was determined 377 kg/10a when planted on April 15th, and Jinbu local root yield was showed 133 kg/10a planted on April 25.