• Archives of Pharmacal Research
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• 제29권5호
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• pp.394-399
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• 2006

Benzothiazole derivatives of thiazolidinediones (TZD) were synthesized using a modified Mitsunobu reaction of 2-(benzothiazol-2-ylmethylamino)ethanol (2) with 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione and assayed for activity on peroxisome proliferator-activated receptor (PPAR) subtypes and inhibitory activity of NO production in lipopolysaccharide-activated macrophages. Most of the tested compounds were identified as potent $PPAR_\gamma$ agonists, indicating their potential as drug candidates for diabetes.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.187.1-187.1
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• 2003

Type 2 diabetes is characterized by high level of blood glucose and insulin and impaired action. In recent years, the treatment of type 2 diabetes has been revolutionized with the advent of thiazolidinedione (TZD) class of molecules that ameliorate insulin resistance and thereby normalize elevated blood glucose levels. These TZDs are synthetic, high-affinity ligands of peroxisome proliferator activated receptor-gamma (PPAR${\gamma}$); a member of the nuclear receptor family that controls the expression of genes in the target tissues of insulin action. (omitted)

• 한국측량학회지
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• 제20권2호
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• pp.215-222
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• 2002

As the GPS signals propagate from the GPS satellites to the receivers on the ground, they are delayed by the atmosphere. The tropospheric delay consists of two components. The hydrostatic (or "dry") component that is dependent on the dry air gasses in the atmosphere and accounts for approximately 90% of the delay. And the "wet" component that depends on the moisture content of the atmosphere and accounts for the remaining effect of the delay. The Zenith Hydrostatic Delay (ZHD) can be calculated from the local surface pressure. The Total Zenith Delay (TZD) will be estimated and the wet component extracted later. Integrated water Vapor (IWV) gives the total amount of water vapor that a signal from the zenith direction would encounter. Precipitable Water Vapor (PWV) is the IWV scaled by the density of water. The quality of this PWV has been verified by comparison with radiosonde data(at Osan). We processed data for JULY 2 and JULY 14, 1999 from four stations(Cheju, Kwangju, Suwon, Daegu). We found the coincidence between PWV of the estimations using GPS and PWV of pressing the radiosonde data. The average of the difference between PWV using GPS and PWV using radiosonde was 3.77 mm(Std. ＝ $\pm$0.013 mm) and 2.70 mm(Std. = $\pm$0.0011 mm) at Suwon & Kwangju.

• Molecules and Cells
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• 제41권10호
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• pp.900-908
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• 2018

Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) ${\gamma}$. Although TZDs are synthetic ligands for $PPAR{\gamma}$, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective.

• 한국자원식물학회지
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• 제28권2호
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• pp.259-262
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• 2015

본 연구는 나리 주요 품종의 종간교잡에서 생기는 삭과의 배유 퇴화방지와 미숙배 형성 시 발생하는 이상증상을 경감하기 위해 나리 종간교잡계통의 자방배양 했을 때 cytokinin 첨가가 신초형성에 미치는 영향을 구명하고자 하였다. FO계통은 BA 2.0 ㎎/L에서 신초 발생율이 18%로 가장 효과적이었고, BA 3.0 ㎎/L와 5.0 ㎎/L에서는 12%로 다소 저조한 결과였다. TDZ 첨가의 경우는 대조구와 같거나 비슷한 경향이었다. FA계통은 TDZ 첨가 시 대체적으로 신초형성율이 높았고 0.3 ㎎/L 처리가 효과적이었다. 반면 BA를 첨가한 배지에서는 14.3%에서 15.7%로 대조구와 큰 차이가 없었다. FLA계통에서 신초발생율은 생장조절제에 의해 증가되었으나 대조구 20%와 비교했을 때 BA 20~24%, TDZ 22~24%로 처리효과는 미미하였다.