• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3085-3090
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• 2015

The telomeric end structures of the DNA are known to contain tandem repeats of TTAGGG sequence bound with specialised protein complex called the "shelterin complex". It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1. All of these assemble together to form a complex with double strand and single strand DNA repeats at the telomere. Such an association contributes to telomere stability and its protection from undesirable DNA damage control-specific responses. However, any alteration in the structure and function of any of these proteins may lead to undesirable DNA damage responses and thus cellular senescence and death. In our review, we throw light on how mutations in the proteins belonging to the shelterin complex may lead to various malfunctions and ultimately have a role in tumorigenesis and cancer progression.

• Journal of Forest and Environmental Science
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• 제34권1호
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• pp.53-56
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• 2018

Elemental carbon (EC) and organic carbon (OC) mass concentrations in PM2.5 were measured from March through October 2015 in Taehwa Research Forest (TRF). The concentration of carbon in the TRF was $3.4{\mu}g/m^3$ and the concentration of EC was $1.4{\mu}g/m^3$. Also the concentration of $OC_{sec}$ was the highest at $2.84{\mu}g/m^3$ in the summer and the lowest at 1.66 in the spring. The ratio of the secondary generation OC in the total OC was the highest at 62% in the summer. Monthly OC concentration was the lowest at $2.38{\mu}g/m^3$ in April and the highest at $6.60{\mu}g/m^3$ in July. In case of EC concentration was the lowest in April ($0.98{\mu}g/m^3$) and the highest in July ($3.41{\mu}g/m^3$). The OC/EC ratio showed the lowest ratio in March and the highest rate in September. It is suggested that the secondary generation reaction of OC component was active due to sufficient irradiation amount in summer.

• Journal of Astronomy and Space Sciences
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• 제30권4호
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• pp.269-277
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• 2013

In this study, we present results of precise orbital geodetic parameter estimation using satellite laser ranging (SLR) observations for the International Laser Ranging Service (ILRS) associate analysis center (AAC). Using normal point observations of LAGEOS-1, LAGEOS-2, ETALON-1, and ETALON-2 in SLR consolidated laser ranging data format, the NASA/GSFC GEODYN II and SOLVE software programs were utilized for precise orbit determination (POD) and finding solutions of a terrestrial reference frame (TRF) and Earth orientation parameters (EOPs). For POD, a weekly-based orbit determination strategy was employed to process SLR observations taken from 20 weeks in 2013. For solutions of TRF and EOPs, loosely constrained scheme was used to integrate POD results of four geodetic SLR satellites. The coordinates of 11 ILRS core sites were determined and daily polar motion and polar motion rates were estimated. The root mean square (RMS) value of post-fit residuals was used for orbit quality assessment, and both the stability of TRF and the precision of EOPs by external comparison were analyzed for verification of our solutions. Results of post-fit residuals show that the RMS of the orbits of LAGEOS-1 and LAGEOS-2 are 1.20 and 1.12 cm, and those of ETALON-1 and ETALON-2 are 1.02 and 1.11 cm, respectively. The stability analysis of TRF shows that the mean value of 3D stability of the coordinates of 11 ILRS core sites is 7.0 mm. An external comparison, with respect to International Earth rotation and Reference systems Service (IERS) 08 C04 results, shows that standard deviations of polar motion $X_P$ and $Y_P$ are 0.754 milliarcseconds (mas) and 0.576 mas, respectively. Our results of precise orbital and geodetic parameter estimation are reasonable and help advance research at ILRS AAC.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회/대한산업공학회 2003년도 춘계공동학술대회
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• pp.448-455
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• 2003

본 논문에서는 MF-TDMA(Multi Frequency - Time Division Multiple Access)체계를 이용하는 광대역 위성 시스템의 리턴 링크를 대상으로 최저타임슬롯 할당 체계를 제시한다. 이를 위해 먼저 clear-sky RCST와 rain-fade RCST가 존재하고 복수의 서비스 및 지연 클래스가 존재하는 광대역 위성 시스템을 대상으로 MF-TDMA 체계 하에서 최적 타임슬롯 할당 체계를 제시한다. Phase 1에서는 clear-sky TRF타임슬롯들의 집합과 rain-fade TRF타임슬롯들의 집합을 결정하고, Phase 2에서는 각 RCST의 각 서비스/지연 클래스에 할당되는 타임슬롯의 수를 결정하고, Phase 3에서는 각 RCST의 각 서비스/지연 클래스에 할당된 타임슬롯들의 스케줄을 결정한다. 마지막으로 불균등 수요 데이터를 활용하여 제시한 최적 타임슬롯 할당 체계의 성능을 분석한다. 성능 분석 결과 제시한 최적 타임슬롯 할당 체계는 빠른 시간 내에 최적해 또는 최적해와 아주 가까운 해를 안정적으로 구한다는 사실을 확인할 수 있었다.

• 천문학회보
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• 제37권2호
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• pp.159.2-159.2
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• 2012

In this study, we propose an effective strategy for precise orbital and geodetic parameter estimation using SLR (Satellite Laser Ranging) observations for ILRS AAC (Associate Analysis Center). The NASA/GSFC GEODYN II software and SLR normal point observations of LAGEOS-1, LAGEOS-2, ETALON-1, and ETALON-2 are utilized for precise orbital and geodetic parameter estimation. Weekly-based precise orbit determination strategy is applied to process SLR observations, and Precise Orbit Ephemeris (POE), TRF (Terrestrial Reference Frame), and EOPs (Earth Orientation Parameters) are obtained as products of ILRS AAC. For improved estimation results, selection strategies of dynamic and measurement models are experimently figured out and configurations of various estimation parameters are also carefully chosen. The results of orbit accuracy assessment of POE and precision analysis of TRF/EOPs for each case are compared with those of existing results. Finally, we find an appropriate strategy for precise orbital and geodetic parameter estimation using SLR observations for ILRS AAC.

• 한국실내디자인학회논문집
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• 제25권6호
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• pp.40-51
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• 2016

The aim of this study is to quantitatively deduce the circulation efficiency and space arrangements of the outpatient department in geriatric hospitals in terms of spatial structure and to find a methodology that could promote the improvement of accessibility and spatial cognition while using the facilities. All space units of the selected twelve geriatric hospitals were located on the first floor. The study adopted the psychological distance concept of space syntax to the unitized spaces, and presented a set of indices, such as TD, PN, RF, PNT and TRF. These indices were calculated according to the standard clinical use procedures. The study evaluated the effectiveness of circulation. The analysis of circulation was based on the four major geriatric illnesses that were selected in this study. The study established the standard clinical use procedure with consideration of the medical treatment, examinations and space units of outpatient departments. The results are as follows: 1) Based on the statistical data, four major geriatric illnesses are examined, and space requirement and standard procedures are established. Development indicators are applied in order to quantitatively deduce the efficiency of spatial cognition. 2) The percentage of the risk of cognitive decline(TRF) has an inversely proportional correlation to the circulation efficiency(PNT) at a certain point. TRF is more influenced by the clinical use procedure than the scale. 3) The arrangement of the waiting space and types of corridor greatly affect the percentage of the risk of cognitive decline. 4) Vulnerable facilities are selected on the basis of the evaluation, and two alternatives that could promote the circulation efficiency are presented. The result of the reanalysis showed that cognitive efficiency had much improved compared to the existing facilities.

• 대한수의학회지
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• 제41권3호
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• pp.401-406
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• 2001

These studies were carried out to survey the genetic contamination of six inbred mice (A, BALB/c, C3H, C57BL/6, CBA and KK) produced and supplied from the conventional breeding unit for improving the quality of mice as experimental animal. We examined alleles of five loci (Akp-1, Car-2, Hbb, Es-1 and Trf) by the use of biochemical markers with celluose acetate electrophoresis. As the results of test, BALB/c, A, C3H, C57BL/6, CBA and KK showed standard alleles in Akp-1, Car-2 and Hbb. But Es-1 of A and C57BL/6 and Trf of A, C3H, C57BL/6 and CBA did allelic divergence in loci. These results suggest that the colonies of A, C3H, C57BL/6 and CBA were genetically contaminated. Therefore, we recommend to eliminate the genetically contaminated mice thoroughly, to check on genetic monitoring regularly and to consider a counterpaln for improving the quality control as soon as possible.

• 한국산업정보학회논문지
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• 제11권2호
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• pp.98-102
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• 2006

최근 정보기술의 발전으로 유비쿼터스 컴퓨팅 환경이 대두되고 있으며 이에 따라 RFID라는 신기술의 등장과 응용에 관한 연구가 활발히 진행되고 있다. 이에 본 논문에서는 기존 RFID 시스템에서 유선망을 사용한 데이터 전송으로 인하여 발생될 수 있는 공간 및 이동성의 제약을 극복하기위하여 저가의 무선전송모듈을 적용하여 휴대형 상품정보제공 시스템을 개발하였다. 무선전송 모듈은 900MHz 대역의 Texas Instruments 사의 TRF6901 chipset을 이용하였고 이를 제어하는 MPU는 TI사의 MSP430F149로 설계하였다. 본 논문에서 개발한 시스템은 도서관리, 출입통제시스템등에 범용적으로 적용될 수 있을 뿐 아니라 이동형 RFID시스템에 혁신적인 기대 효과를 예상할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.795-799
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• 2013

Ku70/80 heterodimer is a central element in the nonhomologous end joining (NHEJ) DNA repair pathway, Ku80 playing a key role in regulating the multiple functions of Ku proteins. It has been found that the Ku80 protein located at telomeres is a major contributor to radiosensitivity in some telomerase positive human cancer cells. However, in ALT human osteosarcoma cells, the precise function in radiosensitivity and telomere maintenance is still unknown. The aim of this study was to investigate the effects of Ku80 depletion in the U2OS ALT cell line cell line. Suppression of Ku80 expression was performed using a vector-based shRNA and stable Ku80 knockdown in cells was verified by Western blotting. U2OS cells treated with shRNA-Ku80 showed lower radiobiological parameters (D0, Dq and SF2) in clonogenic assays. Furthermore, shRNA-Ku80 vector transfected cells displayed shortening of the telomere length and showed less expression of TRF2 protein. These results demonstrated that down-regulation of Ku80 can sensitize ALT cells U2OS to radiation, and this radiosensitization is related to telomere length shortening.

• Journal of Forest and Environmental Science
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• 제34권2호
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• pp.153-161
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• 2018

Ozone absorbs ultraviolet light which is harmful to life. However, the recent increase of ambient ozone level due to climate change is becoming the cause of stimulating human eyes, affecting respiratory system, and damaging crops. In this paper, a study was conducted at the Taehwa Research Forest (TRF) of Seoul National University with the purpose of analyzing the characteristics of forest air chemistry based on the measurement of BVOCs emitted from forests and investigating the correlation of BVOCs with ozone generation. The results showed that levels of isoprene and MVK (Methyl Vinyl Keton)+MACR (Methacrolein) were high in summer, but level of monoterpene was high in spring. Ozone level was high from the middle of May to the middle of June, which was before the rainy season. Comparison of the correlation between ozone and isoprene during the measurement period at the TRF showing limited NOx showed that the $R^2$ was correlated with a low value of about 0.4. However, when the isoprene was actively produced from 6:00 AM to 6:00 PM, correlation analysis showed that $R^2$ was about 0.9, while monoterpene started to increase in the afternoon, and decreased level of ozone at night. Correlation analysis showed negative correlation. Forests have two characteristics: not only the formation of ozone but also the decomposition of ozone.