• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제25권6호
• /
• pp.481-488
• /
• 2022

Purpose: Liver transplantation (LT) is the only curative treatment for acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). In high-volume therapeutic plasma exchange (HV-TPE), extracorporeal liver support filters accumulate toxins and improve the coagulation factor by replacing them. In this study, we aimed to evaluate the effectiveness of HV-TPE in pediatric patients with ALF and ACLF. Methods: We reviewed the records of children waiting for LT at Severance Hospital who underwent HV-TPE between 2017 and 2021. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct bilirubin (TB and DB), gamma-glutamyl transferase (GGT), ammonia, and coagulation parameter-international normalized ratio (INR) were all measured before and after HV-TPE to analyze the liver function. The statistical analysis was performed using IBM SPSS Statistics for Windows, version 26.0 (IBM Co., Armonk, NY, USA). Results: Nine patients underwent HV-TPE with standard medical therapy while waiting for LT. One had neonatal hemochromatosis, four had biliary atresia, and the other four had ALF of unknown etiology. Significant decreases in AST, ALT, TB, DB, GGT, and INR were noted after performing HV-TPE (930.38-331.75 IU/L, 282.62-63.00 IU/L, 11.75-5.59 mg/dL, 8.10-3.66 mg/dL, 205.62-51.75 IU/L, and 3.57-1.50, respectively, p<0.05). All patients underwent LT, and two expired due to acute complications. Conclusion: HV-TPE could remove accumulated toxins and improve coagulation. Therefore, we conclude that HV-TPE can be regarded as a representative bridging therapy before LT.

• 소성∙가공
• /
• 제16권1호
• /
• pp.36-41
• /
• 2007

Thermoplastic elastomer(TPE) can be recycled and molded such as commercial thermoplastic. Therefore TPE has being widely applied on automobile, household and etc. in these days. This study shows the variation of mechanical properties and shrinkage on TPE moldings for variation of injection molding conditions such as injection pressure, holding pressure, melt temperature, mold temperature and etc. Mechanical properties in relation to tensile strength, hardness and shrinkage in connection with precision dimension of part are investigated. The tensile strength and shrinkage of the experimental TPEs are mainly influenced by injection pressure and melt temperature. All injection molding conditions scarcely affect on hardness. To verify the variation of tensile strength and shrinkage, morphology of TPE molding was scanned by the SEM. The morphology showed that as the melt temperature increased, the rubber particles on the TPE became smaller and widely were dispersed. This behavior of rubber particles influenced on the increase of tensile strength.

• 한국소성가공학회:학술대회논문집
• /
• 한국소성가공학회 2005년도 추계학술대회 논문집
• /
• pp.265-268
• /
• 2005

Thermoplastic elastormer (TPE) has many advantages such as high flexibility, high elasticity and high elongation, etc. TPE is easily molded such as plastic materials, therefore, many TPE parts are applied as home appliances and mechanical parts. However, if TPE is once molded, its mechanical properties are changed by injection molding conditions such as melt temperature, mold temperature, injection pressure and holding pressure, etc. In this study, the influences of the injection molding condition on the mechanical properties of thermoplastic vulcanizates(TPVs), which is one of the TPE, were investigated. By the injection molding experiment, as increasing the melt temperature, the tensile strength, shrinkage and hardness decreased. By the scanning electron microscope (SEM) analyzing the TPVs' crystallization, the morphology was affected by the melt temperature.

• 디지털융복합연구
• /
• 제10권10호
• /
• pp.423-430
• /
• 2012

이 연구는 폐 PE/PET/TPE 상용화에 따른 특성에 초점을 맞추었다. 재활용 PET/HDPE blend의 단점인 내열특성과 충격강도 특성이 개선되었고, 내열특성은 polyester계 폐TPE를 첨가한 것이 HDPE가 첨가된것 보다 $50^{\circ}C$ 이상 높은 $150^{\circ}C$이상을 나타내었다. Elastomer의 적용으로 충격강도가 현저히 증가되어 내열 및 탄성이 요구되는 산업분야에 적용할 수 있는 안전소재로의 적용가능성을 확인할 수 있었다. 또한 상용화제를 이용하여 PET를 블렌드 함으로써 폴리올레핀계 수지의 강도를 향상시켰다. 폐HDPE와 폐PET blend의 기계적 물성이 크게 향상되었으며, morphology 특성에서도 상용화제의 첨가에 따라 분산상의 크기가 감소하고 균일해짐이 관찰되었다.

• Journal of Microbiology and Biotechnology
• /
• 제28권7호
• /
• pp.1094-1104
• /
• 2018

The peel of astringent persimmon (Diospyros kaki Thunb. cv. Cheongdo-Bansi) is a by-product of dried persimmon (gotgam). We investigated if deastringent peel extracts of persimmon cv. Cheongdo-Bansi had antioxidative and neuroprotective properties. Two different extracts were prepared: thermally and nonthermally treated persimmon peel extracts (TPE and NTPE, respectively). Both TPE and NTPE were fractionated sequentially in n-hexane, chloroform, ethyl acetate, n-butanol, and water. The TPE and NTPE ethyl acetate fractions had the highest total phenolic and flavonoid contents as well as antioxidant capacities among all the fractions. Pretreatment of neuronal PC-12 and SH-SY5Y cells with the TPE and NTPE ethyl acetate fractions increased cell viability after exposure to oxidative stress. The ethyl acetate fraction of TPE attenuated oxidative stress inside both PC-12 and SH-SY5Y cells more effectively than that of NTPE. Furthermore, the TPE and NTPE ethyl acetate fractions inhibited acetylcholinesterase and butyrylcholinesterase. Analysis of ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry results revealed gallic acid, kaempferol, kaempferol-3-O-galactoside, kaempferol-3-O-glucoside, quercetin, quercetin3-O-galactoside, quercetin-3-O-galactoside-2'-O-gallate, and quercetin-3-O-glucoside as the major phenolics of the TPE and NTPE ethyl acetate fractions. Taken together, these results suggest that the ethyl acetate fraction of deastringent persimmon peel is rich in antioxidants and has potential as a functional food to reduce oxidative stress.

• Elastomers and Composites
• /
• 제45권2호
• /
• pp.94-99
• /
• 2010

자동차용 내외장재로 사용하는 열가소성 엘라스토머(thermoplastic elastomer, TPE)로 제조한 시험편 표면에 340 nm의 자외선을 총 $2500\;kJ/m^2$ 조사하였다. 자외선 조사 후 검정 시험편 표면은 뿌옇게 변했다. 노화 전후 시험편 표면에 있는 물질을 채취하여 GC/MS로 분석하였으나 특이한 점이 발견되지 않았다. 노화된 시험편의 표면에서 잔크랙이 다수 발견되었다. 노화된 시험편의 백화 현상은 노화된 표면을 솔질하거나 불로 지지면 사라졌다. 솔질이나 불로 지진 후에는 표면에 있던 잔크랙이 사라졌다. 노화 전후의 시험편과 노화된 시험편 표면을 솔질 혹은 불로 지진 후의 시험편을 영상 분석기, SEM, EDX, ATR 등으로 분석하여 비교한 결과, 솔질이나 불로 처리한 후 제거된 백화 현상은 솔질이나 불에 의한 가열로 TPE의 구성 성분 중 하나인 폴리프로필렌이 잔크랙을 메웠기 때문으로 설명할 수 있다.

• 대한본초학회지
• /
• 제38권6호
• /
• pp.29-44
• /
• 2023

Objectives : This study was planned to evaluate the therapeutic effectiveness and possible underlying mechanism of TPE (Tetrapanax papyrifer stem(inner part of the stem Extract) and AQE (Akebiae quinata stem Extract) on osteoarthritis. Methods : Osteoarthritis models were induced through intra-articular injection of MIA (monosodium iodoacetate) 50 μL with 80 mg/ml in rats. Excluding the normal group, Osteoarthritis-induced rats were divided into 4 groups (Control, INDO, TPE, AQE). The drug concentrations were indomethacin 5 mg/kg, TPE 200 mg/kg, and AQE 200 mg/kg, and were orally administered once a day for a couple of weeks. After drug supplementation, the effects of TPE and AQE were measured with serum diagnosis, western blotting, and histopathological staining. Results : It was found that the DPPH and ABTS free radical erasure ability of AQE was better than that of TPE. AQE administration improved rear limb overload and it led to relieving pain. Both PTE and AQE significantly reduced the expression of inflammatory mediators COX-2, iNOS, and inflammatory cytokine IL-1β and IL-6 by inhibiting the phosphorylation of IκBα and deactivating the pathway of NF-κBp65. On the other hand, TNF-α was significantly reduced only by administration of AQE. In addition, histopathological analysis showed that the administration of AQE compared to PTE suppressed cartilage degeneration and effectively suppressed damage to proteoglycan, a component of ECM. Conclusion : Reviewing these experimental results, TPE and AQE possessed the effect of delaying the progress of osteoarthritis and protecting cartilage. In addition, the results of this study show that AQE has a better cartilage protection effect than TPE.

• 한국생산제조학회지
• /
• 제19권6호
• /
• pp.847-851
• /
• 2010

It was attempted to develop an auto part by over molding injection mold that produces precision products in high productivity with use of an eco-friendly TPE substitute material for NBR. NBR is currently used in motor gear cover, one of the key parts in motor module for auto doors. Gear cover is composed of plastics and rubber mostly today, which requires a two (2) step process for production using two presses of different types. A hot press is used at this time for forming the rubber, which has drawback of requiring a rather long forming time of 400 seconds for one forming process. Even though this difficulty is overcome by reducing production time through employment of multi-cavity molds, time for forming process must be shortened for improvement of the productivity eventually, and the existing method of insert injection for products that have been formed with plastic material must be outgrown. In this point of view, over molding injection using TPE has a big advantage. Forming time is shortened to 54 seconds, and working the two (2) processes in series by one (1) press could solve the durability problem caused by deflection of the plastics, not to mention shortening the process time. Enhancement of productivity by almost 80% and improvement in the accuracy of the product could thus be achieved.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권2호
• /
• pp.821-824
• /
• 2013

The aim of this study was to investigate the diagnostic value of superoxide dismutase (SOD) in tuberculous pleural effusions (TPEs) and malignant pleural effusions (MPEs). Pleural effusion (PE) samples from 100 patients were classified on the basis of diagnosis as TPE (n=57) and MPE (n=43). The activity of SOD was determined by pyrolgallol assay. A significant difference was observed in SOD activity (P<0.01) between TPE and MPE, levels of being significantly higher in TPE compared to MPE. With a threshold value of 41 U/L, the area under the ROC curve was 0.653, SOD had a sensitivity of 61.4% and a specificity of 61.0% for differential diagnosis. Thus, SOD activity in PE was not a good biomarker in differentiating TPE and MPE. To the best of our knowledge, five SOD isoforms may be present in PE. Identification of which SOD contributes to the difference of SOD level between TPE and MPE is very important for illustrating mechanisms and improving the differential diagnostic value.

• 설비공학논문집
• /
• 제28권12호
• /
• pp.477-482
• /
• 2016

Airtight containers have been widely used in many industries and household. They need a packing for sealing between the inside and outside. Previous packing materials have some drawbacks like stench, stickiness, and difficulty of applying to automated manufacturing systems. So, a new packing material which is harmless and suitable for automation is needed. This study performed a hot plate welding process of thermoplastic elastomer (TPE) as the packing material. The hot plate welding process included a phase change process of solidification and melting. The porosity-enthalpy method was adopted in order to simulate phase change problems. The TPE showed non-Newtonian fluid characteristics during the melting process. Since properties of SEBS are not well-defined, we established TPE properties by observing the melting behavior of TPE. In order to find an optimized condition, a parametric study including packing thickness, shapes, hot plate temperature, and thermal resistance, was conducted.