• BMB Reports
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• v.51 no.1
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• pp.45-53
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• 2018

Mammalian target of rapamycin complex 1 (mTORC1) plays a major role in cell growth, proliferation, polarity, differentiation, development, and controls transitioning between anabolic and catabolic states of the cell. It collects almost all extracellular and intracellular signals from growth factors, nutrients, and maintains cellular homeostasis, and is involved in several pathological conditions including, neurodegeneration, Type 2 diabetes (T2D), obesity, and cancer. In this review, we summarize current knowledge of upstream signaling of mTORC1 to explain etiology of T2D and hypertriglyceridemia, in which state, the role of telomere attrition is explained. We discuss if chronic inhibition of mTORC1 can reverse adverse effects resulting from hyperactivation. In conclusion, we suggest the regulatory roles of telomerase (TERT) and hexokinase II (HKII) on mTORC1 as possible remedies to treat hyperactivation. The former inhibits mTORC1 under nutrient-rich while the latter under starved condition. We provide an idea of TOS (TOR signaling) motifs that can be used for regulation of mTORC1.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.371-376
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• 2006

Recently the container volume in the global trade is steadily increasing. In an effort to cope with this trend, major ports of the world are stepping up the introduction of high-tech equipments, trying to establish a highly efficient information system, and improving the internal work processes of their container terminals. For speedy and effective cargo handling, they are making every effort in the diverse fields. The purpose of this study aims at developing an intelligent multi-agent system for the gate work of a container terminal, which is the place of authority transfer in a container terminal. The agent system suggested in this study has made a comparison between COPINO information by TOS (Terminal Operating System) and information on containers and trucks recognized at the gate passage, checking up their efficiency, and performing the function of controlling outside truck's input-output. Also, based on the records of outside truck's gate passage, some gates can be operated flexibly, consequently enhancing the efficiency of the gate function. The results of job performance will immediately be notified to the customers and terminal managers, thus helping them make decisions speedily.

• Proceedings of the Korea Information Processing Society Conference
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• 2001.10a
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• pp.313-316
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• 2001

At the end of 1999, the TeraCluster project in the KISTI Supercomputing Center was initiated to explore the possibility of PC clusters as a scientific computing platform to replace the Cray T3E system in KISTI by the year 2002. In order to understand whether an application is scalable to tera-flops sized cluster system, running test is inevitable. Extensive performance tests using well-known benchmarking codes with real applications' characteristics in them were carried out with different combinations of CPUs, system boards, network devices. The lessen learned shows the relationships between system performances and varied applications' different needs resulting in promises of How-Tos in building large scale cluster system. The 64/16 node clusters with Alpha EV6(466MHz), Pentium III(667 MHz) i inter-node network of Fast Ethernet. SCI[1] and Myrinet[2] were evaluated. More detailed specifications of the Linux clusters are described in Table 1.

• Journal of Plant Biotechnology
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• v.37 no.4
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• pp.465-471
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• 2010

We assessed whether the cow1 mutant defects are associated with growth of Tos17 and T-DNA insertional rice in blue light (BL). Growth of oscow1 mutants which encoded a member of the YUCCA protein family was retarded in BL. Root to shoot ratios of the mutants were reduced about 2 times lower in the absence of NAA and about 2.5 times lower in the presence of NAA; the shoot growth was not significantly changed by NAA addition. Photosynthetic activity of the mutants was however inhibited in high light. Pigment analysis showed significant difference between wild-type (Chl a:b = 3.02) and mutants (3.84). Carotenoid contents of the mutants were also decreased considerably, implying the involvement of cow1 in pigment formation. These findings lead us to suggest that the growth retardation of oscow1 mutant plants by BL results from the difference of photosynthetic activity in part.

• Journal of the Semiconductor & Display Technology
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• v.18 no.4
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• pp.6-11
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• 2019

For a wider application of laser direct patterning, selective laser ablation of indium tin oxide (ITO) film on transparent oxide semiconductor (TOS) thin film was carried out using a diode-pumped Q-switched Nd:YVO₄ laser at a wavelength of 1064 nm. In case of the laser ablation of ITO on indium gallium zinc oxide (IGZO) film, both of ITO and IGZO films were fully etched for all the conditions of the laser beams even though IGZO monolayer was not ablated at the same laser beam condition. On the contrary, in case of the laser ablation of ITO on zinc oxide (ZnO) film, it was possible to etch ITO selectively with a slight damage on ZnO layer. The selective laser ablation is expected to be due to the different coefficient of thermal expansion (CTE) between ITO and ZnO.

• Journal of Digital Contents Society
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• v.15 no.2
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• pp.283-288
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• 2014

As a way to overcome the problems that when you transmit data to and receive data from End Device to participate in the GRID network, QoS has not been, GARA supports the Diffserv system basically. However, the problem when it is assumed settings related to the Diffserv between the ISP and the ISP is wrong with each other, that it is not possible to receive a complete QoS services began to appear. In this paper, we tried to overcome these drawbacks, in networks based GARA the (Globus Architecture for Reservation and Allocation), using the SLA (Service Level Agrement) server, was treated in the highest priority to the data, the ISP there is provided a method for setting the Diffserv the ISP is even wrong and, using the TOS of the IP header, to solve this, it is described about the direction of future research.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9847-9851
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• 2014

Background: Multiple myeloma (MM) is a haematological cancer characterized by clonal proliferation of plasma cells.The aim of this study was to investigate the activity of serum paraoxonase-1 (PON1) and arylesterase (ARE) in multiple myeloma with and without free light chain excretion(FLCe-MM and NFLCe-MM); as well as to investigate possible alterations in oxidative stress parameters. Materials and Methods: Total thiol (T.thl), oxidative stress index (OSI), total oxidant status (TOS) and total antioxidant status (TAS) were examined in addition to the PON1 and ARE enzyme activities in twenty one FLCe-MM and nineteen NFLCe-MM subjects. Routine parameters like lipid panel, serum total protein, albumin, creatinine, blood urea nitrogen (BUN), uric acid and hemoglobin levels were compared with the oxidative stress markers. Results: Serum total protein, BUN, creatinin, and uric acid levels were significantly higher (p=0.04, p=0.001, p=0.001 and p=0.0022, respectively), while hemoglobin and albumin levels were significantly lower in FLCe-MM patients (p=0.009 and p=0.04,respectively). PON1 and ARE activities were significantly lower in patients with FLCe-MM compared to those with NFLCe-MM (p=0.001 and p=0.008, respectively). Conclusions: Depending on our results of prognostic markers of MM such as age, hemoglobin, albumin, and creatinine we feel confident to presume FLCe-MM as a subgroup with a worse prognosis. A decrease in PON1 and ARE activities may contribute to the prognosis and may be used as a prognostic tool in MM.

• Journal of the Korean Geotechnical Society
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• v.19 no.6
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• pp.379-385
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• 2003

In the existing method to design geosynthetic reinforced embankment, the required strength of reinforcements is determined by vertical stress only rather than strain. This strength is not in accord with tensile strength that behaves as reinforcement in earth structures. The reinforcement and adjacent soil on the failure plan behave in one unit at the initial stress phase but they make a gap in strain as stress increases. This issue may cause a big impact as a critical factor on geosynthetic reinforcement design in earth structures. The quantitative analysis on strain behavior was performed with a PET Mat reinforced embankment on soft ground. From this study, several outstanding discussions are found that tensile strength of reinforcement governs the failure of embankment when the soil stress is greater than failure stress. Also the optimum required tensile strength of geosynthetic reinforcement(Tos) should be determined by stress, displacement, displacement gap and safety factor of soil-PET Mat at the location of PET Mat.

• Archives of Plastic Surgery
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• v.40 no.4
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• pp.304-311
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• 2013

With an increasing emphasis on microsurgery skill acquisition through simulated training, the need has been identified for standardised training programmes in microsurgery. We have reviewed microsurgery training courses available across the six continents of the World. Data was collected of relevant published output from PubMed, MEDLINE (Ovid), and EMBASE (Ovid) searches, and from information available on the Internet of up to six established microsurgery course from each of the six continents of the World. Fellowships and courses that concentrate on flap harvesting rather than microsurgical techniques were excluded. We identified 27 centres offering 39 courses. Total course length ranged from 20 hours to 1,950 hours. Student-to-teacher ratios ranged from 2:1 to 8:1. Only two-thirds of courses offered in-vivo animal models. Instructions in microvascular end-to-end and end-to-side anastomoses were common, but peripheral nerve repair or free groin flap transfer were not consistently offered. Methods of assessment ranged from no formal assessment, where an instructor monitored and gave instant feedback, through immediate assessment of patency and critique on quality of repair, to delayed re-assessment of patency after a 12 to 24 hours period. Globally, training in microsurgery is heterogeneous, with variations primarily due to resource and regulation of animal experimentation. Despite some merit to diversity in curricula, there should be a global minimum standard for microsurgery training.

• Korean Journal of Materials Research
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• v.20 no.5
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• pp.246-251
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• 2010

The composite photocatalysts of a Fe-modified carbon nanotube (CNT)-$TiO_2$ were synthesized by a two-step sol-gel method at high temperature. Its chemical composition and surface properties were investigated by BET surface area, scanning electron microscope (SEM), Transmission Electron Microscope (TEM), X-ray diffraction (XRD) and ultraviolet-visible (UV-Vis) spectroscopy. The results showed that the BET surface area was improved by modification of Fe, which was related to the adsorption capacity for each composite. Interesting thin layer aggregates of nanosized $TiO_2$ were observed from TEM images, probably stabilized by the presence of CNT, and the surface and structural characterization of the samples was carried out. The XRD results showed that the Fe/CNT-$TiO_2$ composites contained a mix of anatase and rutile forms of $TiO_2$ particles when the precursor is $TiOSO_4{\cdot}xH_2O$ (TOS). An excellent photocatalytic activity of Fe/CNT-$TiO_2$ was obtained for the degradation of methylene blue (MB) under visible light irradiation. It was considered that Fe cation could be doped into the matrix of $TiO_2$, which could hinder the recombination rate of the excited electrons/holes. The photocatalytic activity of the composites was also found to depend on the presence of CNT. The synergistic effects among the Fe, CNT and $TiO_2$ components were responsible for improving the visible light photocatalytic activity.