• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2009년도 춘계 종합학술대회 논문집
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• pp.1105-1110
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• 2009

Time Resolved Imaging of Contrast Kinetics 기법을 이용한 4차원 자기공명혈관조영술(TRICKS -MRA)영상과 기존 TOF-MRA영상을 비교하여 임상적 유용성에 대해 알아보고자 하였다. 총 17명 중 뇌 혈관 질환이 의심되는 11명과 뇌 종양을 의심하는 6명을 대상으로 TOF-MRA와 TRICKS -MRA을 시행한 후 17대상자 중 11명에서 DSA를 추가적으로 시행하였다. TOF-MRA는 공간해상력보다 시간해상력이 부족하였고, TRICKS-MRA에서는 TOF-MRA보다 공간분해능은 부족한 점이 많지만 영상판독에 큰 영향은 없었고 모든 대상자에서 동맥과 정맥의 구별이 가능하여 시간분해능이 우수 한 것을 나타났다. 또한 종양과 혈관과의 관계성 평가에서 TOF-MRA보다 좋은 것으로 나타났다. TRICKS-MRA방법은 시간대별로 동맥, 모세혈관, 정맥기를 신속하면서 쉽게 4차원적으로 영상화가 가능하여 앞으로 임상에서 이용도가 더욱 증가 할 것으로 사료된다.

• 정보처리학회논문지B
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• 제17B권4호
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• pp.287-294
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• 2010

TOF(Time of Flight) 기술은 물체의 3차원 깊이 정보 추출을 가능케 하는 기술 중의 하나이다. 하지만, TOF의 카메라의 출력인 깊이 영상을 이용한 물체의 3차원 위치 추출은 몸이나 손 등 크기가 큰 물체의 경우에는 비교적 신뢰성 있는 결과를 얻을 수 있는데 비하여 크기가 작은 손 끝의 경우에는 신뢰할 수 있는 값을 얻기 힘들다. 본 논문에서는 TOF 카메라에서 육면체 손 모델을 이용하여 수정된 손의 영상에서의 위치 정보와 팔 모델을 이용하여 손 끝의 3차원 좌표를 추정한다. 제안된 방법으로 실험을 한 결과 TOF 카메라의 깊이 영상만을 사용하여 인식한 손 끝의 3차원 위치정보와 비교하여 훨씬 더 향상된 결과를 얻을 수 있었다.

• Mass Spectrometry Letters
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• 제9권3호
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• pp.77-80
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• 2018

The focus of this paper is to present techniques to overcome certain difficulties in quantitative analysis with a time-of-flight mass spectrometer (TOF-MS). The method is based on conventional solid-phase extraction, followed by reversed-phase ultra high performance liquid chromatography of the extract, and mass spectrometric analysis. The target compounds included atenolol, atrazine, caffeine, carbamazepine, diclofenac, estrone, ibuprofen, naproxen, simazine, sucralose, sulfamethoxazole, and triclosan. The matrix effects caused by high concentrations of organic compounds in wastewater are especially significant in electrospray ionization mass spectroscopy. Internal-standard calibration with isotopically labeled standards corrects the results for many matrix effects, but some peculiarities were observed. The problems encountered in quantitation of carbamazepine and triclosan, due to nonlinear calibration were solved by changing the internal standard and using a narrower mass window. With simazine, the use of a quadratic calibration curve was the best solution.

• Journal of Microbiology and Biotechnology
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• 제29권6호
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• pp.887-896
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• 2019

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based pathogen identification relies on the ribosomal protein spectra provided in the proprietary database. Although these mass spectra can discern various pathogens at species level, the spectra-based method still has limitations in identifying closely-related microbial species. In this study, to overcome the limits of the current MALDI-TOF MS identification method using ribosomal protein spectra, we applied MALDI-TOF MS of low-mass profiling to the identification of two genetically related Bacillus species, the food-borne pathogen Bacillus cereus, and the insect pathogen Bacillus thuringiensis. The mass spectra of small molecules from 17 type strains of two bacilli were compared to the morphological, biochemical, and genetic identification methods of pathogens. The specific mass peaks in the low-mass range (m/z 500-3,000) successfully identified various closely-related strains belonging to these two reference species. The intensity profiles of the MALDI-TOF mass spectra clearly revealed the differences between the two genetically-related species at strain level. We suggest that small molecules with low molecular weight, 714.2 and 906.5 m/z can be potential mass biomarkers used for reliable identification of B. cereus and B. thuringiensis.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2004년도 추계 종합학술대회 논문집
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• pp.495-500
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• 2004

The neutron capture cross section of $^{99}Tc$ has been measured relative to the $^{10}B$(n,g) standard cross section by the neutron time-of-flight(TOF) method in the energy range of 0.007 eV to 47keV using a 46-MeV electron linear accelerator(linac) at the Research Reactor Institute, Kyoto University(KURRI). In order to experimentally prove the result obtained, the supplementary cross section measurement has been made from 0.3 eV to 1 keV using the Kyoto University Lead slowing-down Spectrometer(KULS) coupling to the linac. The relative measurement by the TOF method has been normalized to the reference value(20.01 b) at 0.0253 eV and the KULS measurement to that by the TOF method. The existing experimental data and the evaluated capture cross sections in ENDF/B-VI, JENDL-3.2, and JEF-2.2 have been compared with the current measurements by the linac TOF and the KULS experiments. The energy dependency of the KULS data is close to that of the TOF data which are energy-broadened by the resolution function of the KULS.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
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• pp.136-136
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• 2001

Purpose： Subclavian steal refers to the retrograde flow of blood in a vertebral artery that supplies t ipsilateral shoulder and arm caused by proximal subclavian artery stenosis or occlusion. T purpose of this exhibit is to demonstrate MR findings of subclavian steal on contrast-enhanc 3D (CE 3DMRA) and 2D TOF MR angiography. Method： Four patients(men 3 and women 1, age： 28-78years) with subclavian steal obtained both CE 3DMRA and digital subtraction angiography(DSA) including subclavian arterie Sequential imaging was undertaken during first pass after double dose of Gd-DTPA (0 mM/kg) Injected by a power injector. Coronal source images were obtained with coronal D-fast low angle shot sequence(TR/TE/flip angle=3.8/l.3/35, acquisition time= 10sec/one measurement). Precontrast imaging was subtracted from enhanced images and maximu intensity projection was done. 2D time-of-flight MR angiography(2D TOF) of the carot bifurcation was added in all cases with post-saturation. All studies were review retrospectively.

• Mass Spectrometry Letters
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• 제5권1호
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• pp.24-29
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• 2014

An advanced and reliable high performance liquid chromatography (HPLC)/ultraviolet detector (UV)/ion-trap time-of-flight (IT-TOF) mass spectrometry was developed for the simultaneous quantification of 19 marker compounds in Bang-poong-tong-sung-san (BPTS), a traditional oriental prescription. Various parameters affecting HPLC separation and IT-TOF detection were investigated, and optimized conditions were identified. The separation was achieved on a Capcell PAK C18 column ($1.5mm{\times}250mm$, $5{\mu}m$ particle size) using a gradient elution of acetonitrile and water containing 0.1% formic acid at a flow rate of 0.1 mL/min. The column temperature was maintained at $40^{\circ}C$ and the injection volume was $2{\mu}L$. IT-TOF system was equipped with an electrospray ion source (ESI) operating in positive or negative ion mode. The optimized electrospray ionization parameters were as follows: ion spray voltage, +4.5 kV (positive ion mode), or -3.5 kV (negative ion mode); drying gas ($N_2$), 1.5 L/min; heat block temperature, $200^{\circ}C$. Automatic $MS^n$ (n = 1~3) analyses were carried out to obtain structural information of analytes. Elemental compositions and their mass errors were calculated based on their accurate masses obtained from a formula predictor software. The marker compounds in BPTS were identified by comparisons between $MS^n$ spectra from standards and those from extracts. Moreover, the libraries of $MS^2$ and $MS^3$ spectra and accurate masses of parent and fragment ions for marker compounds were constructed. The developed method was successfully applied to the BPTS extracts and identified 17 out of 19 marker compounds in the BPTS extracts.

• 한국방사선학회논문지
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• 제4권4호
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• pp.29-32
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• 2010

본 연구는 교토대학 원자로실험소의 46-MeV전자선형가속기에서 발생된 전자선을 Ta표적에 충돌시켜 발생된 중성자를 이용하였다. 발생된 중성자는 납감속측정장치(LSDS:Lead Slowing-down Spectrometer))속에서 감속되었고 중성자비행시간법(TOF:Time-of-Flight)을 이용하여서 중성자에너지를 선별하여 $^{197}Au$의 중성자포획단면적을 중성자에너지 0.1 eV에서 10 keV범위에 걸쳐 측정하였다. 발생된 중성자속을 측정하기 위하여 $BF_3$검출기속의 $^{10}B(n,{\gamma})$반응을 이용하였고 이것을 이용하여 중성자 반응 단면적을 상대적으로 얻었다. TOF방법으로 얻어진 결과는 1 eV에서의 결과(24.5 b)에 규격화되었다. 기존의 실험결과들과 평가결과들인 JENDL/D-99 Dosimetry File과 비교하였다.

• Journal of Electrical Engineering and Technology
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• 제13권2호
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• pp.981-988
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• 2018

In order to acquire an accurate TOF, this paper proposes a method that produces TOF by using a mathematical model for the envelope of the received signal obtained from a system dynamic model of ultrasonic transducer. The proposed method estimates the arrival time of the received signal retrospectively by comparing its wave form obtained after triggering point with its mathematical envelope model. Experimental result shows that the error due to variation of triggering point can be dramatically decreased by implementing the proposed method.

• 한국콘텐츠학회논문지
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• 제5권5호
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• pp.133-139
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• 2005

교토대학 원자로실험소의 46-MeV 전자선형가속구를 이용하여 $^{99}Tc$의 중성자포획단면적을 중성자에너지 0.007 eV에서 47 keV에 걸쳐 중성자 비행시간법을 이용하여 측정을 하였다. 이 중성자포획 결과는 $^{10}B(n,\gamma)$반응의 중성자 반응 단면적에 상대적으로 얻어졌다. 얻어진 결과를 확인하기 위해서 교토대학 원자로실험소의 납감속장치를 이용한 결과를 확인하였다. TOF방법으로 얻어진 결과는 0.0253 eV에서의 결과(20.01 b)에 규격화되었다. 기존의 실험결과들과 평가결과들인 ENDF/B-VI, JENDL-3.2, and JEF-2.2은 본 연구에서 TOF와 납감속장치로 얻어진 결과들과 비교 및 검토하였다.