• Coupled systems mechanics
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• v.7 no.3
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• pp.333-351
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• 2018

In the present paper, the behavior of the Karaj double curvature arch dam is studied focusing on the effects of structural nonlinearity on the responses of the dam body when an underwater explosion occurred in the reservoir medium. The explosive sources are located at different distances from the dam and the effects of the cavitation and the initial shock wave of the explosion are considered. Different amount of TNT are considered. Two different linear and nonlinear behavior are assumed in the analysis and the dam body is assumed with and without contraction joints. Radial, tangential and vertical displacements of the dam crest are obtained. Moreover, maximum and minimum principal stress distributions are plotted. Based on the results, the dam body responses are sensitive to the insertion of joints and constitutive model considered for the dam body.

• Biomedical Science Letters
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• v.15 no.1
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• pp.97-99
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• 2009

Geldanamycin is a benzoquinone ansamycin antibiotic that binds to cytosol HSP90 (Heat Shock Protein 90) and changes its biological function. HSP90 is involved in the intracellular important roles for the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. To identify genes expressed during geldanamycin treatment against neurons of rats (PC12 cells), DNA microarray method was used. We have isolated 2 gene groups (up-or down-regulated genes) which are geldanamycin differentially expressed in neurons. Granzyme B is the gene most significantly increased among 204 up-regulated genes (more than 2 fold over-expression) and Chemokine (C-C motif) ligand 20 is the gene most dramatically decreased among 491 down-regulated genes (more than 2 fold down-expression). The gene increased expression of Cxc110, Cyp11a1, Gadd45a, Gja1, Gpx2, Ifua4, Inpp5e, Sox4, and Stip1 are involved stress-response gene, and Cryab, Dnaja1, Hspa1a, Hspa8, Hspca, Hspcb, Hspd1, Hspd1, and Hsph1 are strongly associated with protein folding. Cell cycle associated genes (Bc13, Brca2, Ccnf, Cdk2, Ddit3, Dusp6, E2f1, Illa, and Junb) and inflammatory response associated genes (Cc12, Cc120, Cxc12, Il23a, Nos2, Nppb, Tgfb1, Tlr2, and Tnt) are down-regulated more than 2 times by geldanamycin treatment. We found that geldanamycin is related to expression of many genes associated with stress response, protein folding, cell cycle, and inflammation by DNA microarray analysis. Further experimental molecular studies will be needed to figure out the exact biological function of various genes described above and the physiological change of neuronal cells by geldanamycin. The resulting data will give the one of the good clues for understanding of geldanamycin under molecular level in the neurons.

• Journal of the Korean Institute of Gas
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• v.12 no.2
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• pp.69-76
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• 2008

Three failure cases of CNG composite vessels were reported since after January 2005. The 1st and 2nd accidents were indebted to vessel defect and installation mistake. The 3rd was caused by gas leak at pipe connections. In this paper various aspects were studied based on information of the three failure analysis, which must be improved for better safety of the CNG bus system. Overpressure region caused by vessel explosion was theoretically predicted and also assessed by PHAST program. Explosion of 120 l vessel under 20 MPa is equivalent to 1.2 kg TNT explosion. The predicted value by PHAST was more serious than theoretical one. However, actual consequence of explosion was much less than both of the predicted consequences. Since the CNG vessel was designed by the performance based design methodology, it is difficult to verify whether the required process and tests were properly conducted or not after production. If material toughness is not enough, the vessel should be weak in brittle fracture at early in the morning of winter season since the metal temperature can be lower than the transition temperature. If autofrettage pressure is not correct, fatigue failure due to tensile stress during repeated charging is possible. One positive aspect is that fire did not ocurred after vessel failure. This may be indebted to fast diffusion of natural gas which hindered starting fire.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.3
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• pp.141-148
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• 2022

In this study, the structural behavior of reinforced concrete members under simultaneous axial and blast loads was analyzed. Nonlinear dynamic analysis verification was performed using the experimental data of panels under fundamental blast load as well as those of reinforced concrete columns subjected to axial and blast loads. Because Autodyn is a program designed only for dynamic analysis, an analysis process is devised to simulate the initial stress state of members under static loads, such as axial loads. A total of 80 nonlinear dynamic finite element analysis procedures were conducted by selecting parameters corresponding to axial load ratios and scaled distances ranging 0%~70% and 1.1~2.0 (depending on the equivalent of TNT), respectively. The structural behavior was compared and analyzed with the corresponding degree of damage and maximum lateral displacement through the changes in axial load ratio and scaled distance. The results show that the maximum lateral displacement decreases due to the increase in column stiffness under axial loads. In view of the foregoing, the formulated analysis process is anticipated to be used in developing blast-resistant design models where structural behavior can be classified into three areas considering axial load ratios of 10%~30%, 30%~50%, and more than 50%.