• Childhood Kidney Diseases
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• v.4 no.2
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• pp.166-169
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• 2000

Tubulointerstitial nephritis and uveitis (TINU) is a rare syndrome of unknown etiology involving the kidney and the eye. This is the first case reput of TINU in Korea. The diagnosis of TINU was confirmed in a 15-year-old girl on the basis of pathologically proven tubulointerstitial nephritis and bilateral uveitis. Although the renal symptoms disappeared spontaneously, uveitis showed only partial response to topical steroid treatment and persisted fir more than 11 months. TINU should be included in the differential diagnosis of tubulointerstitial nephritis of unknown etiology.

• Clinical and Experimental Pediatrics
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• v.59 no.sup1
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• pp.99-102
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• 2016

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease, often underdiagnosed or misdiagnosed in children. We describe the case of a 12-year-old boy who presented to Severance Hospital with a 1-month history of bilateral conjunctival injection. He was first evaluated by an Ophthalmologist in another hospital and diagnosed with panuveitis. Laboratory tests indicated renal failure, and a renal biopsy confirmed the diagnosis of acute tubulointerstitial nephritis. An extensive exclusion of all possible causes allowed a diagnosis of TINU syndrome. The patient was treated with a systemic corticosteroid (initially prednisolone, 2 mg/kg and later deflazacort 1 mg/kg) and topical steroid drops for 1 month. Azathioprine was later added to the treatment regimen and the systemic steroid was slowly tapered. The final outcome of renal-ocular disease was favorable in the patient. However, long-term follow-up is necessary to properly manage frequent relapses and incomplete renal recovery. TINU should be considered as a differential diagnosis in children with uveitis or acute renal failure.

• Childhood Kidney Diseases
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• v.27 no.1
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• pp.40-45
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• 2023

Tubulointerstitial nephritis and uveitis (TINU) syndrome is defined as the occurrence of tubulointerstitial nephritis and uveitis in the absence of other systemic diseases. Three pediatric cases have been reported in the Republic of Korea, and we now report a fourth case. A 15-year-old girl presented to the ophthalmology department with a 1-week history of bilateral ocular discomfort that worsened on the day of presentation with redness and pain in both eyes. She was diagnosed with bilateral uveitis, and her baseline examination revealed moderate renal dysfunction and mild proteinuria. A renal biopsy was performed and confirmed the diagnosis of TINU syndrome. She was started on steroid eye drops and a 12-week course of oral steroids at a dose of 40 mg/m²/day, which completely resolved the proteinuria and mild renal function to an estimated glomerular filtration rate of 60 mL/min/1.73 m². However, the uveitis did not improve, and despite the addition of oral methotrexate as a second-line treatment, the uveitis remains unresponsive to treatment over 21 months. Further evaluation and treatment are ongoing, and active therapeutic intervention is suggested even at a pediatric age, considering the lack of improvement in renal function and uveitis to date.

• Herbal Formula Science
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• v.26 no.4
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• pp.341-362
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• 2018

Objective : This study's purpose was to review the clinical studies of Oryeong-San. Method : We searched papers about Oryeong-San using KISS, KTKP, PUBMED, Embase, Science Direct, and the key words "Goreisan", "Goreito", "Wu Ling San", "Oryeongsan", "Poria Five Powder" were used. Papers not matched with inclusion criteria were excluded. Results : Until today, there have been 133 studies on the effects of head diseases, urinary system diseases, edema, and other various effects of Oryeong-San. Of these, 23 studies were classified as clinical research papers. There were 8 cases of head diseases, 5 cases of urinary system diseases, 3 cases of edema, 2 cases of adjuvant, 1 case of Dysmenorrhea, 1 case of Primary Hypertension, 1 case of Primary Insomnia, 1 case of hydrocele, 1 case of side effects causing TINU syndrome. Conclusion : It can be seen that Oryeong-San has established the basis for application to the purpose of head disease(chronic subdural hematoma, hydrocephalus, hearing loss), urinary system disease(stone, urinary tract infection), edema, adjuvant, other hypertension and insomnia. On the other hand, considering one case that causes side effect of TINU syndrome, caution should be exercised when observing the progress of the patient taking the Oryeong-San.