• 대한지역사회영양학회지
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• 제11권6호
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• pp.771-778
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• 2006

Previous studies have suggested that delta-aminolevulinic acid dehydratase (ALAD) phenotype differently affect mineral metabolism. The objective of this study was to determine the effectiveness of 6-month iron supplementation as syrup of NaFeEDTA in improvement of iron status according to ALAD genotype. One hundred thirty adult women living in rural areas of Asan were provided NaFeEDTA syrup once a week for 6 months at the dose of 64mg Fe/week. Three hundred control subjects were observed during the study period. Fasting blood was obtained for analyzing hemoglobin (Hb) and zinc protophorphyrin (ZPP) and serum was analyzed for ferritin, iron and total iron capacity (TIBC) levels before and after iron supplementation. Ninety percent of ALAD 1-1 (ALAD1) and 10% of ALAD 1-2 (ALAD2) genotype were observed in the control group. However in the intervention group, 98% showed ALAD1 while only 2% was ALAD2, which is significantly lower proportions of ALAD2 compared to the control group (p<0.01). The iron status of Intervention group significantly improved except for ferritin and TIBC regardless or ALAD genotype, while the control group did not show any changes in iron status except for ZPP. ZPP concentration of the control group significantly increased in both ALAD1 and 2 while the intervention group showed significantly decreased ZPP after supplementation in ALAD1. Iron supplementation in the form of NaFeEDTA seems to be effective in reduction of ZPP levels although ALAD2 did not show significant changes due to the small number. However, it is difficult to make a conclusion from these results, and more specified further investigation is needed with more participants.

• 대한임상검사과학회지
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• 제43권1호
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• pp.12-18
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• 2011

The purpose of this study was to evaluate the significance of higher than normal mean corpuscular volume (MCV) and lower than normal mean corpuscular hemoglobin concentration (MCHC) in 20 patients. The hemoglobin (Hb), red blood cell indices (MCV, MCH, MCHC,), red cell distribution width (RDW), serum ferritin, serum iron (Fe) and total iron binding capacity (TIBC) were measured and the transferrin saturation were calculated. 18 (90.0%) cases were categorized as chronic diseases. Chronic renal failure, malignancy, and bleeding were all related to the cases. The mean values of hemoglobin was $9.5{\pm}2.14g/dL$; the MCV was $29.0{\pm}2.8fL$; the MCH was $30.9{\pm}1.0pg$; the MCHC was $31.2{\pm}0.5%$; the RDW was $17.0{\pm}3.6%$; serum Fe was $39{\pm}21{\mu}g/dL$; the TIBC was $219.7{\pm}108.8{\mu}g/dL$; transferrin saturation was $19.2{\pm}9.9%$ and ferritin was $445.5{\pm}499.6{\mu}g/L$ in the patients. The WHO criteria for hemoglobin of patients confirms anemia in 18 of the 20 (90.0%) cases. Anemia of chronic disease was shown in 11 (73.3%) cases; acute gastric ulcer with hemorrhage in 1 (6.7%) case; iron deficiency anemia in 1 (6.7%) case; 2 patients (13.3%) were of normal cases. There were changes in the baseline Hb level results of the 19 (95.0%) cases while no change was shown in 1 case. As a result, diseases associated with anemia and bleeding where the MCV is higher than the normal range and MCHC is lower than normal range are considered relevant findings.

• Journal of Animal Science and Technology
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• 제64권4호
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• pp.707-716
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• 2022

The core intention to undertake this experiment for a period of 21 days is to evaluate the effect of salicylic acid (SA) supplemented diet on the performance and blood metabolites of sows and their litters. Sows weighing 208.5 ± 18.34kg and their neonates were used. From day 114 of gestation to 21st day of lactation(weaning), ten multiparous sows (n = 5/treatment) (Landrace × Yorkshire) were assigned randomly into one of two treatments: CON (basal diet) and TRT (CON + 0.05% SA). There was no significant difference in the body weight, backfat thickness, backfat loss, and body condition score in SA treated sows compared to sows fed the CON diet. However, the bodyweight of sow was dramatically reduced by an average of 16kg from farrowing to weaning time. The dietary inclusion of SA in the sow diet slightly improved the survival rate (p = 0.065) and showed a higher body weight (p = 0.009) in piglets. However, there was no significant difference in red blood cell, Fe, Hematocrit, and Hb concentrations between CON and TRT sows' groups, but the total iron-binding capacity (TIBC) was significantly reduced in sows from the TRT group compared with the CON group from the beginning to weaning. The outcome of this trial shows that dietary addition of SA on sows diet from early lactation could increase the birth weight and TIBC of neonates at the end of the trial.

• 동의생리병리학회지
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• 제22권6호
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• pp.1579-1584
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• 2008

Anemia are often detected among many patients who are treated in oriental traditional medicine hospitals in Korea through blood tests which are taken to diagnose the patients' general state, and most of them are diagnosed to have iron deficiency anemia. This study amis the effect of herbal medicine on the RBC count, hemoglobin, hematocrits and indices of red blood cells such as mean corpuscular volume(MCV), mean corpuscular hemoglobin(MCH), mean corpuscular hemoglobin concentration(MCHC), serum iron, and total iron binding capacity(TIBC) among patients who were treated in oriental medical hospital and diagnosed to have anemia through blood tests other than main symptoms. The subjects of this study were 29 patients(male 7, female 22, mean age: 56.24${\pm}$19.11years) who were chosen ones, they has below hemoglobin 12 gm/dL, serum iron 70 IU/L, MCV 80 fL on laboratory screening test when they first visits our hospital. As a result, the volume of red blood cell(RBC), hematocrit(HCT), and hemoglobin(Hb) in peripheral blood increased from $348.27{\pm}8.95{\times}10^5$ /UL, 28.82${\pm}$0.56%, 9.24${\pm}$0.22 g/dL to $375.62{\pm}9.11{\times}10^5$ /UL, 31.36${\pm}$0.68%, 10.31${\pm}$0.25 g/dL comparing before and after oriental medicine treatment. After the treatment, MCH, MCHC, and MCV also increased from 26.98${\pm}$0.84 Pg, 32.62${\pm}$0.45 g/dl, 79.26${\pm}$0.17 fL to 27.74${\pm}$0.74 Pg, 32.84${\pm}$0.33 g/dl, 84.15${\pm}$1.67 fL. There was statistically significant increase in MCH, MCV(P<0.05); however, there was no significant change in MCHC(P>0.05). The amount of iron in blood increased from 32.96${\pm}$4.20 ug/dL to 67.22${\pm}$7.18 ug/dL, which showed a statistically significant increase(P<0.05). On the other hand, TIBC decreased from 325.08${\pm}$13.97 ug/dL to 315.61${\pm}$18.79 ug/dL, which was not a statistically significant change(P>0.05). Like this, all the patients showed favorable results in anemia based on the measurements of indices of red blood cells except MCHC. According to the classification of herbal medicines, in strengthening energy group(補氣), replenishing blood group(補血), and replenishing both energy and blood group(補氣血), the volume of RBC, HCT, and hemoglobin showed significant increases. Furthermore, in herbal medicines strengthening blood(補血) and replenishing both energy and blood group(補氣血), serum iron also relatively increased compare to strengthening energy group(補氣).

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권2호
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• pp.169-178
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• 2008

목 적: 건강한 모유 수유아의 경우 생후 6개월까지는 철분 결핍이 일어나지 않으며 6개월 이전에는 철분을 보충할 필요가 없다고 알려져 있으나, 최근 건강한 모유 수유아에서도 생후 6개월 이전에 철 결핍과 철 결핍성 빈혈이 발생한다는 보고가 있다. 따라서 본 연구에서는 생후 6개월과 12개월 영아들의 철 영양상태를 알아보고, 생후 2개월부터 조기 저용량 철분보충요법을 시행하여 철 결핍과 철 결핍성 빈혈을 예방하는데 효과가 있는지 알아보고자 하였다. 방 법: 2004년 8월부터 2005년 7월까지 만 1년간 충북대학교병원 산부인과에서 만삭으로 출생한 건강한 신생아 87명을 대상으로 하였다. 이들을 생후 2개월에 분유 수유군(A군), 모유 대조군(B군), 모유 보충군(S군, 철분 5 mg/일 보충)으로 나누어 출생 시(제대혈), 생후 6개월, 12개월에 저장철(ferritin), 혈청 철(iron), 총철결합능(total iron binding capacity, TIBC), 트랜스 페린 포화도(transferrin saturation rate, TFSAT)와 헤모글로빈(hemoglobin), 헤마토크릿(hematocrit), 평균적 혈구용적(mean corpuscular volume, MCV), 평균적혈구혈색소량(mean corpuscular hemoglobin, MCH), 적혈구분포폭(red cell distribution width, RDW)을 측정하였다. 결 과: 1) 생후 6개월에 측정한 저장철, 혈청 철, TFSAT, 헤모글로빈은 세 군 중 모유 대조군에서 가장 낮았으며, 총철결합능과 적혈구분포폭은 가장 높았다. 저장철 고갈, 철 결핍, 철 결핍성 빈혈의 빈도는 모유대조군에서 각각 33, 33, 30%로 분유 수유군의 0, 5, 8%나 모유 보충군의 1, 7, 5%보다 높았다. 2) 생후 12 개월의 저장철, TFSAT, 헤모글로빈, MCV, MCH는 세군 중 모유 대조군에서 가장 낮았으며, 총철결합능과 적혈구분포폭은 가장 높았으나, 혈청 철과 헤마토크릿은 세 군 간에 유의한 차이가 없었다. 저장철 고갈, 철결핍, 철 결핍성 빈혈의 빈도는 모유 대조군에서 각각 73, 64, 50%로 분유 수유군의 4, 4, 3%나 모유 보충군의 9, 9, 7%보다 높았다. 결 론: 철 결핍 상태와 철 결핍성 빈혈은 모유 수유아에서 분유 수유아에 비해 높은 빈도를 보였다. 또한, 철분 보충 없이 모유 수유만 했던 영아의 경우 생후 6개월에도 철 결핍과 철 결핍성 빈혈이 발생하였으며, 조기 저용량 철분보충요법은 모유 수유아에서 철 결핍과철 결핍성 빈혈을 예방하는데 효과가 있었다.

• 대한임상검사과학회지
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• 제46권3호
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• pp.85-90
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• 2014

The purpose of this study was to investigate the prevalence and differences of risk factors of Metabolic syndrome according to menopausal status. From the database of the 5th Korea National Health and Nutrition Examination Survey (KNHANES V) conducted in 2012, data of 3,537 women who responded to health interview and health examination questionnaires. The presence of Metabolic syndrome was assessed using the International Diabetes Federation (IDF) criteria. The prevalence of Metabolic syndrome was 17.3% in premenopause and 54.3% in postmenopause. BMI, waist circumference, blood pressure, total cholesterol, LDL cholesterol, triglyceride, and Ferritin were higher in postmenopausal women compared to premenopausal women. However, postmenopausal women had lower HDL cholesterol and TIBC when compared to premenopausal women. Hypertension was the most prominent characteristic of postmenopausal women. Low HDL cholesterol showed up as a meaningful factor in premenopausal women. According to multiple regression analysis, waist circumference, fasting glucose, and HDL cholesterol were independent predictors of menopause. Therefore, obesity control and blood lipids management is recommended for postmenopausal women.

• Journal of Nutrition and Health
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• 제31권7호
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• pp.1165-1173
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• 1998

The effect of oral iron supplementation was assessed on blood iron levels and Pb and Cd levels in erythrocytes, hair and urine of 101 Puchon 5th grade school children with suboptimal iron status. Treatment with 25mg of elemental iron per day for 8weeks resulted in a significant increase in the intake of most nutrients in addition to iron. Iron supplementation resulted in significant improvements in hemoglobin, MU, MCH, MCHC, serum ferritin, serum iron, TIBC, and transferrin saturation of subjects(p<0.05 - p<0.01) and cocomitantly lowered Pb and Cd levels in erythrocytes, hair, and urine(p<0.01). Regression analysis showed that only iron intake contributed to significant increases in hemoglobin and serum ferritin. It seems that 25mg of iron supplementation is safe and adequate to improve iron status in school children with suboptimal iron status and it also has the benefit of alleviating Pb and Cd status. (Korean J Nutrition 31(7) : 1165-1173, 1998)

• 농업과학연구
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• 제50권2호
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• pp.155-164
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• 2023

A total of 16 sows (average parity = 3.5 ± 0.10, standard deviation = 2.05) and their newborn pigs (Duroc × [Landrace × Yorkshire], initial body weight 1.53 ± 0.07 kg) were used in a 21-day study. On day 3 of age, piglets along with their dam were divided into two groups: CON and TRT. CON group piglets did not receive any iron injection while, TRT group piglets received 200 mg of injectable iron (GleptoForte) in a single dose. The administration of iron at day-3 of birth improved weaning body weight and overall average daily gain in sucking piglets compared with their control counterparts. For blood criteria, injection of 200 mg of iron improved serum iron values and hematocrit and decreased total iron binding capacity (TIBC) during the day 21 period. In summary, 200 mg iron injection at birth resulted in greater growth performance and blood iron status. These results indicate that providing 200 mg of injectable iron is sufficient to optimize the growth performance and blood iron status of suckling piglets.

• Journal of Gastric Cancer
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• 제8권1호
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• pp.35-39
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• 2008

목적: 빈혈을 동반한 위 절제 수술 환자에서 정맥용 철수 크로오스(베노훼럼$^{(R)}$ 투여의 유효성 및 안전성을 평가하고자 하였다. 대상 및 방법: 2006년 9월부터 2007년 2월까지 서울대학교 병원에서 위 질환으로 외과에 입원 또는 외래 치료를 받은 혈색소(Hb)가 7 g/dl 이상 11 g/dl 미만인 환자를 대상으로 수술 $2{\sim}3$주 이전 또는 수술 1개월 이후인 급성출혈의 증거가 없는 환자를 1군으로, 수술 후 1개월 미만으로 생체징후가 안정된 환자를 2군으로 분류하여 나이, 성별, 진단명을 조사하였고, Hb, 적혈구용적률(Hct), 평균적혈구용적(MCV), 혈청페리틴, 총철결합능(TlBC), 혈청철, 망상적혈구수에 대해 철수크로오스 투여 전후를 비교하였고 약물 부작용을 조사하였다. 결과: 대상 환자 수는 1군은 79명, 2군은 46명이었다. 1군에서 약물 투여 전후 비교 시 통계적으로 유의한 증가를 보였던 Hb, Hct, MCV, 혈청페리틴, TIBC, 망상적혈구 각각의 변화량의 평균은 1.3 g/dl, 4.1%, 3.1 fL, 195.0 ng/ml, -86.4 ug/dl, 0.2%였다. 2군에서 통계적으로 유의한 증가를 보였던 Hb, Hct, MCV, 혈청페리틴, 망상적혈구수 각각의 변화량의 평균은 1.8 g/dl, 6.1%, 3.4 fL, 259.6 ng/ml, -0.3%였다. 약물 부작용으로 2명(1.6%)의 환자에게서 국소성 정맥염이 발생하였다. 결론: 빈혈을 동반한 위 절제 수술 환자에서 정맥용 철수 크로오스의 투여는 짧은 시간에 큰 부작용 없이 빈혈 교정에 유효하였다.

• Journal of Nutrition and Health
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• 제7권3호
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• pp.27-44
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• 1974

A general survey of 82 perschool children and 473 school children (from 1st to 3rd grade) residing in the Dongnae area of Shindong Myun, choonseoung Gun, Kangwon Province was conducted from June 12 to 21, 1973, to obtain information concerning nutritional status, especially the protein and iron nutrition of preschool and school children in a rural area of Korea. A sample of 58 children 2 to 9 years old was selected from these 555 children for hematological, biochemical and parasitological tests. The results of these tests are presented below, 1) Both the mean body height and mean body weight of these children were higher and heavier than the averages in the Korean Physical Standards. About 39 per cent were above the 90 th percentile of the Korean Physical Standards of height and 35 per cent were above the 90th percentile of the Korean Physical Standards of weight. 2) The rate of infestation by helminthes was 67.6 per cent and there were no cases of hookworm infestation Among the ascaris-infected children, 61.6 per cent fell within an Ascaris E.P.G. count range of $501{\sim}2,000$. This was considered a rather mild intensify of ascaris infection. Nutrient loss due to helminthes was also estimated to be low. 3) The mean hemoglobin level was 11.3gm% $({\pm}0.94)$, and 68.4 per cent of the children were anemic (less than 11gm% among those 5 years old or less, less than l2gm% among those 6 years old or more). The average hematocrit value was 36.1% $({\pm}2.36)$, and only 3.5 per cent showed more than 34% on the M.C.H.C. test. These results showed that the incidence of anemia, in these rural children was high, and that in general it displayed hypochromic characteristics. 4) The average serum iron level was $78.2{\mu}g%$\;({\pm}29.8). The Proportion of the children showing less than $50{\mu}g% in the serum iron level was 5.6 per cent, while 41.8 percent revealed $450{\mu}g% or more in the TIBC determination. Transferrin saturation was below 15% in 71.4 percent of the preschool children, and in 28.6 percent of the school children. Those who had a serum iron level of $50{\mu}g% or less and a TIBC of more than $450{\mu}g% constituted 11.9 percent of the children examined. From these results, it was concluded that especially preschool children were low in iron nutrition, and that most of the anemia might be iron-deficiency anemia. 5) The mean values of total serum protein and albumin were 6.98gm% and 4.99gm% respectively. Especially in serum albumin, all children stowed more than 4 gm%. 6) The mean urinary urea nitrogen Per creatinine ratio was 11.5 $({\pm}4.2)$, and 21.8 percent had a ratio of more than 15. Considering these results, it was suggested that protein nutrition in these children was relatively good.