• 제목/요약/키워드: TIA

검색결과 136건 처리시간 0.025초

일과성허혈발작 및 급성뇌경색환자에서 경두개도플러로 측정된 중간대뇌동맥 비대칭 지수가 환자 예후에 미치는 영향 (Impact of Asymmetric Middle Cerebral Artery Velocity on Functional Recovery in Patients with Transient Ischemic Attack or Acute Ischemic Stroke)

  • 한민호;남효석
    • 대한임상검사과학회지
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    • 제50권2호
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    • pp.126-135
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    • 2018
  • 본 연구는 일과성허혈발작 및 급성뇌경색환자에서 양쪽 중 간대뇌동맥의 혈류속도 차이가 예후를 예측할 수 있는 지표가 될 수 있고, 이러한 예후예측력이 뇌졸중 아형 간에 차이가 있는 지를 관찰하는 것이다. 모든 대상자는 일과성허혈발작 및 급성뇌경색환자들이며, 기본적인 평가와 경두개도플러검사(TCD)가 실시되었다. 중간대뇌동맥 비대칭 지수(MCA asymmetry index)는 다음의 공식에 의해 구해졌다; MCA asymmetry index=(|RMCA MFV-LMCA MFV|/mean MCA MFV) ${\times}100$. 뇌경색 분류는 TOAST classification에 따라 진행되었다. 나쁜 예후(poor functional outcome)는 mRS score ${\geq}3$ at 3 months after stroke onset로 정의하였다. 총 988명의 급성뇌경색환자가 분석에 포함되었고, 그 중 157명(15.9%)이 나쁜 예후를 가지고 있었다. 뇌경색 하위유형 및 여러 혼란변수를 보정 후 실시한 다변량분석에서 중간대뇌동맥 비대칭 지수만 유일하게 독립적으로 나쁜 예후와 연관성을 보였다. ROC curve 분석에서 중간대뇌동맥 비대칭 지수를 예측모형에 투입하였을 때 투입 전에 비해 나쁜 예후를 예측하는 능력이 상승하는 것을 관찰하였다(from 88.6% [95% CI, 85.2-91.9] to 89.2% [95% CI, 85.9-92.5]). 급성뇌경색환자에서 중대뇌동맥 비대칭 지수는 나쁜 예후를 독립적으로 예측하였다. 따라서 경두개도플러검사는 급성뇌경색환자에서 나쁜 예후를 예측하는데 유용하게 사용될 수 있을 것이다.

사상의학적(四象醫學的) 중풍치험(中風治驗) 157례(例)에 대(對)한 임상적(臨床的) 연구(硏究) (A Clinical Study for 157 Cases of CVA by Sasang Constitutional Medicine)

  • 최재영;박성식
    • 사상체질의학회지
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    • 제10권2호
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    • pp.431-453
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    • 1998
  • 1. 연구배경 및 목적 중풍환자(中風患者)에 대한 임상적 연구를 통하여 중풍치료(中風治療)에 사상의학적(四象醫學的) 관리지침을 설정하고 체질병증(體質病證)의 이해에 도움을 주고자 한다. 2. 방 법 1997년 3월부터 1998년 2월까지 1년간 동국대학교 분당한방병원 체질의학클리닉에 입원치료 받았던 뇌졸중 환자 157명(남자 79명, 여자 78명)을 대상으로 환자의 특성(特性), 병력(病歷), 증상(症狀), 치료경과(治療經過) 등에 관하여 조사하고 분석하였다. 3. 결 과 환자의 체질분포는 태음인(太陰人)이 88명(56.1%), 소양인(少陽人)이 48명(30.6%), 소음인(少陰人)이 21명(13.4%)이었다. 연령의 50세 이상에서 70세 미만이 과반수를 차지하였고 평균은 65세로 나타났다. 뇌졸중의 발병 양태로 뇌경색이 119명(75.8%)으로 대부분을 차지했으며, 뇌출혈이 11명(7.0%), 지주막하출혈이 1명(0.6%), 일과성뇌허혈발작(TIA)이 26명(16.6%)으로 나타났다. 입원시 병증관리지침(病證管理指針)의 상황으로 설태이상(舌苔異常)이 가장 많았고, 수면장애(睡眠障碍), 대사장애(大使障碍), 소변장애(小便障碍) 등의 순서로 나타났으며, 중풍관리지침(中風管理指針)의 호전도(好轉度)를 살펴보면 대사장애(大使障碍)가 87.1%의 호전율(好轉率)로서 가장 높았고, 다음으로 정서장애(情緖障碍), 연하장애(嚥下障碍) 등의 순서였다.

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Lactobacillus plantarum에 의한 흰 민들레 발효물의 항산화 및 광노화 억제 효과 (Antioxidation and Anti-photoaging Effects of White Taraxacum Coreanum Extract by Lactobacillus plantarum)

  • 홍지우;박하영;김준희;염서희;김진우
    • 한국산학기술학회논문지
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    • 제22권4호
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    • pp.554-562
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    • 2021
  • 본 연구는 김치로부터 β-glucosidase 생산하는 Lactobacillus plantarum SM4를 분리하여 흰 민들레 발효를 수행하고 미백과 주름개선 효과를 가지는 생리활성 평가를 위해 총 폴리페놀 함량, 플라보노이드 함량, 항산화 활성, 타이로시네이즈 활성저해, 콜라게네이즈 활성저해, 자외선 차단율을 분석하였다. 흰 민들레 발효물의 총 폴리페놀 함량이 41.8±0.26 mg GAE/g DW로 열수추출물 21.4±0.67 mg GAE/g DW에 비해 2배 가량 증가하였으며 항산화 활성은 65.6±4.7%로 4배 증가하였다. 미백과 주름개선의 지표인 타이로시나아제 및 콜라게네이즈 활성저해에 있어 흰 민들레 발효물이 87.9±4.73%와 66.7±3.48%로 열수추출물에 비해 각각 2.4배와 1.5배 증가한 결과를 보였다. 흰 민들레 발효물과 열수추출물의 자외선 차단 효과를 비교하였을 때, UVA(320 nm) 차단율이 각각 64.7%와 15.2%로 측정되어 흰 민들레 발효물이 열수추출물에 비해 더 높은 효과를 나타내어 김치로부터 분리한 L. plantarum SM4가 생산하는 β-glucosidase를 발효를 통해 피부 미백, 주름 방지, 자외선 차단 효과가 증진됨을 확인하였다.

Water Level Prediction on the Golok River Utilizing Machine Learning Technique to Evaluate Flood Situations

  • Pheeranat Dornpunya;Watanasak Supaking;Hanisah Musor;Oom Thaisawasdi;Wasukree Sae-tia;Theethut Khwankeerati;Watcharaporn Soyjumpa
    • 한국수자원학회:학술대회논문집
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    • 한국수자원학회 2023년도 학술발표회
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    • pp.31-31
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    • 2023
  • During December 2022, the northeast monsoon, which dominates the south and the Gulf of Thailand, had significant rainfall that impacted the lower southern region, causing flash floods, landslides, blustery winds, and the river exceeding its bank. The Golok River, located in Narathiwat, divides the border between Thailand and Malaysia was also affected by rainfall. In flood management, instruments for measuring precipitation and water level have become important for assessing and forecasting the trend of situations and areas of risk. However, such regions are international borders, so the installed measuring telemetry system cannot measure the rainfall and water level of the entire area. This study aims to predict 72 hours of water level and evaluate the situation as information to support the government in making water management decisions, publicizing them to relevant agencies, and warning citizens during crisis events. This research is applied to machine learning (ML) for water level prediction of the Golok River, Lan Tu Bridge area, Sungai Golok Subdistrict, Su-ngai Golok District, Narathiwat Province, which is one of the major monitored rivers. The eXtreme Gradient Boosting (XGBoost) algorithm, a tree-based ensemble machine learning algorithm, was exploited to predict hourly water levels through the R programming language. Model training and testing were carried out utilizing observed hourly rainfall from the STH010 station and hourly water level data from the X.119A station between 2020 and 2022 as main prediction inputs. Furthermore, this model applies hourly spatial rainfall forecasting data from Weather Research and Forecasting and Regional Ocean Model System models (WRF-ROMs) provided by Hydro-Informatics Institute (HII) as input, allowing the model to predict the hourly water level in the Golok River. The evaluation of the predicted performances using the statistical performance metrics, delivering an R-square of 0.96 can validate the results as robust forecasting outcomes. The result shows that the predicted water level at the X.119A telemetry station (Golok River) is in a steady decline, which relates to the input data of predicted 72-hour rainfall from WRF-ROMs having decreased. In short, the relationship between input and result can be used to evaluate flood situations. Here, the data is contributed to the Operational support to the Special Water Resources Management Operation Center in Southern Thailand for flood preparedness and response to make intelligent decisions on water management during crisis occurrences, as well as to be prepared and prevent loss and harm to citizens.

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과로로 인한 업무상 질병의 산재보상 인정기준에 관한 연구 (A Study on the Clauses of the Work-Related Disease due to Overwork in the Workmen's Compensation Law)

  • 김은희
    • 한국직업건강간호학회지
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    • 제6권1호
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    • pp.23-43
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    • 1997
  • The work-related diseases due to continuous overwork are mainly cerebro- and cardio-vascular ones, which is commonly called 'Karoshi', death from overwork. Many factors are capable for Karoshi : occupational stress in relation to technological renovation and industrial rationalization, competitive social structure, and accumulated fatigue accured to long time or irregular working. And its occurence is on the rise. The World Labor Report 1993 released by ILO, pointed out the diseases related to overwork and stress as one of the most important occupational health problem. In Korea, social awareness of Karoshi is at an infant stage, and reliable statistics for its occurence are not compiled in a convenient manner. Despite the rising Karoshi, there are no reliable clauses in workmen's compensation enough to settle down the disputes. Therefore, it is not uncommon that the Labour Ministry and Civil Court find difficulties in reaching an agreement. This study was intended to provide proper compensation and prevention program for workers by suggesting reasonable compensation clauses for the death from overwork. This study consists of two comparative reviews on the compensaton clauses for the death from overwork. One is to review legal standards of Karoshi among three countries, such as Korea, Japan and Taiwan. The other is to investigate the cases of Karoshi in Korea, 121 cases identified at the Labor Welfare Corperation and the Labour Ministrial process of examination and reexamination, and 73 leading cases at the High Court of Justice. The main findings of the study are as follows : 1. Comparisons of comperative review on compensation clauses for the death from overwork among three countries. 1) All of three countries have the same kinds of disease for compensation, which were cerebro-and cardiao-vascular diseases, while for cardiac disease group, Korea has the smaller number of diseases for compensation than Japan. 2) As for the definition of overwork, the three countries share equally that overload for one week prior to collapse is considered as an important factor, but accumulated chronic fatigue is disregarded. 3) As the basis of overwork, in Japan, there is a tendency to move from the conditions of an ordinary healthy adult to those of the individual concerned in Japan, whereas there is no such concern yet in Korea. 4) All the three countries use a common standard of medical judgement in demonstrating causal relationship between a job and a disease. However, Korea is progressive in the sense that in the case of CVA at worksite, the worker himself has no obligation to prove the cause. 2. The results of a comparative review on excutive decisions by Labor Ministry and judicial decisions by the Court in Korea : A judicial decision is based on the legalistic probability, but a excutive decision is not. Therefore, excutive decisions have such restrictions that : 1) TIA (transitory ischemic cerebral attack) and myocarditis are excluded from compensation, and there is little consistency of decision in the case of cause-unknown death. 2) There is a tendency not to compensate for the death from overwork since the work terms such as repeated long-time working, shift work or night-shift work are not considered as overloading. 3) There is a tendency to regard the conditions of a ordinary healthy adult rather than those of the individual concerned(age, existing diseases, health state, etc.) as the comparative basis of overload. 4) There remains a tendency not to compensate for the death from overwork in the case of collapse occuring out of workplace, on the ground of 'on the course of working' and 'in the cause of accident'. Through the study, the fact manifests itself that Korea's compensation clauses for work-related diseases due to overwork are very restrictive. So, it is necessary to extend the Labor Ministry's clauses of compensation for the death from overwork following to the recent changes of other countries and internal judicial decisions. This is very important in the perspective of occupational health that aims at health promotion of workers including prevention of the Karoshi.

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Blue광(光) 조사(照射)가 콩나물의 주요성분(主要成分)에 미치는 영향(影響) (Effect of Blue Light on the Major Components of Soybean-sprouts)

  • 김광수;김순동;김진구;김주남;김경주
    • 한국식품영양과학회지
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    • 제11권4호
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    • pp.7-12
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    • 1982
  • 콩나물 재배시(栽培時)에 $25^{\circ}C$에서 blue광(光)을 120Lux로 1일(日) 1회(回) 3시간(時間) 조사(照射)하면서 생장상태(生長狀態), chlorophyll, vitamin C, 단백질함량(蛋白質含量), 단백질(蛋白質)의 pattern 및 trypsin inhibitor activity의 변화(變化)를 암소(暗所)와 상호비교(相互比較)하였다. 콩나물 배축부(胚軸部)의 길이는 blue광(光)에서 다소(多少) 길었으나 함량(重量)에는 차이(差異)가 인정(認定)되지 않았다. Blue광하(光下)에서의 chlorophyll함량(含量)은 3일(日)에 3.57g/100g-f. w., 7일(日)에 8.45g/100g-f. w.로서 재배일정(栽培日數)의 경과에 따라 현저히 증가(增加)하였다. vitamin C의 함량(含量)은 blue광(光) 조사(照射)에 의(依)하여 현저히 증가(增加)되었으며, 재배(栽培) 5일(日)의 자엽부(子葉部)는 21.7% 배축부(胚軸部)는 30.8%가 암소(暗所)에 비(比)하여 높았다. TIA는 blue광(光)에 의(依)한 영향(影響)이 거의 없었으며, 재배(栽培) 5일(日)의 자엽부(子葉部)는 원료대두(原料大豆)와 거의 비슷하였고, 배축부(胚軸部)는 매우 낮아 자엽부(子葉部)의 약(約) 23%에 불과하였다. 단백질(蛋白質)의 함량(含量) 변화(變化)는 blue광(光)의 효과(效果)를 인정(認定)할 수 없었으며, disc electrophoresis를 행(行)한 결과(結果) 원료대두(原料大豆)에서 10개(個), 자엽부(子葉部)에서 9개(個), 배축부(胚軸部)에서 11개(個)의 단백(蛋白)을 분리(分離) 확인(確認)할 수 있었으며 특(特)히 원료대두(原料大豆)와 자엽부(子葉部)에서 존재(存在)가 확인(確認)되지 않은 band No.3이 배축부(胚軸部)의 주요(主要) 구성단백(構成蛋白)임을 알 수 있었다. 그리고 자엽부(子葉部)에서는 blue광(光)의 영향(影響)이 없었으나 배축부(胚軸部)에서는 band No.5와 11이 blue광(光) 조사시(照射時)에서 존재(存在)가 확인(確認)되었다.

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