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Clinical Trial of Nasal Flumazenil Administration (플루마제닐의 경비 투여)

  • Hong, Soo-Jin;Kim, Hyun-Jung;Yum, Kwang-Won
    • Journal of the korean academy of Pediatric Dentistry
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    • v.28 no.3
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    • pp.441-446
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    • 2001
  • Flumazenil is a competitive antagonist of benzodiazepines. It is usually administered intravenously. However, if the intravenous route is not available then other routes of drug administration should be considered. This study was designed to evaluate the reversal effects of flumazenil after nasal administration. Twenty-five young, healthy adult volunteers participated in this clinical trial. The dosage of 0.08mg/kg midazolam was administered intravenously to induce deep sedation. Ten minutes after midazolam administration, 0.5mg of flumazenil was dropped nasally, over a period of one minute. Blood samples were taken to measure the concentration of midazolam and flumazenil at 0, 5, 10, and 20min after nasal administration of flumazenil, using High Performance Liquid Chromatography. The degree of sedation was evaluated with sedation score and bispectral index (BIS), Statistical analysis was performed by multivariate ANOVA and correlation analysis (P<0.05). Peak serum flumazenil concentration was reached in 10min. Sedation score decreased after midazolam administration and showed a significant increase after flumazenil administration. However, BIS decreased during the first 10min after midazolam administration and then no significant changes after flumazenil administration. There were two instances representing rapid and complete reversal of midazolam after intranasal administration of flumazenil. In conclusion, intranasal flumazenil administration may be effective in some patients when intravenous route is not available in condition of benzodiazepine overdose.

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The Necessity and Method of Stand Density Control Considering the Shape Ratio of Pinus thunbergii Coastal Disaster Prevention Forests in South Korea (곰솔 해안방재림의 형상비를 고려한 밀도 관리의 필요성과 방안)

  • Kim, Suk-Woo;Chun, Kun-Woo;Park, Ki-Hyung;Lim, Young-Hyup;Yun, Ju-Ung;Kwon, Se-Myoung;Youn, Ho-Joong;Lee, Jin-Ho;Teramoto, Yukiyoshi;Ezaki, Tsugio
    • Journal of Korean Society of Forest Science
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    • v.104 no.3
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    • pp.411-420
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    • 2015
  • This study examined methods for stand density control by using shape ratio (tree height/DBH) and its application for effective management of Pinus thunbergii coastal disaster prevention forests. We analyzed the present conditions (height, DBH, and density) of P. thunbergii coastal disaster prevention forests at 123 study sites on Jeju Island and west, south, and east coasts of South Korea and compared them with results from previous studies. The average shape ratio for P. thunbergii showed positive correlations with stand density and was significantly higher on the west coast (66.32) than on the south (49.57) and east (48.19) coasts and Jeju Island (48.29). Stands with shape ratio higher than 70 accounted for 50% of the total study sites on the west coast, indicating a decrease in their disaster prevention function compared to that of other previous studies. The stand density in most coastal areas, except the east coast, was significantly higher than the standards recommended by the Korea Forest Service and the Forestry and Forest Products Research Institute of Japan, indicating the need for stand density control. According to the growth estimation equation for P. thunbergii in the coastal area of South Korea, density control is required for young stands less than 14 years old, which show drastic increase in the shape ratio, to conserve their disaster prevention function. Particularly, the first thinning of P. thunbergii forests should be implemented before the stand age of 8 years that a shape ratio exceeds 70. For disaster-prone young stands (${\leq}20cm$ DBH) of P. thunbergii, the stand density was higher in the standard of Japan considering shape ratio than in that of Korea aiming timber production. Hence, the standard guidelines employed in Japan, which assign higher importance to disaster prevention function based on field surveys, can be applied effectively for controlling the stand density of P. thunbergii coastal forests in South Korea, to improve their disaster prevention function.

Carbon Storage of Natural Pine and Oak Pure and Mixed Forests in Hoengseong, Kangwon (횡성지역 천연 소나무와 참나무류 순림 및 혼효임분의 탄소 저장량 추정)

  • Lee, Sue Kyoung;Son, Yowhan;Noh, Nam Jin;Heo, Su Jin;Yoon, Tae Kyung;Lee, Ah Reum;Sarah, Abdul Razak;Lee, Woo Kyun
    • Journal of Korean Society of Forest Science
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    • v.98 no.6
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    • pp.772-779
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    • 2009
  • This study was conducted to estimate the carbon (C) contents in pure and mixed stands of pine (Pinus densiflora) and oak (Quercus spp.) trees for establishing the C inventory of forest ecosystems. A total of fifteen 20 m${\times}$20 m pure and mixed stands of pine and oak trees were chosen in natural forests in Hoengseong, Kangwon based on the basal area of all trees ${\geq}$ 5 cm DBH: three of 95% of pine and 5% oak trees [pine stand], three of 100% of oak trees [oak stand], and nine of 20 to 70% of pine and 80 to 30% of oak trees [mixed stand]. To estimate C contents in the study stands, biomass in vegetation, forest floor and coarse woody debris (CWD) were calculated and C concentrations in vegetation, forest floor, CWD and soil (0-30 cm) were analyzed. There was no significant difference in vegetation C contents among the stands; 147.6 Mg C/ha for the oak stand, 141.4 Mg C/ha for the pine stand and 115.8 Mg C/ha for the mixed stand. Forest floor C contents were significantly different among the stands (p<0.05); 12.7 Mg/ha for the pine stand, 9.9 Mg/ha for the oak stand, and 8.4 Mg/ha for the mixed stand. However, CWD C contents were not significantly different among the stands (p>0.05); 2.2 Mg/ha for the mixed stand, 1.7 Mg/ha for the oak stand, and 1.1 Mg/ha for the pine stand. Soil C contents up to 30 cm depth were not significantly different among the study stands; 44.4 Mg C/ha for the pine stand, 41.6 Mg C/ha for the mixed stand, and 33.3 Mg C/ha for the oak stand. Total ecosystem C contents were lower in the mixed stand than those in the pure stands, because vegetation C contents which occupied almost total ecosystem C contents were lower in the mixed stand than those in the pure stands; 199.6 Mg C/ha for the pine stand, 192.5 Mg C/ha for the oak stand and 169.1 Mg C/ha for the mixed stand. Lower vegetation C contents in the mixed stand might be influenced by interspecific competition between pine and oak trees and intraspecific competition among the oak trees resulted from high stand density. We suggest that forest management such as thinning to enhance C storage is indispensible for minimizing the competition in forest ecosystems.

Development of a Mobile Tower-yarder with Tractor (I) - Design and Manufacture - (트랙터부착형 타워집재기 개발(I) - 설계 및 제작-)

  • Park, Sang-Jun;Kim, Bo-Kyun
    • Journal of Korean Society of Forest Science
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    • v.97 no.1
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    • pp.61-70
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    • 2008
  • This study was conducted to develop a mobile tower-yarder with tractor for agriculture and forestry that is the efficient yarder in steep terrains, thinning operation and small scale logging operation. It was designed and manufactured that the power source of tower-yarder is equiped three hydraulic pump connected to PTO of tractor, and three hydraulic pump is used to operate the four motor for drum, the cylinder for clutch of interlocker, the cylinder for tower expanding and the out-rigger cylinder. It was to adopt the running skyline system and the inter-lock function, and to equip the double capstan drum, the storage drum and the clutch for interlock in the development of tower-yarder. It was to develop the tower-yarder which the winch torque of double-capstan drum, the traction force of double-capstan drum, the number of rotation of double-capstan drum and the line speed is $191kg{\cdot}m$, 1,910 kgf, 220.5 rpm and 138.5 m/min, respectively. And it was known that the optimum flange diameter of the main and haulback storage drum is about 360 mm and about 460 mm in order to storage the main line length of 250m and the haulback line length of 450 m. The carriage was made to adopt the running skyline system and to equip the lock function in order to the convenience of chocking and the fall down preventing of tree. It was provided to develop the wire remote controller for the inter-lock function, the convenience of control and the efficiency of yarding. In development process, this tower-yarder was attached the 3-point linkage hitch equipment and the tire wheel for the traction and moving of tower-yarder. Also, it was equipped that the out-rigger and the guy line in order to raise the safety and efficiency of yarding of tower-yarder.

DEVELOPMENT OF THREE DIMENSIONAL MEASURING PROGRAM WITH FRONTAL AND LATERAL CEPHALOMETRIC RADIOGRAPHS -PART 1. COMPUTATION OF THE THREE-DIMENSIONAL COORDINATES BY COMPENSATION OF THE ERROR OF THE HEAD POSITION IN ORDINARY NON-BIPLANAR CEPHALOSTAT- (정모 및 측모 두부 방사선 규격사진을 이용한 3차원 계측 프로그램의 개발 -1. 단일 방사선원으로 촬영된 두부 방사선사진의 두부 위치 보정을 이용한 3차원 좌표의 산출-)

  • Lee, Geun-Ho;Lee, Sang-Han;Jang, Hyon-Joong;Kwon, Tae-Geon
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.27 no.3
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    • pp.214-220
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    • 2001
  • The clinical application of the three-dimensional radiographic technique had been limited to standard Broadbent-Bolton cephalometer with biplanar stereoradiography. We developed a new method for compensating the error of head position in ordinary non-biplanar cephalostat. It became to possible to use the three dimensional cephalogram commonly in clinical bases. 1. The method of methemetical compensation of head positioning error in non-biplanar condition was evaluated with dry skull. The error of the method of first and the second trial was $0.46{\pm}1.21$, $0.33{\pm}0.90mm$, which means the error of the head positioning correction in conventional cephalogram was within clinical acceptance. 2. The reproducibility of this system for clinical application was 0.54 mm ($-2.99{\sim}2.26mm$) which defines the absolute mean difference of the first and second trial. Compare to the The landmark identification error $1.2{\pm}1.6mm$, the error of the measurement was within the range of landmark identification error. The result indicates the adequate clinical accuracy of the computation of three-dimensional coordinates by compensation of the error of the head position in ordinary non-biplanar cephalostat.

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Influence of Forest Management on the Facilitation of Purifying Water Quality in Abies holophylla and Pinus koraiensis Watershed (II) (전나무림(林)과 잣나무림(林) 유역(流域)에서 산림시업(山林施業)이 산림(山林)의 수질정화기능(水質淨化機能)에 미치는 영향(影響)(II))

  • Jeong, Yongho;Park, Jae Hyeon;Kim, Kyong Ha;Youn, Ho Joong;Won, Hyoung Kyu
    • Journal of Korean Society of Forest Science
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    • v.88 no.4
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    • pp.498-509
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    • 1999
  • This study aims to clarify the effect of forest management practices(thinning and pruning) in forest hydrological processes on electrical conductivity to get the fundamental information on the facilitation of purifying water quality after forestry practices. Rainfall, throughfall, stemflow, soil and stream water were sampled at the study sites which consist of Abies holophylla and Pinus koraiensis in Kwangnung Experimental Forest for 6 months from March 1 to August 4, 1998. In case of deviding into forest hydrological processes, multiple regression equations of electrical conductivity and total amount of anion, $NO{_3}^-$ of throughfall, stemflow, soil water of management site in Abies holophylla shows high significance. And multiple regression equations of electrical conductivity and total amount of anion, $SO{_4}^{2-}$, $Cl^-$ of throughfall, stemflow, soil water of non-management site in Abies holophylla shows high significance. Multiple regression equations of electrical conductivity and $NO{_3}^-$, before non-rain days of throughfall, stemflow, soil water of management site in Pinus koraiensis shows high significance. And multiple regression equations of electrical conductivity and total amount of ion, $NO{_3}^-$, $K^+$, pH, total amount of anion of throughfall, stemflow, soil water of non-management site in Plinus koraiensis shows high significance. Multiple regression equations of electrical conductivity and pricipitation, total amount of ion, $Na^+$ of stream water in Abies holophylla and Pinus koraiensis shows high significance. In case of combining into forest hydrological processes, multiple regression equations of electrical conductivity and total amount of cation and anion, $Na^+$, $Cl^-$, and pH in rainfall, throughfall, stemflow, soil and stream water shows high significance.

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Perfusion Impairment in Infantile Autism on Brain SPECT Using Tc-99m ECD : Comparison with MR Findings (유아 자폐증 환아에서의 Tc-99m ECD를 이용한 뇌 단일 광전자 방출 전산화 단층 촬영술상의 관류 저하: 자기 공명 영상과의 비교 분석)

  • Ryu, Young-Hoon;Lee, Jong-Doo;Yoon, Pyeong-Ho;Kim, Dong-Ik;Oh, Young-Taik;Lee, Sun-Ah;Lee, Ho-Bun;Shin, Yee-Jin;Lee, Byung-Hee
    • The Korean Journal of Nuclear Medicine
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    • v.31 no.3
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    • pp.320-329
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    • 1997
  • Neuroanatomic substrate of autism has been the subjects of continuing investigation. Because previous studies had not demonstrated consistent and specific neuroimaging findings in autism and most studies comprised adults and school-aged children, we performed a retrospective review in search of common functional and anatomical abnormalities with brain SPECT using Tc-99m ECD and correlative MRI The patient population was composed of 18 children aged 28 to 89 months(mean age : 55 months) who met the diagnostic criteria of autism as defined in the DSM-IV and CARS. Brain SPECT was performed after intravenous injection of 185-370MBq of Tc-99m ECD using brain dedicated annular crystal gamma camera. MRI was performed in all patients including T1, T2 axial and T1 sagittal sequences. SPECT data were visually assessed. Thirteen patients had abnormal SPECT scan revealing focal areas of decreased perfusion. Decreased perfusion of cerebellar vermis(12/18), cerebellar hemisphere(11/18), thalami(13/18), basal ganglia(4/18), posterior parietal(7/18), and temporal(4/18) area were noted on brain SPECT. Whereas, only 3 patients had abnormal MR findings which were subtle volume loss of parieto-occipital white matter in 3 and mild thinning of posterior body of corpus callosum in 2 and slightly decreased volume of cerebellar vermis in 1. Comparison of the numbers of abnormal findings revealed that regional cerebral blood flow (rCBF) abnormalities seen on SPECT were more numerous than anatomical abnormalities seen on MRI. In conclusion, extensive perfusion impairment involving cerebellum, thalami and parietal lobe were found in this study. SPECT may be more sensitive in reflecting pathophysiology of autism than MRI. However, further studies are mandatory to determine the significance of thalamic and parietal perfusion impairment in autism.

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Formation and Evolution of the Paleo-Seomjin River Incised-Valley System, Southern Coast of Korea: 1. Sequence Stratigraphy of Late Quaternary Sediments in Yosu Strait (한반도 남해안 고섬진강 절개곡 시스템의 형성과 진화: 1. 여수해협의 후기 제 4기층에 대한 순차층서)

  • Chun, Seung-Soo;Chang, Jin-Ho
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.6 no.3
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    • pp.142-151
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    • 2001
  • Detailed interpretation of some high-resolution seismic profiles in Yosu Strait reveals that Late Quaternary deposits consist of three allostratigraphic units (UH, LH, PL) formed by fluvial and tidal controls. The top mud unit, UH, thins onshore, and overlies the backstepping modem Seomjin delta deposits, which is interpreted as a transgressive systems tract (757) related to Holocene relative sea-level rise. The unit LH below the unit UH is composed of delta, valley- and basin-fill facies. The delta facies (Unit $LH_1$) occurs only in Gwangyang Bay and shows two prograding sets retrogradationaly stacked, thus it is also interpreted as a transgressive systems tract(757). On the contrary, the valley- and basin-fill facies (Unit $LH_2$), interpreted as 757, occur between the units UH and PL (Pleistocene deposits) in Yosu Strait. The bounding surface between UH and $LH_2$ can be interpreted as a tidal ravinement surface on the basis of trends thinning toward inner bay and becoming young landward. Furthermore its geomorphological pattern is similar to that of recent tidal channels. This allostratigraphy in'ffsu Strait suggests that two 757 deposits (UH and $LH_2$), divided by tidal ravinement surface, have been formed in Yosu Strait, whereas in Gwangyang Bay backstepping delta deposits ($LH_1$) without tidal ravinement surface have been formed during Holocene sea-level rise. These characteristics indicate that different stacking patterns could be formed in these two areas according to different increasing rate of accommodation space caused by different geomorphology, sediment supply and tidal-current patterns even in the same period of Holocene sea-level rise.

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Effect of Seedling Age on Growth and Yield at Transplanting of Sorghum (Sorghum bicolor L. Moench) (수수 묘의 이식 시기가 생육 및 수량에 미치는 영향)

  • Jo, Su-Min;Jung, Ki-Youl;Kang, Hang-Won;Choi, Young-Dae;Lee, Jae-Saeng;Jeon, Seung-Ho
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.61 no.1
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    • pp.50-56
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    • 2016
  • Direct seeding of sorghum (Sorghum bicolor L. Moench) has a problem of low yield including poor establishment. This poor establishment results from poor quality seed, poor seedbed preparation, seedling pests, poor sowing technique and high soil temperature. This study sought to establish the age at which sorghum seedlings can be transplanted with minimal effects on grain yield. Transplants were raised in 128 nursery tray pot. Five seedling ages were established by transplanting at 10 (T10), 15 (T15), 20 (T20), 25 (T25) and 30 (T30) days after planting (DAP). The treatment combinations were arranged in a randomized complete block design and replicated three times with an individual plot size of $6{\times}5m^2$. Each plot had five ridges with a planting space of $0.60{\times}0.20m^2$ at one plants per stand. Results showed that seedling age on transplanting significantly affected growths and yields to sorghum after transplanting. Plant heights and diameters of transplants at T15 were longer than the other transplants. Conclusively, The advantages of this practice were better control of crop density and greater yields; either to fill gaps after emerging and thinning of crops or to compensate for a growth period that was too short for a complete crop cycle.

Effect of Sink and Source Related Characteristics on Grain Weight and Grain Nitrogen Content in Rice (Sink와 Source 관련형질 변이가 벼 종실중 및 종실질소함량 변이에 미치는 영향)

  • Lee, Chung-Kuen;Kwon, Young-Up;Lee, Jae-Eun;Seo, Jong-Ho;Shin, Jin-Chul;Lee, Byun-Woo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.54 no.1
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    • pp.45-54
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    • 2009
  • This experiment was conducted to clarify the effects of source and sink related characteristics on grain weight increase and grain nitrogen accumulation in rice. Source was modified by leaf removing treatment with no sink modification in 2002 and sink and source were modified at the same time by different sowing dates, N fertilization rates, row spacings, and thinning treatments at heading in 2007. Grain weight (GW) and grain assimilates produced by photosynthesis during grain-filling ($GW_P$) increased with the increase of source, while the grain assimilates retranslocated from leaf and stem ($GW_T$) decreased. Among the source-related characters, shoot dry weight were most closely related with GW. GW was dependant on $GW_P$ rather than on $GW_T$. Grain nitrogen content (GN) and grain nitrogen absorbed from soil during grain-filling ($GN_S$) increased with the increase of source, while the grain nitrogen retranslocated from leaf and stem ($GN_T$) decreased. Shoot nitrogen content among the source-related characters was related most closely with GN. The contribution of $GN_T$ to GN was relatively large although GN depended more largely on $GN_S$ than $GN_T$. In addition, GN was supplied firstly from $GN_S$ or from $GN_S$ and $GN_T$ at the same time.