• Biomolecules & Therapeutics
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• v.26 no.5
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• pp.503-511
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• 2018

Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3'-diindolylmethane (DIM) are phytoestrogens that play chemopreventive roles in the inhibition of carcinogenesis and cancer progression. In this study, the influence of TCS, BPA, Kaem, and DIM on proliferation and apoptotic abilities of VM7Luc4E2 breast cancer cells were examined. MTT assay revealed that TCS ($0.1-10{\mu}M$), BPA ($0.1-10{\mu}M$) and E2 ($0.01-0.0001{\mu}M$) induced significant cell proliferation of VM7Luc4E2 cells, which was restored to the control (0.1% DMSO) by co-treatment with Kaem ($30{\mu}M$) or DIM ($15{\mu}M$). Reactive oxygen species (ROS) production assays showed that TCS and BPA inhibited ROS production of VM7Luc4E2 cells similar to E2, but that co-treatment with Kaem or DIM on VM7Luc4E2 cells induced increased ROS production. Based on these results, the effects of TCS, BPA, Kaem, and DIM on protein expression of apoptosis and ROS production-related markers such as Bax and Bcl-xl, as well as endoplasmic reticulum (ER) stress-related markers such as $eIF2{\alpha}$ and CHOP were investigated by Western blot assay. The results revealed that TCS, and BPA induced anti-apoptosis by reducing ROS production and ER stress. However, Kaem and DIM effectively inhibited TCS and BPA-induced anti-apoptotic processes in VM7Luc4E2 cells. Overall, TCS and BPA were revealed to be distinct xenoestrogens that enhanced proliferation and anti-apoptosis, while Kaem and DIM were identified as natural chemopreventive compounds that effectively inhibited breast cancer cell proliferation and increased anti-apoptosis induced by TCS and BPA.

• Journal of Korean Society of Transportation
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• v.26 no.4
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• pp.241-250
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• 2008

With the ever-growing amount of traffic, there is an increasing need for good quality travel time information. Various existing outlier filtering and missing data imputation algorithms using AVI data for interrupted and uninterrupted traffic flow have been proposed. This paper is devoted to development of an outlier filtering and missing data imputation algorithm by using Toll Collection System (TCS) data. TCS travel time data collected from August to September 2007 were employed. Travel time data from TCS are made out of records of every passing vehicle; these data have potential for providing real-time travel time information. However, the authors found that as the distance between entry tollgates and exit tollgates increases, the variance of travel time also increases. Also, time gaps appeared in the case of long distances between tollgates. Finally, the authors propose a new method for making representative values after removal of abnormal and "noise" data and after analyzing existing methods. The proposed algorithm is effective.

• Journal of the Institute of Convergence Signal Processing
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• v.7 no.4
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• pp.195-200
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• 2006

The conventional discrete circuit for ABS/TCS system was examined and the problems of the system were analyzed by computer simulation. In order to improve the performance of ABS/TCS system, interface IC which has error compensation, comparator and under voltage lock-out circuit was designed and their electrical characteristics were investigated. The voltage regulator was included to compensate the temperature variation in the temperature range from $-20^{\circ}C$ to $120^{\circ}C$ for automobile environment. ABS and brake signal were separated using the duty factor of same frequency or different frequencies. UVLO(Under Voltage Lock-Out) circuit and constant current circuit were applied for the elimination of noise, and protection circuit was applied to cut the excess current off. Layout for IC fabrication was designed to enhance the electrical performance of ABS/TCS system. Layout was consisted of 11 masks, arrayed effectively 8 pads to reduce the current loss. We can see that the result of layout simulation was better than the result of bread board.

• Atmosphere
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• v.20 no.4
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• pp.387-398
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• 2010

This study shows that frequency of tropical cyclone (TC) around Korea in summer (June-September) has positive relation with Arctic Oscillation (AO) in the preceding April. In a positive AO phase, each of anomalous cyclone and anomalous anticyclone is developed in low latitude and middle latitude regions of East Asia from the preceding April to summer. As a result, while anomalous southeasterly around Korea serves as a steering flow that TCs move toward this area is strengthened, northwesterly that reinforced in southeastern area of East Asia plays a role in preventing TCs from moving toward this area. In addition, due to this distribution of pressure systems developed in this AO phase, TCs tend to occur, move and recurve in further northeastern region in the western North Pacific than TCs in a negative AO phase. On the contrary, TCs in a negative AO phase mainly move westward toward southern China or Indochina Peninsula from Philippines. Eventually, intensity of TCs is weaker than those in a positive AO phase due to the terrain effect caused by high passage frequency of TCs in mainland China.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.8 s.227
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• pp.1203-1211
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• 2004

A traction control systems (TCSs) composed of either a wheel slip controller or a throttle valve controller or an integrated controller of both systems are proposed in this study. To validatethe dynamic characteristics of a vehicle and TCS, a full car model that can simulate the responses of both front wheel drive (2WD) and four wheel drive (4WD) vehicle is also developed. The wheel slip controller uses a sliding mode control scheme and the throttle valve is controlled by a PID controller. The results shows that tHe brake TCS and the engine TCS achieve rapid acceleration, and reduce slip angle on slippery road. When a vehicle is cornering and accelerating maneuver with the brake or engine TCS, understeer or oversteer occur, depending on the driving conditions. The integrated TCS prevents most of these problems and improves the stability and controllability of the vehicle.

• International Journal of Automotive Technology
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• v.8 no.1
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• pp.49-57
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• 2007

This paper proposes a traction control system (TCS) that uses a sliding mode wheel slip controller and a PID throttle valve controller. In addition, a yaw motion controller (YMC) is also developed to improve lateral stability using a PID rear wheel steering angle controller. The dynamics of a vehicle and characteristics of the controllers are validated using a proposed full-car model. A driver model is also designed to steer the vehicle during maneuvers on a split ${\mu}$ road and double lane change maneuver. The simulation results show that the proposed full-car model is sufficient to predict vehicle responses accurately. The developed TCS provides improved acceleration performances on uniform slippery roads and split ${\mu}$ roads. When the vehicle is cornering and accelerating with the brake or engine TCS, understeer occurs. An integrated TCS eliminates these problems. The YMC with the integrated TCS improved the lateral stability and controllability of the vehicle.

• Journal of the Korean Chemical Society
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• v.36 no.2
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• pp.255-260
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• 1992

A procedure for spectrophotometric determination of traces of phosphorus(P) in high-purity trichlorosilane(TCS) is proposed using an adsorptive separation. $PCl_3$, which is a dominant P impurity within TCS, is first oxidized by oxygen to a stable form as $POCl_3$. $AlCl_3$ is selected as an adsorbent which forms a thermally stable complex with $POCl_3$ in TCS and can be well dissolved in aqueous ethanol solution. The proposed adsorptive separation method is free from the formation of silica gel and gas bubbles during the colorimetric analysis of TCS. The method reveals that the P concentration in a semiconductor-grade TCS is 5.32 ${\mi}g/l$ within the standard deviation of ${\pm}$ 17%. On the other hand, the P concentration of the purified TCS which is separated from the $AlCl_3$${\cdot}$$POCl_3$ complex is reduced to be less than 0.15 ${\mi}g/l$, showing the efficient applicability of $AlCl_3$ to the wet chemical analysis. The proposed method is also tested to verify the effectiveness of other well-known adsorbents.

• Journal of Korean Society of Transportation
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• v.26 no.3
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• pp.75-84
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• 2008

In 2002, the 5-day workweek policy was effective in Korea. As we have expected, the 5-day workweek policy has changed people's travel behavior during weekdays and weekends. Several studies have been done to understand these changes and impacts on transportation systems. However, these studies have only focused on travel pattern changes without considering spatial factors. Said in another way, although individual travel pattern changes are usually investigated, indices adopted cannot describe travel pattern changes in a proper way due to lack of the spatial distribution measure. This study aims to analyze travel change since the 5-day work week policy in effect using a new index (i.e. Travel Vector Index) developed in this study, which can explain travel pattern changes in terms of magnitude and spatial point of views. The new index uses a GIS technology and TCS (Toll Collection System) databases in Korea. The results in this study show that the index is very useful and reliable to measure the travel patterns changes. They are applied to TCS data set and the results show that the 5-day workweek policy significantly affects on travel behaviors.

• Toxicological Research
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• v.35 no.2
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• pp.137-154
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• 2019

Triclosan (TCS) is an antimicrobial compound used in consumer products. The purpose of current study was to examine toxicology and risk assessment of TCS based on available data. Acute toxicities of oral, transdermal and inhalation routes were low, and phototoxicity and neurotoxicity were not observed. Topical treatment of TCS to animal caused mild irritation. TCS did not induce reproductive and developmental toxicity in rodents. In addition, genotoxicity was not considered based on in vitro and in vivo tests of TCS. It is not classified as a carcinogen in international authorities such as International Agency for Research on Cancer (IARC). No-observed-adverse-effect level (NOAEL) was determined 12 mg/kg bw/day for TCS, based on haematoxicity and reduction of absolute and relative spleen weights in a 104-week oral toxicity study in rats. Percutaneous absorption rate was set as 14%, which was human skin absorption study reported by National Industrial Chemicals Notification and Assessment Scheme (NICNAS) (2009). The systemic exposure dosage (SED) of TCS has been derived by two scenarios depending on the cosmetics usage of Koreans. The first scenario is the combined use of representative cosmetics and oral care products. The second scenario is the combined use of rinse-off products of cleansing, deodorants, coloring products, and oral care products. SEDs have been calculated as 0.14337 mg/kg bw/day for the first scenario and 0.04733 mg/kg bw/day for the second scenario. As a result, margin of safety (MOS) for the first and second scenarios was estimated to 84 and 253.5, respectively. Based on these results, exposure of TCS contained in rinse-off products, deodorants, and coloring products would not pose a significant health risk when it is used up to 0.3%.

• Proceedings of the KIEE Conference
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• 2002.07b
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• pp.1220-1222
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• 2002

The railway signaling system consists of several vital computerized equipments. Now the project for development of signaling system for the next-generation high-speed train is progressed according to the consortium. The developing signaling system by this project, kTCS(Korean Train Control System), is composed of kTCS-CTC, kTCS-IXL, kTCS-ATC and etc. The KTCS signaling has to be operated as a integrated system by interface between each signaling. To achieve these, communication protocols between each signaling have to be designed and message codes are defined. In this paper the configuration of integrated kTCS system and designed communication protocol is presented.