• 제목/요약/키워드: TCR $\alpha$ chain KO mouse

검색결과 1건 처리시간 0.014초

Cytokine production profiles of a model for fluorouracil and UVB-induced discoid lupus erythematosus in TCR $\alpha$ chain knockout mouse

  • Yoshimasu, Takashi;Hiroi, Akihisa;Ohtani, Toshio;Uede, Koji;Furukawa, Fukumi
    • Journal of Photoscience
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    • 제9권2호
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    • pp.494-496
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    • 2002

  • Fluorouracil (FU) is well known to induce discoid lupus-like eruption at the sun exposure sites in Japan. It means the associations of UVB with drug induced DLE. It is still obscure which cytokines are involved in the development of DLE. To address the issue, we established a murine model of FU and UVB-induced discoid lupus and could show the Th1 dominant cytokine profiles in DLE model of TCR $\alpha$ chain KO mice treated with FU and UVB.

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