• Archives of design research
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• v.16 no.4
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• pp.277-288
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• 2003

By the needs for design, the leading construction equipment manufacturers have performed the product design newly setting up the design teams of late, but the actual level of designing is just as much as copying without systematic process, Therefore the various studies are needed to set up the differentiated design method targeted only for construction equipment and solving the current problems. In this paper, 1 am going to suggest a basic material as well as a cornerstone predicting future design trend in the construction equipment design field through the study of design transition.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.18 no.1
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• pp.51-57
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• 2010

This study was to analyze the difference in pilot error by using the Signal Detection Theory. The task was to detect the targeted aircraft(signal) which is different shape from many other aircraft(noise). From the two experiments, we differentiated the task difficulty followed by change in noise stimuli. Experiment 1 was to search the signal stimuli(fighter plane) while the noise stimuli(cargo plane) were increasing. The results from the Experiment 1 showed the tendency to decrease the hit rate by increasing the number of noise stimuli. However, the false alarm rate was not increased. The sensitivity(d') showed quite high. In Experiment 2, a disturbance stimulus(helicopter) was added to noise stimuli. The result was generally similar to those of Experiment 1. However, the hit rate was lower than that of Experiment 1.

• Special Issue of the Society of Naval Architects of Korea
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• 2009.09a
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• pp.6-17
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• 2009

The present paper addresses development of a GTT NO96 membrane type 170K m3 LNG carrier targeted to operate in moderate ice infested seas including Baltic Sea, Sakhalin port of Sea of Okhotsk, Murmansk port of Barents Sea, etc. Critical design issues are covered in detail to meet the requirements coming from the missioned operation conditions comprising low design ambient temperature, harsh wave conditions, stringent environmental protection policies, etc.

• The Journal of the Korean dental association
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• v.48 no.8
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• pp.576-586
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• 2010

Recent advancement in molocular biology enhanced further understanding of the carcinogenesis of oral cancer and its relation with various genetic backgrounds. Familial risk factors includes similar habits of the family and polymorphic variations of the genes. Recently, human papilloma virus has been suggested to be linked with oral cancer progression. Enhancement of understanding of the damage or alteration in molecular pathway in various cellular response of oral cancer progression would lead the targeted therapy or precise early diagnosis of the oral cancer.

• BMB Reports
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• v.41 no.3
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• pp.177-183
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• 2008

Ubiquitin is an essential, highly-conserved small regulatory protein in eukaryotic cells. It covalently modifies a wide variety of targeted proteins in the forms of monomer and polymers, altering the conformation and binding properties of the proteins and thus regulating proteasomal delivery, protein activities and localization. Mass spectrometry has emerged as an indispensable tool for in-depth characterization of protein ubiquitination. Ubiquitinated proteins in cell lysates are usually enriched by affinity chromatography and subsequently analyzed by mass spectrometry for identification and quantification. Ubiquitin-conjugated amino acid residues can be determined by unique mass shift caused by the modification. Moreover, the complex structure of polyubiquitin chains on substrates can be dissected by bottom-up and middle-down mass spectrometric approaches, revealing potential novel functions of polyubiquitin linkages. Here I review the advances and caveats of these strategies, emphasizing caution in the validation of ubiquitinated proteins and in the interpretation of raw data.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.10a
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• pp.211-214
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• 2000

The paper presents a case study with application of a performance measurement questionnaire in analyzing a semi-conductor-related manufacturing company. The case may contribute to the development of strategic performance measurement system. The questionnaire contains considerable non-financial measurement indices as well as financial ones, which may strengthen the strategic aspect of measurement system. The strategy, actions, and measures have to be balanced through communication process in an organization. The result shows the usefulness of the congruence and consensus analysis of performance factors in effectively managing strategic action programs and identifying investment task areas to be targeted.

• Journal of Biomedical Engineering Research
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• v.30 no.5
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• pp.362-372
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• 2009

Some serious neck diseases are closely related to negative emotion. In order to explain the etiology deeply, we assumed that upper trapezius is innervated by emotional motor system (EMS), a special motor system. And then we developed an upper trapezius-specific surface electromyography acquisition system concerned with its special innervation to prove our assumption. Through a targeted experiment, we found that upper trapezius is indeed innervated by EMS.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.251-251
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• 1994

1차년도에서 이미 확립한 다양한리포좀의 제조 방법에 따라간세포를표 적하기 위해 이들 리포좀의 조성에 galactocercbroside를 함유시켜 targeted liposomes을 제조하였다. 표적리포좀의 제조 방법에 따른 봉합율 (cncapsulation)과 안정성을 조사했을 때, freezing-thawing 과정을 거친 리포좀이 encapsulation 과 stability가 가장 뛰어남을 알 수 있었다. In vitro 간세포 표적능력을 in vitro cell culture system에서 간세포 cell line (Hep G2, 2.2.15과 다른 cell line (Vero E6, J82)에 대한 표적리포좀과 control liposomes의 uptake를 FTTC 또는 CF 형광으로 측정했을 때, 표적리포좀이 간세포 cell line에 더 많이 uptake하는 것을 알았다. In vivo 실험에서는 6 - 8 주령의 mouse tail vain에 표적리포좀과 control liposomes을 주사하여 각 장기에 존재하는 리포좀의 양을 형광으로 측정했을 때, 표적리포좀 (targetcd liposomes)이 다른 장기에 비해 liver에 선택적으로 많이 분포함을 알수있었다. 또한 간암의 효과적인 치료를 위해 간세포와 암세포를 동시에 표적할 수는 double targeting liposomes을 design 하였다.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.7
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• pp.928-933
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• 2018

Nowadays, gastropathy is a common disease. As endoscopic equipment are developed and used widely, it is possible to provide a large number of endoscopy images. Computer-aided Diagnosis (CADx) systems aim at helping physicians to identify possibly malignant abnormalities more accurately. In this paper, we present a CADx system to detect and classify the abnormalities of gastric lesions which include bleeding, ulcer, neuroendocrine tumor and cancer. We used an Inception module based deep learning model. And we used data augmentation for learning. Our preliminary results demonstrated promising potential for automatically labeled region of interest for endoscopy doctors to focus on abnormal lesions for subsequent targeted biopsy, with Az values of Receiver Operating Characteristic(ROC) curve was 0.83. The proposed CADx system showed reliable performance.

• Journal of Korean Neurosurgical Society
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• v.61 no.3
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• pp.319-332
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• 2018

Germline mutations in cancer causing genes result in high risk of developing cancer throughout life. These cancer predisposition syndromes (CPS) are especially prevalent in childhood brain tumors and impact both the patient's and other family members' survival. Knowledge of specific CPS may alter the management of the cancer, offer novel targeted therapies which may improve survival for these patients, and enables early detection of other malignancies. This review focuses on the role of CPS in pediatric high grade gliomas (PHGG), the deadliest group of childhood brain tumors. Genetic aspects and clinical features are depicted, allowing clinicians to identify and diagnose these syndromes. Challenges in the management of PHGG in the context of each CPS and the promise of innovative options of treatment and surveillance guidelines are discussed with the hope of improving outcome for individuals with these devastating syndromes.