• Asian Pacific Journal of Cancer Prevention
• /
• 제16권16호
• /
• pp.7261-7266
• /
• 2015

Breast cancer, the most common cancer in the women, is the leading cause of death. Necrotic signaling pathways will enable targeted therapeutic agents to eliminate apoptosis-resistant cancer cells. In the present study, the effect of shikonin on the induction of cell necroptosis or apoptosis was evaluated using the T-47D breast cancer cell line. The cell death modes, caspase-3 and 8 activities and the levels of reactive oxygen species (ROS) were assessed. Cell death mainly occurred through necroptosis. In the presence of Nec-1, caspase-3 mediated apoptosis was apparent in the shikonin treated cells. Shikonin stimulates ROS generation in the mitochondria of T-47D cells, which causes necroptosis or apoptosis. Induction of necroptosis, as a backup-programmed cell death pathway via ROS stimulation, offers a new strategy for the treatment of breast cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권6호
• /
• pp.3419-3423
• /
• 2013

Of all gynecologic cancers, endometrial cancer is the most common cancer in the US and Europe. In addition, it is presently the second most common gynecologic cancer in the world. As a result of increasing menopausal, obese and tamoxifen use women, the incidence of the cancer seems to be on the increase. Surgery is the major treatment, whereas postoperative radiation therapy in high-intermediate risk patients many prevent locoregional recurrence. Adjuvant chemotherapy can improve progression free survival in advanced or recurrent cancers. Molecular targeted therapies are now a focus of attention including anti-vascular endothelial growth factor (VEGF), mammalian target of rapamycin (mTOR) inhibitor and tyrosine kinase inhibitor (TKI). They may provide useful future strategies for control of endometrial malignancies in developing countries and across the world.

• 한국음향학회:학술대회논문집
• /
• 한국음향학회 2000년도 하계학술발표대회 논문집 제19권 1호
• /
• pp.51-54
• /
• 2000

This paper describes the fixed-point DSP implementation of a CELP(code-excited linear prediction)-based speech coder. The effective realization methodologies to maximize the utilization of the DSP's architectural features, specifically Parallel movement and pipelining are also presented together with the implementation results targeted for the ITU-T standard G.723.1 using Motorola DSP56309. The operation of the implemented speech coder is verified using the test vectors offered by the standard as well as using the peripheral interface circuits designed for the coder's real-time operation.

• 한국조리학회지
• /
• 제22권6호
• /
• pp.151-159
• /
• 2016

With the targeted coffee consumers in Kwangju city, South Korea, this paper investigates a few determinants such as taste, aroma, mouth-feel, and satisfaction to influence coffee price, based upon self-evaluations by those who enjoy specialty coffee. Using both simple regression and standard multiple regression analyses, it turned out that tastes, smell, mouth-feel, and satisfaction of specialty coffee had effects on coffee price. This study implies that when coffee consumers decide coffee price, they consider multiple factors to influence their overall satisfaction in multiple aspects than a single facet like taste, aroma, and mouth-feel. Practical and theoretical discussion and implications are suggested for the following studies.

• 한국연소학회:학술대회논문집
• /
• 한국연소학회 2014년도 제49회 KOSCO SYMPOSIUM 초록집
• /
• pp.37-40
• /
• 2014

Capturing the carbon dioxide emitted from coal-fired power plants will be necessary if targeted reduction in carbon emissions is to be achieved. Modelling and simulation are the base for optimal operation and control in thermal power plant and also play an important role in energy savings. This study aims to analyze the performance of supercritical coal fired power plant through steady and dynamic simulation using a commercial software gCCS. A whole power plant has been modeled and validated with design data of 500 MWe power plant, base and part load operations of the plant were also evaluated, consequently it had been proven that the simulated result had a good agreement with actual operating data. In addition, the effect of co-firng on the plant efficiency and flue gases were investigated using gCCS simulator.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권5호
• /
• pp.1693-1698
• /
• 2015

The heterogeneous nature of lung cancer has become increasingly apparent since introduction of molecular classification. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. Activating alterations in several potential driver oncogenic genes have been identified, including EGFR, ROS1 and ALK and understanding of their molecular mechanisms underlying development, progression, and survival of lung cancer has led to the design of personalized treatments that have produced superior clinical outcomes in tumours harbouring these mutations. In light of the tsunami of new biomarkers and targeted agents, next generation sequencing testing strategies will be more appropriate in identifying the patients for each therapy and enabling personalized patients care. The challenge now is how best to interpret the results of these genomic tests, in the context of other clinical data, to optimize treatment choices. In genomic era of cancer treatment, the traditional one-size-fits-all paradigm is being replaced with more effective, personalized oncologic care. This review provides an overview of lung cancer genomics and personalized treatment.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권5호
• /
• pp.1683-1686
• /
• 2015

Different types of treatment are available for patients with breast cancer, the most being radiotherapy, chemotherapy, hormonal therapy and combination therapy. Recently, nanoparticles have been emerging as promising agents for cancer therapy and are being investigated as contrast agents, drug carriers, radiosensitizers and also for hyperthermia effects. In this review the focus is on approaches for targeted treatment of breast cancer by combining nanoparticles, chemodrugs and radiation. The availble data suggest the possibility of increased roles for combined therapy, particularly by reducing the dose of each treatment modality, and consequently minimizing related side effects.

• 한국중재학회지:중재연구
• /
• 제21권3호
• /
• pp.165-187
• /
• 2011

This paper investigates on the legal doctrine of "voluntary, knowing, and intelligent" (VKI Doctrine). The main points that were discussed include the history of the VKI doctrine and the US courts' attitudes toward the doctrine. It was also discussed how the VKI doctrine influenced the protection of consumer who agreed to arbitrate with businesses. The US courts' attitudes have shown to be split in application of the VKI doctrine to disputes in the enforceability of arbitration agreement between the consumers and the businesses. In order for the arbitration agreement to be invalidated, the state legislature cannot enact law that are directly targeted toward the validity of arbitration agreement. Rather the contract law in each of the state should be applied to the evaluation of the validity of an arbitration agreement. As the more and more consumers become familiar with the arbitration, the need for the VKI doctrine to protect the individual consumers in arbitration is expected to be diminished in future disputes.

• Child Studies in Asia-Pacific Contexts
• /
• 제6권1호
• /
• pp.17-29
• /
• 2016

To help define future research direction and enhance educational service for children from Asian and Latino immigrant backgrounds, this review examines research investigating social competence with reference to host and heritage language skills. A targeted search obtained 14 peer-reviewed studies published from 1994 to 2014 focusing on children aged from birth to 12 years. Social competence is mainly measured by four dimensions: externalizing behaviours, internalizing behaviours, social skills and relationships with others. The evidence suggests that English proficiency levels are positively associated with social skills and parent-child relationships are of higher quality when parent-child heritage language difference is minimal. However the findings are mixed regarding how English levels are associated with externalizing, internalizing behaviours and relationships with others and how heritage language levels are associated with social competence. This review makes a set of recommendations for future research including assessment of participants' language proficiency with language tests and examination of emotional factors in the relationship between English and social competence. The implications of the findings are also discussed for educators.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2001년도 춘계학술대회논문집D
• /
• pp.807-812
• /
• 2001

This paper represents the wall thinning analysis results for secondary side piping of two types of domestic nuclear power plants based on the DB establishment and F AC analysis study for NPP secondary system piping. CHECWORKS code utilized in this study has been applied world widely to wall thinning analyses for secondary side piping and its reliability has also been proved. The predicted wear rates for several piping systems of a pressurized water reactor NPP are compared with those of a pressurized heavy water reactor NPP and with the measured wear rates. On the basis of comparison results of the predicted and measured wear rates, the analysis results can be effectively applied to the development of a standard thinned pipe management program targeted all domestic nuclear power plants.