• 제목/요약/키워드: TAK1

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Silica Induces Nuclear Factor-kB Activation through TAK1 and NIK in Rat2 cell line

  • Young Lim;Nam, Hae-Yun;Rha, Suk-Joo;Kim, Young-Hoon;Cho, Yong-Yeun;Yang, Ki-Hwa;Kim, Kyoung-Ah;Lee, Kweon-Haeng
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 춘계학술대회 논문집
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    • pp.75-75
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    • 2003

  • Silica has been known to be a factor in acute cell injury and chronic pulmonary fibrosis. In Rat2 fibroblasts, silica induced the activation of NFkB, which plays a crucial role in regulating the expression of many genes involved in the subsequent inflammatory response. In addition, we observed that TAK1 and NIK were involved in silica-mediated NF-kB activation in Rat2 cells. (omitted)

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