• Proceedings of the KSME Conference
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• 2002.08a
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• pp.711-712
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• 2002

A numerical study of a hemodynamical model for the tumor angiogenesis is carried out. The tumor angiogenesis process is comprised of a sequence of events; secretion of tumor angiogenesis factor(TAF) from the solid tumor, degradation of the basement membrane of nearby blood vessels, migration and proliferation of the endothelial cells. The model takes into account the effect of TAF concentration and endothelial cell density, and their conservation equations are represented as a set of one-dimensional initial boundary value problems. These equations are discretized by using a finite difference method in which the second order schemes both in time and in space are used. The effects of the parameters contained in the model are Investigated extensively through the numerical simulation of the discretized model. The result for the typical case compares very well with the known result.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.709-710
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• 2002

Cancer angiogenesis is simulated using a two dimensional model. Governing equation of angiogenesis is a TAE (Tumor angiogenesis factor) conservation equation in time and space. A stochastic process model is utilized to simulate vessel formation, proliferation, and migration to a cancer pellet. Numerical results are presented especially in case of growing cancer.

• Journal of Korean Society for Atmospheric Environment
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• v.13 no.5
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• pp.383-396
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• 1997

Numerical prediction of the pollutant dispersion over a two-dimensional hilly terrain is presented. The dispersion model used in the present work is based on the gradient diffusion theory and the finite-volume method on a non-orthogonal boundary-fitted grid system. The numerical model is validated by comparing the results with the available experimental data for the flat-floor dispersion within a turbulent boundary-layer. The numerical error analysis is performed based on the guideline of Kasibhatla et al.(1988) for the elevated-source dispersion in the flat-floor boundary layer having a power-law velocity and linear eddy-diffusivity profile. The influences of the two-dimensional hilly terrain on the dispersion from a continuously released source are numerically investigated by changing the emission locations and heights. It is found that the distributions of ground-level concentration are strongly influenced by the source location and the emission height. Hence, the terrain amplification factor is greatly enhanced when the pollutant source is located within a flow separation region. Dispersion from a source of short duration is also simulated and the duration time of the pollutant is compared at several downstream locations on a hilly terrain. The results of the numerical prediction are applied to the evaluation of environmental impacts due to the automobile exhausts at the seashore highway with a parallel mountain range.

• Journal of Microbiology and Biotechnology
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• v.18 no.2
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• pp.263-269
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• 2008

Hydrazinocurcumin (HC), a synthetic derivative of curcumin, has been reported to inhibit angiogenesis via unknown mechanisms. Understanding the molecular mechanisms of the drug's action is important for the development of improved compounds with better pharmacological properties. A genome-wide drug-induced haploinsufficiency screening of fission yeast gene deletion mutants has been applied to identify drug targets of HC. As a first step, the 50% inhibition concentration $(IC_{50})$ of HC was determined to be $2.2{\mu}M$. The initial screening of 4,158 mutants in 384-well plates using robotics was performed at concentrations of 2, 3, and $4{\mu}M$. A second screening was performed to detect sensitivity to HC on the plates. The first screening revealed 178 candidates, and the second screening resulted in 13 candidates, following the elimination of 165 false positives. Final filtering of the condition-dependent haploinsufficient genes gave eight target genes. Analysis of the specific targets of HC has shown that they are related to septum formation and the general transcription processes, which may be related to histone acetyltransferase. The target mutants showed 65% growth inhibition in response to HC compared with wild-type controls, as shown by liquid culture assay.