• Journal of Korean society of Dental Hygiene
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• v.20 no.5
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• pp.763-771
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• 2020

Objectives: Erigeron bonariensis is a type of Erigeron found throughout the tropical and subtropical areas as one of the perennial plants or pioneer plants. It is known to show detoxifying, antipyretic, and anticancer effects for various cancers. However, there are no reports on the anticancer effect of E. bonariensis on oral cancer cells. In the present study, we investigated the effects of the methanol extract of Erigeron bonariensis (MEEB) on the inhibition of cell growth and induction of apoptosis in mucoepidermoid carcinoma (MEC) cell lines, including the MC3 and YD15 oral cancer cells. Methods: MC3 Cells were treated by dimethyl sulfoxide (DMSO) or methanol extracts of 20 various natural products 20 ㎍/mL for 48 hours and cell viability were analyzed as Trypan blue exclusion assay. The effects of MEEB treatment on the cell viability of MC3 and YD15 cells, for 48 h, were analyzed by Trypan blue exclusion assay. The anticancer efficacy and apoptosis of oral cancer cell lines were analyzed by western blot analysis. The statistical significance of differences between groups was analyzed by Student's two-tailed t-test. A value of P<0.05 compared to the vehicle control was considered statistically significant. Results: Among 20 different naturally derived products, MEEB significantly inhibited cell viability and increased cleaved poly [ADP-ribose] polymerase 1 (PARP) protein in the MC3 and YD15 cells in a concentration-dependent manner. Conclusions: These results suggest that MEEB can be used as a natural anticancer drug for the treatment of human oral cancer.

• Archives of design research
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• v.14 no.2
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• pp.217-224
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• 2001

Graphic thinking for the idea sketches brings about variations between abstract realm and concrete one, and between conceptual realm and perceptual one. When design information is projected to the thinking process, some images are generated, and transformed. We reviewed the sketching devices for computerization to deal with a lot of design data in the computing environment. The LCD Tablet can be a substitute for the Pen & Paper to get rid of irksome tasks at handling the design data. Using a protocol analysis technique, we examined the influences of different design information, which is consisted of verbal concepts and/or visual images, and abstract information and/or concrete one. The findings show that there are no significant differences of influences between verbal/visual information and abstract concrete information at the conceptual design. These facts support that graphic thinking process is progressed with the perceptual and mental image.

• Journal of Korean Society for Atmospheric Environment
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• v.30 no.2
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• pp.95-109
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• 2014

In this study, the concentration of odorants released from albumin (EA) and yolk (EY) portions of boiled egg samples were determined as a function of storage time. The concentrations were measured at storage days of 0, 1, 3, 6, and 9 under room temperature. As such, odorants produced during both fresh and decay conditions were measured through time. A total of 19 compounds were selected as the main target odorants along with 12 reference compounds. GC-MS (for VOC) and GC-PFPD system (for sulfur gases) equipped with thermal desorption (TD) system were employed for odorant analysis in this work. The initial concentrations measured from the chamber system were converted into flux terms ($ng{\cdot}g^{-1}{\cdot}min^{-1}$). The EA showed the highest concentration of $H_2S$ (234 $ng{\cdot}g^{-1}{\cdot}min^{-1}$) at EA-0, and the concentrations of AT (Acetone) was also seen clearly in the range of 11.7 (EA-0) to 58.6 $ng{\cdot}g^{-1}{\cdot}min^{-1}$ (EA-9). The EY showed similar patterns. EtAl (Ethyl alcohol) increased 9.47 (EA-1) to 96.7 $ng{\cdot}g^{-1}{\cdot}min^{-1}$ (EA-9) in EA samples. Ketone, alcohol, sulfur groups generally exhibited high concentrations compared to other odorants. These data were also compared in relation to olfactometry related dilution-to-threshold (D/T) ratio by air dilution sensory (ADS) test and sum of odor intensity (SOI).

• Archives of Plastic Surgery
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• v.37 no.1
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• pp.52-58
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• 2010

Purpose: The digital artery perforator flap was recently introduced and has been proven to be useful for reconstruction of various finger defects. Short operative time, less invasive surgery, and reliable flap circulation are the major advantages of this flap. The authors presented the clinical cases of the digital artery perforator flap and compared them with the distant flaps within a hand (thenar and hypothenar flaps) to reveal their differences. Methods: From May of 2006 to February of 2009, the authors performed reconstructions of finger defects with the digital artery perforator flaps in 10 patients as with the distant flaps within hand in 9 patients (7 thenar and 2 hypothenar flaps). In these two groups of the patients, flap size, use of skin graft, length of stay in hospital, healing time, complications were reviewed retrospectively and compared with statistical analysis (Student's t-test). Results: All flaps survived completely. The mean size of the perforator flap was $0.9{\times}1.9\;cm$ and the mean distant flap within a hand was $1.9{\times}2.0\;cm$. The use of skin graft was reduced in the perforator group because the donor site of the flap was closed primarily. The hospitalization period and healing time also reduced significantly in the perforator group. Minor complications (partial flap loss) were noted in small percentages in both groups but resolved with conservative management. Mean follow-up period was about 6 weeks. Conclusion: The digital artery perforator flap was smaller than the distant flap but its reconstruction of finger defects was reliable and comparable to the conventional distant flaps within a hand. This flap would be not only an alternative method but very useful in the management of various finger defects, because of ease of operative technique, less invasive surgery, decreased need of skin graft, and shorter period of hospitalization and healing time.

• The Journal of Korean Physical Therapy
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• v.14 no.4
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• pp.323-330
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• 2002

This study purposes at applying knee joint taping to preventing muscle fatigue. Twenty six subjects between the ages of 20s and 30s were randomly sampled among healthy males, with an average age of 26yr(range, 22 to 31yr). None of the subjects had a recent or remote history of significant lower extremity injury, No subjects had a history of central nervous system equilibrium problems. To develop muscle fatigue, Isokinetic exercise, which is a repetition of flexion and extension knee joint to $180^{\circ}$/sec, was performed 50 times per person. During the exercise, change of proprioception were measured by applying taping on both knee joints. Analysis has carried out by means of one-way ANOVA with repeated measures and independent t-test at the significance level of $\alpha$=0.05 to detect statistic significance. The results of this study were as follows: First, it was found that the generation of lower extremity muscle fatigue significant affects on proprioception (p < 0.05). Second, the application of taping to knee joint after the generation of lower extremity muscle fatigue significant affect proprioception (p < 0.05). Third, while continual exercise after the generation of muscle fatigue, taping group was significant differences in proprioceptive loss than non-taping group(p < 0.05).

• The Journal of Korean Physical Therapy
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• v.24 no.3
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• pp.216-222
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• 2012

Purpose: Weight-bearing exercise is a type of physical exercise that is widely performed for rehabilitation after acquiring nervous-system diseases or sports-related injuries. It is one of the most commonly prescribed rehabilitation programs for strengthing of the lower extremities. Weight-bearing exercise is important for the conduct of such activity of daily living (ADLs) as walking, and up and down the stairs. The purpose of this study was to investigate the muscle activities during one-leg standing and one-leg squatting, the two most representative weight-bearing exercises. Methods: A total of 43 elderly (60~70 years old) males who could perform weight-bearing exercises were included in the study. During the one-leg standing and one-leg squatting, the electromyographic (EMG) signals were quantified as maximum voluntary isometric contraction (%MVIC) using surface EMG, and then the muscle activities of the lower extremities during the two exercises were compared. For statistical analysis, an independent sample t-test and one-way ANOVA were performed. Results: The results of the study are as follows: (1) in the one-leg standing, the activity of the gluteus medius was the greatest among the vastus medialis, vastus lateralis, bicep femoris, (2) in the one-leg squatting, the activity of the vastus medialis was the greatest; and (3) the activity was greater in the one-leg squatting than in the single-leg standing exercise. Conclusion: The one-leg standing and squatting exercises are suitable for strengthening the muscles for the prevention of and recovery from lower-extremity injury, and for functional ADL in elderly people. In addition, dynamic exercise was shown to be more effective than static exercise for strengthening the muscles.

• The Journal of Korean Physical Therapy
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• v.24 no.2
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• pp.82-89
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• 2012

Purpose: In this study, the effects of stability exercise, extracorporeal shock wave therapy, and taping on pain and function in patients with myofascial pain syndrome of upper trapezius were compared. Methods: The subjects were divided into the stability exercise, ESWT and the taping treatment group and the clinical outcomes were evaluated by visual analog scale (VAS), pressure pain threshold (PPT) and a constant-murley scale (CMS) at pre-treatment and post-treatment. Paired t-test and ANOVA was used for statistical analysis. Results: All groups were statistical significance in the change in visual analog scale (p<0.05). The difference between the ESWT group and taping group was statistical significance in the change in pressure pain threshold (p<0.05) except for the taping group. Using the constant-murley scale, the stability exercise group showed a significant decrease in pain, and a significant increase in ROM, ADL, strength, total score of shoulder (p<0.05); however, the ESWT group showed no difference on ADL. In addition, there was no difference in strength for the taping group. The comparison of the effect between the stability exercise group, ESWT group and taping group in CMS showed a statistical significant difference in pain, ADL and ROM (p<0.05). Conclusion: These results indicate that stability exercise, ESWT and taping could be considered an effective and efficient treatment modality for myofascial pain syndrome of upper trapezius.

• Journal of Oriental Neuropsychiatry
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• v.23 no.4
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• pp.107-122
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• 2012

Objectives : The purpose of this study is to examine the general personality profiles of patients who visited an oriental neuropsychiatric clinic and to investigate the specific profiles of patients diagnosed with Hwa-byung. Methods : We analyzed the profiles of 122 patients who completed TCI-RS questionnaire for the purpose of counseling. Patients were divided by sex, age and diagnosis related groups. Scales and subscales of each group were compared by an independent t-test and ANCOVA with SPSS windows 16.0. Types of temperament and character were classified by percentile ranks of the total patients and diagnosis related groups. Results : 1. Total patients were classified as the high harm avoidance type of temperament and of low self-directedness type of character. 2. Male patients showed significantly higher scores on NS, all subscales of NS, P2 and P3 than female patients. HA4 and C5 scores were significantly higher in the female group. Younger patients showed significantly higher scores on NS, all subscales of NS, HA1 and P3. However, older patients had significantly higher scores on SD4, SD5, ST2 and ST3. 3. Between diagnosis related groups, Hwa-byung group had significantly higher scores on RD, ST, SD3 and ST2. However P3 score of non-hwa-byung patients was higher than hwa-byung patients. In typical classification, both hwa-byung and non-hwa-byung groups were classified as the same types as total patients. Conclusions : This study showed that the patients visited an oriental neuropsychiatric clinic and had similar personality with that of general psychiatric disorders. Hwa-byung patients exhibited higher RD and ST scores than other disorders, but they had no typical differences.

• Journal of Plant Biotechnology
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• v.43 no.3
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• pp.332-340
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• 2016

Seed size traits are controlled by multiple genes in crops and determine grain yield, quality and appearance. However, the molecular mechanisms controlling the size of plant seeds remain unclear. We performed functional analysis of BrPATL4 encoding Sec14-like protein to determine the genetic architecture of seed size, shape and their association analyses. We used 60 $T_3$ transgenic rice lines to evaluate seed length, seed width and seed height as seed size traits, and the ratios of these values as seed shape traits. Pleiotropic effects on general architecture included small seed size, erect panicles, decreased grain weight, reduced plant height and increased sterility, which are common to other mutants deficient in gibberellic acid (GA) biosynthesis. To test whether BrPATL4 overexpression is deleterious for GA signal transduction, we compared the relative expression of GA related gene and the growth rate of second leaf sheath supplied with exogenous $GA_3$. Overexpression of BrPATL4 did not affect GA biosynthesis or signaling pathway, with the same response shown under GA treatment compared to the wild type. However, the causal genes for the small seed phenotype (D1, SRS1, and SRS5) and the erection of panicles showed significantly decreased levels in mRNA accumulation compared to the wild type. These results suggest that the overexpression of BrPATL4 can control seed size through the suppression of those genes related to seed size regulation. Although the molecular function of BrPATL4 is not clear for small seed and erect panicles of BrPALT4 overexpression line, this study provides some clues about the genetic engineering of rice seed architecture.

• Journal of Internet Computing and Services
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• v.9 no.6
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• pp.89-97
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• 2008

Recently, many organizations such as companies or institutions have demanded induction of very large-scale workflow management system in order to process a large number of business-instances. Workflow-related vendors have focused on physical extension of workflow engines based on device-level clustering, so as to provide very large-scale workflow services. Performance improvement of workflow engine by simple physical-connection among computer systems which don't consider logical-level software architecture lead to wastes of time and cost for construction of very large-scale workflow service environment. In this paper, we propose methodology for performance improvement based on logical software architectures of workflow engine. We also evaluate scalable performance between workflow engines using the activity instance based architecture and workcase based architecture, our proposed architecture. Through analysis of this test's result, we can observe that software architectures to be applied on a workflow engine have an effect on scalable performance.