• Parasites, Hosts and Diseases
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• 제38권4호
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• pp.267-273
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• 2000

We report 5 cases of ocular toxocariasis in Korean adults complaining of visual impairment along with floating or bubbling sensation. Fundoscopic examination revealed a retinal detachment along with exudate in 4 cases. They all showed typical reaction by ELISA and immunoblot against Toxocra excretory-secretory antigen. One case showed high level of anti-Toxocara IgE antibodies (34.000 Toxocara units/L) as well as increased level of serum total IgE antibodies and the specific IgE antibodies for 3 inhalant antigens, suggesting that high level of anti-Toxocara IgE antibodies was associated with an atopic status. Clinical manifestations were improved after the sequential use of steroids then mebendazole. We also suggest that ocular toxocariasis should be thoroughly investigated even when an evocative uniocular inflammatory lesion is encountered in peripheral retina without a systematic disease.

• 성인간호학회지
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• 제23권6호
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• pp.564-573
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• 2011

Purpose: The purposes of this study were to identify the factors associated with the first reported fracture in osteoporotic patients. Methods: One hundred and sixty-four patients who presented with osteoporosis at K hospital in G city, South Korea between July and September 2010 were participated in study. Modified Korea National Health and Nutrition Examination Survey tool were used to measure participants' living habits. Computer aided nutritional analysis program (CAN-PRO) designed by Nutrition Information Center in the Korean Nutrition Society (2002) was used to analyze foods intake and to calculate the individual nutrients intake. Results: The risk of developing the first osteoporotic fracture was ten times higher in the patients between 65 to 74 years (OR=10.06, p=.010), and 28.41 times greater in those with increasing falls (OR=28.41, p<.001). Patients with higher bone marrow density (BMD) and higher consumption of animal protein diet had lower risks of developing the first osteoporotic fracture (OR=0.37, p=.011; OR=0.88, p=.040, respectively). Conclusion: Risk factors for osteoporotic fracture included the age from 65 to 74 years, an increase in falls, low animal protein consumption, and reduced BMD. Systematic educational program is needed to prevent fracture in osteoporotic patients.

• Genomics & Informatics
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• 제18권1호
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• pp.3.1-3.8
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• 2020

Patient-derived xenograft (PDX) mouse models are frequently used to test the drug efficacy in diverse types of cancer. They are known to recapitulate the patient characteristics faithfully, but a systematic survey with a large number of cases is yet missing in lung cancer. Here we report the comparison of genomic characters between mouse and patient tumor tissues in lung cancer based on exome sequencing data. We established PDX mouse models for 132 lung cancer patients and performed whole exome sequencing for trio samples of tumor-normal-xenograft tissues. Then we computed the somatic mutations and copy number variations, which were used to compare the PDX and patient tumor tissues. Genomic and histological conclusions for validity of PDX models agreed in most cases, but we observed eight (~7%) discordant cases. We further examined the changes in mutations and copy number alterations in PDX model production and passage processes, which highlighted the clonal evolution in PDX mouse models. Our study shows that the genomic characterization plays complementary roles to the histological examination in cancer studies utilizing PDX mouse models.

• 대한치과기공학회지
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• 제41권4호
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• pp.337-345
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• 2019

Purpose: The purpose of this study was to enhance curriculum satisfaction of dental laboratory technology and curriculum demands. Methods: From March 5 to March 31, 2019, a self-written questionnaire was conducted for 195 students from the department of dental laboratory technology at a university in Gangwon-do. The analytical methods used were descriptive statistical analysis, frequency analysis, cross analysis, correlation analysis and reliability analysis. The collected data was used for SPSS 18.0 for Windows statistics program. Results: The demand of the school education includes systematic experiments and demand of practical training, acquisition of professional knowledge, introduction of advanced technology curriculum, reduction of national examination-oriented curriculum, and increased professionalism and professionalism as professional professionals. Investigated by the ethics. In addition, they were strongly aware of the necessity of digital education related to CAD / CAM, and there was a high demand for how to operate programs, scanning and design. Conclusion: The curriculum needs to be reorganized to cultivate dental technicians in a changing era, and in-depth centralized curriculum in fields with high practical needs, as well as vocational and ethical views as professionals.

• Journal of Yeungnam Medical Science
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• 제3권1호
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• pp.1-11
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• 1986

As public awareness of the various warning signs of malignancy increases, so does the concern evoked by the self identified finding of mass in the head and neck area. Not all the palpable masses are always significantly abnormal, but any nontender mass especially to the adult is significant enough to warrent further full investigation and follow up, the object of which should be to determine the possibility of malignancy and urgency of treatment. Approach to the diagnosis of the neck mass is so important in that it affects decision regarding further evaluation would lead to the determination of the most efficacious mode of therapy, eventually to the good prognosis. So, it should be emphasized that approach to the diagnosis of neck mass should be planned, systematic and thorough, this begins with the taking careful history following performance of complete examination of the head and neck especially to the nasopharynx, tongue base, pyriform sinus, palatine tonsil and larynx. Then a number of laboratory and radiologic studies are available, following triple endoscopy under general anesthesia and blind biopsy if needed. The most important rule to keep is that any biopsy procedures should be delayed to the last modality of effort to the diagnosis and if it should be done, under the plan of radical neck dissection.

• Journal of Korean Society for Atmospheric Environment
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• 제21권E3호
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• pp.95-105
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• 2005

The concentrations of sulfur dioxide ($SO_{2}$) were measured from seven major cities and nine provinces in Korea for the period covering 1998 to 2003. Its concentration data were analyzed to explore the possible influences of spatial and temporal factors on the $SO_{2}$ distribution characteristics. Examination of spatial trends of $SO_{2}$ distribution and behavior indicated several interesting features. Although its annual trends appeared to be affected by the changes in the surrounding environmental conditions (e.g., regulation on the use of S-containing fuels), the seasonal trends indicated a cyclic and systematic pattern that may be characterized as: a gradual decrease in concentrations across winter, spring, fall, and summer. The results showed the generally enhanced mean concentrations of $SO_{2}$ from Ulsan, Busan, and Daegu with 12.8, 10.1, and 8.80 ppb, respectively. On the other hand, notably reduced $SO_{2}$ concentrations were seen from Gwangju and Jeju sites with its mean values of 5.43 and 3.88 ppb, respectively. The overall results of our study indicate that a decrease in $SO_{2}$ concentration levels continued through time, while its spatial distribution appears to be affected most sensitively by such factor as city scale and industrial activities.

• 정보관리학회지
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• 제30권4호
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• pp.175-193
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• 2013

본 연구는 국내 대학도서관의 디지털참고정보서비스 현황을 분석하고 전자게시판을 중심으로 그 이용행태를 분석하여 향후 디지털 참고정보서비스 활성화를 위한 방법을 제언하고자 하였다. 205개 대학도서관 웹사이트를 분석하여 디지털참고정보서비스의 개괄적인 현황을 파악하고, 봉사대상 인구수와 도서관 웹 사이트 접속건수, 참고정보서비스 제공건수를 기준으로 선정된 4개의 대학에 실제 접수된 디지털 참고정보서비스의 질의유형, 답변의 구성형식, 정확성, 응답기간 등을 분석하였다. 본 연구의 결과가 대학도서관 디지털 참고정보서비스가 당면하고 있는 현실적 문제점을 파악하고, 이를 개선하기 위한 해결책으로 실제적인 지침과 모형개발의 기초자료로 활용되기를 기대한다.

• Journal of Nutrition and Health
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• 제45권3호
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• pp.283-292
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• 2012

Flavonoids have been hypothesized to reduce the risk of chronic diseases, but the lack of a flavonoid database hampered epidemiological studies addressing this issue in Korea. In this study, we developed a flavonoid database, based on a systematic review. A total of 1549 food items containing flavonoids were selected using the Korean Nutrient Database. Among them, flavonoid contents for only 649 food items were evaluated with analytical values and the remaining 900 items were replaced with adaptations or calculations from similar items. The developed flavonoid database covered 93.2% of fruits and fruit juices, 76.1% of vegetables, 98.4% of legumes and legume products, and 85.0% of all plant foods overall (1,549 items) as reported by the 24-hr dietary recall method regarding the 2008 Korean National Health and Nutrition Examination Survey. We found that this flavonoid database, overall, included 95.6% of all mainly consumed plant foods by Koreans. This flavonoid database is expected to be useful in regards to the correlation study of flavonoid intake and chronic diseases.

• 대한인간공학회지
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• 제34권2호
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• pp.103-113
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• 2015

Objective: This study proposes a systematic process to present the analysis methods and solutions of organizational root causes to human errors on the railroad. Background: In fact, organizational root cause such as organizational culture is an important factor in the safety concerns on human errors in the nuclear power plant, railroad and aircraft. Method: The proposed process is as follows: 1) define analysis boundary 2) select human error taxonomy 3) perform accident analysis 4) draw root causes with FGI 5) review root causes analysis with survey 6) chart analysis of root causes, and 7) propose alternatives and solutions. Results: As a result, root causes of the organizations like railroad and nuclear power plant came from the educational problems, violations, payoff system, safety culture and so forth. Conclusion: The proposed process does predict potential railroad accident through retrospect error analysis by building new human error taxonomies and problem solution. Application: This study would contribute to examination of the relationship between human error-based accidents and organizational root causes.

• Child Health Nursing Research
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• 제26권1호
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• pp.98-106
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• 2020

Purpose: This study utilized data from the Korean National Health and Nutrition Examination Survey (KNHANES) to explore differences in the timing of menarche in Korean girls according to blood heavy metal concentrations. Methods: This study performed a secondary analysis of cross-sectional data from the sixth KNHANES. Data from 179 female children and adolescents aged 10~18 were included in this study. The relationships of blood heavy metal concentrations (lead, mercury, and cadmium) with age of menarche were analyzed using complex sample multiple logistic regression. Results: In the participants of this study, the geometric mean values of blood lead, mercury, and cadmium concentrations were 1.15±0.04 ㎍/dL, 1.80±0.08 ㎍/L, and 0.30±0.03 ㎍/L, respectively. Mercury poisoning (>5 ㎍/L) was found in 1.5% of participants. Furthermore, significant relationships were found between blood lead and mercury concentrations and age at menarche (p for trend: p<.001 and p=.015, respectively). Conclusion: Through an analysis of national big data, this study found evidence that Korean girls showed a younger age at menarche in response to higher blood lead and mercury concentrations. To prevent and manage precocious puberty in Korean children and adolescents, a systematic policy that monitors both exposure to environmental hazards and blood heavy metal concentrations is needed.