• Korean Journal of Biological Psychiatry
• /
• v.7 no.2
• /
• pp.131-139
• /
• 2000

Even the pharmacotherapy is more effective than placebo for the treatment of depression, the outcome of pharmacoltherapy remains unsatisfactory for many patients. Apart from side effects, there are two major limitations of antidepressant therapy. One is the delayed onset of improvement and another is partial response. In order to address these clinical dilemmas, many psychiatrists more commonly employ add-on therapy. In past, the practice of using multiple drugs to enhance treatment response was called polypharamcy, and was disparaged as poor clinical practice. However, with improved understanding of how drugs affects the central nervous system and increased communication in journals and on computer networks about the relative merits of specific combinations, the scientific basis for the combining drugs is being defined. Indeed, the use of multiple medications as a stratege to enhance response has become both acceptable and widespread now a days. It is now referred to more positively as add-on therapy, co-medication, combination therapy, or drug augmentation. Thus, as the methods of practical strategies for treatment of depression, switching classes antidepressant drugs, combination therapy, augmentation strategies and brief treatment algorithm will be presented with items of considerations. However, when combination of drugs being tried, knowledges about the action of mechanism, pharamcokinetics, and pharmacodynamics are essential to cope with the possible adversive reactions and to get the appropriate responses for the treatment of depressive symptoms.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.26 no.9
• /
• pp.1312-1319
• /
• 2022

This paper defines an effectiveness index for optical continuous observation of unknown space objects and presents a range of design variables combinations that can satisfy the effectiveness index from a telescope/mount control system perspective using integrated simulation. The overall system-level simulation was implemented and the tracking performance was analyzed by considering design variables such as target position prediction and frame rate, image processing time and measurement error, target trajectory characteristics, and maneuver performance of mount gimbal. As a result of the analysis, it was confirmed that the continuous tracking performance of the optical observation system is dependent on the combination of frame rate and mount maneuver performance. In a situation where an optical observation system is designed or a similar system is implemented using COTS, an appropriate combination of parameters between design variables can be found through effectiveness analysis simulation as in this study.

• Archives of Plastic Surgery
• /
• v.47 no.5
• /
• pp.419-427
• /
• 2020

Background This study evaluated the Blossom system, an innovative self-filling, rate-controlled, pressure-responsive saline tissue expander (TE) system. We investigated the feasibility of utilizing this technology to facilitate implant-based and combined flap with implant-based breast reconstruction in comparison to conventional tissue expansion. Methods In this prospective, single-center, single-surgeon pilot study, participants underwent either implant-based breast reconstruction or a combination of autologous flap and implantbased breast reconstruction. Outcome measures included time to full expansion, complications, total expansion volume, and pain scores. Results Fourteen patients (TEs; n=22), were included in this study. The mean time to full expansion was 13.4 days (standard error of the mean [SEM], 1.3 days) in the combination group and 11.7 days (SEM, 1.4 days) in the implant group (P=0.78). The overall major complication rate was 4.5% (n=1). No statistically significant differences were found in the complication rate between the combination group and the implant group. The maximum patient-reported pain scores during the expansion process were low, but were significantly higher in the combination group (mean, 2.00±0.09) than in the implant group (mean, 0.29±0.25; P=0.005). Conclusions The reported average duration for conventional subcutaneous TE expansion is 79.4 days, but this pilot study using the Blossom system achieved an average expansion duration of less than 14 days in both groups. The Blossom system may accommodate single-stage breast reconstruction. The overall complication rate of this study was 4.5%, which is promising compared to the reported complication rates of two-stage breast reconstruction with TEs (20%-45%).

• Journal of the Institute of Electronics and Information Engineers
• /
• v.53 no.2
• /
• pp.62-69
• /
• 2016

This paper proposes to select Measure of Performance(MOP) for object attainment in the counterfire operation and deduce the reasonable combination of blue force's hitting resources satisfying MOP's optimal value and regression equation for the object achievement time. Also, in the study-methodological perspective, a series of procedures for drawing the regression equation from the real world is presented. Firstly the model was made by simplifying the weapon-system information of red force and blue force, then the time for object attainment was derived from its simulation. Simulating the model for the counterfire operation was divided into three phases-detection, decision and hitting. The probability method by applying the random numbers were used for detection, fixed constant numbers for decision and hitting. The simulation was repeatedly performed to get the minimum time for the object attainment against the fixed enemy, and it was estimated as the optimal value of simulation. From this result, the optimum combination of blue force's weapon system against the red force and finally, the regression equation were obtained by using the response surface analyzing method in MINITAB. Thereafter this equation was completely verified by using 'the 2-sample t-test.' As a result, the regression equation is suitable.

• Journal of Korea Multimedia Society
• /
• v.18 no.4
• /
• pp.460-472
• /
• 2015

Most of previous visual attention system finds attention regions based on saliency map which is combined by multiple extracted features. The differences of these systems are in the methods of feature extraction and combination. This paper presents a new system which has an improvement in feature extraction method of color and motion, and in weight decision method of spatial and temporal features. Our system dynamically extracts one color which has the strongest response among two opponent colors, and detects the moving objects not moving pixels. As a combination method of spatial and temporal feature, the proposed system sets the weight dynamically by each features' relative activities. Comparative results show that our suggested feature extraction and integration method improved the detection rate of attention region.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2014.05a
• /
• pp.196-197
• /
• 2014

Low carbon construction is an important operation management goal such as cost, time, and quality in construction community. This paper introduces a system which measures the variability of carbon dioxide amounts. First, this system allows creating construction operation models of which the level of detail is breakdown into the work task level. Second, the system implements sensitivity analysis along with a ranges of resources that are allocated in an operation model. It facilitates to find the optimal resource combination using the operation performances such as the amount of emissions, operation completion time, and cost. Lastly, it identifies the best fit probability distribution functions of performance criteria given a certain resource combination. It allows project manager to query the percentages to complete the operation within a limitation specified by the system users.

• Proceedings of the Korean Society for Agricultural Machinery Conference
• /
• 1996.06c
• /
• pp.658-667
• /
• 1996

A computer vision system was developed to automatically detect and locate the oyster hinge line, one step in shucking an oyster. The computer vision system consisted of a personal computer, a color frame grabber, a color CCD video camera with a zoom lens, two video monitor, a specially designed fixture to hold the oyster, a lighting system to illuminate the oyster and the system software. The software consisted of a combination of commercially available programs and custom designed programs developed using the Microsoft CTM . Test results showed that the image resolution was the most important variable influencing hinge detection efficiency. Whether or not the trimmed -off-flat-white surface area was dry or wet, the oyster size relative to the image size selected , and the image processing methods used all influenced the hinge locating efficiency. The best computer software and hardware combination used successfully located 97% of the oyster hinge lines tested. This efficienc was achieve using camera field of view of 1.9 by 1.5cm , a 180 by 170 pixel image window, and a dry trimmed -off oyster hinge end surface.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.12 no.6
• /
• pp.166-174
• /
• 2004

In urban area narrow commuter vehicles have attracted interest as a possible solution to reduce traffic congestion and parking problems. However, a narrow vehicle has an increased to overturn during hard cornering when compared to conventional vehicles. This tendency can be reduced by tilting it toward the inside of the turn. Two types of automatic tilting control systems which are Direct Tilt Control(DTC) and Steering Tilt Control(STC) have been developed. In this paper as one of the technique to improve the handling performance for the unusual vehicle the control system which blends both the DTC and the STC system is considered. It uses the merits of both the DTC and the STC system. As a control strategy for combination the switching control method is used. Finally, the fact that the unusual vehicle is safe under an emergency situation such as slippery road surface is proved by computer simulation.

• Smart Structures and Systems
• /
• v.10 no.1
• /
• pp.15-31
• /
• 2012

This study proposes an active control method to suppress beam-rotating machinery system vibrations. The present control method is a combination of the fuzzy input estimation method (FIEM) and linear quadratic Gaussian problem (LQG) algorithms. The FIEM can estimate the unknown input and optimal states by measuring the dynamic displacement, the optimal estimated states into the feedback control; thereby obtaining the optimal control force for a random linear system. Active vibration control of a beam-rotating machinery system is performed to verify the feasibility and effectiveness of the proposed algorithm. The simulation results demonstrate that the proposed method can suppress vibrations in a beam-machine system more efficiently than the conventional LQG method.

• Structural Engineering and Mechanics
• /
• v.75 no.1
• /
• pp.87-100
• /
• 2020

The present paper investigates the combination resonance behavior of imperfect spiral stiffened functionally graded (SSFG) cylindrical shells with internal and external functionally graded stiffeners under two-term large amplitude excitations. The structure is embedded within a generalized nonlinear viscoelastic foundation, which is composed of a two-parameter Winkler-Pasternak foundation augmented by a Kelvin-Voigt viscoelastic model with a nonlinear cubic stiffness, to account for the vibration hardening/softening phenomena and damping considerations. With regard to classical plate theory of shells, von-Kármán equation and Hook law, the relations of stress-strain are derived for shell and stiffeners. The spiral stiffeners of the cylindrical shell are modeled according to the smeared stiffener technique. According to the Galerkin method, the discretized motion equation is obtained. The combination resonance is obtained by using the multiple scales method. Finally, the influences of the stiffeners angles, foundation type, the nonlinear elastic foundation coefficients, material distribution, and excitation amplitude on the system resonances are investigated comprehensively.